LOCUS       NM_054110               5057 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens polypeptide N-acetylgalactosaminyltransferase 15
            (GALNT15), transcript variant 1, mRNA.
ACCESSION   NM_054110
VERSION     NM_054110.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5057)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5057)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 5057)
  AUTHORS   Cheng,L., Tachibana,K., Iwasaki,H., Kameyama,A., Zhang,Y.,
            Kubota,T., Hiruma,T., Tachibana,K., Kudo,T., Guo,J.M. and
            Narimatsu,H.
  TITLE     Characterization of a novel human UDP-GalNAc transferase,
            pp-GalNAc-T15
  JOURNAL   FEBS Lett 566 (1-3), 17-24 (2004)
   PUBMED   15147861
REFERENCE   4  (bases 1 to 5057)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 5057)
  AUTHORS   Kumar,S., Connor,J.R., Dodds,R.A., Halsey,W., Van Horn,M., Mao,J.,
            Sathe,G., Mui,P., Agarwal,P., Badger,A.M., Lee,J.C., Gowen,M. and
            Lark,M.W.
  TITLE     Identification and initial characterization of 5000 expressed
            sequenced tags (ESTs) each from adult human normal and
            osteoarthritic cartilage cDNA libraries
  JOURNAL   Osteoarthritis Cartilage 9 (7), 641-653 (2001)
   PUBMED   11597177
REFERENCE   6  (bases 1 to 5057)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK312425.1, AY035399.1 and AC090953.2.
            
            On Nov 23, 2018 this sequence version replaced NM_054110.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.61410.1,
                                           SRR1803615.237839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339732.10/ ENSP00000344260.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AK312425.1         5-290
            287-2599            AY035399.1         98-2410
            2600-4638           AC090953.2         103747-105785
            4639-5057           AC090953.2         105786-106204
FEATURES             Location/Qualifiers
     source          1..5057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1"
     gene            1..5057
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /note="polypeptide N-acetylgalactosaminyltransferase 15"
                     /db_xref="GeneID:117248"
                     /db_xref="HGNC:HGNC:21531"
                     /db_xref="MIM:615131"
     exon            1..1011
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..2392
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /EC_number="2.4.1.41"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UDP-GalNAc transferase T15;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 7; polypeptide
                     N-acetylgalactosaminyltransferase-like protein 2;
                     pregnancy-induced hypertension syndrome-related protein 5;
                     polypeptide N-acetylgalactosaminyltransferase 13;
                     galNAc-T-like protein 2; pp-GaNTase-like protein 2;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 15; polypeptide GalNAc
                     transferase 15; polypeptide GalNAc transferase-like
                     protein 2; protein-UDP
                     acetylgalactosaminyltransferase-like protein 2;
                     UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase-like protein 2;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase-like 2"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 15
                     isoform 1"
                     /protein_id="NP_473451.3"
                     /db_xref="CCDS:CCDS33711.1"
                     /db_xref="GeneID:117248"
                     /db_xref="HGNC:HGNC:21531"
                     /db_xref="MIM:615131"
                     /translation="MLLRKRYRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTV
                     TAQASKHSPEARYRLDFGESQDWVLEAEDEGEEYSPLEGLPPFISLREDQLLVAVALP
                     QARRNQSQGRRGGSYRLIKQPRRQDKEAPKRDWGADEDGEVSEEEELTPFSLDPRGLQ
                     EALSARIPLQRALPEVRHPLCLQQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTV
                     PRAFLKEIILVDDLSQQGQLKSALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATG
                     DVLVFMDAHCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLD
                     WKLDFHWEPLPEHVRKALQSPISPIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGE
                     NLELSFKAWLCGGSVEILPCSRVGHIYQNQDSHSPLDQEATLRNRVRIAETWLGSFKE
                     TFYKHSPEAFSLSKAEKPDCMERLQLQRRLGCRTFHWFLANVYPELYPSEPRPSFSGK
                     LHNTGLGLCADCQAEGDILGCPMVLAPCSDSRQQQYLQHTSRKEIHFGSPQHLCFAVR
                     QEQVILQNCTEEGLAIHQQHWDFQENGMIVHILSGKCMEAVVQENNKDLYLRPCDGKA
                     RQQWRFDQINAVDER"
     exon            1012..1178
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1383
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1551
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1669
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1864
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1996
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2101
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2245
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..5057
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3909..3914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /note="hexamer: AATAAA"
     polyA_site      3939
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /note="major polyA site"
     regulatory      4615..4620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /note="hexamer: AATAAA"
     polyA_site      4638
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /note="major polyA site"
     polyA_site      5057
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
ORIGIN      
        1 acatctgttg atctgacctg actggaagcg tccaaagagg gacggctgtc agccctgctt
       61 gactgagaac ccaccagctc atcccagaca cctcatagca acctatttat acaaaggggg
      121 aaagaaacac ctgagcagaa tggaatcatt atttttttcc caaggagaaa accggggtaa
      181 agggagggaa gcaattcaat ttgaagtccc tgtgaatggg ctttcagaag gcaattaaag
      241 aaatccactc agagaggact tggggtgaaa cttgggtcct gtggttttct gattgtaagt
      301 ggaagcaggt cttgcacacg ctgttggcaa atgtcaggac caggttaagt gactggcaga
      361 aaaacttcca ggtggaacaa gcaacccagg ttctgctgca agcttgaagg agcctggagc
      421 gggagaaagc taacttgaac atgacctgtt gcatttggca agttctagca acatgctcct
      481 aaggaagcga tacaggcaca gaccatgcag actccagttc ctcctgctgc tcctgatgct
      541 gggatgcgtc ctgatgatgg tggcgatgtt gcaccctccc caccacaccc tgcaccagac
      601 tgtcacagcc caagccagca agcacagccc tgaagccagg taccgcctgg actttgggga
      661 atcccaggat tgggtactgg aagctgagga tgagggtgaa gagtacagcc ctctggaggg
      721 cctgccaccc tttatctcac tgcgggagga tcagctgctg gtggccgtgg ccttacccca
      781 ggccagaagg aaccagagcc agggcaggag aggtgggagc taccgcctca tcaagcagcc
      841 aaggaggcag gataaggaag ccccaaagag ggactggggg gctgatgagg acggggaggt
      901 gtctgaagaa gaggagttga ccccgttcag cctggaccca cgtggcctcc aggaggcact
      961 cagtgcccgc atccccctcc agagggctct gcccgaggtg cggcacccac tgtgtctgca
     1021 gcagcaccct caggacagcc tgcccacagc cagcgtcatc ctctgtttcc atgatgaggc
     1081 ctggtccact ctcctgcgga ctgtacacag catcctcgac acagtgccca gggccttcct
     1141 gaaggagatc atcctcgtgg acgacctcag ccagcaagga caactcaagt ctgctctcag
     1201 cgaatatgtg gccaggctgg agggggtgaa gttactcagg agcaacaaga ggctgggtgc
     1261 catcagggcc cggatgctgg gggccaccag agccaccggg gatgtgctcg tcttcatgga
     1321 tgcccactgc gagtgccacc caggctggct ggagcccctc ctcagcagaa tagctggtga
     1381 caggagccga gtggtatctc cggtgataga tgtgattgac tggaagactt tccagtatta
     1441 cccctcaaag gacctgcagc gtggggtgtt ggactggaag ctggatttcc actgggaacc
     1501 tttgccagag catgtgagga aggccctcca gtcccccata agccccatca ggagccctgt
     1561 ggtgcccgga gaggtggtgg ccatggacag acattacttc caaaacactg gagcgtatga
     1621 ctctcttatg tcgctgcgag gtggtgaaaa cctcgaactg tctttcaagg cctggctctg
     1681 tggtggctct gttgaaatcc ttccctgctc tcgggtagga cacatctacc aaaatcagga
     1741 ttcccattcc cccctcgacc aggaggccac cctgaggaac agggttcgca ttgctgagac
     1801 ctggctgggg tcattcaaag aaaccttcta caagcatagc ccagaggcct tctccttgag
     1861 caaggctgag aagccagact gcatggaacg cttgcagctg caaaggagac tgggttgtcg
     1921 gacattccac tggtttctgg ctaatgtcta ccctgagctg tacccatctg aacccaggcc
     1981 cagtttctct ggaaagctcc acaacactgg acttgggctc tgtgcagact gccaggcaga
     2041 aggggacatc ctgggctgtc ccatggtgtt ggctccttgc agtgacagcc ggcagcaaca
     2101 gtacctgcag cacaccagca ggaaggagat tcactttggc agcccacagc acctgtgctt
     2161 tgctgtcagg caggagcagg tgattcttca gaactgcacg gaggaaggcc tggccatcca
     2221 ccagcagcac tgggacttcc aggagaatgg gatgattgtc cacattcttt ctgggaaatg
     2281 catggaagct gtggtgcaag aaaacaataa agatttgtac ctgcgtccgt gtgatggaaa
     2341 agcccgccag cagtggcgtt ttgaccagat caatgctgtg gatgaacgat gaatgtcaat
     2401 gtcagaagga aaagagaatt ttggccatca aaatccagct ccaagtgaac ttaaagagct
     2461 tatatatttc atgaagctga tccttttgtg tgtgtgctcc tggtgttagg agagaaaaaa
     2521 gctctatgaa agaatatagg aagtttctcc ttttcacacc ttatttcatt gactgctggc
     2581 tgctttaaaa aaaaaaaaaa aggatccatt gtaccgttgt cttcatcact gggaaatgat
     2641 tattacatag tacagaagat tctttgtttt tctccactga gcacttaaca attgctttct
     2701 ctctggcctg gacattctct ggcagcacct ccaggataca taaattcaat ggatcaattt
     2761 atttgtcttc aaatggcctt aacttggatt gtctgtttgg ccaaccatga aaattaaaga
     2821 gtgaagcaga tgtaatggcc tgacattcca aaaactctga attgggttta ttagcacaaa
     2881 tgttgtgttc atttgttgag ccatatctca gaagaaggaa agggagctac agaaaggagg
     2941 tttaggattg cagagaagat gcaagagcac tttggcccaa ttctccagct caacccagca
     3001 gctgaaaagc ttcaagagat ctaggaaaag acattttcat gttaatgaga atttccacca
     3061 ttgtagagaa tttccttcct actgagaatc tacctctatt ccccctgccc tagctcttct
     3121 ctaacttggt taaccataac cataaccaga ttcccttgca atcgatttct ctttagtcgt
     3181 tggtgttaga agtaccagca caatttgagc attcccatta acaaaggtgt tcacagttga
     3241 gaaactctcc tgccgggcgc ggtggctcat gcctgtaatt ccagcacttt gggaggcaga
     3301 gttgggagga tcacctgatg tcaggggttt gagaccagcc tggtcaacat tgcaaaacct
     3361 tgtctctact aaaaatacaa aaattagctg ggcatggtgg cgcatacctg taatcccagc
     3421 tacttgggag gctgaggcaa gagaatcgct tgaacccagg aggcagaggt tgcagtgagc
     3481 tgagatcatg ccattgcact ccaacctggg tgacagagtg agactccatc tcaaaaaaaa
     3541 aaaaaaagag agaaactctc ctgatgccct gttacagggt ttgcactgac tggagcagaa
     3601 acagcaacct ttctaaaaaa gcaaaccttt ttcctgggag gaaaatgcca gagcctgagc
     3661 caaaattctt atgacaggta acatttgggt gttaatgtcc atgagagctg acagggccat
     3721 ctctgagccc atataactgt ctggaacccc caaatgtgtc cacaggttga atgtccatga
     3781 gtgtgggaag aacacggctc atctggagca cagctgaggc tagtaagagc taaatgactt
     3841 tccttgctat gacttggctt acctgaatta gctgtaagag ttgccgaatg ggatgggttc
     3901 tgctatttaa taaacagcat tcatattcat ttttccccag atggagttac ctacctttcc
     3961 acatggtcag cttagaaatc ttcccctaaa gatgctaatc tcctttgggc tgtctcagaa
     4021 cacagtatcc ttcaaataag aaaaactgag tgggaagtgc agtgtttcca aacaatacct
     4081 atcataacta cgtattcatt gtctacctgc taagtcaagg gttcactgca tttctccttc
     4141 ctcagaatac actctggacc tgtgctgtct aatatggtag ccactaacaa aatgtggcca
     4201 ttttgatgga aatccattaa aatcaaagaa aatttaaaac tcaattcctc aattgggctg
     4261 gccacatttc aaatgctcac tacccacctg tggctagggt ctacttctac tgtattggcg
     4321 agcatggata tagaacattt catcacagtt ctgttggacc aatctagata gattcattat
     4381 cccatctaga gaagagactt tagtcactgt cttcttgctt cagacccatc tatatttaaa
     4441 acaaatttcc ctaaatcctg agactgagac ggagctacaa attctcagat ggcgaccgtg
     4501 taaatggtat tagcggctga agaaaaaaaa tttttcaaga cctctgtttt ttaactgaac
     4561 tttatcattg gcattgtggg tctttgaagt tgctgggata aattaatata attaaataaa
     4621 agactgaatt taattgcata aattgtatta ggtggcaatt aacaaaagga cccagatggc
     4681 ttattgccta attgggtgaa caaagcaaga atatggtgtt tcttgcttcc ttaaccagct
     4741 ccatgattta ttactttatt gcagaagtgg ctgtcaactc agtccctggc tggtatttac
     4801 agacccttaa tttaagtaaa acagatgcct ccatttagtt ctagaaggac cttctccttt
     4861 agtgtaacca agtgttcaaa ttcccttctt ctctatgaac tcagcattca ttttatccat
     4921 aatgatcaat ttaaaagtag agaaacttgt cagttgagag atctgattcc caagagattg
     4981 gtttcacttg tctacctgaa ttttgtgatt ggattttgtt gttcgttttt taagattgaa
     5041 ttttgttacc accccca
//
