LOCUS       NM_198321               5958 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens polypeptide N-acetylgalactosaminyltransferase 10
            (GALNT10), mRNA.
ACCESSION   NM_198321
VERSION     NM_198321.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5958)
  AUTHORS   Zhao,F.Y., Zhang,Q., Wang,J.M., Jiang,J.Y., Huyan,L.Y., Liu,B.Q.,
            Yan,J., Li,C. and Wang,H.Q.
  TITLE     BAG3 epigenetically regulates GALNT10 expression via WDR5 and
            facilitates the stem cell-like properties of platin-resistant
            ovarian cancer cells
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (9), 119077 (2021)
   PUBMED   34111434
  REMARK    GeneRIF: BAG3 epigenetically regulates GALNT10 expression via WDR5
            and facilitates the stem cell-like properties of platin-resistant
            ovarian cancer cells.
REFERENCE   2  (bases 1 to 5958)
  AUTHORS   Liu,Z., Pan,L., Yan,X. and Duan,X.
  TITLE     The long noncoding RNA DLGAP1-AS2 facilitates cholangiocarcinoma
            progression via miR-505 and GALNT10
  JOURNAL   FEBS Open Bio 11 (2), 413-422 (2021)
   PUBMED   33301605
  REMARK    GeneRIF: The long noncoding RNA DLGAP1-AS2 facilitates
            cholangiocarcinoma progression via miR-505 and GALNT10.
REFERENCE   3  (bases 1 to 5958)
  AUTHORS   Xu,G., Wu,Y.L., Li,N., Xu,R., Zhang,J.B., Ming,H. and Zhang,Y.
  TITLE     GALNT10 promotes the proliferation and metastatic ability of
            gastric cancer and reduces 5-fluorouracil sensitivity by activating
            HOXD13
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (22), 11610-11619 (2020)
   PUBMED   33275228
  REMARK    GeneRIF: GALNT10 promotes the proliferation and metastatic ability
            of gastric cancer and reduces 5-fluorouracil sensitivity by
            activating HOXD13.
REFERENCE   4  (bases 1 to 5958)
  AUTHORS   Zhang,G., Lu,J., Yang,M., Wang,Y., Liu,H. and Xu,C.
  TITLE     Elevated GALNT10 expression identifies immunosuppressive
            microenvironment and dismal prognosis of patients with high grade
            serous ovarian cancer
  JOURNAL   Cancer Immunol Immunother 69 (2), 175-187 (2020)
   PUBMED   31853576
  REMARK    GeneRIF: high GALNT10 expression confers with immunosuppressive
            microenvironment to promote tumor progression and predicts poor
            clinical outcomes in HGSC patients.
REFERENCE   5  (bases 1 to 5958)
  AUTHORS   Liu,L., Xiong,Y., Xi,W., Wang,J., Qu,Y., Lin,Z., Chen,X., Yao,J.,
            Xu,J. and Guo,J.
  TITLE     Prognostic role of N-Acetylgalactosaminyltransferase 10 in
            metastatic renal cell carcinoma
  JOURNAL   Oncotarget 8 (9), 14995-15003 (2017)
   PUBMED   28122358
  REMARK    GeneRIF: identified that GALNT10 was an independent prognostic
            factor for overall survival
REFERENCE   6  (bases 1 to 5958)
  AUTHORS   Monda,K.L., Chen,G.K., Taylor,K.C., Palmer,C., Edwards,T.L.,
            Lange,L.A., Ng,M.C., Adeyemo,A.A., Allison,M.A., Bielak,L.F.,
            Chen,G., Graff,M., Irvin,M.R., Rhie,S.K., Li,G., Liu,Y., Liu,Y.,
            Lu,Y., Nalls,M.A., Sun,Y.V., Wojczynski,M.K., Yanek,L.R.,
            Aldrich,M.C., Ademola,A., Amos,C.I., Bandera,E.V., Bock,C.H.,
            Britton,A., Broeckel,U., Cai,Q., Caporaso,N.E., Carlson,C.S.,
            Carpten,J., Casey,G., Chen,W.M., Chen,F., Chen,Y.D., Chiang,C.W.,
            Coetzee,G.A., Demerath,E., Deming-Halverson,S.L., Driver,R.W.,
            Dubbert,P., Feitosa,M.F., Feng,Y., Freedman,B.I., Gillanders,E.M.,
            Gottesman,O., Guo,X., Haritunians,T., Harris,T., Harris,C.C.,
            Hennis,A.J., Hernandez,D.G., McNeill,L.H., Howard,T.D.,
            Howard,B.V., Howard,V.J., Johnson,K.C., Kang,S.J., Keating,B.J.,
            Kolb,S., Kuller,L.H., Kutlar,A., Langefeld,C.D., Lettre,G.,
            Lohman,K., Lotay,V., Lyon,H., Manson,J.E., Maixner,W., Meng,Y.A.,
            Monroe,K.R., Morhason-Bello,I., Murphy,A.B., Mychaleckyj,J.C.,
            Nadukuru,R., Nathanson,K.L., Nayak,U., N'diaye,A., Nemesure,B.,
            Wu,S.Y., Leske,M.C., Neslund-Dudas,C., Neuhouser,M., Nyante,S.,
            Ochs-Balcom,H., Ogunniyi,A., Ogundiran,T.O., Ojengbede,O.,
            Olopade,O.I., Palmer,J.R., Ruiz-Narvaez,E.A., Palmer,N.D.,
            Press,M.F., Rampersaud,E., Rasmussen-Torvik,L.J.,
            Rodriguez-Gil,J.L., Salako,B., Schadt,E.E., Schwartz,A.G.,
            Shriner,D.A., Siscovick,D., Smith,S.B., Wassertheil-Smoller,S.,
            Speliotes,E.K., Spitz,M.R., Sucheston,L., Taylor,H., Tayo,B.O.,
            Tucker,M.A., Van Den Berg,D.J., Edwards,D.R., Wang,Z.,
            Wiencke,J.K., Winkler,T.W., Witte,J.S., Wrensch,M., Wu,X.,
            Yang,J.J., Levin,A.M., Young,T.R., Zakai,N.A., Cushman,M.,
            Zanetti,K.A., Zhao,J.H., Zhao,W., Zheng,Y., Zhou,J., Ziegler,R.G.,
            Zmuda,J.M., Fernandes,J.K., Gilkeson,G.S., Kamen,D.L., Hunt,K.J.,
            Spruill,I.J., Ambrosone,C.B., Ambs,S., Arnett,D.K., Atwood,L.,
            Becker,D.M., Berndt,S.I., Bernstein,L., Blot,W.J., Borecki,I.B.,
            Bottinger,E.P., Bowden,D.W., Burke,G., Chanock,S.J., Cooper,R.S.,
            Ding,J., Duggan,D., Evans,M.K., Fox,C., Garvey,W.T.,
            Bradfield,J.P., Hakonarson,H., Grant,S.F., Hsing,A., Chu,L.,
            Hu,J.J., Huo,D., Ingles,S.A., John,E.M., Jordan,J.M.,
            Kabagambe,E.K., Kardia,S.L., Kittles,R.A., Goodman,P.J.,
            Klein,E.A., Kolonel,L.N., Le Marchand,L., Liu,S., McKnight,B.,
            Millikan,R.C., Mosley,T.H., Padhukasahasram,B., Williams,L.K.,
            Patel,S.R., Peters,U., Pettaway,C.A., Peyser,P.A., Psaty,B.M.,
            Redline,S., Rotimi,C.N., Rybicki,B.A., Sale,M.M., Schreiner,P.J.,
            Signorello,L.B., Singleton,A.B., Stanford,J.L., Strom,S.S.,
            Thun,M.J., Vitolins,M., Zheng,W., Moore,J.H., Williams,S.M.,
            Ketkar,S., Zhu,X., Zonderman,A.B., Kooperberg,C.,
            Papanicolaou,G.J., Henderson,B.E., Reiner,A.P., Hirschhorn,J.N.,
            Loos,R.J., North,K.E. and Haiman,C.A.
  CONSRTM   NABEC Consortium; UKBEC Consortium; BioBank Japan Project; AGEN
            Consortium
  TITLE     A meta-analysis identifies new loci associated with body mass index
            in individuals of African ancestry
  JOURNAL   Nat Genet 45 (6), 690-696 (2013)
   PUBMED   23583978
REFERENCE   7  (bases 1 to 5958)
  AUTHORS   Ng,M.C., Hester,J.M., Wing,M.R., Li,J., Xu,J., Hicks,P.J.,
            Roh,B.H., Lu,L., Divers,J., Langefeld,C.D., Freedman,B.I.,
            Palmer,N.D. and Bowden,D.W.
  TITLE     Genome-wide association of BMI in African Americans
  JOURNAL   Obesity (Silver Spring) 20 (3), 622-627 (2012)
   PUBMED   21701570
REFERENCE   8  (bases 1 to 5958)
  AUTHORS   Perrine,C.L., Ganguli,A., Wu,P., Bertozzi,C.R., Fritz,T.A.,
            Raman,J., Tabak,L.A. and Gerken,T.A.
  TITLE     Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc
            T10), involved in mucin-type O-glycosylation, has a unique
            GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in
            ppGalNAc T1 or T2
  JOURNAL   J Biol Chem 284 (30), 20387-20397 (2009)
   PUBMED   19460755
  REMARK    GeneRIF: GalNAc T10 has a large and pronounced glycopeptide
            preference for Ser/Thr-O-GalNAc only at the +1 position from the
            acceptor site, whereas T1 and T2 have significantly reduced and
            variable preferences for Ser/Thr-O-GalNAc.
REFERENCE   9  (bases 1 to 5958)
  AUTHORS   Raman,J., Fritz,T.A., Gerken,T.A., Jamison,O., Live,D., Liu,M. and
            Tabak,L.A.
  TITLE     The catalytic and lectin domains of UDP-GalNAc:polypeptide
            alpha-N-Acetylgalactosaminyltransferase function in concert to
            direct glycosylation site selection
  JOURNAL   J Biol Chem 283 (34), 22942-22951 (2008)
   PUBMED   18562306
  REMARK    GeneRIF: sequence recognition by the catalytic domain differs
            between hT2 and hT10 in that hT10 requires a pre-existing GalNAc
            residue while hT2 does not
REFERENCE   10 (bases 1 to 5958)
  AUTHORS   Cheng,L., Tachibana,K., Zhang,Y., Guo,Jm., Kahori Tachibana,K.,
            Kameyama,A., Wang,H., Hiruma,T., Iwasaki,H., Togayachi,A., Kudo,T.
            and Narimatsu,H.
  TITLE     Characterization of a novel human UDP-GalNAc transferase,
            pp-GalNAc-T10
  JOURNAL   FEBS Lett 531 (2), 115-121 (2002)
   PUBMED   12417297
  REMARK    GeneRIF: Molecular cloning and characterization of pp-GalNAc-T10 as
            a UDP-GalNAc transferase.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010295.7, BC050333.1,
            AJ505950.1, AC008625.5 and BQ549377.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198321.3.
            
            Summary: This gene encodes a member of the GalNAc polypeptide
            N-acetylgalactosaminyltransferases. These enzymes catalyze the
            first step in the synthesis of mucin-type oligosaccharides. These
            proteins transfer GalNAc from UDP-GalNAc to either serine or
            threonine residues of polypeptide acceptors. The protein encoded by
            this locus may have increased catalytic activity toward
            glycosylated peptides compared to activity toward non-glycosylated
            peptides.[provided by RefSeq, Apr 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127135.1, AB078145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297107.11/ ENSP00000297107.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC010295.7         7494-7495           c
            3-134               BC050333.1         1-132
            135-1946            AJ505950.1         1-1812
            1947-5316           AC008625.5         39296-42665         c
            5317-5958           BQ549377.1         17-658              c
FEATURES             Location/Qualifiers
     source          1..5958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.2"
     gene            1..5958
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /note="polypeptide N-acetylgalactosaminyltransferase 10"
                     /db_xref="GeneID:55568"
                     /db_xref="HGNC:HGNC:19873"
                     /db_xref="MIM:608043"
     exon            1..293
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1946
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /EC_number="2.4.1.41"
                     /note="GalNAc transferase 10; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 10;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 10 (GalNAc-T10)"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase
                     10"
                     /protein_id="NP_938080.1"
                     /db_xref="CCDS:CCDS4325.1"
                     /db_xref="GeneID:55568"
                     /db_xref="HGNC:HGNC:19873"
                     /db_xref="MIM:608043"
                     /translation="MRRKEKRLLQAVALVLAALVLLPNVGLWALYRERQPDGTPGGSG
                     AAVAPAAGQGSHSRQKKTFFLGDGQKLKDWHDKEAIRRDAQRVGNGEQGRPYPMTDAE
                     RVDQAYRENGFNIYVSDKISLNRSLPDIRHPNCNSKRYLETLPNTSIIIPFHNEGWSS
                     LLRTVHSVLNRSPPELVAEIVLVDDFSDREHLKKPLEDYMALFPSVRILRTKKREGLI
                     RTRMLGASVATGDVITFLDSHCEANVNWLPPLLDRIARNRKTIVCPMIDVIDHDDFRY
                     ETQAGDAMRGAFDWEMYYKRIPIPPELQKADPSDPFESPVMAGGLFAVDRKWFWELGG
                     YDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSRVGHIYRKYVPYKVPAGVSLARNLKR
                     VAEVWMDEYAEYIYQRRPEYRHLSAGDVAVQKKLRSSLNCKSFKWFMTKIAWDLPKFY
                     PPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLEGCVRGRGEAAWNNMQVFTFTWR
                     EDIRPGDPQHTKKFCFDAISHTSPVTLYDCHSMKGNQLWKYRKDKTLYHPVSGSCMDC
                     SESDHRIFMNTCNPSSLTQQWLFEHTNSTVLEKFNRN"
     exon            294..396
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     exon            397..535
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     exon            536..702
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     exon            703..888
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1072
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1190
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1298
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1520
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1637
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1787
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..5958
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5934..5939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /note="hexamer: AGTAAA"
     polyA_site      5958
                     /gene="GALNT10"
                     /gene_synonym="GALNACT10; PPGALNACT10; PPGANTASE10"
                     /note="major polyA site"
ORIGIN      
        1 gagttggagc ggggccggcg ccgcagccgc ttctgctggc tgagctgctg ccgccgccgg
       61 gcggacgggc ggacgcgcgg agctgggggc ggcgcggcgg ggccggcggg gcgcggcggg
      121 gctgaccggc cccgatgagg cggaaggaga agcggctcct gcaggcggtg gcgctggtgc
      181 tggcggccct ggtcctcctg cccaacgtgg ggctttgggc gctgtaccgc gagcggcagc
      241 ccgacggcac ccctggggga tcgggggcgg cggtggcgcc ggcggcggga cagggctcac
      301 acagtcgaca aaagaaaacg tttttcttgg gagatgggca gaagctgaag gactggcatg
      361 acaaggaggc catccggagg gacgctcagc gcgtaggaaa tggagaacaa ggaagacctt
      421 accccatgac cgatgctgag agagtggatc aggcataccg agaaaatgga tttaacatct
      481 acgtcagtga taaaatctcc ttgaatcgct ctctcccaga tatccggcac ccaaactgca
      541 acagcaagcg ctacctggag acacttccca acacaagcat catcatcccc ttccacaacg
      601 agggctggtc ctccctcctc cgcaccgtcc acagtgtgct caatcgctcg cctccagagc
      661 tggtcgccga gattgtactg gtcgacgact tcagtgatcg agagcacctg aagaagcctc
      721 ttgaagacta catggccctt ttccccagtg tgaggattct tcgaaccaag aaacgggaag
      781 ggctgataag gacccgaatg ctgggggcct cagtggcaac tggggatgtc atcacattct
      841 tggattcaca ctgtgaagcc aatgtcaact ggcttccccc cttgcttgac cgcattgctc
      901 ggaaccgcaa gaccattgtg tgcccgatga ttgatgtaat tgaccatgac gactttcggt
      961 acgagacaca ggcaggggat gccatgcggg gagcctttga ctgggagatg tactacaagc
     1021 ggatcccgat ccctccagaa ctgcagaaag ctgaccccag cgacccattt gagtctcccg
     1081 tgatggccgg tggactgttc gccgtggatc ggaagtggtt ctgggaactc ggcgggtatg
     1141 acccaggctt ggagatctgg ggaggggagc agtatgaaat ctccttcaag gtgtggatgt
     1201 gtgggggccg catggaggac atcccctgct ccagggtggg ccatatctac aggaagtatg
     1261 tgccctacaa ggtcccggcc ggagtcagcc tggcccggaa ccttaagcgg gtggccgaag
     1321 tgtggatgga tgagtacgca gagtacattt accagcgccg gcctgaatac cgccacctct
     1381 ccgctgggga tgtcgcagtc cagaaaaagc tccgcagctc ccttaactgc aagagtttca
     1441 agtggtttat gacgaagata gcctgggacc tgcccaaatt ctacccaccc gtggagcccc
     1501 cggctgcagc ttggggggag atccgaaatg tgggcacagg gctgtgtgca gacacaaagc
     1561 acggggcctt gggctcccca ctaaggctag agggctgcgt ccgaggccgt ggggaggctg
     1621 cctggaacaa catgcaggta ttcaccttca cctggagaga ggacatccgg cctggagacc
     1681 cccagcacac caagaagttc tgctttgatg ccatttccca caccagccct gtcacgctgt
     1741 acgactgcca cagcatgaag ggcaaccagc tgtggaaata ccgcaaagac aagaccctgt
     1801 accaccctgt cagtggcagc tgcatggact gcagtgaaag tgaccatagg atcttcatga
     1861 acacctgcaa cccatcctct ctcacccagc agtggctgtt tgaacacacc aactcaacag
     1921 tcttggaaaa attcaatagg aactgagccc tcatgtcccc ttggcaggcc ccccagggtc
     1981 tggcactcac tgcagacttc ctctttcaag ggaggcaggg cccctgtggg cactaggtgt
     2041 aaaaggtgct ggccaaatgg ttcagggtga agagggctct tgattcaggg gctggggtct
     2101 gcctggtcct tgagcccctg agttgtgggg gtagggtgaa gagcatatcc cacaagaggc
     2161 cccacaggga gcagagactg ctttaatccc tgctgacatc acggaaaagc aacagagcct
     2221 tttcaacttt gtcactatgt ccccttgaac attatgtggg agaacaccaa ggtagcctag
     2281 gccacccaaa agtgagtcct gcgaggttgc ccagccctca gatggctctc ctacatgatg
     2341 gtgctttaga aacaaaggta aaatttgcct gtttggggca gcttttagta tcgatgccac
     2401 tcatctgcag cagaagagaa agaagtcctc ttggggcttt ttagtttctg ccgtcctggg
     2461 gggaacattg cagttactgc acagcttctg ttctctgtca caaccccagg tgatttggtc
     2521 cggtcaaagg ccatacttgg ggccctaaga gtgttcagta ttgaatgctg atcagctgcc
     2581 aggtgaggag tcagaagagg gagcccccct agacatttct ttgcagctat ggacatgcgg
     2641 gatatctccc cctgctctct gggtatttga aatgtcaatt ttagcactct ccaggcacaa
     2701 ggacagccca gcaccagctt tacagggcag tgtttcagat ggccctgagc ccacggaaaa
     2761 ggccaggtag acctccaaac tagaaatgct ggctgatttg ccctgatcca tgcttccatt
     2821 tccctgtctc tcttccccag gcaattactg gcctcaaaag aggaacagag gtgctgcgag
     2881 gtgctcacct cacagagtct ggaggcctcc aggatcaact gtgggcaaag tgcctgcctc
     2941 tgacctcatc atggttctag ttctcataca gaactccaga atttttaaag aactctataa
     3001 ttggattgca aactaggatg ctacatagga ttctggtatt ccacatccaa tatggatttc
     3061 tagaatgctg tgattaaagg agccagccag gtgtaataca gtcaaggcag cccccagcct
     3121 agagacaatc tgtgaaatcc aaagttggtg gtgttgggaa agcaggggga catgtgtccc
     3181 tcagctcagc agaggctgtg gtacaacatg gtccttggtg aagacctgca cccctggaac
     3241 ctcccaccat catcacaact gtagtctcat ttgcagtgga gaaaagaacc cgacgtccca
     3301 cagccagata tacacccagc tccatgccag cccttcatgt ttaccttttg ctttgttaat
     3361 tacatgtcag actcctagag ggcctccaga ctaataggaa gcatttctgt aaccaacctg
     3421 ccacccactg attcagaaat ggaaatcaca ttccacaatc tatggcttcc accagctagc
     3481 ccaggaaata cttgaaatca gcattccaat tagtgttgag tctcttgatt gtgtcattta
     3541 ccaattaaat aactgagacc taagtctggg aacagagcca cgaatctgcc tttgagatgc
     3601 tggcagatct caaggccatc aattattggg ggagggaggg acaaacactc ccaatcatcc
     3661 accagtcaga ctgaatgtgt agctggcgag gaattacttc cacttctggc ccagcacaag
     3721 ccctgctttg gccacctgtc tgcaagagag gcggcccctg tgcttgcaac gcttacgtgt
     3781 tgatcccagt gtccttttcc aaatgagtgc tgtagcttta gaagtggccc tctatagaaa
     3841 gaagtcaaaa gatgaggccc cttctagaat ctaggataac aagagtgttg acagtttgag
     3901 gagtcgaatt gagattcatc atcaaagagc aatgcagcgt cgttaaaata aaaactgtgc
     3961 cttttaaaaa gaaaaatgca aatatagagc aaatccctaa acttgaacca tttcctagtg
     4021 ccttgctaga caaacataaa ggggcagggt tgtggggagg ggaacgtttt tggtggtgtg
     4081 tgcagttcct actggatgag tgtgtgtttc ttaatgtctc atttcaagca ggagatgttg
     4141 ggtctggagc aagatctgag actgagatgt cccccaaggg tgacaggtca gatttatttc
     4201 agtcagtgca agtcacactc caaactaaag gctgggcagt gcgtttagtc tgtggcctag
     4261 aagacctcat cagcccccga gaggaggcct tgcattacct cactgggacc tgtttggggg
     4321 ccatccctgc ggtccaccct ctgaaccccc agcatgtttg tcctgtttct caccattggg
     4381 ttaaggggtg ccgagcacta gctagacttc cacatagtcc caccccaagt gggcggcagt
     4441 gttcctggca tgaccaggat tcctgtgaaa gcaggagcag cagcaagccg tcccgggcct
     4501 gcctttccca tcctttggtt ctcctttcca gtctgggttc acaccctgaa aagggatggg
     4561 tgtgtcctct gagcactctg gcatttgtca ttgctgagcc catatcagta ggtcctggga
     4621 cttgacaaag tatgtgggag gggaaggaag gacagaactt gactggctcc atttcatgga
     4681 ccaactgatc aattgccagt actaagccac tcattgttat ggcttccttt ttgaaaacca
     4741 cctgtctcaa ggattcaggt ttctgctcac atccccagct gatgctcaat aaaactcagc
     4801 caggagcata tggagatgct gacagccagg taatgggtga gactgtgggg tcccttttcc
     4861 tctaaagcct ttactctgag gataaggtca caaagtaggg tgtgacttga aagtatcgtg
     4921 accatgtggc ccaccagcag cctttccaaa ggggaactcc agagacattt cataatgcaa
     4981 acagcactgt tgctttaaga acaaggcctt tggaggtggc taaacttgca cgcacgtgtg
     5041 tgaaaagcca tcccatcttc tgcctccagt tggagctttc agctgttaaa acagtcagaa
     5101 actattgatt cttcccttta ggaaaaaatg ctcaggcaga acggggtaca tccacaggag
     5161 gaatcggacg agaggatgtg acattcggtc caggagagaa agagcagttt ctgttaaaga
     5221 tgtaacaaat ggatttccaa agtctacatg acattcactt ttcaaacttc ccaccagttg
     5281 aatttctttt tttccttaag aaacaggtga tgtcttggaa aacagctcct tatgtctctc
     5341 tgtgcatctc cattttccta gtctctggag tctcaaaaag agtggcaaag cactttacag
     5401 tagtaactga ggaatcagag tctctgcttc agcgatatct agtttgtaca gttgggtgat
     5461 cttttgtaat tcctaggagg taatgcattt ttaatgtttt ctgaagcttt gtaagtgtga
     5521 gagagggaca agaagtgcag ttctgttctg gaattcctta ttgctttcaa cggacactct
     5581 ttgtgaaaaa tccaagtaat attttagttc aaacttgatc ttgagccaag gcccactgcc
     5641 acctctggga tgggagtcgg acctacatac caagtgacaa gttcacctta acatctgctt
     5701 ccagaatggc tttgattcag ccgtgccagg caacagaaca gggtcagact cctgctctgt
     5761 tattggcttg aagactagga tcccaaaggg gttggaggca gggaatattt gaaaattcag
     5821 actggaattc caggccaaaa gctcaagacc accagcctct cctcctgcct ggaaaaataa
     5881 gcctttgtga aagactgatt taccatgtac aattgtgatt gtgaacgttg ttgagtaaac
     5941 ctccagactt tctctaaa
//
