LOCUS       NM_006705               1066 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens growth arrest and DNA damage inducible gamma
            (GADD45G), mRNA.
ACCESSION   NM_006705
VERSION     NM_006705.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1066)
  AUTHORS   Wang,C., Shan,S., Li,X., Wang,H., Qi,J. and Zhao,S.
  TITLE     The role of GADD45G methylation in endometrial cancer: Insights
            into CDK1/CCNB1 activation and therapeutic opportunities
  JOURNAL   J Cancer Res Ther 20 (4), 1214-1223 (2024)
   PUBMED   39206984
  REMARK    GeneRIF: The role of GADD45G methylation in endometrial cancer:
            Insights into CDK1/CCNB1 activation and therapeutic opportunities.
REFERENCE   2  (bases 1 to 1066)
  AUTHORS   Zhang,P., You,N., Ding,Y., Zhu,W., Wang,N., Xie,Y., Huang,W.,
            Ren,Q., Qin,T., Fu,R., Zhang,L., Xiao,Z., Cheng,T. and Ma,X.
  TITLE     Gadd45g insufficiency drives the pathogenesis of myeloproliferative
            neoplasms
  JOURNAL   Nat Commun 15 (1), 2989 (2024)
   PUBMED   38582902
  REMARK    GeneRIF: Gadd45g insufficiency drives the pathogenesis of
            myeloproliferative neoplasms.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1066)
  AUTHORS   Zeng,L.P., Qin,Y.Q., Lu,X.M., Feng,Z.B. and Fang,X.L.
  TITLE     Identify GADD45G as a potential target of 4-methoxydalbergione in
            treatment of liver cancer: bioinformatics analysis and in vivo
            experiment
  JOURNAL   World J Surg Oncol 21 (1), 324 (2023)
   PUBMED   37833694
  REMARK    GeneRIF: Identify GADD45G as a potential target of
            4-methoxydalbergione in treatment of liver cancer: bioinformatics
            analysis and in vivo experiment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1066)
  AUTHORS   Li,Y. and Wang,B.
  TITLE     Circular RNA circCHFR downregulation protects against oxidized
            low-density lipoprotein-induced endothelial injury via regulation
            of microRNA-15b-5p/growth arrest and DNA damage inducible gamma
  JOURNAL   Bioengineered 13 (2), 4481-4492 (2022)
   PUBMED   35137664
  REMARK    GeneRIF: Circular RNA circCHFR downregulation protects against
            oxidized low-density lipoprotein-induced endothelial injury via
            regulation of microRNA-15b-5p/growth arrest and DNA damage
            inducible gamma.
REFERENCE   5  (bases 1 to 1066)
  AUTHORS   Shin,G.T., Park,J.E. and Lee,M.J.
  TITLE     MAGEH1 interacts with GADD45G and induces renal tubular cell
            apoptosis
  JOURNAL   PLoS One 16 (11), e0260135 (2021)
   PUBMED   34788311
  REMARK    GeneRIF: MAGEH1 interacts with GADD45G and induces renal tubular
            cell apoptosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1066)
  AUTHORS   Zhang,W., Bae,I., Krishnaraju,K., Azam,N., Fan,W., Smith,K.,
            Hoffman,B. and Liebermann,D.A.
  TITLE     CR6: A third member in the MyD118 and Gadd45 gene family which
            functions in negative growth control
  JOURNAL   Oncogene 18 (35), 4899-4907 (1999)
   PUBMED   10490824
REFERENCE   7  (bases 1 to 1066)
  AUTHORS   Nakayama,K., Hara,T., Hibi,M., Hirano,T. and Miyajima,A.
  TITLE     A novel oncostatin M-inducible gene OIG37 forms a gene family with
            MyD118 and GADD45 and negatively regulates cell growth
  JOURNAL   J Biol Chem 274 (35), 24766-24772 (1999)
   PUBMED   10455148
REFERENCE   8  (bases 1 to 1066)
  AUTHORS   Suzuki,M., Watanabe,T.K., Fujiwara,T., Nakamura,Yp.6., Takahashi,E.
            and Tanigami,A.
  TITLE     Molecular cloning, expression, and mapping of a novel human cDNA,
            GRP17, highly homologous to human gadd45 and murine MyD118
  JOURNAL   J Hum Genet 44 (5), 300-303 (1999)
   PUBMED   10496071
REFERENCE   9  (bases 1 to 1066)
  AUTHORS   Takekawa,M. and Saito,H.
  TITLE     A family of stress-inducible GADD45-like proteins mediate
            activation of the stress-responsive MTK1/MEKK4 MAPKKK
  JOURNAL   Cell 95 (4), 521-530 (1998)
   PUBMED   9827804
REFERENCE   10 (bases 1 to 1066)
  AUTHORS   Beadling,C., Johnson,K.W. and Smith,K.A.
  TITLE     Isolation of interleukin 2-induced immediate-early genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (7), 2719-2723 (1993)
   PUBMED   7681987
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA420966.1 and BC019325.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006705.3.
            
            Summary: This gene is a member of a group of genes whose transcript
            levels are increased following stressful growth arrest conditions
            and treatment with DNA-damaging agents. The protein encoded by this
            gene responds to environmental stresses by mediating activation of
            the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly
            expressed in placenta. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF079806.1, SRR1803613.413299.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252506.11/ ENSP00000252506.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               DA420966.1         1-553
            554-1066            BC019325.1         535-1047
FEATURES             Location/Qualifiers
     source          1..1066
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.2"
     gene            1..1066
                     /gene="GADD45G"
                     /gene_synonym="CR6; DDIT2; GADD45gamma; GRP17"
                     /note="growth arrest and DNA damage inducible gamma"
                     /db_xref="GeneID:10912"
                     /db_xref="HGNC:HGNC:4097"
                     /db_xref="MIM:604949"
     exon            1..163
                     /gene="GADD45G"
                     /gene_synonym="CR6; DDIT2; GADD45gamma; GRP17"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..590
                     /gene="GADD45G"
                     /gene_synonym="CR6; DDIT2; GADD45gamma; GRP17"
                     /note="GADD45-gamma; gadd-related protein, 17 kD; DDIT-2;
                     cytokine-responsive protein CR6; DNA damage-inducible
                     transcript 2 protein"
                     /codon_start=1
                     /product="growth arrest and DNA damage-inducible protein
                     GADD45 gamma"
                     /protein_id="NP_006696.1"
                     /db_xref="CCDS:CCDS6686.1"
                     /db_xref="GeneID:10912"
                     /db_xref="HGNC:HGNC:4097"
                     /db_xref="MIM:604949"
                     /translation="MTLEEVRGQDTVPESTARMQGAGKALHELLLSAQRQGCLTAGVY
                     ESAKVLNVDPDNVTFCVLAAGEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLA
                     AIVGAGEEAGAPGDLHCILISNPNEDAWKDPALEKLSLFCEESRSVNDWVPSITLPE"
     exon            164..265
                     /gene="GADD45G"
                     /gene_synonym="CR6; DDIT2; GADD45gamma; GRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            266..479
                     /gene="GADD45G"
                     /gene_synonym="CR6; DDIT2; GADD45gamma; GRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            480..1066
                     /gene="GADD45G"
                     /gene_synonym="CR6; DDIT2; GADD45gamma; GRP17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1047..1052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GADD45G"
                     /gene_synonym="CR6; DDIT2; GADD45gamma; GRP17"
                     /note="hexamer: AATAAA"
     polyA_site      1066
                     /gene="GADD45G"
                     /gene_synonym="CR6; DDIT2; GADD45gamma; GRP17"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgctg gtggtgggcg cgccgtgctg agctctggct gtcagtgtgt tcgcccgcgt
       61 cccctccgcg ctctccgctt gtggataact agctgctggt tgatcgcact atgactctgg
      121 aagaagtccg cggccaggac acagttccgg aaagcacagc caggatgcag ggtgccggga
      181 aagcgctgca tgagttgctg ctgtcggcgc agcgtcaggg ctgcctcact gccggcgtct
      241 acgagtcagc caaagtcttg aacgtggacc ccgacaatgt gaccttctgt gtgctggctg
      301 cgggtgagga ggacgagggc gacatcgcgc tgcagatcca ttttacgctg atccaggctt
      361 tctgctgcga gaacgacatc gacatagtgc gcgtgggcga tgtgcagcgg ctggcggcta
      421 tcgtgggcgc cggcgaggag gcgggtgcgc cgggcgacct gcactgcatc ctcatttcga
      481 accccaacga ggacgcctgg aaggatcccg ccttggagaa gctcagcctg ttttgcgagg
      541 agagccgcag cgttaacgac tgggtgccca gcatcaccct ccccgagtga cagcccggcg
      601 gggaccttgg tctgatcgac gtggtgacgc cccggggcgc ctagagcgcg gctggctctg
      661 tggaggggcc ctccgagggt gcccgagtgc ggcgtggaga ctggcaggcg gggggggcgc
      721 ctggagagcg aggaggcgcg gcctcccgag gaggggcccg gtggcggcag ggccaggctg
      781 gtccgagctg aggactctgc aagtgtctgg agcggctgct cgcccaggaa ggcctaggct
      841 aggacgttgg cctcagggcc aggaaggaca gactggccgg gcaggcgtga ctcagcagcc
      901 tgcgctcggc aggaaggagc ggcgccctgg acttggtaca gttgcaggag cgtgaaggac
      961 ttagccgact gcgctgcttt ttcaaaacgg atccgggcaa tgcttcgttt tctaaaggat
     1021 gctgctgttg aagctttgaa ttttacaata aactttttga aacaaa
//
