LOCUS       NM_001127212             558 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens G antigen 2A (GAGE2A), mRNA.
ACCESSION   NM_001127212 XM_001130991
VERSION     NM_001127212.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 558)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 558)
  AUTHORS   Sun,F., Chan,E., Wu,Z., Yang,X., Marquez,V.E. and Yu,Q.
  TITLE     Combinatorial pharmacologic approaches target EZH2-mediated gene
            repression in breast cancer cells
  JOURNAL   Mol Cancer Ther 8 (12), 3191-3202 (2009)
   PUBMED   19934278
  REMARK    GeneRIF: Data show that EZH2 is a crucial regulator of GAGE2
            expression.
REFERENCE   3  (bases 1 to 558)
  AUTHORS   Van den Eynde,B., Peeters,O., De Backer,O., Gaugler,B., Lucas,S.
            and Boon,T.
  TITLE     A new family of genes coding for an antigen recognized by
            autologous cytolytic T lymphocytes on a human melanoma
  JOURNAL   J Exp Med 182 (3), 689-698 (1995)
   PUBMED   7544395
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142497.3.
            
            On Jan 12, 2021 this sequence version replaced NM_001127212.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY197178.1, HY011356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362097.2/ ENSP00000355421.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC142497.3         61102-61209
            109-197             AC142497.3         62249-62337
            198-318             AC142497.3         62803-62923
            319-444             AC142497.3         65724-65849
            445-558             AC142497.3         68317-68430
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..558
                     /gene="GAGE2A"
                     /gene_synonym="CT4.2; GAGE-2; GAGE-2A; GAGE2"
                     /note="G antigen 2A"
                     /db_xref="GeneID:729447"
                     /db_xref="HGNC:HGNC:4099"
                     /db_xref="MIM:300720"
     exon            1..108
                     /gene="GAGE2A"
                     /gene_synonym="CT4.2; GAGE-2; GAGE-2A; GAGE2"
                     /inference="alignment:Splign:2.1.0"
     exon            109..197
                     /gene="GAGE2A"
                     /gene_synonym="CT4.2; GAGE-2; GAGE-2A; GAGE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..467
                     /gene="GAGE2A"
                     /gene_synonym="CT4.2; GAGE-2; GAGE-2A; GAGE2"
                     /note="cancer/testis antigen family 4, member 2;
                     cancer/testis antigen 4.2; G antigen 2"
                     /codon_start=1
                     /product="G antigen 2A/2B"
                     /protein_id="NP_001120684.1"
                     /db_xref="CCDS:CCDS48114.1"
                     /db_xref="GeneID:729447"
                     /db_xref="HGNC:HGNC:4099"
                     /db_xref="MIM:300720"
                     /translation="MSWRGRSTYRPRPRRYVEPPEMIGPMRPEQFSDEVEPATPEEGE
                     PATQRQDPAAAQEGQDEGASAGQGPKPEAHSQEQGHPQTGCECEDGPDGQEMDPPNPE
                     EVKTPEEGEKQSQC"
     exon            198..318
                     /gene="GAGE2A"
                     /gene_synonym="CT4.2; GAGE-2; GAGE-2A; GAGE2"
                     /inference="alignment:Splign:2.1.0"
     exon            319..444
                     /gene="GAGE2A"
                     /gene_synonym="CT4.2; GAGE-2; GAGE-2A; GAGE2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..558
                     /gene="GAGE2A"
                     /gene_synonym="CT4.2; GAGE-2; GAGE-2A; GAGE2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttctgcc cggccccttc gcccacgtga agaacgccag ggagctgtga ggcagtgctg
       61 tgtggttcct gccgtccgga ctctttttcc tctactgaga ttcatctgtg tgaaatatga
      121 gttggcgagg aagatcgacc tatcggccta gaccaagacg ctacgtagag cctcctgaaa
      181 tgattgggcc tatgcggccc gagcagttca gtgatgaagt ggaaccagca acacctgaag
      241 aaggggaacc agcaactcaa cgtcaggatc ctgcagctgc tcaggaggga caggatgagg
      301 gagcatctgc aggtcaaggg ccgaagcctg aagctcatag ccaggaacag ggtcacccac
      361 agactgggtg tgagtgtgaa gatggtcctg atgggcagga gatggacccg ccaaatccag
      421 aggaggtgaa aacgcctgaa gaaggtgaaa agcaatcaca gtgttaaaag aagacacgtt
      481 gaaatgatgc aggctgctcc tatgttggaa atttgttcat taaaattctc ccaataaagc
      541 tttacagcct tctgcaaa
//
