LOCUS       NM_022134               1452 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens galactose-3-O-sulfotransferase 2 (GAL3ST2), mRNA.
ACCESSION   NM_022134
VERSION     NM_022134.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1452)
  AUTHORS   Qin,F., Song,Z., Chang,M., Song,Y., Frierson,H. and Li,H.
  TITLE     Recurrent cis-SAGe chimeric RNA, D2HGDH-GAL3ST2, in prostate cancer
  JOURNAL   Cancer Lett 380 (1), 39-46 (2016)
   PUBMED   27322736
  REMARK    GeneRIF: D2HGDH-GAL3ST2 is more frequently seen in prostate cancer
            samples, and seems to be enriched in African Americans.
REFERENCE   2  (bases 1 to 1452)
  AUTHORS   Guerra,L.N., Suarez,C., Soto,D., Schiappacasse,A., Sapochnik,D.,
            Sacca,P., Piwien-Pilipuk,G., Peral,B. and Calvo,J.C.
  TITLE     GAL3ST2 from mammary gland epithelial cells affects differentiation
            of 3T3-L1 preadipocytes
  JOURNAL   Clin Transl Oncol 17 (7), 511-520 (2015)
   PUBMED   25532485
  REMARK    GeneRIF: GAL3ST2 is present in breast cancer cell lines and is more
            strongly expressed in more metastatic tumors.
REFERENCE   3  (bases 1 to 1452)
  AUTHORS   Seko,A., Sumiya,J. and Yamashita,K.
  TITLE     Porcine, mouse and human galactose 3-O-sulphotransferase-2 enzymes
            have different substrate specificities; the porcine enzyme requires
            basic compounds for its catalytic activity
  JOURNAL   Biochem J 391 (Pt 1), 77-85 (2005)
   PUBMED   15926885
  REMARK    GeneRIF: The substrate specificity and cofactor requirements of
            human, porcine, and murine GAL3ST are reported
REFERENCE   4  (bases 1 to 1452)
  AUTHORS   Shi,B.Z., Hu,P., Geng,F., He,P.J. and Wu,X.Z.
  TITLE     Gal3ST-2 involved in tumor metastasis process by regulation of
            adhesion ability to selectins and expression of integrins
  JOURNAL   Biochem Biophys Res Commun 332 (4), 934-940 (2005)
   PUBMED   15921657
  REMARK    GeneRIF: Gal3ST-2 is involved in tumor metastasis process by
            regulation of adhesion ability to selectins and expression of
            integrin alphaV but not beta3
REFERENCE   5  (bases 1 to 1452)
  AUTHORS   Chandrasekaran,E.V., Lakhaman,S.S., Chawda,R., Piskorz,C.F.,
            Neelamegham,S. and Matta,K.L.
  TITLE     Identification of physiologically relevant substrates for cloned
            Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of
            Gal3ST-2 and LS180 sulfotransferase for the globo H backbone,
            Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and
            6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2
            trisaccharide
  JOURNAL   J Biol Chem 279 (11), 10032-10041 (2004)
   PUBMED   14701868
REFERENCE   6  (bases 1 to 1452)
  AUTHORS   Koma,M., Miyagawa,S., Honke,K., Nakai,R., Miyoshi,S., Ohta,M.,
            Matsuda,H., Shirakura,R. and Taniguchi,N.
  TITLE     The possibility of reducing xenoantigen levels with a novel gal
            3'-sulfotransferase (GP3ST)
  JOURNAL   J Biochem 131 (4), 517-522 (2002)
   PUBMED   11926988
REFERENCE   7  (bases 1 to 1452)
  AUTHORS   Ikeda,N., Eguchi,H., Nishihara,S., Narimatsu,H., Kannagi,R.,
            Irimura,T., Ohta,M., Matsuda,H., Taniguchi,N. and Honke,K.
  TITLE     A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x
            epitopes
  JOURNAL   J Biol Chem 276 (42), 38588-38594 (2001)
   PUBMED   11504739
REFERENCE   8  (bases 1 to 1452)
  AUTHORS   Seko,A., Hara-Kuge,S. and Yamashita,K.
  TITLE     Molecular cloning and characterization of a novel human galactose
            3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc
            residue in O-glycans
  JOURNAL   J Biol Chem 276 (28), 25697-25704 (2001)
   PUBMED   11333265
REFERENCE   9  (bases 1 to 1452)
  AUTHORS   Suzuki,A., Hiraoka,N., Suzuki,M., Angata,K., Misra,A.K.,
            McAuliffe,J., Hindsgaul,O. and Fukuda,M.
  TITLE     Molecular cloning and expression of a novel human
            beta-Gal-3-O-sulfotransferase that acts preferentially on
            N-acetyllactosamine in N- and O-glycans
  JOURNAL   J Biol Chem 276 (26), 24388-24395 (2001)
   PUBMED   11323440
REFERENCE   10 (bases 1 to 1452)
  AUTHORS   Honke,K., Tsuda,M., Koyota,S., Wada,Y., Iida-Tanaka,N.,
            Ishizuka,I., Nakayama,J. and Taniguchi,N.
  TITLE     Molecular cloning and characterization of a human
            beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2
            (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides
  JOURNAL   J Biol Chem 276 (1), 267-274 (2001)
   PUBMED   11029462
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114730.5 and BC117295.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_022134.2.
            
            Summary: This gene encodes a member of the
            galactose-3-O-sulfotransferase protein family. The product of this
            gene catalyzes sulfonation by transferring a sulfate group to the
            hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can
            act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R)
            oligosaccharides with similar efficiencies, and on core 1 glycans.
            This enzyme has been implicated in tumor metastasis processes. This
            gene is different from the GAL3ST3 gene located on chromosome 11,
            which has also been referred to as GAL3ST2 and encodes a related
            enzyme with distinct tissue distribution and substrate
            specificities, compared to galactose-3-O-sulfotransferase 2.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117295.1, AB040610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000192314.7/ ENSP00000192314.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC114730.5         71980-71982         c
            4-144               AC114730.5         71839-71979         c
            145-1373            BC117295.1         60-1288
            1374-1452           AC114730.5         44517-44595         c
FEATURES             Location/Qualifiers
     source          1..1452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..1452
                     /gene="GAL3ST2"
                     /gene_synonym="GAL3ST-2; GP3ST"
                     /note="galactose-3-O-sulfotransferase 2"
                     /db_xref="GeneID:64090"
                     /db_xref="HGNC:HGNC:24869"
                     /db_xref="MIM:608237"
     exon            1..163
                     /gene="GAL3ST2"
                     /gene_synonym="GAL3ST-2; GP3ST"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1331
                     /gene="GAL3ST2"
                     /gene_synonym="GAL3ST-2; GP3ST"
                     /note="gal 3-O-sulphotransferase; galbeta1-3GalNAc
                     3'-sulfotransferase 2; beta-galactose-3-O-sulfotransferase
                     2; glycoprotein beta-Gal 3'-sulfotransferase 2;
                     gal-beta-1, 3-GalNAc 3'-sulfotransferase 2"
                     /codon_start=1
                     /product="galactose-3-O-sulfotransferase 2"
                     /protein_id="NP_071417.2"
                     /db_xref="CCDS:CCDS33427.1"
                     /db_xref="GeneID:64090"
                     /db_xref="HGNC:HGNC:24869"
                     /db_xref="MIM:608237"
                     /translation="MMSMLGGLQRYFRVILLLLLALTLLLLAGFLHSDLELDTPLFGG
                     QAEGPPVTNIMFLKTHKTASSTVLNILYRFAETHNLSVALPAGSRVHLGYPWLFLARY
                     VEGVGSQQRFNIMCNHLRFNLPQVQKVMPNDTFYFSILRNPVFQLESSFIYYKTYAPA
                     FRGAPSLDAFLASPRTFYNDSRHLRNVYAKNNMWFDFGFDPNAQCEEGYVRARIAEVE
                     RRFRLVLIAEHLDESLVLLRRRLRWALDDVVAFRLNSRSARSVARLSPETRERARSWC
                     ALDWRLYEHFNRTLWAQLRAELGPRRLRGEVERLRARRRELASLCLQDGGALKNHTQI
                     RDPRLRPYQSGKADILGYNLRPGLDNQTLGVCQRLVMPELQYMARLYALQFPEKPLKN
                     IPFLGA"
     exon            164..253
                     /gene="GAL3ST2"
                     /gene_synonym="GAL3ST-2; GP3ST"
                     /inference="alignment:Splign:2.1.0"
     exon            254..509
                     /gene="GAL3ST2"
                     /gene_synonym="GAL3ST-2; GP3ST"
                     /inference="alignment:Splign:2.1.0"
     exon            510..1452
                     /gene="GAL3ST2"
                     /gene_synonym="GAL3ST-2; GP3ST"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttcacctg ccccacagcc gcaccctgcc tgtgcctgca ccctggggag cccagagccg
       61 gcaggggccg aggcggtggg acctcggggg agctcaagcc tcgactgtcc cctcgctgga
      121 ggccagaggc caagatgatg tccatgctgg gcggcttgca gagatacttc cgggtcatcc
      181 tcctcctcct cctggccctg actctgctcc tgctggccgg attcctgcac tcggacttag
      241 agctggacac acccctgttt gggggccagg ctgaggggcc gccggtcacc aacatcatgt
      301 tcctgaagac gcacaagacg gccagcagca cggtgctcaa catcctctac cgcttcgccg
      361 agacccacaa cctgtccgtg gcgctgcccg ccggctcacg cgtccacctg ggctacccct
      421 ggctcttcct ggcgcgctac gtggaaggcg tggggtcgca gcagcgcttc aacatcatgt
      481 gcaaccacct gaggttcaac ctgcctcagg tgcagaaagt catgcccaac gacaccttct
      541 acttctccat cctgaggaac cccgtgttcc agctggagtc ctccttcatc tactacaaaa
      601 cctacgcccc cgccttccgg ggcgccccga gcctggacgc gttcctggcc tcgccgcgga
      661 cgttctacaa cgacagccgc cacctcagga acgtctacgc caagaacaac atgtggttcg
      721 acttcggctt cgaccccaac gcgcagtgcg aggagggcta cgtgcgcgcg cgcatcgccg
      781 aggtggagcg gcgcttccgg ctggtgctca tcgccgagca cctggacgag tccctggtgc
      841 tgctgcggcg ccggctgcgc tgggcgctgg acgacgtggt ggccttcagg ctcaactccc
      901 gcagcgcgcg ctccgtggcc cgcctgtcgc ccgagacccg ggagcgcgcg cggagctggt
      961 gcgcgctgga ctggcgcctg tacgagcatt tcaaccgcac cctctgggcg cagctgcgcg
     1021 ccgagctggg gccgcggcgg ctgcgcgggg aggtggagcg gctgcgcgcc cggaggcgcg
     1081 aactcgcgag cctgtgcctg caggacggcg gcgcgctcaa gaaccacacg cagatcagag
     1141 acccgcgcct gcgcccctac cagtccggca aggccgacat cctgggttac aacctccggc
     1201 cgggcctgga caaccagacg ctgggcgtgt gccagaggct tgtgatgcct gagctccagt
     1261 acatggcccg cctgtacgcc ctgcagttcc cggagaagcc cctcaagaac atcccgttcc
     1321 tgggggcgta gaggggccgg gccggggacg aggcctcctg cggacaccag ctcctctctc
     1381 cgccgtcacc ggggaggccg gggatccttg cagggcttct ggggcgttgg gaaacccagg
     1441 cccgccggcc ac
//
