LOCUS       NM_015675               1371 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens growth arrest and DNA damage inducible beta (GADD45B),
            mRNA.
ACCESSION   NM_015675
VERSION     NM_015675.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1371)
  AUTHORS   Huang,M., Tao,X., Bao,J., Wang,J., Gong,X., Luo,L., Pan,S.,
            Yang,R., Gui,Y., Zhou,H., Xia,Y., Yang,Y., Sun,B., Liu,W. and
            Shu,X.
  TITLE     GADD45B in the ventral hippocampal CA1 modulates aversive memory
            acquisition and spatial cognition
  JOURNAL   Life Sci 346, 122618 (2024)
   PUBMED   38614306
  REMARK    GeneRIF: GADD45B in the ventral hippocampal CA1 modulates aversive
            memory acquisition and spatial cognition.
REFERENCE   2  (bases 1 to 1371)
  AUTHORS   Chen,L., Fang,C., Yuan,X., Liu,M., Wu,P., Zhong,L. and Chen,Z.
  TITLE     Has-miR-300-GADD45B promotes melanoma growth via cell cycle
  JOURNAL   Aging (Albany NY) 15 (23), 13920-13943 (2023)
   PUBMED   38070141
  REMARK    GeneRIF: Has-miR-300-GADD45B promotes melanoma growth via cell
            cycle.
            Erratum:[Aging (Albany NY). 2024 Jan 14;16(1):983. doi:
            10.18632/aging.205515.. PMID: 38219232]
REFERENCE   3  (bases 1 to 1371)
  AUTHORS   Li,C., Wei,A. and Qin,Y.
  TITLE     Expression of GADD45B in Renal Tissue of Children with IgA
            Nephropathy and Correlation with Mesangial Hypercellularity
  JOURNAL   Fetal Pediatr Pathol 42 (5), 785-795 (2023)
   PUBMED   37534585
  REMARK    GeneRIF: Expression of GADD45B in Renal Tissue of Children with IgA
            Nephropathy and Correlation with Mesangial Hypercellularity.
REFERENCE   4  (bases 1 to 1371)
  AUTHORS   Li,Y., Shen,L., Tao,K., Xu,G. and Ji,K.
  TITLE     Key Roles of p53 Signaling Pathway-Related Factors GADD45B and
            SERPINE1 in the Occurrence and Development of Gastric Cancer
  JOURNAL   Mediators Inflamm 2023, 6368893 (2023)
   PUBMED   37662480
  REMARK    GeneRIF: Key Roles of p53 Signaling Pathway-Related Factors GADD45B
            and SERPINE1 in the Occurrence and Development of Gastric Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1371)
  AUTHORS   Xu,W., Jiang,T., Shen,K., Zhao,D., Zhang,M., Zhu,W., Liu,Y. and
            Xu,C.
  TITLE     GADD45B regulates the carcinogenesis process of chronic atrophic
            gastritis and the metabolic pathways of gastric cancer
  JOURNAL   Front Endocrinol (Lausanne) 14, 1224832 (2023)
   PUBMED   37608794
  REMARK    GeneRIF: GADD45B regulates the carcinogenesis process of chronic
            atrophic gastritis and the metabolic pathways of gastric cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1371)
  AUTHORS   Sakaue,M., Adachi,H. and Jetten,A.M.
  TITLE     Post-transcriptional regulation of MyD118 and GADD45 in human lung
            carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-
            naphthalene carboxylic acid-induced apoptosis
  JOURNAL   Mol Pharmacol 55 (4), 668-676 (1999)
   PUBMED   10101024
REFERENCE   7  (bases 1 to 1371)
  AUTHORS   Takekawa,M. and Saito,H.
  TITLE     A family of stress-inducible GADD45-like proteins mediate
            activation of the stress-responsive MTK1/MEKK4 MAPKKK
  JOURNAL   Cell 95 (4), 521-530 (1998)
   PUBMED   9827804
REFERENCE   8  (bases 1 to 1371)
  AUTHORS   Koonin,E.V.
  TITLE     Cell cycle and apoptosis: possible roles of Gadd45 and MyD118
            proteins inferred from their homology to ribosomal proteins
  JOURNAL   J Mol Med (Berl) 75 (4), 236-238 (1997)
   PUBMED   9151207
REFERENCE   9  (bases 1 to 1371)
  AUTHORS   Vairapandi,M., Balliet,A.G., Fornace,A.J. Jr., Hoffman,B. and
            Liebermann,D.A.
  TITLE     The differentiation primary response gene MyD118, related to
            GADD45, encodes for a nuclear protein which interacts with PCNA and
            p21WAF1/CIP1
  JOURNAL   Oncogene 12 (12), 2579-2594 (1996)
   PUBMED   8700517
REFERENCE   10 (bases 1 to 1371)
  AUTHORS   Abdollahi,A., Lord,K.A., Hoffman-Liebermann,B. and Liebermann,D.A.
  TITLE     Sequence and expression of a cDNA encoding MyD118: a novel myeloid
            differentiation primary response gene induced by multiple cytokines
  JOURNAL   Oncogene 6 (1), 165-167 (1991)
   PUBMED   1899477
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK293087.1 and BM670459.1.
            
            On Nov 24, 2018 this sequence version replaced NM_015675.3.
            
            Summary: This gene is a member of a group of genes whose transcript
            levels are increased following stressful growth arrest conditions
            and treatment with DNA-damaging agents. The genes in this group
            respond to environmental stresses by mediating activation of the
            p38/JNK pathway.  This activation is mediated via their proteins
            binding and activating MTK1/MEKK4 kinase, which is an upstream
            activator of both p38 and JNK MAPKs. The function of these genes or
            their protein products is involved in the regulation of growth and
            apoptosis. These genes are regulated by different mechanisms, but
            they are often coordinately expressed and can function
            cooperatively in inhibiting cell growth. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.236157.1,
                                           SRR3476690.397772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215631.9/ ENSP00000215631.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-935               AK293087.1         1-935
            936-1371            BM670459.1         21-456              c
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1371
                     /gene="GADD45B"
                     /gene_synonym="GADD45BETA; MYD118"
                     /note="growth arrest and DNA damage inducible beta"
                     /db_xref="GeneID:4616"
                     /db_xref="HGNC:HGNC:4096"
                     /db_xref="MIM:604948"
     exon            1..276
                     /gene="GADD45B"
                     /gene_synonym="GADD45BETA; MYD118"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..715
                     /gene="GADD45B"
                     /gene_synonym="GADD45BETA; MYD118"
                     /note="negative growth regulatory protein MyD118; myeloid
                     differentiation primary response protein MyD118"
                     /codon_start=1
                     /product="growth arrest and DNA damage-inducible protein
                     GADD45 beta"
                     /protein_id="NP_056490.2"
                     /db_xref="CCDS:CCDS32868.1"
                     /db_xref="GeneID:4616"
                     /db_xref="HGNC:HGNC:4096"
                     /db_xref="MIM:604948"
                     /translation="MTLEELVACDNAAQKMQTVTAAVEELLVAAQRQDRLTVGVYESA
                     KLMNVDPDSVVLCLLAIDEEEEDDIALQIHFTLIQSFCCDNDINIVRVSGMQRLAQLL
                     GEPAETQGTTEARDLHCLLVTNPHTDAWKSHGLVEVASYCEESRGNNQWVPYISLQER
                     "
     exon            277..378
                     /gene="GADD45B"
                     /gene_synonym="GADD45BETA; MYD118"
                     /inference="alignment:Splign:2.1.0"
     exon            379..601
                     /gene="GADD45B"
                     /gene_synonym="GADD45BETA; MYD118"
                     /inference="alignment:Splign:2.1.0"
     exon            602..1371
                     /gene="GADD45B"
                     /gene_synonym="GADD45BETA; MYD118"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1353..1358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GADD45B"
                     /gene_synonym="GADD45BETA; MYD118"
                     /note="hexamer: AATAAA"
     polyA_site      1371
                     /gene="GADD45B"
                     /gene_synonym="GADD45BETA; MYD118"
                     /note="major polyA site"
ORIGIN      
        1 agatcgccga agcgtcggac taccgttggt ttccgcaact tcctggatta tcctcgccaa
       61 ggactttgca atatattttt ccgccttttc tggaaggatt tcgctgcttc ccgaaggtct
      121 tggacgagcg ctctagctct gtgggaaggt tttgggctct ctggctcgga ttttgcaatt
      181 tctccctggg gactgccgtg gagccgcatc cactgtggat tataattgca acatgacgct
      241 ggaagagctc gtggcgtgcg acaacgcggc gcagaagatg cagacggtga ccgccgcggt
      301 ggaggagctt ttggtggccg ctcagcgcca ggatcgcctc acagtggggg tgtacgagtc
      361 ggccaagttg atgaatgtgg acccagacag cgtggtcctc tgcctcttgg ccattgacga
      421 ggaggaggag gatgacatcg ccctgcaaat ccacttcacg ctcatccagt ccttctgctg
      481 tgacaacgac atcaacatcg tgcgggtgtc gggcatgcag cgcctggcgc agctcctggg
      541 agagccggcc gagacccagg gcaccaccga ggcccgagac ctgcattgtc tcctggtcac
      601 gaaccctcac acggacgcct ggaagagcca cggcttggtg gaggtggcca gctactgcga
      661 agaaagccgg ggcaacaacc agtgggtccc ctacatctct cttcaggaac gctgaggccc
      721 ttcccagcag cagaatctgt tgagttgctg ccacaaacaa aaaatacaat aaatatttga
      781 accccctccc ccccagcaca acccccccaa aacaacccaa cccacgagga ccatcggggg
      841 cagagtcgtt ggagactgaa gaggaagagg aggaggagaa ggggagtgag cggccgcccc
      901 cagggcggag atccaggagc tggcggccgc cgatccgatg gagaaggggg gacccaggcc
      961 agcaggagac aggacccccg aagctgaggc cttgggatgg agcagaagcc ggagtggcgg
     1021 ggcacgctgc cgccttcccc atcacggagg gtccagactg tccactcggg ggtggagtga
     1081 gactgactgc aagccccacc ctccttgaga ctggagctgg cgtctgcata cgagagactt
     1141 ggttgaactt ggttggtcct tgtctgcacc ctcgacaaga ccacactttg ggacttggga
     1201 gctggggctg aagttgctct gtacccatga actcccagtt tgcgaattat agagacaatc
     1261 tattttgtta cttgcacttg ttattcgaac cactgagagc gagatgggaa gcatagatat
     1321 ctatattttt atttctacta tgagggcctt gtaataaatt tctaaagcct c
//
