LOCUS       NM_207359               3658 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens glutamate decarboxylase like 1 (GADL1), mRNA.
ACCESSION   NM_207359
VERSION     NM_207359.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3658)
  AUTHORS   Wu,T.N., Chen,C.K., Liu,I.C., Wu,L.S. and Cheng,A.T.
  TITLE     Effects of GADL1 overexpression on cell migration and the
            associated morphological changes
  JOURNAL   Sci Rep 9 (1), 5298 (2019)
   PUBMED   30923325
  REMARK    GeneRIF: Effects of GADL1 overexpression on cell migration and the
            associated morphological changes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3658)
  AUTHORS   Moreira,J., Courtin,C., Geoffroy,P.A., Curis,E., Bellivier,F. and
            Marie-Claire,C.
  TITLE     Lithium response in bipolar disorder: No difference in GADL1 gene
            expression between cell lines from excellent-responders and
            non-responders
  JOURNAL   Psychiatry Res 251, 217-220 (2017)
   PUBMED   28214779
  REMARK    GeneRIF: No difference in GADL1 expression was observed among
            lymphoblastoid cells from excellent-responders, non-responders or
            controls. Furthermore, lithium did not induce significant changes
            in GADL1 expression levels after 4 or 8 days. These results did not
            support an association of GADL1 expression in the determination of
            a lithium response in BD patients.
REFERENCE   3  (bases 1 to 3658)
  AUTHORS   Winge,I., Teigen,K., Fossbakk,A., Mahootchi,E., Kleppe,R.,
            Skoldberg,F., Kampe,O. and Haavik,J.
  TITLE     Mammalian CSAD and GADL1 have distinct biochemical properties and
            patterns of brain expression
  JOURNAL   Neurochem Int 90, 173-184 (2015)
   PUBMED   26327310
  REMARK    GeneRIF: taurine biosynthesis in vertebrates involves two
            structurally related PLP-dependent decarboxylases (cysteine
            sulfinic acid decarboxylase and glutamic acid decarboxylase like 1)
REFERENCE   4  (bases 1 to 3658)
  AUTHORS   Kotambail,A., Mathur,A., Bhat,S.M., Rai,P.S., Sharma,P.S. and
            Satyamoorthy,K.
  TITLE     GADL1 gene polymorphisms and lithium response in bipolar I
            disorder: lack of association from an Indian population
  JOURNAL   Psychiatr Genet 25 (1), 39-40 (2015)
   PUBMED   25415457
  REMARK    GeneRIF: The study did not identify a major relationship between
            the GADL1 polymorphisms and lithium response in an Indian
            population.
REFERENCE   5  (bases 1 to 3658)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   6  (bases 1 to 3658)
  AUTHORS   Chen,C.H., Lee,C.S., Lee,M.T., Ouyang,W.C., Chen,C.C., Chong,M.Y.,
            Wu,J.Y., Tan,H.K., Lee,Y.C., Chuo,L.J., Chiu,N.Y., Tsang,H.Y.,
            Chang,T.J., Lung,F.W., Chiu,C.H., Chang,C.H., Chen,Y.S., Hou,Y.M.,
            Chen,C.C., Lai,T.J., Tung,C.L., Chen,C.Y., Lane,H.Y., Su,T.P.,
            Feng,J., Lin,J.J., Chang,C.J., Teng,P.R., Liu,C.Y., Chen,C.K.,
            Liu,I.C., Chen,J.J., Lu,T., Fan,C.C., Wu,C.K., Li,C.F., Wang,K.H.,
            Wu,L.S., Peng,H.L., Chang,C.P., Lu,L.S., Chen,Y.T. and Cheng,A.T.
  CONSRTM   Taiwan Bipolar Consortium
  TITLE     Variant GADL1 and response to lithium therapy in bipolar I disorder
  JOURNAL   N Engl J Med 370 (2), 119-128 (2014)
   PUBMED   24369049
  REMARK    GeneRIF: Genetic variations in GADL1 are associated with the
            response to lithium maintenance treatment for bipolar I disorder in
            patients of Han Chinese descent.
            Erratum:[N Engl J Med. 2014 May 8;370(19):1866]
REFERENCE   7  (bases 1 to 3658)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL832766.1, AC138391.2, BC093701.1, AK128643.1 and AC096921.2.
            
            On Nov 19, 2020 this sequence version replaced NM_207359.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.78609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465413 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282538.10/ ENSP00000282538.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AL832766.1         1-243
            244-244             AC138391.2         172178-172178       c
            245-582             AL832766.1         245-582
            583-1633            BC093701.1         6-1056
            1634-2753           AC138391.2         37674-38793         c
            2754-3655           AK128643.1         2185-3086
            3656-3658           AC096921.2         200818-200820       c
FEATURES             Location/Qualifiers
     source          1..3658
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.1-p23"
     gene            1..3658
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /note="glutamate decarboxylase like 1"
                     /db_xref="GeneID:339896"
                     /db_xref="HGNC:HGNC:27949"
                     /db_xref="MIM:615601"
     exon            1..84
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1613
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /EC_number="4.1.1.11"
                     /EC_number="4.1.1.29"
                     /note="glutamate decarboxylase-like protein 1; aspartate
                     1-decarboxylase; cysteine sulfinic acid decarboxylase"
                     /codon_start=1
                     /product="acidic amino acid decarboxylase GADL1"
                     /protein_id="NP_997242.2"
                     /db_xref="CCDS:CCDS2649.2"
                     /db_xref="GeneID:339896"
                     /db_xref="HGNC:HGNC:27949"
                     /db_xref="MIM:615601"
                     /translation="MSSDSDRQCPVDGDIDQQEMIPSKKNAVLVDGVVLNGPTTDAKA
                     GEKFVEEACRLIMEEVVLKATDVNEKVCEWRPPEQLKQLLDLEMRDSGEPPHKLLELC
                     RDVIHYSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVL
                     KKMIEFIGWKEGDGIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSGSPRLILFTSAEC
                     HYSMKKAASFLGIGTENVCFVETDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTT
                     VLGAFDPLDEIADICERHSLWLHVDASWGGSALMSRKHRKLLHGIHRADSVAWNPHKM
                     LMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQDKFYDVSYDTGDKSIQCSRRPDAFK
                     FWMTWKALGTLGLEERVNRALALSRYLVDEIKKREGFKLLMEPEYANICFWYIPPSLR
                     EMEEGPEFWAKLNLVAPAIKERMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSREDMD
                     FLLDEIDLLGKDM"
     exon            85..257
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            258..384
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            385..475
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            476..582
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            583..698
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            699..778
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            779..833
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            834..950
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1015
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1097
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1297
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1349
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1439
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..3658
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3630..3635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /note="hexamer: AATAAA"
     polyA_site      3658
                     /gene="GADL1"
                     /gene_synonym="ADC; CSADC; HuADC; HuCSADC"
                     /note="major polyA site"
ORIGIN      
        1 agactgcggg agccgcgccc ggggcagcct ggagtggggg agcggagatg agcagcgact
       61 cggaccgcca gtgtcctgtg gacggagata ttgatcaaca agagatgatt ccaagtaaga
      121 agaatgctgt tcttgtggat ggggttgtgc tgaatggtcc tacaacagat gcaaaagctg
      181 gagaaaaatt tgttgaagag gcctgtaggc taataatgga agaggtggtt ttgaaagcta
      241 cagatgtcaa tgagaaggtg tgtgaatgga ggcctcctga acaactgaaa cagcttcttg
      301 atttggagat gagagactca ggcgagccac cccataaact attggaactc tgtcgggatg
      361 tcatacacta cagtgtcaaa actaaccacc caagattttt caaccaattg tatgctggac
      421 ttgattatta ctccttggtg gcccgattta tgaccgaagc attgaatcca agtgtttata
      481 cgtatgaggt gtccccagtg tttctgttag tggaagaagc ggttctgaag aaaatgattg
      541 aatttattgg ctggaaagaa ggggatggaa tatttaaccc aggtggctca gtgtccaata
      601 tgtatgcaat gaatttagct agatacaaat attgtcctga tattaaggaa aaggggctgt
      661 ctggttcgcc aagattaatc cttttcacat ctgcagagtg tcattactct atgaagaagg
      721 cagcctcttt tcttgggatt ggcactgaga atgtttgctt tgtggaaaca gatggaagag
      781 gtaaaatgat acctgaggaa ctggagaagc aagtctggca agccagaaaa gagggggcag
      841 caccgtttct tgtctgtgcc acttctggta caactgtgtt gggagctttt gaccctctgg
      901 atgaaatagc agacatctgc gagaggcaca gcctctggct tcatgtagat gcttcttggg
      961 gtggctcagc tttgatgtcg aggaagcacc gcaagcttct gcatggcatc cacagggctg
     1021 actctgtggc ctggaaccca cacaagatgc tgatggctgg gatccagtgc tgtgctctcc
     1081 ttgtgaaaga caaatctgat cttcttaaaa aatgctactc tgccaaggca tcttacctct
     1141 tccagcagga taaattctat gatgtgagct atgacacagg agacaagtct atccagtgta
     1201 gcagaagacc agatgcattc aagttctgga tgacctggaa ggccctgggt acattaggcc
     1261 ttgaagaaag agttaatcgt gctcttgctt tatctaggta cctagtagat gaaatcaaga
     1321 aaagagaagg attcaagtta ctgatggaac ctgaatatgc caatatttgc ttttggtaca
     1381 ttccaccgag cctcagagag atggaagaag gacccgagtt ctgggcaaaa cttaatttgg
     1441 tggccccagc cattaaggag aggatgatga agaagggaag cttgatgctg ggctaccagc
     1501 cgcaccgggg aaaggtcaac ttcttccgcc aggtggtgat cagccctcaa gtgagccggg
     1561 aggacatgga cttcctcctg gatgagatag acttactggg taaagacatg tagctgtggc
     1621 tttggtcccc cagaggcata gatcctatcc tgggagagtt tagatccaga acatcttgga
     1681 gatacacagt agattgcagc ccttctgatg agaaataggg aatactccca gtccaggccc
     1741 agcaaaacca aaatgctaag caatgaatat taaggactct ctagctgcct gggcattact
     1801 gttgctaaaa gaagaaagtt taaaaaaaaa aatgattttc tcaaggaatg cccctggaac
     1861 acagctctga agagagttta gtaagtacca tgtaggttct ggattctaag cttacattgc
     1921 tctttaaaga acttataaac taacggttta aagcagtggt tctcaaagtg tggtccctgg
     1981 actatcagca tcaaagcatc acctgggaac ttgctaaaaa tgcagattct caggctttct
     2041 ctagaccaac tggatcagaa gctctggggg tgaggcccag tattctgtgt tttaacaagc
     2101 ccgtcaggga attctgatgc acagtaaaat ccgagaaaca ctggtttaag aaaaaccttg
     2161 taatgatcga atacccactc tgatgttttg ccagcaaagg gatatctaat atttcagaag
     2221 cctctgagcc agtctttgaa aaaatacaac tatggcatct gcagcacaaa tatttaagga
     2281 catcagaagc atgtcaaagc tatttttaaa gagagaaact gtataagatg tttacttcat
     2341 agagatttat gttttatgca ggctgaatgt ttatctcaaa agttaaaatt atccattctc
     2401 aaaagttaaa attatatata tatatatata tacacacaca cacatatata tatatatata
     2461 attcaaagca caataattga aagcacaata attgacagaa aaatacaggt tctattaata
     2521 aattaataaa ctgttggtct tcaaaataga aatgcatgta atatccatat tagttttttc
     2581 ttggtagaca actggaaggt tttctttttt ttcgtctatg actaattttc tttattcaag
     2641 atacctgaac tggggtgctt tttaagaaaa atttgggaaa tatatatgtt tctgtgatat
     2701 acatatatac atatatatgt atatatatac acacacatac atatgtgtgt gtatagtata
     2761 tatatatata cacacatata tgtttctgtg ttcctctttt agcttgaggg gcttgtttat
     2821 tatcttgctc tgtgcctcat agggaataaa cacaatgaag tccagggttg tacaacattc
     2881 cctttcctaa gctttgaaat gtcagtatag attattaagt ggtttatatt acagaatctg
     2941 ggattcagca gactttcagt gtaaatgctt cctccatttc tcctgagagt gggtgatttt
     3001 aattctatct ctgaccctgg tcctaggttt ctaggagagt tttgtttaac taagaaattg
     3061 acagaattca taggtgtggg tgtagagttc accaagataa gattatgaat ataattaaag
     3121 gtctgcatta aaaggtgaat gattgaagag tgttaaagca ttagacttag cacattcaat
     3181 aaccttttcg tactccattg ttaaccaatg tcatttaaat tttgagtact atttgctttt
     3241 attgcttatt ttcattttag tgtgcacagt ttctcggtat ctctattggt caaagaatat
     3301 taaatctgtc tctgaattac ttcaaattct caggtgaaac ctattggtgt gtgtgtgtgt
     3361 gtgtgtgtgt ttattttgca tttcttgttg cctttttgtt ttaatgtcta cataaaatat
     3421 ttctaaaatt gatgtttgta acaatttggg tttcatgaaa caaaaaggaa cattactata
     3481 cttagtgttg ttgacttttc ttttcctgtc atctcctctt tactggattg taccaataca
     3541 ttttagaagt gaactggact tggttggcat tttagtttaa tgactgaaaa agtaggttga
     3601 aagctctctg tattttagtt aacaccttga ataaaatgga aaaagcagtt atagcaaa
//
