LOCUS       NM_001319052            3325 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens polypeptide N-acetylgalactosaminyltransferase 15
            (GALNT15), transcript variant 3, mRNA.
ACCESSION   NM_001319052
VERSION     NM_001319052.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3325)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3325)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3325)
  AUTHORS   Cheng,L., Tachibana,K., Iwasaki,H., Kameyama,A., Zhang,Y.,
            Kubota,T., Hiruma,T., Tachibana,K., Kudo,T., Guo,J.M. and
            Narimatsu,H.
  TITLE     Characterization of a novel human UDP-GalNAc transferase,
            pp-GalNAc-T15
  JOURNAL   FEBS Lett 566 (1-3), 17-24 (2004)
   PUBMED   15147861
REFERENCE   4  (bases 1 to 3325)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 3325)
  AUTHORS   Kumar,S., Connor,J.R., Dodds,R.A., Halsey,W., Van Horn,M., Mao,J.,
            Sathe,G., Mui,P., Agarwal,P., Badger,A.M., Lee,J.C., Gowen,M. and
            Lark,M.W.
  TITLE     Identification and initial characterization of 5000 expressed
            sequenced tags (ESTs) each from adult human normal and
            osteoarthritic cartilage cDNA libraries
  JOURNAL   Osteoarthritis Cartilage 9 (7), 641-653 (2001)
   PUBMED   11597177
REFERENCE   6  (bases 1 to 3325)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090953.2, BC030625.1, BQ005863.1, BG926921.1, BQ014148.1,
            DA358505.1 and BX088662.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001319052.1.
            
            Transcript Variant: This variant (3) lacks several exons in the 5'
            coding region, and uses an alternate 5'-terminal exon and a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (3) has a shorter N-terminus than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030625.1, BG722206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC090953.2         92809-92861
            54-604              BC030625.1         53-603
            605-869             BQ005863.1         4-268               c
            870-1814            BC030625.1         866-1810
            1815-2207           BG926921.1         201-593
            2208-2528           BQ014148.1         395-715             c
            2529-3067           DA358505.1         21-559
            3068-3325           BX088662.1         216-473
FEATURES             Location/Qualifiers
     source          1..3325
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1"
     gene            1..3325
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /note="polypeptide N-acetylgalactosaminyltransferase 15"
                     /db_xref="GeneID:117248"
                     /db_xref="HGNC:HGNC:21531"
                     /db_xref="MIM:615131"
     exon            1..132
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            133..264
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..660
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /EC_number="2.4.1.41"
                     /note="isoform 3 is encoded by transcript variant 3;
                     UDP-GalNAc transferase T15;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 7; polypeptide
                     N-acetylgalactosaminyltransferase-like protein 2;
                     pregnancy-induced hypertension syndrome-related protein 5;
                     polypeptide N-acetylgalactosaminyltransferase 13;
                     galNAc-T-like protein 2; pp-GaNTase-like protein 2;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 15; polypeptide GalNAc
                     transferase 15; polypeptide GalNAc transferase-like
                     protein 2; protein-UDP
                     acetylgalactosaminyltransferase-like protein 2;
                     UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase-like protein 2;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase-like 2"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 15
                     isoform 3"
                     /protein_id="NP_001305981.1"
                     /db_xref="GeneID:117248"
                     /db_xref="HGNC:HGNC:21531"
                     /db_xref="MIM:615131"
                     /translation="MERLQLQRRLGCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGL
                     GLCADCQAEGDILGCPMVLAPCSDSRQQQYLQHTSRKEIHFGSPQHLCFAVRQEQVIL
                     QNCTEEGLAIHQQHWDFQENGMIVHILSGKCMEAVVQENNKDLYLRPCDGKARQQWRF
                     DQINAVDER"
     exon            265..369
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            370..513
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     exon            514..3325
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2177..2182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /note="hexamer: AATAAA"
     polyA_site      2207
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /note="major polyA site"
     regulatory      2883..2888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /note="hexamer: AATAAA"
     polyA_site      2906
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
                     /note="major polyA site"
     polyA_site      3325
                     /gene="GALNT15"
                     /gene_synonym="GALNACT15; GALNT13; GALNT7; GALNTL2; PIH5;
                     pp-GalNAc-T15"
ORIGIN      
        1 gttaccagtt gcgcattccc ggaggaaggt catgtaccag ttaaacgcca ccattttgcc
       61 tcttagtgca catgcttgag cccacttgcc caactcctga gatcatatcg ggaagctgat
      121 caccaatttc aggctgagaa gccagactgc atggaacgct tgcagctgca aaggagactg
      181 ggttgtcgga cattccactg gtttctggct aatgtctacc ctgagctgta cccatctgaa
      241 cccaggccca gtttctctgg aaagctccac aacactggac ttgggctctg tgcagactgc
      301 caggcagaag gggacatcct gggctgtccc atggtgttgg ctccttgcag tgacagccgg
      361 cagcaacagt acctgcagca caccagcagg aaggagattc actttggcag cccacagcac
      421 ctgtgctttg ctgtcaggca ggagcaggtg attcttcaga actgcacgga ggaaggcctg
      481 gccatccacc agcagcactg ggacttccag gagaatggga tgattgtcca cattctttct
      541 gggaaatgca tggaagctgt ggtgcaagaa aacaataaag atttgtacct gcgtccgtgt
      601 gatggaaaag cccgccagca gtggcgtttt gaccagatca atgctgtgga tgaacgatga
      661 atgtcaatgt cagaaggaaa agagaatttt ggccatcaaa atccagctcc aagtgaactt
      721 aaagagctta tatatttcat gaagctgatc cttttgtgtg tgtgctcctg gtgttaggag
      781 agaaaaaagc tctatgaaag aatataggaa gtttctcctt ttcacacctt atttcattga
      841 ctgctggctg ctttaaaaaa aaaaaaaaag gatccattgt accgttgtct tcatcactgg
      901 gaaatgatta ttacatagta cagaagattc tttgtttttc tccactgagc acttaacaat
      961 tgctttctct ctggcctgga cattctctgg cagcacctcc aggatacata aattcaatgg
     1021 atcaatttat ttgtcttcaa atggccttaa cttggattgt ctgtttggcc aaccatgaaa
     1081 attaaagagt gaagcagatg taatggcctg acattccaaa aactctgaat tgggtttatt
     1141 agcacaaatg ttgtgttcat ttgttgagcc atatctcaga agaaggaaag ggagctacag
     1201 aaaggaggtt taggattgca gagaagatgc aagagcactt tggcccaatt ctccagctca
     1261 acccagcagc tgaaaagctt caagagatct aggaaaagac attttcatgt taatgagaat
     1321 ttccaccatt gtagagaatt tccttcctac tgagaatcta cctctattcc ccctgcccta
     1381 gctcttctct aacttggtta accataacca taaccagatt cccttgcaat cgatttctct
     1441 ttagtcgttg gtgttagaag taccagcaca atttgagcat tcccattaac aaaggtgttc
     1501 acagttgaga aactctcctg ccgggcgcgg tggctcatgc ctgtaattcc agcactttgg
     1561 gaggcagagt tgggaggatc acctgatgtc aggggtttga gaccagcctg gtcaacattg
     1621 caaaaccttg tctctactaa aaatacaaaa attagctggg catggtggcg catacctgta
     1681 atcccagcta cttgggaggc tgaggcaaga gaatcgcttg aacccaggag gcagaggttg
     1741 cagtgagctg agatcatgcc attgcactcc aacctgggtg acagagtgag actccatctc
     1801 aaaaaaaaaa aaaaagagag aaactctcct gatgccctgt tacagggttt gcactgactg
     1861 gagcagaaac agcaaccttt ctaaaaaagc aaaccttttt cctgggagga aaatgccaga
     1921 gcctgagcca aaattcttat gacaggtaac atttgggtgt taatgtccat gagagctgac
     1981 agggccatct ctgagcccat ataactgtct ggaaccccca aatgtgtcca caggttgaat
     2041 gtccatgagt gtgggaagaa cacggctcat ctggagcaca gctgaggcta gtaagagcta
     2101 aatgactttc cttgctatga cttggcttac ctgaattagc tgtaagagtt gccgaatggg
     2161 atgggttctg ctatttaata aacagcattc atattcattt ttccccagat ggagttacct
     2221 acctttccac atggtcagct tagaaatctt cccctaaaga tgctaatctc ctttgggctg
     2281 tctcagaaca cagtatcctt caaataagaa aaactgagtg ggaagtgcag tgtttccaaa
     2341 caatacctat cataactacg tattcattgt ctacctgcta agtcaagggt tcactgcatt
     2401 tctccttcct cagaatacac tctggacctg tgctgtctaa tatggtagcc actaacaaaa
     2461 tgtggccatt ttgatggaaa tccattaaaa tcaaagaaaa tttaaaactc aattcctcaa
     2521 ttgggctggc cacatttcaa atgctcacta cccacctgtg gctagggtct acttctactg
     2581 tattggcgag catggatata gaacatttca tcacagttct gttggaccaa tctagataga
     2641 ttcattatcc catctagaga agagacttta gtcactgtct tcttgcttca gacccatcta
     2701 tatttaaaac aaatttccct aaatcctgag actgagacgg agctacaaat tctcagatgg
     2761 cgaccgtgta aatggtatta gcggctgaag aaaaaaaatt tttcaagacc tctgtttttt
     2821 aactgaactt tatcattggc attgtgggtc tttgaagttg ctgggataaa ttaatataat
     2881 taaataaaag actgaattta attgcataaa ttgtattagg tggcaattaa caaaaggacc
     2941 cagatggctt attgcctaat tgggtgaaca aagcaagaat atggtgtttc ttgcttcctt
     3001 aaccagctcc atgatttatt actttattgc agaagtggct gtcaactcag tccctggctg
     3061 gtatttacag acccttaatt taagtaaaac agatgcctcc atttagttct agaaggacct
     3121 tctcctttag tgtaaccaag tgttcaaatt cccttcttct ctatgaactc agcattcatt
     3181 ttatccataa tgatcaattt aaaagtagag aaacttgtca gttgagagat ctgattccca
     3241 agagattggt ttcacttgtc tacctgaatt ttgtgattgg attttgttgt tcgtttttta
     3301 agattgaatt ttgttaccac cccca
//
