LOCUS       NM_052850               1769 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens GADD45G interacting protein 1 (GADD45GIP1), mRNA.
ACCESSION   NM_052850
VERSION     NM_052850.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1769)
  AUTHORS   Lee,S., Song,S.G., Kim,G., Kim,S., Yoo,H.J., Koh,J., Kim,Y.J.,
            Tian,J., Cho,E., Choi,Y.S., Chang,S., Shin,H.M., Jung,K.C.,
            Kim,J.H., Kim,T.M., Jeon,Y.K., Kim,H.Y., Shong,M., Kim,J.H. and
            Chung,D.H.
  TITLE     CRIF1 deficiency induces FOXP3LOW inflammatory non-suppressive
            regulatory T cells, thereby promoting antitumor immunity
  JOURNAL   Sci Adv 10 (13), eadj9600 (2024)
   PUBMED   38536932
  REMARK    GeneRIF: CRIF1 deficiency induces FOXP3[LOW] inflammatory
            non-suppressive regulatory T cells, thereby promoting antitumor
            immunity.
REFERENCE   2  (bases 1 to 1769)
  AUTHORS   Heo,J.Y., Park,A.H., Lee,M.J., Ryu,M.J., Kim,Y.K., Jang,Y.S.,
            Kim,S.J., Shin,S.Y., Son,H.J., Stein,T.D., Huh,Y.H., Chung,S.K.,
            Choi,S.Y., Kim,J.M., Hwang,O., Shong,M., Hyeon,S.J., Lee,J.,
            Ryu,H., Kim,D. and Kweon,G.R.
  TITLE     Crif1 deficiency in dopamine neurons triggers early-onset
            parkinsonism
  JOURNAL   Mol Psychiatry 28 (10), 4474-4484 (2023)
   PUBMED   37648779
  REMARK    GeneRIF: Crif1 deficiency in dopamine neurons triggers early-onset
            parkinsonism.
            Erratum:[Mol Psychiatry. 2023 Oct;28(10):4485. doi:
            10.1038/s41380-023-02254-1.. PMID: 37783789]
REFERENCE   3  (bases 1 to 1769)
  AUTHORS   Wang,Q., Xie,Z., Li,C., Xu,C., Ding,C., Ju,S., Chen,J., Cui,Z.,
            Chen,C., Gu,B., Wei,T. and Zhao,J.
  TITLE     CRIF1 promotes the progression of non-small-cell lung cancer by
            SIRT3- mediated deacetylation of PYCR1
  JOURNAL   J Mol Histol 53 (4), 657-667 (2022)
   PUBMED   35716330
  REMARK    GeneRIF: CRIF1 promotes the progression of non-small-cell lung
            cancer by SIRT3- mediated deacetylation of PYCR1.
REFERENCE   4  (bases 1 to 1769)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 1769)
  AUTHORS   Oh,N.S., Yoon,S.H., Lee,W.K., Choi,J.Y., Min do,S. and Bae,Y.S.
  TITLE     Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes
            cell proliferation
  JOURNAL   Gene 386 (1-2), 147-153 (2007)
   PUBMED   17069992
  REMARK    GeneRIF: Phosphorylation of serine-221 in CKBBP2/CRIF1 promotes
            proliferation of green monkey COS7 cells.
REFERENCE   6  (bases 1 to 1769)
  AUTHORS   Park,K.C., Song,K.H., Chung,H.K., Kim,H., Kim,D.W., Song,J.H.,
            Hwang,E.S., Jung,H.S., Park,S.H., Bae,I., Lee,I.K., Choi,H.S. and
            Shong,M.
  TITLE     CR6-interacting factor 1 interacts with orphan nuclear receptor
            Nur77 and inhibits its transactivation
  JOURNAL   Mol Endocrinol 19 (1), 12-24 (2005)
   PUBMED   15459248
REFERENCE   7  (bases 1 to 1769)
  AUTHORS   Chung,H.K., Yi,Y.W., Jung,N.C., Kim,D., Suh,J.M., Kim,H.,
            Park,K.C., Song,J.H., Kim,D.W., Hwang,E.S., Yoon,S.H., Bae,Y.S.,
            Kim,J.M., Bae,I. and Shong,M.
  TITLE     CR6-interacting factor 1 interacts with Gadd45 family proteins and
            modulates the cell cycle
  JOURNAL   J Biol Chem 278 (30), 28079-28088 (2003)
   PUBMED   12716909
  REMARK    GeneRIF: results suggest that CRIF1 is a novel nuclear protein that
            interacts with Gadd45 and may play a role in negative regulation of
            cell cycle progression and cell growth
REFERENCE   8  (bases 1 to 1769)
  AUTHORS   Gornemann,J., Hofmann,T.G., Will,H. and Muller,M.
  TITLE     Interaction of human papillomavirus type 16 L2 with cellular
            proteins: identification of novel nuclear body-associated proteins
  JOURNAL   Virology 303 (1), 69-78 (2002)
   PUBMED   12482659
REFERENCE   9  (bases 1 to 1769)
  AUTHORS   Ahn,B.H., Kim,T.H. and Bae,Y.S.
  TITLE     Mapping of the interaction domain of the protein kinase CKII beta
            subunit with target proteins
  JOURNAL   Mol Cells 12 (2), 158-163 (2001)
   PUBMED   11710515
REFERENCE   10 (bases 1 to 1769)
  AUTHORS   Horikoshi,N., Cong,J., Kley,N. and Shenk,T.
  TITLE     Isolation of differentially expressed cDNAs from p53-dependent
            apoptotic cells: activation of the human homologue of the
            Drosophila peroxidasin gene
  JOURNAL   Biochem Biophys Res Commun 261 (3), 864-869 (1999)
   PUBMED   10441517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF479749.1, AI309741.1 and
            AC092069.2.
            
            On Nov 23, 2018 this sequence version replaced NM_052850.3.
            
            Summary: This gene encodes a nuclear-localized protein that may be
            induced by p53 and regulates the cell cycle by inhibiting G1 to S
            phase progression. The encoded protein may interact with other cell
            cycle regulators. [provided by RefSeq, Aug 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1158843.1,
                                           SRR3476690.885567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316939.3/ ENSP00000323065.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-730               AF479749.1         14-743
            731-732             AI309741.1         10-11               c
            733-1769            AC092069.2         35522-36558
FEATURES             Location/Qualifiers
     source          1..1769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..1769
                     /gene="GADD45GIP1"
                     /gene_synonym="CKBBP2; CKbetaBP2; CRIF1; mL64; MRP-L59;
                     PLINP; PLINP-1; Plinp1; PRG6"
                     /note="GADD45G interacting protein 1"
                     /db_xref="GeneID:90480"
                     /db_xref="HGNC:HGNC:29996"
                     /db_xref="MIM:605162"
     exon            1..361
                     /gene="GADD45GIP1"
                     /gene_synonym="CKBBP2; CKbetaBP2; CRIF1; mL64; MRP-L59;
                     PLINP; PLINP-1; Plinp1; PRG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..680
                     /gene="GADD45GIP1"
                     /gene_synonym="CKBBP2; CKbetaBP2; CRIF1; mL64; MRP-L59;
                     PLINP; PLINP-1; Plinp1; PRG6"
                     /note="papillomavirus L2 interacting nuclear protein 1;
                     growth arrest and DNA damage-inducible
                     proteins-interacting protein 1; CKII beta binding protein
                     2; CR6 interacting factor 1; 39S ribosomal protein L59,
                     mitochondrial; CKII beta-associating protein;
                     p53-responsive gene 6 protein; growth arrest- and DNA
                     damage-inducible GADD45G-interacting protein; growth
                     arrest and DNA-damage-inducible, gamma interacting protein
                     1; mitochondrial large ribosomal subunit protein CRIF1;
                     mitochondrial large ribosomal subunit protein mL64"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL64"
                     /protein_id="NP_443082.2"
                     /db_xref="CCDS:CCDS12290.1"
                     /db_xref="GeneID:90480"
                     /db_xref="HGNC:HGNC:29996"
                     /db_xref="MIM:605162"
                     /translation="MAASVRQARSLLGVAATLAPGSRGYRARPPPRRRPGPRWPDPED
                     LLTPRWQLGPRYAAKQFARYGAASGVVPGSLWPSPEQLRELEAEEREWYPSLATMQES
                     LRVKQLAEEQKRREREQHIAECMAKMPQMIVNWQQQQRENWEKAQADKERRARLQAEA
                     QELLGYQVDPRSARFQELLQDLEKKERKRLKEEKQKRKKEARAAALAAAVAQDPAASG
                     APSS"
     exon            362..1769
                     /gene="GADD45GIP1"
                     /gene_synonym="CKBBP2; CKbetaBP2; CRIF1; mL64; MRP-L59;
                     PLINP; PLINP-1; Plinp1; PRG6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      697..702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GADD45GIP1"
                     /gene_synonym="CKBBP2; CKbetaBP2; CRIF1; mL64; MRP-L59;
                     PLINP; PLINP-1; Plinp1; PRG6"
                     /note="hexamer: AATAAA"
     polyA_site      732
                     /gene="GADD45GIP1"
                     /gene_synonym="CKBBP2; CKbetaBP2; CRIF1; mL64; MRP-L59;
                     PLINP; PLINP-1; Plinp1; PRG6"
                     /note="major polyA site"
     polyA_site      1274
                     /gene="GADD45GIP1"
                     /gene_synonym="CKBBP2; CKbetaBP2; CRIF1; mL64; MRP-L59;
                     PLINP; PLINP-1; Plinp1; PRG6"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GADD45GIP1"
                     /gene_synonym="CKBBP2; CKbetaBP2; CRIF1; mL64; MRP-L59;
                     PLINP; PLINP-1; Plinp1; PRG6"
                     /note="hexamer: AATAAA"
     polyA_site      1769
                     /gene="GADD45GIP1"
                     /gene_synonym="CKBBP2; CKbetaBP2; CRIF1; mL64; MRP-L59;
                     PLINP; PLINP-1; Plinp1; PRG6"
ORIGIN      
        1 gcacagccaa gatggcggcg tccgtgcgac aggcacgcag cctactaggt gtggcggcga
       61 ccctggcccc gggttcccgt ggctaccggg cgcggccgcc cccgcgccgc aggccgggac
      121 cccggtggcc agaccccgag gacctcctga ccccgcggtg gcagctggga ccgcgctacg
      181 cggctaagca gttcgcgcgt tacggcgccg cctccggggt ggtccccggt tcgttatggc
      241 cgtcgccgga gcagctgcgg gagctggagg ccgaagaacg cgaatggtac ccgagcctgg
      301 cgaccatgca ggagtcgctg cgggtgaagc agctggccga agagcagaag cgtcgggaga
      361 gggagcagca catcgcagag tgcatggcca agatgccaca gatgattgtg aactggcagc
      421 agcagcagcg ggagaactgg gagaaggccc aggctgacaa ggagaggagg gcccgactgc
      481 aggctgaggc ccaggagctc ctgggctacc aggtggaccc aaggagtgcc cgcttccagg
      541 agctgctcca ggacctagag aagaaggagc gcaagcgcct caaggaggaa aaacagaaac
      601 ggaagaagga ggcgcgagct gctgcattgg ctgcagctgt ggctcaagac ccagcagcct
      661 ctggggcacc cagctcctga ggctttgtcc cttcccaata aagcctgcta cctggcagta
      721 cccctgaaga gatctgcgtc ctctcaaggt gtgcctctct gggtcccctg gttcctcccc
      781 caatacttaa gagctgggga atcccccact tggctgtact caaaagggga cagggactct
      841 aggccctgct gactaactgg ggcttcagtg ggaggaaaag gggggtgtac aatgggcaaa
      901 taatggagaa gcagatggca gaagagaaga aggcttctgt ttaccaacat tcatctccag
      961 taattagcca attacaaggc tggtgggggg ggaagtatag ccaaaacaga ctgtggtgat
     1021 gatggtgggg gccggggaga agcagtcctt gtaacgttgg gctggggtcc actgcctgga
     1081 aatgacacac tgggggagga gacaccggaa gcctcaatct gcagggactc acagactcct
     1141 ctcccccttc caggcacccg tcaccatgcc tgcctgtgcc cagccagccc cccaagaccc
     1201 agacaggtgg gcgcggggag ccccagcagg cacagaccat agggctagtt tttaaaactt
     1261 tattcacttc aaaaccttta tcagagacac ggttctgttc tggggtgggg gtggccttga
     1321 caatgagctg atgttagccc ttctccaggc tggaggccaa ggccagactg gggagggggc
     1381 cttgggcctt tcaggacttg ccctagatgg aaagatttgg gccactccaa tggaggatca
     1441 aagttggggc tccagcttcc cctcatccta gaagaggatg ggggggggtc ctcaggggtt
     1501 tttcggagga tggagaggca agcagccgcc tttccgtctg gctgcagaga gctgggacag
     1561 aggccaagag gggcccatct gtcgcctccc agtcctgcca gcttctctga gcaggctggg
     1621 ctggggagga ggacgggggg acagctgtct ggcccgggag atgggaacag gggccacttt
     1681 aggaggacag gaagctggac tgtttgcttg tttttttaag atttttgatt tttttttcca
     1741 tttcttaaat aaacatgaat atatatata
//
