LOCUS       NP_078913                486 aa            linear   PRI 04-APR-2024
DEFINITION  galactose-3-O-sulfotransferase 4 [Homo sapiens].
ACCESSION   NP_078913
VERSION     NP_078913.3
DBSOURCE    REFSEQ: accession NM_024637.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 486)
  AUTHORS   Yuan,Y., You,Y., Wen,Y., Liu,J., Li,H., Zhang,Y., Wu,N., Liu,S.,
            Zhang,S., Chen,J., Ai,J., Zhang,W. and Zhang,Y.
  TITLE     Identification of novel genetic loci GAL3ST4 and CHGB involved in
            susceptibility to leprosy
  JOURNAL   Sci Rep 7 (1), 16352 (2017)
   PUBMED   29180661
  REMARK    GeneRIF: the GAL3ST4 and the CHGB allele variants 23 and 48 are
            novel genetic loci involved in susceptibility to leprosy among
            female and male population, respectively
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 486)
  AUTHORS   Karner,C.M., Long,F., Solnica-Krezel,L., Monk,K.R. and Gray,R.S.
  TITLE     Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and
            pectus excavatum in mice
  JOURNAL   Hum Mol Genet 24 (15), 4365-4373 (2015)
   PUBMED   25954032
  REMARK    GeneRIF: we found that loss of Gpr126 upregulated the expression of
            Gal3st4, a gene implicated in human PE, encoding
            Galactose-3-O-sulfotransferase 4
REFERENCE   3  (residues 1 to 486)
  AUTHORS   Wu,S., Sun,X., Zhu,W., Huang,Y., Mou,L., Liu,M., Li,X., Li,F.,
            Li,X., Zhang,Y., Wang,Z., Li,W., Li,Z., Tang,A., Gui,Y., Wang,R.,
            Li,W., Cai,Z. and Wang,D.
  TITLE     Evidence for GAL3ST4 mutation as the potential cause of pectus
            excavatum
  JOURNAL   Cell Res 22 (12), 1712-1715 (2012)
   PUBMED   23147795
  REMARK    GeneRIF: The genetic mutation of GAL3ST4 affects the functions of
            the encoded protein.
REFERENCE   4  (residues 1 to 486)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (residues 1 to 486)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   6  (residues 1 to 486)
  AUTHORS   Chandrasekaran,E.V., Lakhaman,S.S., Chawda,R., Piskorz,C.F.,
            Neelamegham,S. and Matta,K.L.
  TITLE     Identification of physiologically relevant substrates for cloned
            Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of
            Gal3ST-2 and LS180 sulfotransferase for the globo H backbone,
            Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and
            6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2
            trisaccharide
  JOURNAL   J Biol Chem 279 (11), 10032-10041 (2004)
   PUBMED   14701868
  REMARK    GeneRIF: Gal3ST-4 is a substrate for the mucin core-2 trisaccharide
REFERENCE   7  (residues 1 to 486)
  AUTHORS   Seko,A., Hara-Kuge,S. and Yamashita,K.
  TITLE     Molecular cloning and characterization of a novel human galactose
            3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc
            residue in O-glycans
  JOURNAL   J Biol Chem 276 (28), 25697-25704 (2001)
   PUBMED   11333265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073842.5 and AF316113.1.
            
            On Jun 9, 2003 this sequence version replaced NP_078913.2.
            
            Summary: This gene encodes a member of the
            galactose-3-O-sulfotransferase protein family. The product of this
            gene catalyzes sulfonation by transferring a sulfate to the C-3'
            position of galactose residues in O-linked glycoproteins. This
            enzyme is highly specific for core 1 structures, with asialofetuin,
            Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being
            good substrates. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012976.2, AF316113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360039.9/ ENSP00000353142.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     Protein         1..486
                     /product="galactose-3-O-sulfotransferase 4"
                     /note="beta-galactose-3-O-sulfotransferase 4;
                     gal-beta-1,3-GalNAc 3'-sulfotransferase"
                     /calculated_mol_wt=54035
     Region          18..469
                     /region_name="Sulfotransfer_2"
                     /note="Sulfotransferase family; cl22970"
                     /db_xref="CDD:451469"
     Site            19..39
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RP7.1)"
     Site            374
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q96RP7.1)"
     CDS             1..486
                     /gene="GAL3ST4"
                     /gene_synonym="GAL3ST-4"
                     /coded_by="NM_024637.5:261..1721"
                     /db_xref="CCDS:CCDS5688.1"
                     /db_xref="GeneID:79690"
                     /db_xref="HGNC:HGNC:24145"
                     /db_xref="MIM:608235"
ORIGIN      
        1 mgplspartl rlwgprslgv algvfmtigf alqllggpfq rrlpglqlrq psapslrpal
       61 pscpprqrlv flkthksgss svlsllhryg dqhglrfalp aryqfgypkl fqasrvkgyr
      121 pqgggtqlpf hilchhmrfn lkevlqvmps dsfffsivrd paalarsafs yykstssafr
      181 kspslaafla nprgfyrpga rgdhyarnll wfdfglpfpp ekrakrgnih pprdpnppql
      241 qvlpsgagpr aqtlnpnali hpvstvtdhr sqisspasfd lgsssfiqwg lawldsvfdl
      301 vmvaeyfdes lvlladalcw glddvvgfmh naqaghkqgl stvsnsglta edrqltarar
      361 awnnldwaly vhfnrslwar iekygqgrlq tavaelrarr ealakhclvg geasdpkyit
      421 drrfrpfqfg sakvlgyilr sglspqdqee cerlatpelq ykdkldakqf pptvslplkt
      481 srplsp
//
