LOCUS       NM_001040663            2993 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens G antigen 1 (GAGE1), transcript variant 2, mRNA.
ACCESSION   NM_001040663
VERSION     NM_001040663.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2993)
  AUTHORS   Chao,N.X., Li,L.Z., Luo,G.R., Zhong,W.G., Huang,R.S., Fan,R. and
            Zhao,F.L.
  TITLE     Cancer-testis antigen GAGE-1 expression and serum immunoreactivity
            in hepatocellular carcinoma
  JOURNAL   Niger J Clin Pract 21 (10), 1361-1367 (2018)
   PUBMED   30297572
  REMARK    GeneRIF: These data illustrate that the GAGE1 protein exhibits
            moderate cancerrestricted pattern of expression and immunogenicity,
            laying the foundation for the application of GAGE1 in immunotherapy
            and for the diagnosis of HCC[hepatocellular carcinoma].
REFERENCE   2  (bases 1 to 2993)
  AUTHORS   Li,Y., Hu,J., Li,L., Cai,S., Zhang,H., Zhu,X., Guan,G. and Dong,X.
  TITLE     Upregulated circular RNA circ_0016760 indicates unfavorable
            prognosis in NSCLC and promotes cell progression through
            miR-1287/GAGE1 axis
  JOURNAL   Biochem Biophys Res Commun 503 (3), 2089-2094 (2018)
   PUBMED   30103946
  REMARK    GeneRIF: The circ_0016760/miR-1287/GAGE1 signaling might play vital
            roles in the tumorigenesis and progression of Non-small cell lung
            cancer (NSCLC).
REFERENCE   3  (bases 1 to 2993)
  AUTHORS   Karia,B.T.R., Zamuner,F.T., Carlin,V., de Oliveira,C.Z.,
            Carvalho,A.L. and Vettore,A.L.
  TITLE     Expression and Prognostic Relevance of GAGE1 and XAGE1
            Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma
  JOURNAL   Curr Mol Med 17 (10), 707-717 (2017)
   PUBMED   29577858
  REMARK    GeneRIF: High GAGE1 expression is associated with metastasis in
            Head and Neck Squamous Cell Carcinoma.
REFERENCE   4  (bases 1 to 2993)
  AUTHORS   Zhang,S., Zhou,X., Yu,H. and Yu,Y.
  TITLE     Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian
            cancer tissues and cell lines
  JOURNAL   BMC Cancer 10, 163 (2010)
   PUBMED   20423514
  REMARK    GeneRIF: Tumor-specific antigen GAGE may play a role in the
            occurrence and development of ovarian cancer and can be used as one
            of the important indicators for early diagnosis, efficacy
            evaluation and prognostic determination of ovarian cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2993)
  AUTHORS   Mishra,D.K., Chen,Z., Wu,Y., Sarkissyan,M., Koeffler,H.P. and
            Vadgama,J.V.
  TITLE     Global methylation pattern of genes in androgen-sensitive and
            androgen-independent prostate cancer cells
  JOURNAL   Mol Cancer Ther 9 (1), 33-45 (2010)
   PUBMED   20053773
REFERENCE   6  (bases 1 to 2993)
  AUTHORS   Nagel,H., Laskawi,R., Eiffert,H. and Schlott,T.
  TITLE     Analysis of the tumour suppressor genes, FHIT and WT-1, and the
            tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3,
            in benign and malignant neoplasms of the salivary glands
  JOURNAL   Mol Pathol 56 (4), 226-231 (2003)
   PUBMED   12890744
REFERENCE   7  (bases 1 to 2993)
  AUTHORS   Chen,Z., Shao,J.B. and Wu,W.
  TITLE     Expression of A, G and B melanoma antigen genes in human
            hepatocellular carcinoma
  JOURNAL   Hepatobiliary Pancreat Dis Int 1 (4), 570-573 (2002)
   PUBMED   14607688
REFERENCE   8  (bases 1 to 2993)
  AUTHORS   De Backer,O., Arden,K.C., Boretti,M., Vantomme,V., De Smet,C.,
            Czekay,S., Viars,C.S., De Plaen,E., Brasseur,F., Chomez,P., Van den
            Eynde,B., Boon,T. and van der Bruggen,P.
  TITLE     Characterization of the GAGE genes that are expressed in various
            human cancers and in normal testis
  JOURNAL   Cancer Res 59 (13), 3157-3165 (1999)
   PUBMED   10397259
REFERENCE   9  (bases 1 to 2993)
  AUTHORS   Chen,M.E., Lin,S.H., Chung,L.W. and Sikes,R.A.
  TITLE     Isolation and characterization of PAGE-1 and GAGE-7. New genes
            expressed in the LNCaP prostate cancer progression model that share
            homology with melanoma-associated antigens
  JOURNAL   J Biol Chem 273 (28), 17618-17625 (1998)
   PUBMED   9651357
REFERENCE   10 (bases 1 to 2993)
  AUTHORS   Van den Eynde,B., Peeters,O., De Backer,O., Gaugler,B., Lucas,S.
            and Boon,T.
  TITLE     A new family of genes coding for an antigen recognized by
            autologous cytolytic T lymphocytes on a human melanoma
  JOURNAL   J Exp Med 182 (3), 689-698 (1995)
   PUBMED   7544395
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC231643.3, BC069470.1 and
            BC036094.1.
            
            On Jan 12, 2021 this sequence version replaced NM_001040663.3.
            
            Summary: This gene belongs to a family of genes that are expressed
            in a variety of tumors but not in normal tissues, except for the
            testis. The sequences of the family members are highly related but
            differ by scattered nucleotide substitutions. The antigenic peptide
            YRPRPRRY, which is also encoded by several other family members, is
            recognized by autologous cytolytic T lymphocytes. Nothing is
            presently known about the function of this protein. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jun 2010].
            
            Transcript Variant: This variant (2) encodes the functional
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: This CCDS representation is supported by the mRNA
            accession BC069470.1, which has its best hit to this GAGE family
            member.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.995500.1,
                                           SRR14038195.560005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381700.11/ ENSP00000371119.5
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC231643.3         146074-146115       c
            43-514              BC069470.1         1-472
            515-2991            BC036094.1         653-3129
            2992-2993           AC231643.3         136597-136598       c
FEATURES             Location/Qualifiers
     source          1..2993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..2993
                     /gene="GAGE1"
                     /gene_synonym="CT4.1; CT4.4; GAGE-1; GAGE-4; GAGE4"
                     /note="G antigen 1"
                     /db_xref="GeneID:2543"
                     /db_xref="HGNC:HGNC:4098"
                     /db_xref="MIM:300594"
     exon            1..108
                     /gene="GAGE1"
                     /gene_synonym="CT4.1; CT4.4; GAGE-1; GAGE-4; GAGE4"
                     /inference="alignment:Splign:2.1.0"
     exon            109..200
                     /gene="GAGE1"
                     /gene_synonym="CT4.1; CT4.4; GAGE-1; GAGE-4; GAGE4"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..470
                     /gene="GAGE1"
                     /gene_synonym="CT4.1; CT4.4; GAGE-1; GAGE-4; GAGE4"
                     /note="cancer/testis antigen family 4, member 1; MZ2-F
                     antigen; G antigen 4; Cancer/testis antigen 4.4;
                     cancer/testis antigen 4.1"
                     /codon_start=1
                     /product="G antigen 1"
                     /protein_id="NP_001035753.1"
                     /db_xref="CCDS:CCDS43950.1"
                     /db_xref="GeneID:2543"
                     /db_xref="HGNC:HGNC:4098"
                     /db_xref="MIM:300594"
                     /translation="MSWRGRSTYYWPRPRRYVQPPEMIGPMRPEQFSDEVEPATPEEG
                     EPATQRQDPAAAQEGEDEGASAGQGPKPEADSQEQGHPQTGCECEDGPDGQEMDPPNP
                     EEVKTPEEGEGQSQC"
     exon            201..321
                     /gene="GAGE1"
                     /gene_synonym="CT4.1; CT4.4; GAGE-1; GAGE-4; GAGE4"
                     /inference="alignment:Splign:2.1.0"
     exon            322..447
                     /gene="GAGE1"
                     /gene_synonym="CT4.1; CT4.4; GAGE-1; GAGE-4; GAGE4"
                     /inference="alignment:Splign:2.1.0"
     exon            448..2993
                     /gene="GAGE1"
                     /gene_synonym="CT4.1; CT4.4; GAGE-1; GAGE-4; GAGE4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      536..541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAGE1"
                     /gene_synonym="CT4.1; CT4.4; GAGE-1; GAGE-4; GAGE4"
                     /note="hexamer: AATAAA"
     polyA_site      564
                     /gene="GAGE1"
                     /gene_synonym="CT4.1; CT4.4; GAGE-1; GAGE-4; GAGE4"
                     /note="major polyA site"
     regulatory      2972..2977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAGE1"
                     /gene_synonym="CT4.1; CT4.4; GAGE-1; GAGE-4; GAGE4"
                     /note="hexamer: AATAAA"
     polyA_site      2993
                     /gene="GAGE1"
                     /gene_synonym="CT4.1; CT4.4; GAGE-1; GAGE-4; GAGE4"
ORIGIN      
        1 gtcttctgcc cggccccttc gcccacgtga agaacgccag ggagctgtga ggcagtgctg
       61 tgtggttcct gccgtccgga ctctttttcc tctactgaga ttcatctgtg tgaaatatga
      121 gttggcgagg aagatcgacc tattattggc ctagaccaag gcgctatgta cagcctcctg
      181 aaatgattgg gcctatgcgg cccgagcagt tcagtgatga agtggaacca gcaacacctg
      241 aagaagggga accagcaact caacgtcagg atcctgcagc tgctcaggag ggagaggatg
      301 agggagcatc tgcaggtcaa gggccgaagc ctgaagctga tagccaggaa cagggtcacc
      361 cacagactgg gtgtgagtgt gaagatggtc ctgatgggca ggagatggac ccgccaaatc
      421 cagaggaggt gaaaacgcct gaagaaggtg aagggcaatc acagtgttaa aagaagacat
      481 gctgaaatgt tgcaggctgc tcctatgttg gaaaattctt cattgaagtt ctcccaataa
      541 agctttacag ccttctgcaa agaagtcttg tgaatctttt gtcaatttta tttctagcta
      601 tttgatgctg tgaaatgttt cattctttgc aattttgtat tctatctcct tgagctgtgt
      661 gtagaggcat aattctcatg tattgatttt ctatccagca accttgttaa atatgcttat
      721 gaattttaaa agtttacttc taggtttttt cagttttcaa cctacagaat catatcattt
      781 ttgaataaga acaattttgt ttctgccttt tttgtttgtt ttttcttttg tatttttcgt
      841 agaggtggga ttttggcctg tgtcctaggc tttttttgaa ctcctgagcg caagtaatcc
      901 actctccttg gcctttcaaa gtgttgggat tacaggcatg ggccaccgtg ctggtcctgt
      961 ttttgccatt ttaaaccctt ttatttcctt ttctgatttt atggcattga gcagatctac
     1021 cggatacaat tgtgatagtg gaaatttttg tgttattcct gatgagaaat ggaaaaattt
     1081 caacatttca cgacaatatt tagtgtactt tttttgtaga tggacttttt cagagtaagt
     1141 caagccattc tgttttagtt tgttgagagt gttcattttg aatatatgtt gaatttcatc
     1201 aaacactgac ctgagtcatc ttaaaacatg tgaattgaga tttctttgct actaagaaag
     1261 tgagcgggca ctctgcttca tgtttacttt tgtcatgttg catgaaaaac attttgcttc
     1321 atgtttgatt ctgtatgttg aaaactgaaa tcatctattg tgattaccac agggtttttt
     1381 cccccagtaa tctgtttatg tagtcaatta cgttgataaa tctgtacttt ttaaatttta
     1441 acaattgaga caggtctcac tctgtcaccc atgctgactg cagtagtgtg atcacagctt
     1501 actgcaacct caacctcctg ggctcaggcg atcctcccac ctcaccctcc tcagtagcta
     1561 ggactatagg tacatgccac catgccaagc taatttttct gttttagaga tggtattttt
     1621 tcatgttgcc caggctggtt ttatactcct aatctcaagc catccactag cctcagcctc
     1681 ccaaagtgct gggattacag gaatgagtca cggtgcctgg aaattttgta catttaaacc
     1741 aacaatttgg tcatgggtaa tctatgtcct aataatttat ttaaggattt ttatgtatat
     1801 cctcatgagt gacattacct gtacttttat ttcatatgct catttgttgg acgttgttat
     1861 caaggttcct ctagcttcat aaaacgggtt ggtatgtaaa acctcttttt ccattcactg
     1921 gaactcaagt ctcctcaagg ctgtgagtaa tgcagggcta ggctttccca taatgagctt
     1981 ttctagaatg cttctctcag atttggaccc tacttaaaca gcagtgacca aacgggcagc
     2041 tccaggtacc tatcccctca aactttgtga gggtcgcgtt ctctgaagat gcctcttcaa
     2101 tttgaaagct atctgttcct gtttctctgc tgatattaac tctctgtgca cagaaagtta
     2161 aacgtcactg gttattaatt tccctagatt ttgatctgtg ctgtgtggct gagaatgggc
     2221 tgactgaccc tagatctgtg tataattatg acaatggctc catttatttt taaaataaga
     2281 ggaattatta taaaattcct atttactgga tgtgtactat ctatgaatta cttctttgtg
     2341 ctaggttgtg tacatgtatg acctctttag atcctcacaa gataaggcag aattttcatg
     2401 aaattgatga ctgactccag taagaagcag atttgggggg atttcaattt ctaagctcaa
     2461 agcccttgca cttttctcaa agtaaagctt ttgaaagtgt taaatgtaca cgaactgatg
     2521 gtgtatatga tgattttagt tgtaatctga tgttttcttt aaaaatttac atatacaaaa
     2581 gtgtttgact caaaaggctt tgttcttccc ttaaaggaag catctaccaa aatgtggcac
     2641 acaaaccttg catggtgtct ctagggcctc ctaccccgca tttcccctgc tttttctctt
     2701 gttctgactg aaaaacaaag tgctttgact gtgctgtgac ccagccagct gcatgtttac
     2761 ccagcatgct tgaacccaag ctggagcctt gaacataaag gtgtttaagt tgttgctcaa
     2821 aatatggaaa gaatctagct ctggccttga accaaatccc ttaaactctc ctataaaact
     2881 ccataacctg accccctcag tgcggatata cctaggcatg acattcttgt tgcctgttgc
     2941 gaggatgctt tagcctactc taagttctcc caataaatgc tttggactga tca
//
