LOCUS       NM_024572               2447 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens polypeptide N-acetylgalactosaminyltransferase 14
            (GALNT14), transcript variant 1, mRNA.
ACCESSION   NM_024572
VERSION     NM_024572.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2447)
  AUTHORS   Zhan,S., Qiu,M., Wei,X., Wei,J., Qin,L., Jiang,B., Wen,Q., Chen,P.,
            Lin,Q., Wei,X., Zhou,Z., Jiang,Y., Liang,X., Li,R., Liu,Y. and
            Yu,H.
  TITLE     Potentially functional genetic variants in ferroptosis-related
            CREB3 and GALNT14 genes predict survival of hepatitis B
            virus-related hepatocellular carcinoma
  JOURNAL   Cancer Med 13 (1), e6848 (2024)
   PUBMED   38151984
  REMARK    GeneRIF: Potentially functional genetic variants in
            ferroptosis-related CREB3 and GALNT14 genes predict survival of
            hepatitis B virus-related hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 2447)
  AUTHORS   Chu,Y.D., Fan,T.C., Lai,M.W. and Yeh,C.T.
  TITLE     GALNT14-mediated O-glycosylation on PHB2 serine-161 enhances cell
            growth, migration and drug resistance by activating IGF1R cascade
            in hepatoma cells
  JOURNAL   Cell Death Dis 13 (11), 956 (2022)
   PUBMED   36376274
  REMARK    GeneRIF: GALNT14-mediated O-glycosylation on PHB2 serine-161
            enhances cell growth, migration and drug resistance by activating
            IGF1R cascade in hepatoma cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2447)
  AUTHORS   Li,H.W., Liu,M.B., Jiang,X., Song,T., Feng,S.X., Wu,J.Y., Deng,P.F.
            and Wang,X.Y.
  TITLE     GALNT14 regulates ferroptosis and apoptosis of ovarian cancer
            through the EGFR/mTOR pathway
  JOURNAL   Future Oncol 18 (2), 149-161 (2022)
   PUBMED   34643088
  REMARK    GeneRIF: GALNT14 regulates ferroptosis and apoptosis of ovarian
            cancer through the EGFR/mTOR pathway.
REFERENCE   4  (bases 1 to 2447)
  AUTHORS   Yu,Y., Wang,Z., Zheng,Q. and Li,J.
  TITLE     GALNT2/14 overexpression correlate with prognosis and methylation:
            potential therapeutic targets for lung adenocarcinoma
  JOURNAL   Gene 790, 145689 (2021)
   PUBMED   33964375
  REMARK    GeneRIF: GALNT2/14 overexpression correlate with prognosis and
            methylation: potential therapeutic targets for lung adenocarcinoma.
REFERENCE   5  (bases 1 to 2447)
  AUTHORS   Lin,W.R. and Yeh,C.T.
  TITLE     GALNT14: An Emerging Marker Capable of Predicting Therapeutic
            Outcomes in Multiple Cancers
  JOURNAL   Int J Mol Sci 21 (4), 1491 (2020)
   PUBMED   32098271
  REMARK    GeneRIF: GALNT14: An Emerging Marker Capable of Predicting
            Therapeutic Outcomes in Multiple Cancers.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2447)
  AUTHORS   Wu,C., Guo,X., Wang,W., Wang,Y., Shan,Y., Zhang,B., Song,W., Ma,S.,
            Ge,J., Deng,H. and Zhu,M.
  TITLE     N-Acetylgalactosaminyltransferase-14 as a potential biomarker for
            breast cancer by immunohistochemistry
  JOURNAL   BMC Cancer 10, 123 (2010)
   PUBMED   20356418
  REMARK    GeneRIF: Results provide evidence that GalNAc-T14 may be a
            potential biomarker for breast cancer by immunohistochemistry.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2447)
  AUTHORS   Stern,H.M., Padilla,M., Wagner,K., Amler,L. and Ashkenazi,A.
  TITLE     Development of immunohistochemistry assays to assess GALNT14 and
            FUT3/6 in clinical trials of dulanermin and drozitumab
  JOURNAL   Clin Cancer Res 16 (5), 1587-1596 (2010)
   PUBMED   20179215
  REMARK    GeneRIF: GALNT14 and FUT3/6 H-scores were significantly higher in
            non-small cell lung cancer cell lines sensitive to dulanermin and
            drozitumab versus resistant cell lines
REFERENCE   8  (bases 1 to 2447)
  AUTHORS   Wu,C., Shan,Y., Liu,X., Song,W., Wang,J., Zou,M., Wang,M. and Xu,D.
  TITLE     GalNAc-T14 may be involved in regulating the apoptotic action of
            IGFBP-3
  JOURNAL   J Biosci 34 (3), 389-395 (2009)
   PUBMED   19805900
  REMARK    GeneRIF: GALNT14 may be involved in regulating the apoptotic action
            of IGFBP-3.
REFERENCE   9  (bases 1 to 2447)
  AUTHORS   Wu,C., Yao,G., Zou,M., Chen,G., Wang,M., Liu,J., Wang,J. and Xu,D.
  TITLE     N-Acetylgalactosaminyltransferase 14, a novel insulin-like growth
            factor binding protein-3 binding partner
  JOURNAL   Biochem Biophys Res Commun 357 (2), 360-365 (2007)
   PUBMED   17434446
  REMARK    GeneRIF: The role of GalNAc-T14 as an intracellular mediator of the
            effects of IGFBP-3 need to be verified in future studies.
REFERENCE   10 (bases 1 to 2447)
  AUTHORS   Wang,H., Tachibana,K., Zhang,Y., Iwasaki,H., Kameyama,A., Cheng,L.,
            Guo,Jm., Hiruma,T., Togayachi,A., Kudo,T., Kikuchi,N. and
            Narimatsu,H.
  TITLE     Cloning and characterization of a novel UDP-GalNAc:polypeptide
            N-acetylgalactosaminyltransferase, pp-GalNAc-T14
  JOURNAL   Biochem Biophys Res Commun 300 (3), 738-744 (2003)
   PUBMED   12507512
  REMARK    GeneRIF: cloning and characterization; results provide evidence
            that pp-GalNAc-T14 is a new member of the pp-GalNAc-T family and
            suggest that it may be involved in the O-glycosylation in kidney
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC010659.1 and AY358758.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024572.3.
            
            Summary: This gene encodes a Golgi protein which is a member of the
            polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein
            family. These enzymes catalyze the transfer of
            N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines
            and threonines in target peptides. The encoded protein has been
            shown to transfer GalNAc to large proteins like mucins. Alterations
            in this gene may play a role in cancer progression and response to
            chemotherapy. [provided by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358758.1, BC010659.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349752.10/ ENSP00000288988.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-845               BC010659.1         287-1131
            846-2447            AY358758.1         825-2426
FEATURES             Location/Qualifiers
     source          1..2447
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.1"
     gene            1..2447
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /note="polypeptide N-acetylgalactosaminyltransferase 14"
                     /db_xref="GeneID:79623"
                     /db_xref="HGNC:HGNC:22946"
                     /db_xref="MIM:608225"
     exon            1..483
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..2013
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /EC_number="2.4.1.41"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
                     T10; polypeptide N-acetylgalactosaminyltransferase 15;
                     pp-GaNTase 14; polypeptide GalNAc transferase 14;
                     protein-UDP acetylgalactosaminyltransferase 14;
                     UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
                     14; UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 14 (GalNAc-T14)"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 14
                     isoform 1"
                     /protein_id="NP_078848.2"
                     /db_xref="CCDS:CCDS1773.2"
                     /db_xref="GeneID:79623"
                     /db_xref="HGNC:HGNC:22946"
                     /db_xref="MIM:608225"
                     /translation="MRRLTRRLVLPVFGVLWITVLLFFWVTKRKLEVPTGPEVQTPKP
                     SDADWDDLWDQFDERRYLNAKKWRVGDDPYKLYAFNQRESERISSNRAIPDTRHLRCT
                     LLVYCTDLPPTSIIITFHNEARSTLLRTIRSVLNRTPTHLIREIILVDDFSNDPDDCK
                     QLIKLPKVKCLRNNERQGLVRSRIRGADIAQGTTLTFLDSHCEVNRDWLQPLLHRVKE
                     DYTRVVCPVIDIINLDTFTYIESASELRGGFDWSLHFQWEQLSPEQKARRLDPTEPIR
                     TPIIAGGLFVIDKAWFDYLGKYDMDMDIWGGENFEISFRVWMCGGSLEIVPCSRVGHV
                     FRKKHPYVFPDGNANTYIKNTKRTAEVWMDEYKQYYYAARPFALERPFGNVESRLDLR
                     KNLRCQSFKWYLENIYPELSIPKESSIQKGNIRQRQKCLESQRQNNQETPNLKLSPCA
                     KVKGEDAKSQVWAFTYTQQILQEELCLSVITLFPGAPVVLVLCKNGDDRQQWTKTGSH
                     IEHIASHLCLDTDMFGDGTENGKEIVVNPCESSLMSQHWDMVSS"
     exon            484..653
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            654..752
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            753..820
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            821..886
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1008
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1096
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1181
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1285
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1412
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1505
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1589
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1734
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1854
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2447
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2417..2422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /note="hexamer: AATAAA"
     polyA_site      2447
                     /gene="GALNT14"
                     /gene_synonym="GalNac-T10; GalNac-T14; GALNT15"
                     /note="major polyA site"
ORIGIN      
        1 gtttccctat cggcggcagc gggcaaggcg gcggcggcgg cggcggcagc cgcggtggcg
       61 gcgtggggaa catctcggca gccaccgcgc ttctcccgct ggagcgggcg tccagcttgg
      121 ctgccctcgg tccttccctg ccacgtttcg ggtcgccctg caccccccac ccaggctcgc
      181 ttctcttcga agcgggaagg gcgccttgca ggatcctgcc gcccctccaa ccggatcctg
      241 ggtctagagc tccccagagc gaggcgctcg ccaggactcc tgccccgcca accctgaccg
      301 ccggggggtg cccccgggac gtagcgccgc ggagaggaag cggcaaaggg gaccatgcgg
      361 cgcctgactc gtcggctggt tctgccagtc ttcggggtgc tctggatcac ggtgctgctg
      421 ttcttctggg taaccaagag gaagttggag gtgccgacgg gacctgaagt gcagacccct
      481 aagccttcgg acgctgactg ggacgacctg tgggaccagt ttgatgagcg gcggtatctg
      541 aatgccaaaa agtggcgcgt tggtgacgac ccctataagc tgtatgcttt caaccagcgg
      601 gagagtgagc ggatctccag caatcgggcc atcccggaca ctcgccatct gagatgcaca
      661 ctgctggtgt attgcacgga ccttccaccc actagcatca tcatcacctt ccacaacgag
      721 gcccgctcca cgctgctcag gaccatccgc agtgtattaa accgcacccc tacgcatctg
      781 atccgggaaa tcatattagt ggatgacttc agcaatgacc ctgatgactg taaacagctc
      841 atcaagttgc ccaaggtgaa atgcttgcgc aataatgaac ggcaaggtct ggtccggtcc
      901 cggattcggg gcgctgacat cgcccagggc accactctga ctttcctcga cagccactgt
      961 gaggtgaaca gggactggct ccagcctctg ttgcacaggg tcaaagagga ctacacgcgg
     1021 gtggtgtgcc ctgtgatcga tatcattaac ctggacacct tcacctacat cgagtctgcc
     1081 tcggagctca gaggggggtt tgactggagc ctccacttcc agtgggagca gctctcccca
     1141 gagcagaagg ctcggcgcct ggaccccacg gagcccatca ggactcctat catagctgga
     1201 gggctcttcg tgatcgacaa agcttggttt gattacctgg ggaaatatga tatggacatg
     1261 gacatctggg gtggggagaa ctttgaaatc tccttccgag tgtggatgtg cgggggcagc
     1321 ctagagatcg tcccctgcag ccgagtgggg cacgtcttcc ggaagaagca cccctacgtt
     1381 ttccctgatg gaaatgccaa cacgtatata aagaacacca agcggacagc tgaagtgtgg
     1441 atggatgaat acaagcaata ctattacgct gcccggccat tcgccctgga gaggcccttc
     1501 gggaatgttg agagcagatt ggacctgagg aagaatctgc gctgccagag cttcaagtgg
     1561 tacctggaga atatctaccc tgaactcagc atccccaagg agtcctccat ccagaagggc
     1621 aatatccgac agagacagaa gtgcctggaa tctcaaaggc agaacaacca agaaacccca
     1681 aacctaaagt tgagcccctg tgccaaggtc aaaggcgaag atgcaaagtc ccaggtatgg
     1741 gccttcacat acacccagca gatcctccag gaggagctgt gcctgtcagt catcaccttg
     1801 ttccctggcg ccccagtggt tcttgtcctt tgcaagaatg gagatgaccg acagcaatgg
     1861 accaaaactg gttcccacat cgagcacata gcatcccacc tctgcctcga tacagatatg
     1921 ttcggtgatg gcaccgagaa cggcaaggaa atcgtcgtca acccatgtga gtcctcactc
     1981 atgagccagc actgggacat ggtgagctct tgaggacccc tgccagaagc agcaagggcc
     2041 atggggtggt gcttccctgg accagaacag actggaaact gggcagcaag cagcctgcaa
     2101 ccacctcaga catcctggac tgggaggtgg aggcagagcc ccccaggaca ggagcaactg
     2161 tctcagggag gacagaggaa aacatcacaa gccaatgggg ctcaaagaca aatcccacat
     2221 gttctcaagg ccgttaagtt ccagtcctgg ccagtcattc cctgattggt atctggagac
     2281 agaaacctaa tgggaagtgt ttattgttcc ttttcctaca aaggaagcag tctctggagg
     2341 ccagaaagaa aagccttctt tttcactagg ccaggactac attgagagat gaagaatgga
     2401 ggttgtttcc aaaagaaata aagagaaact tagaagttgt ctctgga
//
