LOCUS       NM_005255               4461 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cyclin G associated kinase (GAK), transcript variant
            1, mRNA.
ACCESSION   NM_005255 XM_938227 XM_943587 XM_943590 XM_943594 XM_943598
            XM_943600 XM_943603
VERSION     NM_005255.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4461)
  AUTHORS   Munson,M.J., Mathai,B.J., Ng,M.Y.W., Trachsel-Moncho,L., de la
            Ballina,L.R., Schultz,S.W., Aman,Y., Lystad,A.H., Singh,S.,
            Singh,S., Wesche,J., Fang,E.F. and Simonsen,A.
  TITLE     GAK and PRKCD are positive regulators of PRKN-independent mitophagy
  JOURNAL   Nat Commun 12 (1), 6101 (2021)
   PUBMED   34671015
  REMARK    GeneRIF: GAK and PRKCD are positive regulators of PRKN-independent
            mitophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4461)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4461)
  AUTHORS   Tian,X., Inoue,K., Zhang,Y., Wang,Y., Sperati,C.J., Pedigo,C.E.,
            Zhao,T., Yan,M., Groener,M., Moledina,D.G., Ebenezer,K., Li,W.,
            Zhang,Z., Liebermann,D.A., Greene,L., Greer,P., Parikh,C.R. and
            Ishibe,S.
  TITLE     Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout
            mice mitigates podocyte injury
  JOURNAL   JCI Insight 5 (22), 142740 (2020)
   PUBMED   33208557
  REMARK    GeneRIF: Inhibiting calpain 1 and 2 in cyclin G associated
            kinase-knockout mice mitigates podocyte injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4461)
  AUTHORS   Li,C., Ou,R., Chen,Y., Gu,X., Wei,Q., Cao,B., Zhang,L., Hou,Y.,
            Liu,K., Chen,X., Song,W., Zhao,B., Wu,Y. and Shang,H.
  TITLE     Mutation Analysis of DNAJC Family for Early-Onset Parkinson's
            Disease in a Chinese Cohort
  JOURNAL   Mov Disord 35 (11), 2068-2076 (2020)
   PUBMED   32662538
  REMARK    GeneRIF: Mutation Analysis of DNAJC Family for Early-Onset
            Parkinson's Disease in a Chinese Cohort.
REFERENCE   5  (bases 1 to 4461)
  AUTHORS   He,K., Song,E., Upadhyayula,S., Dang,S., Gaudin,R., Skillern,W.,
            Bu,K., Capraro,B.R., Rapoport,I., Kusters,I., Ma,M. and
            Kirchhausen,T.
  TITLE     Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic
  JOURNAL   J Cell Biol 219 (3) (2020)
   PUBMED   31962345
  REMARK    GeneRIF: Dynamics of Auxilin 1 and GAK in clathrin-mediated
            traffic.
REFERENCE   6  (bases 1 to 4461)
  AUTHORS   Zhao,X., Greener,T., Al-Hasani,H., Cushman,S.W., Eisenberg,E. and
            Greene,L.E.
  TITLE     Expression of auxilin or AP180 inhibits endocytosis by
            mislocalizing clathrin: evidence for formation of nascent pits
            containing AP1 or AP2 but not clathrin
  JOURNAL   J Cell Sci 114 (Pt 2), 353-365 (2001)
   PUBMED   11148137
REFERENCE   7  (bases 1 to 4461)
  AUTHORS   Umeda,A., Meyerholz,A. and Ungewickell,E.
  TITLE     Identification of the universal cofactor (auxilin 2) in clathrin
            coat dissociation
  JOURNAL   Eur J Cell Biol 79 (5), 336-342 (2000)
   PUBMED   10887964
REFERENCE   8  (bases 1 to 4461)
  AUTHORS   Greener,T., Zhao,X., Nojima,H., Eisenberg,E. and Greene,L.E.
  TITLE     Role of cyclin G-associated kinase in uncoating clathrin-coated
            vesicles from non-neuronal cells
  JOURNAL   J Biol Chem 275 (2), 1365-1370 (2000)
   PUBMED   10625686
REFERENCE   9  (bases 1 to 4461)
  AUTHORS   Kimura,S.H., Tsuruga,H., Yabuta,N., Endo,Y. and Nojima,H.
  TITLE     Structure, expression, and chromosomal localization of human GAK
  JOURNAL   Genomics 44 (2), 179-187 (1997)
   PUBMED   9299234
REFERENCE   10 (bases 1 to 4461)
  AUTHORS   Kanaoka,Y., Kimura,S.H., Okazaki,I., Ikeda,M. and Nojima,H.
  TITLE     GAK: a cyclin G associated kinase contains a tensin/auxilin-like
            domain
  JOURNAL   FEBS Lett 402 (1), 73-80 (1997)
   PUBMED   9013862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA680073.1, D88435.1, BC000816.1, AA287110.1 and AI138676.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005255.3.
            
            Summary: In all eukaryotes, the cell cycle is governed by
            cyclin-dependent protein kinases (CDKs), whose activities are
            regulated by cyclins and CDK inhibitors in a diverse array of
            mechanisms that involve the control of phosphorylation and
            dephosphorylation of Ser, Thr or Tyr residues. Cyclins are
            molecules that possess a consensus domain called the 'cyclin box.'
            In mammalian cells, 9 cyclin species have been identified, and they
            are referred to as cyclins A through I. Cyclin G is a direct
            transcriptional target of the p53 tumor suppressor gene product and
            thus functions downstream of p53. GAK is an association partner of
            cyclin G and CDK5. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D88435.1, SRR1803611.215171.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314167.9/ ENSP00000314499.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                DA680073.1         76-158
            84-147              DA680073.1         160-223
            148-3131            D88435.1           19-3002
            3132-3263           BC000816.1         64-195
            3264-3264           AA287110.1         198-198
            3265-4341           BC000816.1         197-1273
            4342-4461           AI138676.1         2-121               c
FEATURES             Location/Qualifiers
     source          1..4461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..4461
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="cyclin G associated kinase"
                     /db_xref="GeneID:2580"
                     /db_xref="HGNC:HGNC:4113"
                     /db_xref="MIM:602052"
     exon            1..274
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..4065
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     auxilin-2; dnaJ homolog subfamily C member 26"
                     /codon_start=1
                     /product="cyclin-G-associated kinase isoform 1"
                     /protein_id="NP_005246.2"
                     /db_xref="CCDS:CCDS3340.1"
                     /db_xref="GeneID:2580"
                     /db_xref="HGNC:HGNC:4113"
                     /db_xref="MIM:602052"
                     /translation="MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRR
                     VLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFC
                     SAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQ
                     HMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEI
                     TRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKY
                     SIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELLEQ
                     NGGYGSATLSRGPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFTNLKDT
                     SSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHY
                     AVYNLSPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHC
                     MDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMVAEE
                     PITPHSKPILVRAVVMTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIE
                     DGKAVIPLGVTVQGDVLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVK
                     FAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAPPWENSSMRGLNPKILFSSRE
                     EQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDSPPSSSADASRFLHTLDWQ
                     EEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEGQEPRADPEPPGLAAGL
                     VQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQACKAPSSNTDLLSCL
                     LGPPEAASQGPPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADPFGPLLPSSGNNS
                     QPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGEPSKMTASSSN
                     PDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNPDPFADLGD
                     LSSGLQGSPAGFPPGGFIPKTATTPKGSSSWQTSRPPAQGASWPPQAKPPPKACTQPR
                     PNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKTIAEM
                     RKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMADLVAPEQ
                     VKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF"
     exon            275..336
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            337..396
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            397..511
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            512..654
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            655..780
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            781..870
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1006
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1119
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1210
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1334
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1384
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1533
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1656
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1790
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1985
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2103
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2183
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2377
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2524
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..3001
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3172
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3295
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3412
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3637
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3786
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..3963
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     exon            3964..4461
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4442..4447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="hexamer: ATTAAA"
     polyA_site      4461
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="major polyA site"
ORIGIN      
        1 cgtcacggcg tcgaggcgga agatggtgca cctccgggcc ggcggttgct gagctgaccc
       61 ggacggcgag ggagcgggag cccgagcccg accactccgg ctgccgcggg gtgcggcgca
      121 gccaccgcca tgtcgctgct gcagtcggcg ctcgacttct tggcgggtcc aggctccctg
      181 ggcggtgctt ccggccgcga ccagagtgac ttcgtggggc agacggtgga actgggcgag
      241 ctgcggctgc gggtgcggcg ggtcctggcc gaaggagggt ttgcatttgt gtatgaagct
      301 caagatgtgg ggagtggcag agagtatgca ttaaagaggc tattatccaa tgaagaggaa
      361 aagaacagag ccatcattca agaagtttgc ttcatgaaaa agctttccgg ccacccgaac
      421 attgtccagt tttgttctgc agcgtctata ggaaaagagg agtcagacac ggggcaggct
      481 gagttcctct tgctcacaga gctctgtaaa gggcagctgg tggaattttt gaagaaaatg
      541 gaatctcgag gccccctttc gtgcgacacg gttctgaaga tcttctacca gacgtgccgc
      601 gccgtgcagc acatgcaccg gcagaagccg cccatcatcc acagggacct caaggttgag
      661 aacttgttgc ttagtaacca agggaccatt aagctgtgtg actttggcag tgccacgacc
      721 atctcgcact accctgacta cagctggagc gcccagaggc gagccctggt ggaggaagag
      781 atcacgagga atacaacacc aatgtataga acaccagaaa tcatagactt gtattccaac
      841 ttcccgatcg gcgagaagca ggatatctgg gccctgggct gcatcttgta cctgctgtgc
      901 ttccggcagc acccttttga ggatggagcg aaacttcgaa tagtcaatgg gaagtactcg
      961 atccccccgc acgacacgca gtacacggtc ttccacagcc tcatccgcgc catgctgcag
     1021 gtgaacccgg aggagcggct gtccatcgcc gaggtggtgc accagctgca ggagatcgcg
     1081 gccgcccgca acgtgaaccc caagtctccc atcacagagc tcctggagca gaatggaggc
     1141 tacgggagcg ccacactgtc ccgagggcca ccccctcccg tgggccccgc tggcagtggc
     1201 tacagtggag gcctggcgct ggcggagtac gaccagccgt atggcggctt cctggacatt
     1261 ctgcggggtg ggacagagcg gctcttcacc aacctcaagg acacctcctc caaggtcatc
     1321 cagtccgtcg ctaattatgc aaagggtgac ctggacatat cttacatcac atccagaatt
     1381 gcagtgatgt cattcccagc agaaggtgtg gagtcagcgc tcaaaaacaa catcgaagat
     1441 gtgcggttgt tcctggactc caagcaccca gggcactatg ccgtctacaa cctgtccccg
     1501 aggacctacc ggccctccag gttccacaac cgggtctccg agtgtggctg ggcagcacgg
     1561 cgggccccac acctgcacac cctgtacaac atctgcagga acatgcacgc ctggctgcgg
     1621 caggaccaca agaacgtctg cgtcgtgcac tgcatggacg ggagagccgc gtctgctgtg
     1681 gccgtctgct ccttcctgtg cttctgccgt ctcttcagca ccgcggaggc cgccgtgtac
     1741 atgttcagca tgaagcgctg cccaccaggc atctggccat cccacaaaag gtacatcgag
     1801 tacatgtgtg acatggtggc ggaggagccc atcacacccc acagcaagcc catcctggtg
     1861 agggccgtgg tcatgacacc cgtgccgctg ttcagcaagc agaggagcgg ctgcaggccc
     1921 ttctgcgagg tctacgtggg ggacgagcgt gtggccagca cctcccagga gtacgacaag
     1981 atgcgggact ttaagattga agatggcaaa gcggtgattc ccctgggcgt cacggtgcaa
     2041 ggagacgtgc tcatcgtcat ctatcacgcc cggtccactc tgggcggccg gctgcaggcc
     2101 aagatggcat ccatgaagat gttccagatt cagttccaca cggggtttgt gcctcggaac
     2161 gccaccactg tgaaatttgc caagtatgac ctggacgcgt gtgacattca agaaaaatac
     2221 ccggatttat ttcaagtgaa cctggaagtg gaggtggagc ccagggacag gccgagccgg
     2281 gaagccccac catgggagaa ctcgagcatg agggggctga accccaaaat cctgttttcc
     2341 agccgggagg agcagcaaga cattctgtct aagtttggga agccggagct tccccggcag
     2401 cctggctcca cggctcagta tgatgctggg gcagggtccc cggaagccga acccacagac
     2461 tctgactcac cgccaagcag cagcgcggac gccagtcgct tcctgcacac gctggactgg
     2521 caggaagaga aggaggcaga gactggtgca gaaaatgcct cttccaagga gagcgagtct
     2581 gccctgatgg aggacagaga cgagagtgag gtgtcagatg aagggggatc cccgatctcc
     2641 agcgagggcc aggaacccag ggccgaccca gagccccccg gcctggcagc agggctggtg
     2701 cagcaggact tggtttttga ggtggagaca ccggctgtgc tgccagagcc tgtgccacag
     2761 gaagacgggg tcgacctcct gggcctgcac tccgaggtgg gcgcagggcc agctgtaccc
     2821 ccgcaggcct gcaaggcccc ctccagcaac accgacctgc tcagctgcct ccttgggccc
     2881 cctgaggccg cctcccaggg gcccccggag gatctgctca gcgaggaccc gctgctcctg
     2941 gcaagcccgg cccctcccct gagcgtgcag agcaccccaa gaggagggcc ccctgccgct
     3001 gctgacccct ttggcccgct tctgccgtct tcaggcaaca actcccagcc ctgctccaat
     3061 cctgatctct tcggcgaatt tctcaattcg gactctgtga ccgtcccacc atccttcccg
     3121 tctgcccaca gtgctccgcc cccatcctgc agcgccgact tcctgcacct gggggatctg
     3181 ccaggagagc ccagcaagat gacagcctcg tccagcaacc cagacctgct gggaggatgg
     3241 gctgcctgga ccgagactgc agcatcggca gtggccccca cgccagccac agaaggcccc
     3301 ctcttctctc ctggaggtca gccggcccct tgtggctctc aggccagctg gaccaagtct
     3361 cagaacccgg acccatttgc tgaccttggc gacctcagct ccggcctcca aggctcacca
     3421 gctggattcc ctcctggggg cttcattccc aaaacggcca ccacgcccaa aggcagcagc
     3481 tcctggcaga caagtcggcc gccagcccag ggcgcctcat ggccccctca ggccaagccg
     3541 ccccccaaag cctgcacaca gccaaggcct aactatgcct cgaacttcag tgtgatcggg
     3601 gcgcgggagg agcggggggt ccgcgcaccc agctttgctc aaaagccaaa agtctctgag
     3661 aacgactttg aagatctgtt gtccaatcaa ggcttctcct ccaggtctga caagaaaggg
     3721 ccaaagacca ttgcagagat gaggaagcag gacctggcta aagacacgga cccactcaag
     3781 ctgaagctcc tggactggat tgagggcaag gagcggaaca tccgggccct gctgtccacg
     3841 ctgcacacag tgctgtggga cggggagagc cgctggacgc ccgtgggcat ggccgacctg
     3901 gtggctccgg agcaagtgaa gaagcactat cgccgcgcgg tgctggctgt gcaccccgac
     3961 aaggctgcgg ggcagccgta cgagcagcac gccaagatga tcttcatgga gctgaatgac
     4021 gcctggtcgg agtttgagaa ccagggctcc cggcccctct tctgaggccg cagtggtggt
     4081 ggctgcgcac acagctccac aggttgggag ccgtcgtggg acctgggtcc ccaccgtgag
     4141 gaccccgtgg gcgacagcag gtgtggccag ggtggggctc cgagccccgg gtcaccgccc
     4201 gcccagcgtt ccaggcacat gaagagaaag cattccaaag cctctgattg ttgtttcctt
     4261 tttctcctcc cgaaggaaca gctgattcat gctcctcccg caattgtcac gtctgtgatt
     4321 tatttggtgt ttcgggcgtg gcctctggag ccccggcacg tggtgggcca cgctgctggc
     4381 gctcatgggc cctggtgttt gcaccgcact ttgtaatcag tcccgtggtt gtctgtacag
     4441 aattaaacta ttttccgatg a
//
