LOCUS       NM_014211               3304 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens gamma-aminobutyric acid type A receptor subunit pi
            (GABRP), transcript variant 1, mRNA.
ACCESSION   NM_014211 XM_005265871
VERSION     NM_014211.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3304)
  AUTHORS   Meng,Y., Li,R., Geng,S., Chen,W., Jiang,W., Li,Z., Hao,J. and Xu,Z.
  TITLE     GABRP Promotes the Metastasis of Pancreatic Cancer by Activation of
            the MEK/ERK Signaling Pathway
  JOURNAL   Biochem Genet 62 (1), 242-253 (2024)
   PUBMED   37326897
  REMARK    GeneRIF: GABRP Promotes the Metastasis of Pancreatic Cancer by
            Activation of the MEK/ERK Signaling Pathway.
REFERENCE   2  (bases 1 to 3304)
  AUTHORS   Chen,C., Wu,B., Wang,M., Chen,J., Huang,Z. and Shi,J.S.
  TITLE     GABRP promotes CD44s-mediated gemcitabine resistance in pancreatic
            cancer
  JOURNAL   PeerJ 10, e12728 (2022)
   PUBMED   35846884
  REMARK    GeneRIF: GABRP promotes CD44s-mediated gemcitabine resistance in
            pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3304)
  AUTHORS   Juvale,I.I.A., Hassan,Z. and Has,A.T.C.
  TITLE     The Emerging Roles of pi Subunit-Containing GABAA Receptors in
            Different Cancers
  JOURNAL   Int J Med Sci 18 (16), 3851-3860 (2021)
   PUBMED   34790061
  REMARK    GeneRIF: The Emerging Roles of pi Subunit-Containing GABAA
            Receptors in Different Cancers.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3304)
  AUTHORS   Li,X., Wang,H., Yang,X., Wang,X., Zhao,L., Zou,L., Yang,Q., Hou,Z.,
            Tan,J., Zhang,H., Nie,J. and Jiao,B.
  TITLE     GABRP sustains the stemness of triple-negative breast cancer cells
            through EGFR signaling
  JOURNAL   Cancer Lett 514, 90-102 (2021)
   PUBMED   34023418
  REMARK    GeneRIF: GABRP sustains the stemness of triple-negative breast
            cancer cells through EGFR signaling.
REFERENCE   5  (bases 1 to 3304)
  AUTHORS   Karvas,R.M., McInturf,S., Zhou,J., Ezashi,T., Schust,D.J.,
            Roberts,R.M. and Schulz,L.C.
  TITLE     Use of a human embryonic stem cell model to discover GABRP, WFDC2,
            VTCN1 and ACTC1 as markers of early first trimester human
            trophoblast
  JOURNAL   Mol Hum Reprod 26 (6), 425-440 (2020)
   PUBMED   32359161
  REMARK    GeneRIF: Use of a human embryonic stem cell model to discover
            GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester
            human trophoblast.
REFERENCE   6  (bases 1 to 3304)
  AUTHORS   Petryshen,T.L., Middleton,F.A., Tahl,A.R., Rockwell,G.N.,
            Purcell,S., Aldinger,K.A., Kirby,A., Morley,C.P., McGann,L.,
            Gentile,K.L., Waggoner,S.G., Medeiros,H.M., Carvalho,C., Macedo,A.,
            Albus,M., Maier,W., Trixler,M., Eichhammer,P., Schwab,S.G.,
            Wildenauer,D.B., Azevedo,M.H., Pato,M.T., Pato,C.N., Daly,M.J. and
            Sklar,P.
  TITLE     Genetic investigation of chromosome 5q GABAA receptor subunit genes
            in schizophrenia
  JOURNAL   Mol Psychiatry 10 (12), 1074-1088 (2005)
   PUBMED   16172613
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3304)
  AUTHORS   Neelands,T.R. and Macdonald,R.L.
  TITLE     Incorporation of the pi subunit into functional gamma-aminobutyric
            Acid(A) receptors
  JOURNAL   Mol Pharmacol 56 (3), 598-610 (1999)
   PUBMED   10462548
REFERENCE   8  (bases 1 to 3304)
  AUTHORS   Taylor,P.M., Thomas,P., Gorrie,G.H., Connolly,C.N., Smart,T.G. and
            Moss,S.J.
  TITLE     Identification of amino acid residues within GABA(A) receptor beta
            subunits that mediate both homomeric and heteromeric receptor
            expression
  JOURNAL   J Neurosci 19 (15), 6360-6371 (1999)
   PUBMED   10414965
REFERENCE   9  (bases 1 to 3304)
  AUTHORS   Mehta,A.K. and Ticku,M.K.
  TITLE     An update on GABAA receptors
  JOURNAL   Brain Res Brain Res Rev 29 (2-3), 196-217 (1999)
   PUBMED   10209232
  REMARK    Review article
REFERENCE   10 (bases 1 to 3304)
  AUTHORS   Hedblom,E. and Kirkness,E.F.
  TITLE     A novel class of GABAA receptor subunit in tissues of the
            reproductive system
  JOURNAL   J Biol Chem 272 (24), 15346-15350 (1997)
   PUBMED   9182563
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL708685.1, BC109106.1 and
            AC008514.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014211.2.
            
            Summary: The gamma-aminobutyric acid (GABA) A receptor is a
            multisubunit chloride channel that mediates the fastest inhibitory
            synaptic transmission in the central nervous system. The subunit
            encoded by this gene is expressed in several non-neuronal tissues
            including the uterus and ovaries. This subunit can assemble with
            known GABA A receptor subunits, and the presence of this subunit
            alters the sensitivity of recombinant receptors to modulatory
            agents such as pregnanolone. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U95367.1, BC109105.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265294.9/ ENSP00000265294.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AL708685.1         15-83
            70-1364             BC109106.1         1-1295
            1365-3304           AC008514.8         108158-110097       c
FEATURES             Location/Qualifiers
     source          1..3304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..3304
                     /gene="GABRP"
                     /note="gamma-aminobutyric acid type A receptor subunit pi"
                     /db_xref="GeneID:2568"
                     /db_xref="HGNC:HGNC:4089"
                     /db_xref="MIM:602729"
     exon            1..150
                     /gene="GABRP"
                     /inference="alignment:Splign:2.1.0"
     exon            151..245
                     /gene="GABRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1515
                     /gene="GABRP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; gamma-aminobutyric acid receptor subunit pi;
                     GABA(A) receptor subunit pi; GABA(A) receptor, pi;
                     gamma-aminobutyric acid (GABA) A receptor, pi;
                     gamma-aminobutyric acid type A receptor pi subunit; GABAAR
                     subunit pi"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit pi
                     isoform 1 precursor"
                     /protein_id="NP_055026.1"
                     /db_xref="CCDS:CCDS4375.1"
                     /db_xref="GeneID:2568"
                     /db_xref="HGNC:HGNC:4089"
                     /db_xref="MIM:602729"
                     /translation="MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENL
                     TAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGN
                     KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC
                     NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTL
                     VTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTC
                     IGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQ
                     MAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFK
                     FVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMYF"
     exon            246..364
                     /gene="GABRP"
                     /inference="alignment:Splign:2.1.0"
     exon            365..432
                     /gene="GABRP"
                     /inference="alignment:Splign:2.1.0"
     exon            433..650
                     /gene="GABRP"
                     /inference="alignment:Splign:2.1.0"
     exon            651..733
                     /gene="GABRP"
                     /inference="alignment:Splign:2.1.0"
     exon            734..871
                     /gene="GABRP"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1024
                     /gene="GABRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1212
                     /gene="GABRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..3304
                     /gene="GABRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3278..3283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABRP"
                     /note="hexamer: AATATA"
     polyA_site      3304
                     /gene="GABRP"
                     /note="major polyA site"
ORIGIN      
        1 actccatctg agggtggctg cgtgtccaca tacgagggga cagggctgag gatgaggaga
       61 accctgggga cccagaagac cgtgccttgc ctggaagtcc tgcctgtagg cctgaaggac
      121 ttgccctaac agagcctcaa caactacctg gtgattccta cttcagcccc ttggtgtgag
      181 cagcttctca acatgaacta cagcctccac ttggccttcg tgtgtctgag tctcttcact
      241 gagaggatgt gcatccaggg gagtcagttc aacgtcgagg tcggcagaag tgacaagctt
      301 tccctgcctg gctttgagaa cctcacagca ggatataaca aatttctcag gcccaatttt
      361 ggtggagaac ccgtacagat agcgctgact ctggacattg caagtatctc tagcatttca
      421 gagagtaaca tggactacac agccaccata tacctccgac agcgctggat ggaccagcgg
      481 ctggtgtttg aaggcaacaa gagcttcact ctggatgccc gcctcgtgga gttcctctgg
      541 gtgccagata cttacattgt ggagtccaag aagtccttcc tccatgaagt cactgtggga
      601 aacaggctca tccgcctctt ctccaatggc acggtcctgt atgccctcag aatcacgaca
      661 actgttgcat gtaacatgga tctgtctaaa taccccatgg acacacagac atgcaagttg
      721 cagctggaaa gctggggcta tgatggaaat gatgtggagt tcacctggct gagagggaac
      781 gactctgtgc gtggactgga acacctgcgg cttgctcagt acaccataga gcggtatttc
      841 accttagtca ccagatcgca gcaggagaca ggaaattaca ctagattggt cttacagttt
      901 gagcttcgga ggaatgttct gtatttcatt ttggaaacct acgttccttc cactttcctg
      961 gtggtgttgt cctgggtttc attttggatc tctctcgatt cagtccctgc aagaacctgc
     1021 attggagtga cgaccgtgtt atcaatgacc acactgatga tcgggtcccg cacttctctt
     1081 cccaacacca actgcttcat caaggccatc gatgtgtacc tggggatctg ctttagcttt
     1141 gtgtttgggg ccttgctaga atatgcagtt gctcactaca gttccttaca gcagatggca
     1201 gccaaagata gggggacaac aaaggaagta gaagaagtca gtattactaa tatcatcaac
     1261 agctccatct ccagctttaa acggaagatc agctttgcca gcattgaaat ttccagcgac
     1321 aacgttgact acagtgactt gacaatgaaa accagcgaca agttcaagtt tgtcttccga
     1381 gaaaagatgg gcaggattgt tgattatttc acaattcaaa accccagtaa tgttgatcac
     1441 tattccaaac tactgtttcc tttgattttt atgctagcca atgtatttta ctgggcatac
     1501 tacatgtatt tttgagtcaa tgttaaattt cttgcatgcc ataggtcttc aacaggacaa
     1561 gataatgatg taaatggtat tttaggccaa gtgtgcaccc acatccaatg gtgctacaag
     1621 tgactgaaat aatatttgag tctttctgct caaagaatga agctccaacc attgttctaa
     1681 gctgtgtaga agtcctagca ttataggatc ttgtaataga aacatcagtc cattcctctt
     1741 tcatcttaat caaggacatt cccatggagc ccaagattac aaatgtactc agggctgttt
     1801 attcggtggc tccctggttt gcatttacct catataaaga atgggaagga gaccattggg
     1861 taaccctcaa gtgtcagaag ttgtttctaa agtaactata catgtttttt actaaatctc
     1921 tgcagtgctt ataaaataca ttgttgccta tttagggagt aacattttct agtttttgtt
     1981 tctggttaaa atgaaatatg ggcttatgtc aattcattgg aagtcaatgc actaactcaa
     2041 taccaagatg agtttttaaa taatgaatat tatttaatac cacaacagaa ttatccccaa
     2101 tttccaataa gtcctatcat tgaaaattca aatataagtg aagaaaaaat tagtagatca
     2161 acaatctaaa caaatccctc ggttctaaga tacaatggat tccccatact ggaaggactc
     2221 tgaggcttta ttcccccact atgcatatct tatcatttta ttattataca cacatccatc
     2281 ctaaactata ctaaagccct tttcccatgc atggatggaa atggaagatt tttttttaac
     2341 ttgttctaga agtcttaata tgggctgttg ccatgaaggc ttgcagaatt gagtccattt
     2401 tctagctgcc tttattcaca tagtgatggg gtactaaaag tactgggttg actcagagag
     2461 tcgctgtcat tctgtcattg ctgctactct aacactgagc aacactctcc cagtggcaga
     2521 tcccctgtat cattccaaga ggagcattca tccctttgct ctaatgatca ggaatgatgc
     2581 ttattagaaa acaaactgct tgacccagga acaagtggct tagcttaagt aaacttggct
     2641 ttgctcagat ccctgatcct tccagctggt ctgctatgag tggcttatcc cgcatgagca
     2701 ggagcgtgct ggccctgagt actgaacttt ctgagtaaca atgagatacg ttacagaacc
     2761 tatgttcagg ttgcgggtga gctgccctct ccaaatccag ccagagatgc acattcctcg
     2821 gccagtctca gccaacagta ccaaaagtga tttttgagtg tgccagggta aaggcttcca
     2881 gttcagcctc agttatttta gacaatctcg ccatctttaa tttcttagct tcctgttcta
     2941 ataaatgcac ggctttacct ttcctgtcag aaataaacca aggctctaaa agatgatttc
     3001 ccttctgtaa ctccctagag ccacaggttc tcattccttt tcccattata cttctcacaa
     3061 ttcagtttct atgagtttga tcacctgatt tttttaacaa aatatttcta acgggaatgg
     3121 gtgggagtgc tggtgaaaag aggtgaaatg tggttgtatg agccaatcat atttgtgatt
     3181 ttttaaaaaa agtttaaaag gaaatatctg ttctgaaacc ccacttaagc attgttttta
     3241 tataaaaaca atgataaaga tgtgaaactg tgaaataaat ataccatatt agctacccac
     3301 caaa
//
