LOCUS       NM_033036               3301 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens galactose-3-O-sulfotransferase 3 (GAL3ST3), mRNA.
ACCESSION   NM_033036
VERSION     NM_033036.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3301)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3301)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3301)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3301)
  AUTHORS   Chandrasekaran,E.V., Lakhaman,S.S., Chawda,R., Piskorz,C.F.,
            Neelamegham,S. and Matta,K.L.
  TITLE     Identification of physiologically relevant substrates for cloned
            Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of
            Gal3ST-2 and LS180 sulfotransferase for the globo H backbone,
            Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and
            6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2
            trisaccharide
  JOURNAL   J Biol Chem 279 (11), 10032-10041 (2004)
   PUBMED   14701868
  REMARK    GeneRIF: Gal3ST-2 and LS180 sulfotransferase is a substrate for the
            globo H backbone; Gal3ST-3 is a substrate for N-glycan
            multiterminal Galbeta1
REFERENCE   5  (bases 1 to 3301)
  AUTHORS   El-Fasakhany,F.M., Uchimura,K., Kannagi,R. and Muramatsu,T.
  TITLE     A novel human Gal-3-O-sulfotransferase: molecular cloning,
            characterization, and its implications in biosynthesis of
            (SO(4)-3)Galbeta1-4(Fucalpha1-3)GlcNAc
  JOURNAL   J Biol Chem 276 (29), 26988-26994 (2001)
   PUBMED   11356829
REFERENCE   6  (bases 1 to 3301)
  AUTHORS   Seko,A., Hara-Kuge,S. and Yamashita,K.
  TITLE     Molecular cloning and characterization of a novel human galactose
            3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc
            residue in O-glycans
  JOURNAL   J Biol Chem 276 (28), 25697-25704 (2001)
   PUBMED   11333265
REFERENCE   7  (bases 1 to 3301)
  AUTHORS   Suzuki,A., Hiraoka,N., Suzuki,M., Angata,K., Misra,A.K.,
            McAuliffe,J., Hindsgaul,O. and Fukuda,M.
  TITLE     Molecular cloning and expression of a novel human
            beta-Gal-3-O-sulfotransferase that acts preferentially on
            N-acetyllactosamine in N- and O-glycans
  JOURNAL   J Biol Chem 276 (26), 24388-24395 (2001)
   PUBMED   11323440
REFERENCE   8  (bases 1 to 3301)
  AUTHORS   Chandrasekaran,E.V., Jain,R.K., Rhodes,J.M., Chawda,R., Piskorz,C.
            and Matta,K.L.
  TITLE     Characterization of distinct Gal:3-O-sulfotransferase activities in
            human tumor epithelial cell lines and of calf lymph node GlcNAc :
            6-O-sulfotransferase activity
  JOURNAL   Glycoconj J 16 (9), 523-536 (1999)
   PUBMED   10815989
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB053232.1, AP006287.2 and
            BM673570.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033036.2.
            
            Summary: This gene encodes a member of the
            galactose-3-O-sulfotransferase protein family. The product of this
            gene catalyzes sulfonation by transferring a sulfate group to the
            3' position of galactose in N-acetyllactosamine in both type 2
            (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched
            O-glycans, but not on type 1 or core-1-branched structures. This
            gene, which has also been referred to as GAL3ST2, is different from
            the GAL3ST2 gene located on chromosome 2 that encodes a related
            enzyme with distinct tissue distribution and substrate
            specificities, compared to galactose-3-O-sulfotransferase 3.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB053232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312006.5/ ENSP00000308591.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-787               AB053232.1         20-806
            788-788             AP006287.2         158529-158529       c
            789-1327            AB053232.1         808-1346
            1328-1328           AP006287.2         157989-157989       c
            1329-1661           AB053232.1         1348-1680
            1662-3070           AP006287.2         156247-157655       c
            3071-3301           BM673570.1         16-246              c
FEATURES             Location/Qualifiers
     source          1..3301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..3301
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
                     /note="galactose-3-O-sulfotransferase 3"
                     /db_xref="GeneID:89792"
                     /db_xref="HGNC:HGNC:24144"
                     /db_xref="MIM:608234"
     exon            1..151
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..388
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1559
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
                     /note="beta-galactose-3-O-sulfotransferase 3;
                     galbeta1-3GalNAc 3'-sulfotransferase 3; galactose
                     3'-sulfotransferase; gal-beta-1, 3-GalNAc
                     3'-sulfotransferase 3"
                     /codon_start=1
                     /product="galactose-3-O-sulfotransferase 3"
                     /protein_id="NP_149025.1"
                     /db_xref="CCDS:CCDS8128.1"
                     /db_xref="GeneID:89792"
                     /db_xref="HGNC:HGNC:24144"
                     /db_xref="MIM:608234"
                     /translation="MPPILQRLQQATKMMSRRKILLLVLGCSTVSLLIHQGAQLSWYP
                     KLFPLSCPPLRNSPPRPKHMTVAFLKTHKTAGTTVQNILFRFAERHNLTVALPHPSCE
                     HQFCYPRNFSAHFVHPATRPPHVLASHLRFDRAELERLMPPSTVYVTILREPAAMFES
                     LFSYYNQYCPAFRRVPNASLEAFLRAPEAYYRAGEHFAMFAHNTLAYDLGGDNERSPR
                     DDAAYLAGLIRQVEEVFSLVMIAEYFDESLVLLRRLLAWDLDDVLYAKLNARAASSRL
                     AAIPAALARAARTWNALDAGLYDHFNATFWRHVARAGRACVEREARELREARQRLLRR
                     CFGDEPLLRPAAQIRTKQLQPWQPSRKVDIMGYDLPGGGAGPATEACLKLAMPEVQYS
                     NYLLRKQKRRGGARARPEPVLDNPPPRPIRVLPRGPQGP"
     exon            389..3301
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2093..2098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
                     /note="hexamer: AATAAA"
     polyA_site      2114
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
                     /note="major polyA site"
     regulatory      2987..2992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
                     /note="hexamer: AATAAA"
     polyA_site      3007
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
     regulatory      3233..3238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
                     /note="hexamer: AATAAT"
     polyA_site      3256
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
     regulatory      3283..3288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
                     /note="hexamer: AGTAAA"
     polyA_site      3301
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
ORIGIN      
        1 gatcccatcc aggcgctgag aggcaagcca ccggcactcg gcgcgcaggg ccccgggcac
       61 cctcggaccc cgtgcggatt tcgagacaag ggtccagaga tagcggcggc cgcccccaac
      121 ccgggccaga ggcagagccc aggcgtgcgg tgcttctcgg gaacactggc cctgctacca
      181 gagccgcagg atcccccatg agtgcctgtg aagggagtcc tggatagtga ggccctggct
      241 ggtccagggg tgggtactcc gccatgccac ccatcctcca gcgcctgcag caggccacca
      301 agatgatgag ccgccggaaa atcctgctgc tggtgctagg gtgcagcacc gtaagccttc
      361 tcatccacca gggggcgcag ctcagctggt accccaagct gttccccttg agctgccctc
      421 ctctgcggaa ctcgccgccg cgccccaagc acatgactgt ggccttcctg aagactcaca
      481 agacggcagg cacgacggtg cagaacatcc tgtttcgctt tgccgagcgc cacaacctga
      541 cggtggccct gccgcacccg agctgcgagc accagttctg ctacccccgc aacttctcgg
      601 cgcacttcgt gcacccggcc acgcggccgc cgcacgtgct ggccagccac ctgcgcttcg
      661 accgtgcgga gctggagcgc ctcatgccgc ccagcaccgt ctatgtcacc atcctgcgcg
      721 agccggccgc catgttcgag tcgctcttca gctactacaa ccagtactgc ccggccttcc
      781 ggcgcgtacc caacgcctcg ctcgaggcct tcctgcgcgc gcccgaggca tactaccgcg
      841 ctggcgagca cttcgccatg ttcgcacaca acacgctggc ctacgacctg ggcggcgaca
      901 atgagcgcag cccgcgcgac gacgccgcct acctggcggg cctcatccgc caggtggagg
      961 aggttttctc gctcgtcatg atcgccgagt acttcgacga gtcgctagtg ctgctgcggc
     1021 gcctactggc ctgggacctg gacgacgtgc tctacgccaa gctcaacgcg cgcgccgcca
     1081 gctcgcgcct ggccgccatc cccgcggcgc tggcgcgggc ggcgcgcacc tggaacgccc
     1141 tggacgccgg cctctacgac cacttcaacg ccaccttctg gcgccacgtg gcgcgcgcgg
     1201 gccgcgcgtg cgtggagcgc gaggcgcgcg agctgcgcga ggcccgccag cgcctactgc
     1261 ggcgctgctt cggggacgag ccactgctgc ggcctgccgc gcagatccgc accaagcagc
     1321 tgcagccgtg gcagcccagc cgcaaggtgg acattatggg ctatgacctg cccggcggcg
     1381 gcgccggccc ggccaccgag gcctgcctca agctggccat gcccgaggtc cagtactcga
     1441 actacctgtt gcgcaagcag aagcgccggg gcggtgcgcg ggctcggccc gagcccgtcc
     1501 tggacaatcc cccgcctcgg cccatccgag tgctgcctcg cggccctcaa ggtccctgag
     1561 ctccgcaggc ctccaggagt atgggtcctg ccctgccctc ccaggagtcc agccaggggc
     1621 tgcctccatg tcctgccccc atgagagccc tttcttttca aggggcttga gtccctcgct
     1681 gaactttggg gtacgcctcc ctatctgagc ccccgctccc gatcgtgggc tgaaccttgc
     1741 cttcgggcac ggcgctgata ggctggatcc agcgctgggc caccctctcc ttcccagctg
     1801 gttggtgatt ttgacaagag gcctgagggc tgtccagaac tgctcaccct gcctttttct
     1861 gggggctgag cccccacaac ctgtcttttc caagtggata agcccaggcc ccatggagag
     1921 aggctcagcc ctagggaaag gctgctcttg ctctccctcc cagggcttga ggctccctat
     1981 acttttctgt cttccaggtt ctaccctccc cacagaccta agctgctccc agtctcccag
     2041 aaccaagagt tcttgggttg ggatttttgt ttggttggtt tttctttttt ttaataaaac
     2101 atctttaaaa tgtgcgagtt gtatgtcagt catagaagcc ggattcccca catttgagga
     2161 tgaaacggat gcccaggagg agctgtggct ggacccatga ggatgggggc ctggactcaa
     2221 ggtcccccgc cacctggcat aggcctacaa ccctcctcaa ccgcttgacc gactgggccc
     2281 ccaacacaga ctggccacct tagccccact cactttccac atcgttcttt ttcacaaaat
     2341 tctgcgacat ttactgagca tcatctctgt aacttgggga tacaggtgaa ccagatagat
     2401 agggccttat tttcatggag cttatgggga aacattggaa caggagcaag acaggtaagc
     2461 aaagaggaag gactggaggg gttagagcac aacacctctt tgggtggaag gaggatcatt
     2521 ttcagataag gagctgccta actcagaatt tgacctcctc ctgtgaatca ctgacttcac
     2581 taatggcctg ctttcctcac aagaagacaa cttggactca gatgaagacc agtccctttc
     2641 tgcagtttcc tttaacacag caagatagcc agcacttcca ggtgaaatct cccttaagac
     2701 tagcagagaa ttggaacttt ttctgttact ttcttcagag ctatatcgac gtatctggac
     2761 aagtgataaa aaacaatagc tattatggtc tacggtgtgc cagccactgt ttaagggctt
     2821 tatgtatgtt aactttggag atgggtgccg ttttccaggt gagggaactg aaacttgggg
     2881 gaaattaagt cagggtcaca cagccagaaa gtggccacta ggatctcaac caaggcagtg
     2941 tggcttcaga gtttgtgctc acaagtgctg tctgtagtgc cattcaaata aaaaaggtca
     3001 catgccacaa gctaggctga ttcccagcac cttcccccaa aagaatgtaa agggaagaac
     3061 caggacactg ctatcagcaa ctctttatcc agtttttcat ggagacaacg gttgacctgt
     3121 ttggacaatg gacattacag tgattgattg gcaggatgca tgacacgctg ggcttgaaaa
     3181 gggactgttt gtatggcacc ccacttttta ccagcagagc tctgaaaaag gcaataatta
     3241 gaatcatgca aaagcataat taagtttctg acattaagca gcagtaaaga attgtaccag
     3301 a
//
