LOCUS       NM_024637               2405 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens galactose-3-O-sulfotransferase 4 (GAL3ST4), mRNA.
ACCESSION   NM_024637
VERSION     NM_024637.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2405)
  AUTHORS   Yuan,Y., You,Y., Wen,Y., Liu,J., Li,H., Zhang,Y., Wu,N., Liu,S.,
            Zhang,S., Chen,J., Ai,J., Zhang,W. and Zhang,Y.
  TITLE     Identification of novel genetic loci GAL3ST4 and CHGB involved in
            susceptibility to leprosy
  JOURNAL   Sci Rep 7 (1), 16352 (2017)
   PUBMED   29180661
  REMARK    GeneRIF: the GAL3ST4 and the CHGB allele variants 23 and 48 are
            novel genetic loci involved in susceptibility to leprosy among
            female and male population, respectively
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2405)
  AUTHORS   Karner,C.M., Long,F., Solnica-Krezel,L., Monk,K.R. and Gray,R.S.
  TITLE     Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and
            pectus excavatum in mice
  JOURNAL   Hum Mol Genet 24 (15), 4365-4373 (2015)
   PUBMED   25954032
  REMARK    GeneRIF: we found that loss of Gpr126 upregulated the expression of
            Gal3st4, a gene implicated in human PE, encoding
            Galactose-3-O-sulfotransferase 4
REFERENCE   3  (bases 1 to 2405)
  AUTHORS   Wu,S., Sun,X., Zhu,W., Huang,Y., Mou,L., Liu,M., Li,X., Li,F.,
            Li,X., Zhang,Y., Wang,Z., Li,W., Li,Z., Tang,A., Gui,Y., Wang,R.,
            Li,W., Cai,Z. and Wang,D.
  TITLE     Evidence for GAL3ST4 mutation as the potential cause of pectus
            excavatum
  JOURNAL   Cell Res 22 (12), 1712-1715 (2012)
   PUBMED   23147795
  REMARK    GeneRIF: The genetic mutation of GAL3ST4 affects the functions of
            the encoded protein.
REFERENCE   4  (bases 1 to 2405)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 2405)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   6  (bases 1 to 2405)
  AUTHORS   Chandrasekaran,E.V., Lakhaman,S.S., Chawda,R., Piskorz,C.F.,
            Neelamegham,S. and Matta,K.L.
  TITLE     Identification of physiologically relevant substrates for cloned
            Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of
            Gal3ST-2 and LS180 sulfotransferase for the globo H backbone,
            Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and
            6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2
            trisaccharide
  JOURNAL   J Biol Chem 279 (11), 10032-10041 (2004)
   PUBMED   14701868
  REMARK    GeneRIF: Gal3ST-4 is a substrate for the mucin core-2 trisaccharide
REFERENCE   7  (bases 1 to 2405)
  AUTHORS   Seko,A., Hara-Kuge,S. and Yamashita,K.
  TITLE     Molecular cloning and characterization of a novel human galactose
            3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc
            residue in O-glycans
  JOURNAL   J Biol Chem 276 (28), 25697-25704 (2001)
   PUBMED   11333265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073842.5 and AF316113.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024637.4.
            
            Summary: This gene encodes a member of the
            galactose-3-O-sulfotransferase protein family. The product of this
            gene catalyzes sulfonation by transferring a sulfate to the C-3'
            position of galactose residues in O-linked glycoproteins. This
            enzyme is highly specific for core 1 structures, with asialofetuin,
            Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being
            good substrates. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012976.2, AF316113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360039.9/ ENSP00000353142.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC073842.5         36077-36100
            25-1928             AF316113.1         1-1904
            1929-2405           AC073842.5         44974-45450
FEATURES             Location/Qualifiers
     source          1..2405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2405
                     /gene="GAL3ST4"
                     /gene_synonym="GAL3ST-4"
                     /note="galactose-3-O-sulfotransferase 4"
                     /db_xref="GeneID:79690"
                     /db_xref="HGNC:HGNC:24145"
                     /db_xref="MIM:608235"
     exon            1..72
                     /gene="GAL3ST4"
                     /gene_synonym="GAL3ST-4"
                     /inference="alignment:Splign:2.1.0"
     exon            73..385
                     /gene="GAL3ST4"
                     /gene_synonym="GAL3ST-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1721
                     /gene="GAL3ST4"
                     /gene_synonym="GAL3ST-4"
                     /note="beta-galactose-3-O-sulfotransferase 4;
                     gal-beta-1,3-GalNAc 3'-sulfotransferase"
                     /codon_start=1
                     /product="galactose-3-O-sulfotransferase 4"
                     /protein_id="NP_078913.3"
                     /db_xref="CCDS:CCDS5688.1"
                     /db_xref="GeneID:79690"
                     /db_xref="HGNC:HGNC:24145"
                     /db_xref="MIM:608235"
                     /translation="MGPLSPARTLRLWGPRSLGVALGVFMTIGFALQLLGGPFQRRLP
                     GLQLRQPSAPSLRPALPSCPPRQRLVFLKTHKSGSSSVLSLLHRYGDQHGLRFALPAR
                     YQFGYPKLFQASRVKGYRPQGGGTQLPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRD
                     PAALARSAFSYYKSTSSAFRKSPSLAAFLANPRGFYRPGARGDHYARNLLWFDFGLPF
                     PPEKRAKRGNIHPPRDPNPPQLQVLPSGAGPRAQTLNPNALIHPVSTVTDHRSQISSP
                     ASFDLGSSSFIQWGLAWLDSVFDLVMVAEYFDESLVLLADALCWGLDDVVGFMHNAQA
                     GHKQGLSTVSNSGLTAEDRQLTARARAWNNLDWALYVHFNRSLWARIEKYGQGRLQTA
                     VAELRARREALAKHCLVGGEASDPKYITDRRFRPFQFGSAKVLGYILRSGLSPQDQEE
                     CERLATPELQYKDKLDAKQFPPTVSLPLKTSRPLSP"
     exon            386..689
                     /gene="GAL3ST4"
                     /gene_synonym="GAL3ST-4"
                     /inference="alignment:Splign:2.1.0"
     exon            690..2405
                     /gene="GAL3ST4"
                     /gene_synonym="GAL3ST-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2386..2391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAL3ST4"
                     /gene_synonym="GAL3ST-4"
                     /note="hexamer: AATAAA"
     polyA_site      2405
                     /gene="GAL3ST4"
                     /gene_synonym="GAL3ST-4"
                     /note="major polyA site"
ORIGIN      
        1 aagagtcggg cggtggctgg gatgggcggg agggcccggc ccgatttccc ttgctgctcc
       61 ccttgtggcc tgacgctgac agaggcaaaa atctgctaac tcagggggca gactcaacca
      121 agactgtgag caggcctggg gaatgacccc ccgatctcca accagtgcct tccgcagctg
      181 cacggctgtc tccagctgtc tctgcccctc ttcctggccc tggctccatc tctctgtcac
      241 ctcacccttc cctgtgccac atgggccctc tctctcctgc caggacgctg cggctctggg
      301 gacctcggag cctgggggtg gctctgggag tcttcatgac cattggcttt gcactccagc
      361 tcttgggagg gcccttccag aggaggctac ctgggctaca gctccgacag ccctcggccc
      421 catccctacg accagccctt ccgtcctgcc caccccggca gcgactggtg ttcctgaaga
      481 cacataaatc cgggagcagc tctgtgctga gcctgcttca ccgctatggg gaccagcacg
      541 ggctgcgctt cgccctccct gcccgctacc agtttggcta cccaaagctc ttccaggcct
      601 ctagggtaaa aggctaccgc ccacagggtg gaggcaccca gctccccttc cacatcctct
      661 gtcaccacat gaggttcaac ctgaaagagg tacttcaggt catgccttct gacagcttct
      721 ttttttccat tgtccgagac ccagcggctc tggctcgctc tgccttctcc tactataaat
      781 ccacctcatc agccttccgc aagtcaccat ctttggctgc cttcctggcc aatcctcgag
      841 gcttctacag gcctggggcc cgtggggacc actacgctcg caacttacta tggtttgact
      901 ttggcctgcc ctttccccca gagaagaggg ccaagagagg gaatattcat ccccccagag
      961 accccaaccc cccacagctg caggtcttgc cttctggtgc tggccctcga gcccaaaccc
     1021 tcaatcccaa tgccctcatc catcctgttt ccactgttac tgatcatcgc agccagatat
     1081 caagccctgc ctctttcgat ttggggtctt catccttcat ccagtggggt ctggcatggc
     1141 tggactctgt ctttgacctg gtcatggtgg ctgagtactt cgatgagtca ttggttctgc
     1201 tggcagatgc cctgtgctgg ggtctagatg acgtggtggg cttcatgcac aatgcccagg
     1261 ctggacataa gcagggcctc agcactgtca gcaacagtgg actgactgcg gaggaccggc
     1321 agctgactgc acgggcccga gcctggaaca acctggactg ggctctctat gtccacttca
     1381 accgcagtct ctgggcacgg atagagaaat acggccaggg ccggctgcag acagctgtgg
     1441 ccgagctccg ggctcgccga gaggccctag cgaaacattg tctggtaggg ggtgaggctt
     1501 ctgaccccaa atacatcact gatcgccggt tccgcccctt ccagtttggg tcagctaagg
     1561 ttttgggcta tatacttcgg agtggattga gcccccaaga ccaagaggaa tgtgagcgcc
     1621 tagctacccc tgagctccag tacaaggaca agctggatgc caagcagttc ccccctaccg
     1681 tctcactgcc cctcaagact tcaaggccac tctccccata aacatcagac tacagattta
     1741 ggtggaagag cagccatgtt tgaagggcac atgtgatgag tggggggcag caagatgcca
     1801 tttctgcatc tcccagaagg gatgagtctt tgtcccgatg caagccccct cttcgctggg
     1861 ctcccagcag tgcttccctc ctccaccctc cactcatttt gttctttccc cccaactttt
     1921 tttttttttg aaacggagtc ttgctctgtc ccccaggctg gagtgcagtg gcatgatctc
     1981 ggctcactgc aacctctgcc tcccaggttc aagcgattct cctgcctcag cctccagagt
     2041 agctaggatt acagatacgt gccaccatac ccggctaatt tttatatttt tagagacagg
     2101 gattcaacat gttggttagg ctggtcttga actcctcacc tcaggtgatc cacatgactc
     2161 tgcctcccaa agtgctgcca ttacaggcgt gagccactag gcctgacctc cccttcccct
     2221 ttcctgcccc aaggcagatc cacatcaccg aagctcccta gaggggcaaa agatggagtg
     2281 agccacagga agtttggggc gtggtgagtt ggaatgatac gtccatttct ctatgaaata
     2341 tttgctacta gactgttcat ttctctctga catgtttgtt gaatgaataa ataatttgaa
     2401 acttc
//
