LOCUS       NM_018558               6468 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens gamma-aminobutyric acid type A receptor subunit theta
            (GABRQ), mRNA.
ACCESSION   NM_018558
VERSION     NM_018558.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6468)
  AUTHORS   Gami-Patel,P., Scarioni,M., Bouwman,F.H., Boon,B.D.C., van
            Swieten,J.C., Brain Bank,N., Rozemuller,A.J.M., Smit,A.B.,
            Pijnenburg,Y.A.L., Hoozemans,J.J.M. and Dijkstra,A.A.
  TITLE     The severity of behavioural symptoms in FTD is linked to the loss
            of GABRQ-expressing VENs and pyramidal neurons
  JOURNAL   Neuropathol Appl Neurobiol 48 (4), e12798 (2022)
   PUBMED   35152451
  REMARK    GeneRIF: The severity of behavioural symptoms in FTD is linked to
            the loss of GABRQ-expressing VENs and pyramidal neurons.
REFERENCE   2  (bases 1 to 6468)
  AUTHORS   Saha,S., Chatterjee,M., Sinha,S. and Mukhopadhyay,K.
  TITLE     A pioneering study indicate role of GABRQ rs3810651 in ASD severity
            of Indo-Caucasoid female probands
  JOURNAL   Sci Rep 11 (1), 7010 (2021)
   PUBMED   33772085
  REMARK    GeneRIF: A pioneering study indicate role of GABRQ rs3810651 in ASD
            severity of Indo-Caucasoid female probands.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6468)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6468)
  AUTHORS   Nuwer,J.L. and Fleck,M.W.
  TITLE     Anterograde trafficking signals in GABAA subunits are required for
            functional expression
  JOURNAL   Channels (Austin) 13 (1), 440-454 (2019)
   PUBMED   31610743
  REMARK    GeneRIF: The intracellular domain of GABRQ disrupts GABRB3
            homomeric plasma membrane expression.
REFERENCE   5  (bases 1 to 6468)
  AUTHORS   Garcia-Martin,E., Esguevillas,G., Serrador,M., Alonso-Navarro,H.,
            Navacerrada,F., Amo,G., Garcia-Albea,E., Agundez,J.A.G. and
            Jimenez-Jimenez,F.J.
  TITLE     Gamma-aminobutyric acid (GABA) receptors GABRA4, GABRE, and GABRQ
            gene polymorphisms and risk for migraine
  JOURNAL   J Neural Transm (Vienna) 125 (4), 689-698 (2018)
   PUBMED   29299688
  REMARK    GeneRIF: data from the present study suggest a possible role of
            GABRQ rs3810651 single nucleotide polymorphism in the modification
            of the age at onset of migraine in the Caucasian Spanish people
REFERENCE   6  (bases 1 to 6468)
  AUTHORS   Ranna,M., Sinkkonen,S.T., Moykkynen,T., Uusi-Oukari,M. and
            Korpi,E.R.
  TITLE     Impact of epsilon and theta subunits on pharmacological properties
            of alpha3beta1 GABAA receptors expressed in Xenopus oocytes
  JOURNAL   BMC Pharmacol 6, 1 (2006)
   PUBMED   16412217
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6468)
  AUTHORS   Sinkkonen,S.T., Hanna,M.C., Kirkness,E.F. and Korpi,E.R.
  TITLE     GABA(A) receptor epsilon and theta subunits display unusual
            structural variation between species and are enriched in the rat
            locus ceruleus
  JOURNAL   J Neurosci 20 (10), 3588-3595 (2000)
   PUBMED   10804200
REFERENCE   8  (bases 1 to 6468)
  AUTHORS   Bonnert,T.P., McKernan,R.M., Farrar,S., le Bourdelles,B.,
            Heavens,R.P., Smith,D.W., Hewson,L., Rigby,M.R.,
            Sirinathsinghji,D.J., Brown,N., Wafford,K.A. and Whiting,P.J.
  TITLE     theta, a novel gamma-aminobutyric acid type A receptor subunit
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9891-9896 (1999)
   PUBMED   10449790
REFERENCE   9  (bases 1 to 6468)
  AUTHORS   Whiting,P.J., Bonnert,T.P., McKernan,R.M., Farrar,S., Le
            Bourdelles,B., Heavens,R.P., Smith,D.W., Hewson,L., Rigby,M.R.,
            Sirinathsinghji,D.J., Thompson,S.A. and Wafford,K.A.
  TITLE     Molecular and functional diversity of the expanding GABA-A receptor
            gene family
  JOURNAL   Ann N Y Acad Sci 868, 645-653 (1999)
   PUBMED   10414349
  REMARK    Review article
REFERENCE   10 (bases 1 to 6468)
  AUTHORS   Levin,M.L., Chatterjee,A., Pragliola,A., Worley,K.C., Wehnert,M.,
            Zhuchenko,O., Smith,R.F., Lee,C.C. and Herman,G.E.
  TITLE     A comparative transcription map of the murine bare patches (Bpa)
            and striated (Str) critical regions and human Xq28
  JOURNAL   Genome Res 6 (6), 465-477 (1996)
   PUBMED   8828036
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244102.3 and AF189259.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018558.3.
            
            Summary: The gamma-aminobutyric acid (GABA) A receptor is a
            multisubunit chloride channel that mediates the fastest inhibitory
            synaptic transmission in the central nervous system. This gene
            encodes the theta subunit of the GABA A receptor. The gene is
            mapped to chromosome Xq28 in a cluster of genes including those
            that encode the alpha 3 and epsilon subunits of the GABA A
            receptor. [provided by RefSeq, Jul 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF189259.1, BC109210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000598523.3/ ENSP00000469332.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AC244102.3         52455-52742
            289-2288            AF189259.1         1-2000
            2289-6468           AC244102.3         67923-72102
FEATURES             Location/Qualifiers
     source          1..6468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..6468
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     theta"
                     /db_xref="GeneID:55879"
                     /db_xref="HGNC:HGNC:14454"
                     /db_xref="MIM:300349"
     exon            1..457
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..2207
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /note="gamma-aminobutyric acid type A receptor theta
                     subunit; GABA(A) receptor subunit theta;
                     gamma-aminobutyric acid (GABA) A receptor, theta; GABAAR
                     subunit theta"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit theta
                     precursor"
                     /protein_id="NP_061028.3"
                     /db_xref="CCDS:CCDS14707.1"
                     /db_xref="GeneID:55879"
                     /db_xref="HGNC:HGNC:14454"
                     /db_xref="MIM:300349"
                     /translation="MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVV
                     LNLFNCKNCANEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNM
                     DYTITMFFHQTWKDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVEN
                     RVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDN
                     GNAIHMTEELHIPQFTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPT
                     VLTTITSWISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILV
                     CLFFVFLSLLEYVYINYLFYSRGPRRQPRRHRRPRRVIARYRYQQVVVGNVQDGLINV
                     EDGVSSLPITPAQAPLASPESLGSLTSTSEQAQLATSESLSPLTSLSGQAPLATGESL
                     SDLPSTSEQARHSYGVRFNGFQADDSIIPTEIRNRVEAHGHGVTHDHEDSNESLSSDE
                     RHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDKSDCLAIKEQFKCDTNSTWGLNDDELM
                     AHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNI
                     VYWVYHMY"
     exon            458..546
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /inference="alignment:Splign:2.1.0"
     exon            547..614
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /inference="alignment:Splign:2.1.0"
     exon            615..835
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /inference="alignment:Splign:2.1.0"
     exon            836..918
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1056
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1209
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1466
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..6468
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5904..5909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /note="hexamer: GATAAA"
     polyA_site      5925
                     /gene="GABRQ"
                     /gene_synonym="THETA"
     regulatory      6444..6449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /note="hexamer: AATAAA"
     polyA_site      6468
                     /gene="GABRQ"
                     /gene_synonym="THETA"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcagcc aggagcggcc gcagacggag cgcacctcgc agctgccggg cgggccctgg
       61 ggggagctgc gtccagcaga gctgctgggt ggttgctcct cccgggctct catctccggt
      121 atccgggccg acccccgcac cccctacttc ccttgccctc gctgctctct ccttagaggc
      181 gactctttgg ggaagggcca gcaatcccgc cttccccggc cccagtagtc acccactctc
      241 ccaccccacc tctgttcctt ttcgcggccc cgtctcccgc gccctcaggc gcccagaacg
      301 ccccggccat gggcatccga ggcatgctgc gagccgcagt gatcctgctg ctcatcagga
      361 cctggctcgc ggagggcaac taccccagtc ccatcccgaa attccacttc gagttctcct
      421 ctgctgtgcc cgaagtcgtc ctgaacctct tcaactgcaa aaattgtgca aatgaagctg
      481 tggttcaaaa gattttggac agggtgctgt caagatacga tgtccgcctg agaccgaatt
      541 ttggaggtgc ccctgtgcct gtgagaatat ctatttatgt cacgagcatt gaacagatct
      601 cagaaatgaa tatggactac acgatcacga tgttttttca tcagacttgg aaagattcac
      661 gcttagcata ctatgagacc accctgaact tgaccctgga ctatcggatg catgagaagt
      721 tgtgggtccc tgactgctac tttctgaaca gcaaggatgc tttcgtgcat gatgtgactg
      781 tggagaatcg cgtgtttcag cttcacccag atggaacggt gcggtacggc atccgactca
      841 ccactacagc agcttgttcc ctggatctgc ataaattccc tatggacaag caggcctgca
      901 acctggtggt agagagctat ggttacacgg ttgaagacat catattattc tgggatgaca
      961 atgggaacgc catccacatg actgaggagc tgcatatccc tcagttcact ttcctgggaa
     1021 ggacgattac tagcaaggag gtgtatttct acacaggttc ctacatacgc ctgatactga
     1081 agttccaggt tcagagggaa gttaacagct accttgtgca agtctactgg cctactgtcc
     1141 tcaccactat tacctcttgg atatcgtttt ggatgaacta tgattcctct gcagccaggg
     1201 tgacaattgg cttaacttca atgctcatcc tgaccaccat cgactcacat ctgcgggata
     1261 agctccccaa catttcctgt atcaaggcca ttgatatcta tatcctcgtg tgcttgttct
     1321 ttgtgttcct gtccttgctg gagtatgtct acatcaacta tcttttctac agtcgaggac
     1381 ctcggcgcca gcctaggcga cacaggagac cccgaagagt cattgcccgc taccgctacc
     1441 agcaagtggt ggtaggaaac gtgcaggatg gcctgattaa cgtggaagac ggagtcagct
     1501 ctctccccat caccccagcg caggcccccc tggcaagccc ggaaagcctc ggttctttga
     1561 cgtccacctc cgagcaggcc cagctggcca cctcggaaag cctcagccca ctcacttctc
     1621 tctcaggcca ggcccccctg gccactggag aaagcctgag cgatctcccc tccacctcag
     1681 agcaggcccg gcacagctat ggtgttcgct ttaatggttt ccaggctgat gacagtatta
     1741 ttcctaccga aatccgcaac cgtgtcgaag cccatggcca tggtgttacc catgaccatg
     1801 aagattccaa tgagagcttg agctcggatg agcgccatgg ccatggcccc agtgggaagc
     1861 ccatgcttca ccatggcgag aagggtgtgc aagaagcagg ctgggacctt gatgacaaca
     1921 atgacaagag cgactgcctt gccattaagg agcaattcaa gtgtgatact aacagtacct
     1981 ggggccttaa tgatgatgag ctcatggccc atggccaaga gaaggacagt agctcagagt
     2041 ctgaggatag ttgcccccca agccctgggt gctccttcac tgaagggttc tccttcgatc
     2101 tctttaatcc tgactacgtc ccaaaggtcg acaagtggtc ccggttcctc ttccctctgg
     2161 cctttgggtt gttcaacatt gtttactggg tataccatat gtattagtcc cccagtgctc
     2221 cagaacagcg ggagcactgt gctgtgctcc tttcagtttc ttttgggttt gtttttccct
     2281 ctttcctttg ttccttttat tttgtggtta tttgggcaat ccaataagtt catacttctc
     2341 tttataaaca tgaggtgggg agtaattgga aagaacatgt tctagctgga agggaaggga
     2401 ttgaggagga gttggaggta tacagcacat ggatttcctt tcctgctaga agactctcac
     2461 cttttcaaag acttgtaaca aggaataagc atagaaaagc ccctggaaat gtttagagga
     2521 cagagaagag ccaggttggg ggatggggca aggatctggg ccttttgccc acaaacattt
     2581 ctggggggct tttctgtccc ccttgaggtg tcaacatttc tttttcatta catgttttct
     2641 tctttttttg tttcctccta gggattatgg gtcttgttca ccctctgctt agggctttat
     2701 agaagaaagt caagctgggt tgggctgggg ttcatagcta aagggctagc catggcttag
     2761 aagttcaggg aacttcctat aggaaactta gggagcattt gtaagtgcct ttcccccact
     2821 gtatggcatt tgactgtggt gttttgatgc aagcgtggaa ggggaatgtg ggtggatggg
     2881 gctgcagagt gagacatcag ggtgagagag cacatactca gcttgtgggg ttggcagagg
     2941 gtggggggtg atgtcaggtt ggaaattaca cagttgagct ggcctcttcg gagggattgg
     3001 aacttgccta tatttctgct tcagaacgct tggcaataga gactcaatac atctgtctaa
     3061 gtcaggagtt agctttccgt cagttgctga gttgatcacc agttacagca cttggtgaat
     3121 aagcactaag gttaggataa ttcacacttg ctattttacc atctgatcta gactagcaga
     3181 tgaatatcta tcgtaagtct atatactaat cctttctatt tgtctagtgc atagtaagtg
     3241 tcaacaagct ccctgaccca ttacatcact ggagcctcac aggagccctg taagccaggg
     3301 aaggcaaagc acattgtccc cagtgttcca aggaaaacga atggagctta tgccgcatgc
     3361 ttgaggacat gcagccagtg agtggtagat ccaccccact tgctctttct tgtctttttc
     3421 ctcctgactg tcccaactga ggcatttcct tttcttccct ccctaaagag ggtgctccag
     3481 agggccccca ccacatcctc tagcacctgg ggcatctctg caggaatagg ctggtgacca
     3541 gccaatgagc gtgacgtgag cagatggaga acacactctg cccactgagc agggccccta
     3601 acggaagtag gattggccag cattccaact tgccaagcag ctccacctca ctgatggagg
     3661 ttgtgaggga gtgaactttg ccgagcactc aacatatgcc acctcttcct ccctatgcag
     3721 tctctccctc agtcccttac ccctctaccc actcaccctt taactgtgct tctgtgtttg
     3781 tgtttctgta tatacctggg tgtatgcata tgcagcaggg tgggtgtatg tacatataca
     3841 accatttgag aagctgcata gtgccgtgtc tagtggtgta aatctacatt ggtgtgtaca
     3901 gaattgtatc tacagcatgt ggatgcatgc gtgtgtgtgc acatccctgt gaaagtgtgg
     3961 cttatgtatg tgtatgcttg tgtacacatg ggtctatgct gagtgcatgt atataagggc
     4021 atgtctgcat atctatgttt atctgatttg aatgggtgtg aaaggaaata cccctgaaag
     4081 catatgtatt ccctgttggt gacccttcta gaaccactat aattcccttg gcctgctccc
     4141 atatggtgga ggggccctat ttggccgggc tgcttaactg actgtttctt tccaacttcc
     4201 tgttccaggg agcagcatct cccagttccc ttccactgtt tgccctgtcc ctccatccat
     4261 ctgtgctgtc tcctagatag aagactgggg aagtgaatgt agtcctaaga agtggtgagc
     4321 tagtgccttg aggtaggaag tggttaatcc atggaagaag ctgcaagtac agagcatttc
     4381 actttgtcct agaggaacat gtttcggggt aacaggctgg ggagtgaggc tgaaagaggc
     4441 attgagaata gacacttgta cagtcacata cacatacaca cacacaaatc ttgtacgaca
     4501 gttgaaaaca agaaagttac cactggaaga gctaaaattg cctctttatt tttggatacc
     4561 ccatacagag attcaggtgg aggggagagc agtgactcca tgtctgaagc tcccaatgtg
     4621 gctattgaaa ggctggcttc ctggagccta agcattggtt ggttgacgtg gatttgggtc
     4681 tccagcaccc tggaggtgct ttcaaccctg tggtggcaag cagttcattt gggataaagt
     4741 cataaaggga gattggagca gtgtgaagaa aaggagggtt ttaagatttg tctggaagca
     4801 atgcacatga aggcttcaca gcacagagga agggcagcga ggccagttgt aaatatctct
     4861 atagatccat atagctagat ataatactat accttaaaaa ggatatcttg ccctgacgtg
     4921 ctgcaatgag agcagttgaa ctctactgcg actcatactc tgtaggttaa gtgtcaaaat
     4981 gaggtggaga tttggcagtg acaccctttc gggaacgtga accttctgag tttgctatgg
     5041 atttggtcat tttagcctgc acgttgccag atctcccctt gttgagtctt gtatgtggtc
     5101 tgtcctctgt gtcatttgag tcctcagctg tccccaaccc cttcccagcc cctccccagc
     5161 ctgcagtcac cccctgtcca gcaagctgcc tccatcccat ccctctcctc acctcacacc
     5221 aggtaactct ggaagtgcag aatgcttggt agtttggagc ttgggcagca tctgggatgc
     5281 aacaacccct attttactct tctacccacc ttccatttct ttccttccca tcgacttccc
     5341 cgacccagga tcccttcttt gccactatca tgggaaggac acccctgtct gtctttctga
     5401 agtatcattt tattgtgggg atgtgtgaca cgtttcctac caagttcttg ccagttccat
     5461 ctgccactgt ggggtgcctt tgcacaggtc atggacgatc tgctgggtct tactagagcc
     5521 tgtcaaatgt attcttacaa ttcatgtcat cttgttaata gcaggacttc aaagtctttg
     5581 catatttaga gctgagtttt gctgagactg tggccattcc taatgaggtt tcctcattcc
     5641 atatatataa tagctaaccc ttaaagccat taactaatga atgcatttat taagctatcc
     5701 actcgcatgg taccctgctg tggtgatgag cagtaacttt ctagctattc catagcccaa
     5761 catcaaagga aatcgtgact cgtcctacta gaagtgtagt gtctttgtgt ttgttgtgta
     5821 gtgtcctgtg atcaatataa aatctatatt atcagtgttg ggttttcagg ggagggaggg
     5881 agaggatgtt aaagtctctc tttgataaac ttaaattatg aaatagccca gttgttcagg
     5941 gtcacttcta ttgactcaat ttgtgtgaga ctttgcactc actatctcgc cggccggact
     6001 gcatgcccag ggtcagtagt cagcagagct aaaggtgccc gaatttagca cagctggctg
     6061 tggtgcctga catagggcag taccggggga ttcttcagag gtcagccaag tcggtaacat
     6121 tctgtgaagc agattaaata cagtaaaatc aaacaaacgg aggtctttgg aagtgatgct
     6181 gggcccaggc agtgaaaatc aagaaaagag gagaaagacc aagacctgga tgtcctggac
     6241 gacctgaccc aaaaaggggc acaaagcagc agagcttcac caggtgactg ggtggcttct
     6301 ttgtcctcat taaatgtaca tctttgcatg aaaaggacct tgactggtct ggactttaac
     6361 aaagtaaaat atgaagaaac gtaaaattat gcttctgaaa aatatactga aataaaattt
     6421 tgtaaatagc taaaagaaaa ataaataaat ataataacaa gtactcta
//
