LOCUS       NM_020474               3970 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens polypeptide N-acetylgalactosaminyltransferase 1
            (GALNT1), transcript variant 1, mRNA.
ACCESSION   NM_020474
VERSION     NM_020474.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3970)
  AUTHORS   Zhang,J., Wang,H., Wu,J., Yuan,C., Chen,S., Liu,S., Huo,M.,
            Zhang,C. and He,Y.
  TITLE     GALNT1 Enhances Malignant Phenotype of Gastric Cancer via
            Modulating CD44 Glycosylation to Activate the Wnt/beta-catenin
            Signaling Pathway
  JOURNAL   Int J Biol Sci 18 (16), 6068-6083 (2022)
   PUBMED   36439876
  REMARK    GeneRIF: GALNT1 Enhances Malignant Phenotype of Gastric Cancer via
            Modulating CD44 Glycosylation to Activate the Wnt/beta-catenin
            Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3970)
  AUTHORS   Zhang,L., Lv,B., Shi,X. and Gao,G.
  TITLE     High Expression of N-Acetylgalactosaminyl-transferase 1 (GALNT1)
            Associated with Invasion, Metastasis, and Proliferation in
            Osteosarcoma
  JOURNAL   Med Sci Monit 26, e927837 (2020)
   PUBMED   33284788
  REMARK    GeneRIF: High Expression of N-Acetylgalactosaminyl-transferase 1
            (GALNT1) Associated with Invasion, Metastasis, and Proliferation in
            Osteosarcoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3970)
  AUTHORS   Fang,R., Xu,F., Shi,H., Wu,Y., Cao,C., Li,H., Ye,K., Zhang,Y.,
            Liu,Q., Zhang,S., Zhang,W. and Ye,L.
  TITLE     LAMTOR5 raises abnormal initiation of O-glycosylation in breast
            cancer metastasis via modulating GALNT1 activity
  JOURNAL   Oncogene 39 (11), 2290-2304 (2020)
   PUBMED   31836847
  REMARK    GeneRIF: LAMTOR5 raises abnormal initiation of O-glycosylation in
            breast cancer metastasis via modulating GALNT1 activity.
REFERENCE   4  (bases 1 to 3970)
  AUTHORS   Simon,E.J. and Linstedt,A.D.
  TITLE     Site-specific glycosylation of Ebola virus glycoprotein by human
            polypeptide GalNAc-transferase 1 induces cell adhesion defects
  JOURNAL   J Biol Chem 293 (51), 19866-19873 (2018)
   PUBMED   30389789
  REMARK    GeneRIF: a mechanism of Ebola GP-induced cell detachment that
            depends solely on ectodomain bulkiness and identify a single
            host-derived glycosylation enzyme, ppGalNAc-T1
REFERENCE   5  (bases 1 to 3970)
  AUTHORS   Shan,Y., Ma,J., Pan,Y., Hu,J., Liu,B. and Jia,L.
  TITLE     LncRNA SNHG7 sponges miR-216b to promote proliferation and liver
            metastasis of colorectal cancer through upregulating GALNT1
  JOURNAL   Cell Death Dis 9 (7), 722 (2018)
   PUBMED   29915311
  REMARK    GeneRIF: SNHG7 positively regulated GALNT1 level through sponging
            miR-216b, and played an oncogenic role in colorectal cancer
            progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3970)
  AUTHORS   Bennett,E.P., Hassan,H. and Clausen,H.
  TITLE     cDNA cloning and expression of a novel human
            UDP-N-acetyl-alpha-D-galactosamine. Polypeptide
            N-acetylgalactosaminyltransferase, GalNAc-t3
  JOURNAL   J Biol Chem 271 (29), 17006-17012 (1996)
   PUBMED   8663203
REFERENCE   7  (bases 1 to 3970)
  AUTHORS   Meurer,J.A., Drong,R.F., Homa,F.L., Slightom,J.L. and Elhammer,A.P.
  TITLE     Organization of a human UDP-GalNAc:polypeptide,
            N-acetylgalactosaminyltransferase gene and a related processed
            pseudogene
  JOURNAL   Glycobiology 6 (2), 231-241 (1996)
   PUBMED   8727794
REFERENCE   8  (bases 1 to 3970)
  AUTHORS   White,T., Bennett,E.P., Takio,K., Sorensen,T., Bonding,N. and
            Clausen,H.
  TITLE     Purification and cDNA cloning of a human
            UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase
  JOURNAL   J Biol Chem 270 (41), 24156-24165 (1995)
   PUBMED   7592619
REFERENCE   9  (bases 1 to 3970)
  AUTHORS   Meurer,J.A., Naylor,J.M., Baker,C.A., Thomsen,D.R., Homa,F.L. and
            Elhammer,A.P.
  TITLE     cDNA cloning, expression, and chromosomal localization of a human
            UDP-GalNAc:polypeptide, N-acetylgalactosaminyltransferase
  JOURNAL   J Biochem 118 (3), 568-574 (1995)
   PUBMED   8690719
REFERENCE   10 (bases 1 to 3970)
  AUTHORS   Paulson,J.C. and Colley,K.J.
  TITLE     Glycosyltransferases. Structure, localization, and control of cell
            type-specific glycosylation
  JOURNAL   J Biol Chem 264 (30), 17615-17618 (1989)
   PUBMED   2681181
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090220.13 and AC090229.15.
            
            On Jun 18, 2020 this sequence version replaced NM_020474.3.
            
            Summary: This gene encodes a member of the
            UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes.
            GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi
            apparatus by catalyzing the transfer of GalNAc to serine and
            threonine residues on target proteins. They are characterized by an
            N-terminal transmembrane domain, a stem region, a lumenal catalytic
            domain containing a GT1 motif and Gal/GalNAc transferase motif, and
            a C-terminal ricin/lectin-like domain. GalNAc-Ts have different,
            but overlapping, substrate specificities and patterns of
            expression. Transcript variants derived from this gene that utilize
            alternative polyA signals have been described in the literature.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2537545.1, U41514.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269195.6/ ENSP00000269195.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC090220.13        64787-64909
            124-365             AC090220.13        137607-137848
            366-540             AC090220.13        146675-146849
            541-707             AC090220.13        160638-160804
            708-915             AC090220.13        166438-166645
            916-1086            AC090220.13        170063-170233
            1087-1204           AC090220.13        172220-172337
            1205-1385           AC090220.13        174059-174239
            1386-1525           AC090220.13        175228-175367
            1526-1624           AC090220.13        185944-186042
            1625-1759           AC090220.13        186556-186690
            1760-3423           AC090220.13        192671-194334
            3424-3970           AC090229.15        41208-41754
FEATURES             Location/Qualifiers
     source          1..3970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..3970
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /note="polypeptide N-acetylgalactosaminyltransferase 1"
                     /db_xref="GeneID:2589"
                     /db_xref="HGNC:HGNC:4123"
                     /db_xref="MIM:602273"
     exon            1..123
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            124..365
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1906
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /EC_number="2.4.1.41"
                     /note="UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 1; GalNAc transferase 1;
                     protein-UDP acetylgalactosaminyltransferase 1; pp-GaNTase
                     1; polypeptide GalNAc transferase 1;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 1 (GalNAc-T1)"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 1"
                     /protein_id="NP_065207.2"
                     /db_xref="CCDS:CCDS11915.1"
                     /db_xref="GeneID:2589"
                     /db_xref="HGNC:HGNC:4123"
                     /db_xref="MIM:602273"
                     /translation="MRKFAYCKVVLATSLIWVLLDMFLLLYFSECNKCDEKKERGLPA
                     GDVLEPVQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPDVR
                     LEGCKTKVYPDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASER
                     DFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSKGQVITFLDAHCECTVGW
                     LEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMD
                     RRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTL
                     EIVTCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVD
                     YGDISSRVGLRHKLQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKE
                     NEKVGIFNCHGMGGNQVFSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEY
                     DPVKLTLQHVNSNQCLDKATEEDSQVPSIRDCNGSRSQQWLLRNVTLPEIF"
     exon            366..540
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..707
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..915
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1086
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1204
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1385
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1525
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1624
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1759
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..3970
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /note="hexamer: AATAAA"
     polyA_site      3132
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
     regulatory      3737..3742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /note="hexamer: AATAAA"
     polyA_site      3760
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /note="major polyA site"
     regulatory      3924..3929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /note="hexamer: ATTAAA"
     regulatory      3950..3955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
                     /note="hexamer: AATACA"
     polyA_site      3958
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
     polyA_site      3970
                     /gene="GALNT1"
                     /gene_synonym="GALNAC-T1"
ORIGIN      
        1 agtggccgag gagcgcgcgg cggacggcgg cccgagagta gcgcgctggc cgcgggaccg
       61 gccgcgaccg ccgcggccgg cccggaggac gcctgccgcc gccgccgccg cgcgcctagc
      121 gagggtatga acgtgatttc tgatgaaact ggattggaat aattttcatg atctttgtat
      181 atttatatat atatattttt aaattttgca tttgacttaa agtgccatga gaaaatttgc
      241 atactgcaag gtggtcctag ccacctcctt gatttgggta ctcttggata tgttcctgct
      301 gctttacttc agtgaatgca acaaatgtga tgaaaaaaag gagagaggac ttcctgctgg
      361 agatgttcta gagccagtac aaaagcctca tgaaggtcct ggagaaatgg ggaaaccagt
      421 cgtcattcct aaagaggatc aagaaaagat gaaagagatg tttaaaatca atcagttcaa
      481 tttaatggca agtgagatga ttgcactcaa cagatcttta ccagatgtta ggttagaagg
      541 gtgtaaaaca aaggtgtatc cagataatct tcctacaaca agtgtggtga ttgttttcca
      601 caatgaggct tggagcacac ttctgcgaac tgtccatagt gtcattaatc gctcaccaag
      661 acacatgata gaagaaattg ttctagtaga tgatgccagt gaaagagact ttttgaaaag
      721 gcctttagag agttatgtga aaaaactaaa agtaccagtt catgtaattc gaatggaaca
      781 acgttctgga ttgatcagag ctagattaaa aggagctgct gtgtctaaag gccaagtgat
      841 caccttcctg gatgcccatt gtgagtgtac agtgggatgg ctggagcctc tcttggccag
      901 gatcaaacat gacaggagaa cagtggtgtg tcccatcatc gatgtgatca gtgatgatac
      961 ttttgagtac atggcaggct ctgatatgac ctatggtggg ttcaactgga agctcaattt
     1021 tcgctggtat cctgttcccc aaagagaaat ggacagaagg aaaggtgatc ggactcttcc
     1081 tgtcaggaca cctaccatgg caggaggcct tttttcaata gacagagatt actttcagga
     1141 aattggaaca tatgatgctg gaatggatat ttggggagga gaaaacctag aaatttcctt
     1201 taggatttgg cagtgtggag gaactttgga aattgttaca tgctcacatg ttggacatgt
     1261 gtttcggaaa gctacacctt acacgtttcc aggaggcaca gggcagatta tcaataaaaa
     1321 taacagacga cttgcagaag tgtggatgga tgaattcaag aatttcttct atataatttc
     1381 tccaggtgtt acaaaggtag attatggaga tatatcgtca agagttggtc taagacacaa
     1441 actacaatgc aaaccttttt cctggtacct agagaatata tatcctgatt ctcaaattcc
     1501 acgtcactat ttctcattgg gagagatacg aaatgtggaa acgaatcagt gtctagataa
     1561 catggctaga aaagagaatg aaaaagttgg aatttttaat tgccatggta tggggggtaa
     1621 tcaggttttc tcttatactg ccaacaaaga aattagaaca gatgaccttt gcttggatgt
     1681 ttccaaactt aatggcccag ttacaatgct caaatgccac cacctaaaag gcaaccaact
     1741 ctgggagtat gacccagtga aattaaccct gcagcatgtg aacagtaatc agtgcctgga
     1801 taaagccaca gaagaggata gccaggtgcc cagcattaga gactgcaatg gaagtcggtc
     1861 ccagcagtgg cttcttcgaa acgtcaccct gccagaaata ttctgagacc aaatttacaa
     1921 aaaaacgaaa aaaataagga ttgactgggc tacctcagca tacatttctg ccacattctt
     1981 aagtagcaaa aaaggaaaag tgctttcctc ctctgcagga tgtaaggttt atcagccatt
     2041 aaaacttaga cttctctagc ttttcactag ctgtgaacca gccttcctgt ccatggacgt
     2101 gaaactgcat agtaatgaga ctgtgcacac tgatgtttac aagattgaaa gagtctttct
     2161 ccgaaaatca tggtaaagaa tactgagaca atgaaaaaaa atcaacaaaa tatgctttct
     2221 ggagaactgt accttttatg gtttgcttgc acatcagtag tttctgctga acgtgctgtc
     2281 ataatgaaga gatttccaag attttttttc ctgattagaa ctggtagcca gtatattaaa
     2341 tattgatata aaaataaaag aactggaacc agattcagaa tcatgaaaac aacattttta
     2401 caacaacaaa aaaactatat taaacagggt ttaaaggaaa ttaaaacaga actatgagaa
     2461 gtacaatttg ttatagtata gtatcaaatt tctatataga ttttatacct cagtggggaa
     2521 aaataactga ttccaatgac attcattttg ttttcatctg tgatagtcat ggatgctttt
     2581 attttccttg gggtgctgaa attgagctga aaaaaaaagg ctctttgaat atagttttaa
     2641 tttctctcta cagttttttt tgtttggttt gtgggctgtt ggaattgtaa tttttaattg
     2701 ccttctaaaa aatggaaatt taacaatgtc tgatctcagc tgaacaaatt agatgtttca
     2761 gttgctcttg ggtcaactgg cttacagatt tacatgtgca cacacacaca aatttcttat
     2821 cacattttcg acttcttcac ttgacctaac tgattatgcg aaatacccaa gattcatgct
     2881 actgtaccac agatttgttt tcacagcaat aaatcttcag ttctttgttt atgattccac
     2941 ttaacaaaag gcctgcagaa gtgatttatt atttgggtat ttggagataa tacatttgat
     3001 ggttttttgg aaaacctttt tcactccata ctcagatatg cttcattgtc aaatgcatat
     3061 ttagattaga ttattgaatt gtaatgttta tctgctgctt tttttaaata aaatttgact
     3121 gaaaatgttt aattggcatt ttttaatgac ttagccaaag aagtgcagct attattccat
     3181 attaataggc ttgcatttct tttcctaaat cttatttagg ctaaatcagt tttatttttc
     3241 tctgattttt tttaatacca cagaatcacc tgagtgtcaa ttgaaagttg tcaattaaaa
     3301 ggtaaccttt taatctcgta ggaggaatct cattaagaca tttttcctga tatgtagagc
     3361 agtctgttgg caaaaatgca tatattttct ttcatatttg taaaattata tttaatggaa
     3421 ttcttttctt tgattatcaa ggactttcac tgcaggcagt gctatttctt gtgcctaaga
     3481 atgtttccaa aagtcgcatc gctaatgata tttgccaagt tgagtgtaca caaagtttct
     3541 catatcctgt tcaagttaat caacatcaag cacatgggga tgctttaggg tgagtctata
     3601 gtacaaaatg cataaaccat gtccccagga aatttgaaag gaagcaggtg ctgaatggaa
     3661 tttttttcct tttccatgag ctgtgttaat tctatctcca gtaggcctaa tgcttgaata
     3721 agcaagatgt ctaatcaata aattattttc atgctcagaa tttcaggttt ttgtactcca
     3781 gcatagcttg gtcttatttc ttactgtatg aaagcttaac agcaatgtga tttaaggttt
     3841 tgttttaaat gggagatgta agtgatttaa ttcatgggta cttttagaac ctgatagata
     3901 atcccattgc ctttattttt ctaattaaag aattcctaaa tactttgaaa atacaaaata
     3961 ttcctgaata
//
