LOCUS       NM_000807               8520 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens gamma-aminobutyric acid type A receptor subunit alpha2
            (GABRA2), transcript variant 1, mRNA.
ACCESSION   NM_000807
VERSION     NM_000807.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8520)
  AUTHORS   Chakraborty,A., Dey,S., Kumar,K., Dixit,A.B., Tripathi,M.,
            Sharma,M.C., Chandra,P.S. and Banerjee,J.
  TITLE     Novel variants in GABAA receptor subunits: A possible association
            with benzodiazepine resistance in patients with drug-resistant
            epilepsy
  JOURNAL   Epilepsy Res 189, 107056 (2023)
   PUBMED   36469977
  REMARK    GeneRIF: Novel variants in GABAA receptor subunits: A possible
            association with benzodiazepine resistance in patients with
            drug-resistant epilepsy.
REFERENCE   2  (bases 1 to 8520)
  AUTHORS   Preuss,U.W., Koller,G. and Zill,P.
  TITLE     Prospective DNA Methylation Analysis of the CpG GABRA2 Receptor
            Subunit in Alcohol Dependence during Detoxification
  JOURNAL   Medicina (Kaunas) 58 (11), 1653 (2022)
   PUBMED   36422192
  REMARK    GeneRIF: Prospective DNA Methylation Analysis of the CpG GABRA2
            Receptor Subunit in Alcohol Dependence during Detoxification.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8520)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   4  (bases 1 to 8520)
  AUTHORS   Hawkins,N.A., Nomura,T., Duarte,S., Barse,L., Williams,R.W.,
            Homanics,G.E., Mulligan,M.K., Contractor,A. and Kearney,J.A.
  TITLE     Gabra2 is a genetic modifier of Dravet syndrome in mice
  JOURNAL   Mamm Genome 32 (5), 350-363 (2021)
   PUBMED   34086081
  REMARK    GeneRIF: Gabra2 is a genetic modifier of Dravet syndrome in mice.
REFERENCE   5  (bases 1 to 8520)
  AUTHORS   Yu,W., Hill,S.F., Xenakis,J.G., Pardo-Manuel de Villena,F.,
            Wagnon,J.L. and Meisler,M.H.
  TITLE     Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse
  JOURNAL   Epilepsia 61 (12), 2847-2856 (2020)
   PUBMED   33140451
  REMARK    GeneRIF: Gabra2 is a genetic modifier of Scn8a encephalopathy in
            the mouse.
REFERENCE   6  (bases 1 to 8520)
  AUTHORS   Bonnert,T.P., McKernan,R.M., Farrar,S., le Bourdelles,B.,
            Heavens,R.P., Smith,D.W., Hewson,L., Rigby,M.R.,
            Sirinathsinghji,D.J., Brown,N., Wafford,K.A. and Whiting,P.J.
  TITLE     theta, a novel gamma-aminobutyric acid type A receptor subunit
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9891-9896 (1999)
   PUBMED   10449790
REFERENCE   7  (bases 1 to 8520)
  AUTHORS   Russek,S.J.
  TITLE     Evolution of GABA(A) receptor diversity in the human genome
  JOURNAL   Gene 227 (2), 213-222 (1999)
   PUBMED   10023064
REFERENCE   8  (bases 1 to 8520)
  AUTHORS   Davies,P.A., Hanna,M.C., Hales,T.G. and Kirkness,E.F.
  TITLE     Insensitivity to anaesthetic agents conferred by a class of GABA(A)
            receptor subunit
  JOURNAL   Nature 385 (6619), 820-823 (1997)
   PUBMED   9039914
REFERENCE   9  (bases 1 to 8520)
  AUTHORS   Togel,M., Mossier,B., Fuchs,K. and Sieghart,W.
  TITLE     gamma-Aminobutyric acidA receptors displaying association of gamma
            3-subunits with beta 2/3 and different alpha-subunits exhibit
            unique pharmacological properties
  JOURNAL   J Biol Chem 269 (17), 12993-12998 (1994)
   PUBMED   8175718
REFERENCE   10 (bases 1 to 8520)
  AUTHORS   Hadingham,K.L., Wingrove,P., Le Bourdelles,B., Palmer,K.J.,
            Ragan,C.I. and Whiting,P.J.
  TITLE     Cloning of cDNA sequences encoding human alpha 2 and alpha 3
            gamma-aminobutyric acidA receptor subunits and characterization of
            the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-,
            alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA
            receptors
  JOURNAL   Mol Pharmacol 43 (6), 970-975 (1993)
   PUBMED   8391122
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC095060.3, DA778940.1,
            DN991770.1, DB478542.1, AB209295.1, BX108394.1, AC104072.3 and
            AF086092.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_000807.3.
            
            Summary: GABA is the major inhibitory neurotransmitter in the
            mammalian brain where it acts at GABA-A receptors, which are
            ligand-gated chloride channels. Chloride conductance of these
            channels can be modulated by agents such as benzodiazepines that
            bind to the GABA-A receptor. At least 16 distinct subunits of
            GABA-A receptors have been identified. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2893033.1,
                                           SRR14038197.1038810.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381620.9/ ENSP00000371033.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC095060.3         42099-42158         c
            61-89               DA778940.1         1-29
            90-188              DN991770.1         9-107
            189-373             DB478542.1         1-185
            374-2018            AB209295.1         1-1645
            2019-2510           BX108394.1         6-497               c
            2511-7852           AC104072.3         69700-75041         c
            7853-8520           AF086092.1         1-668
FEATURES             Location/Qualifiers
     source          1..8520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p12"
     gene            1..8520
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /note="gamma-aminobutyric acid type A receptor subunit
                     alpha2"
                     /db_xref="GeneID:2555"
                     /db_xref="HGNC:HGNC:4076"
                     /db_xref="MIM:137140"
     exon            1..394
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /inference="alignment:Splign:2.1.0"
     exon            395..475
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..1760
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; GABA(A) receptor subunit alpha-2;
                     gamma-aminobutyric acid type A receptor alpha2 subunit;
                     GABAAR subunit alpha-2"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor subunit alpha-2
                     isoform a precursor"
                     /protein_id="NP_000798.2"
                     /db_xref="CCDS:CCDS3471.1"
                     /db_xref="GeneID:2555"
                     /db_xref="HGNC:HGNC:4076"
                     /db_xref="MIM:137140"
                     /translation="MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTR
                     ILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL
                     KFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRL
                     TVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQY
                     DLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNR
                     ESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATV
                     NYFTKRGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSAT
                     TPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVS
                     P"
     exon            476..591
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /inference="alignment:Splign:2.1.0"
     exon            592..659
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /inference="alignment:Splign:2.1.0"
     exon            660..880
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /inference="alignment:Splign:2.1.0"
     exon            881..963
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1107
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1260
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1463
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..8520
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3593..3598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /note="hexamer: AATAAA"
     regulatory      3598..3603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /note="hexamer: AATAAA"
     polyA_site      3615
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /note="major polyA site"
     polyA_site      3620
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /note="major polyA site"
     regulatory      4689..4694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /note="hexamer: ATTAAA"
     polyA_site      4714
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /note="major polyA site"
     regulatory      8500..8505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /note="hexamer: ATTAAA"
     polyA_site      8520
                     /gene="GABRA2"
                     /gene_synonym="DEE78; EIEE78"
                     /note="major polyA site"
ORIGIN      
        1 aggcgcgggg ctcgtgcccg ccaccgccgg cgcgcaccgc gcctccgccc gcgtcccccc
       61 aatttccccc cccggcccca gctcctgtca tcgttttccc cctcctcctc ttcctcctcc
      121 tcctcttcct cctcctccgc ccatcaccgc cactacgaac gccttcgcct ccttctacac
      181 ctcgcgccgc cgccgcggct cctagcgctc ctctccggct tccaccagcc catcgctcca
      241 cgctctcttg gctgctgcag tctcggtctc tctctctctc tctctctctc tctctctctc
      301 tctctctctc tctctctctc tctctcccaa gtttcctatc tcgtcaagat cagggcaaaa
      361 ggaagaaaac accgaattct gcttgccgtt tcagagcggc ggtgatgaag acaaaattga
      421 acatctacaa catgcagttc ctgctttttg ttttcttggt gtgggaccct gccaggttgg
      481 tgctggctaa catccaagaa gatgaggcta aaaataacat taccatcttt acgagaattc
      541 ttgacagact tctggatggt tacgataatc ggcttagacc aggactggga gacagtatta
      601 ctgaagtctt cactaacatc tacgtgacca gttttggccc tgtctcagat acagatatgg
      661 aatatacaat tgatgttttc tttcgacaaa aatggaaaga tgaacgttta aaatttaaag
      721 gtcctatgaa tatccttcga ctaaacaatt taatggctag caaaatctgg actccagata
      781 ccttttttca caatgggaaa aaatcagtag ctcataatat gacaatgcca aataagttgc
      841 ttcgaattca ggatgatggg actctgctgt ataccatgag gcttacagtt caagctgaat
      901 gcccaatgca cttggaggat ttcccaatgg atgctcattc atgtcctctg aaatttggca
      961 gctatgcata tacaacttca gaggtcactt atatttggac ttacaatgca tctgattcag
     1021 tacaggttgc tcctgatggc tctaggttaa atcaatatga cctgctgggc caatcaatcg
     1081 gaaaggagac aattaaatcc agtacaggtg aatatactgt aatgacagct catttccacc
     1141 tgaaaagaaa aattgggtat tttgtgattc aaacctatct gccttgcatc atgactgtca
     1201 ttctctccca agtttcattc tggcttaaca gagaatctgt gcctgcaaga actgtgtttg
     1261 gagtaacaac tgtcctaaca atgacaactc taagcatcag tgctcggaat tctctcccca
     1321 aagtggctta tgcaactgcc atggactggt ttattgctgt ttgttatgca tttgtgttct
     1381 ctgccctaat tgaatttgca actgttaatt acttcaccaa aagaggatgg gcttgggatg
     1441 ggaagagtgt agtaaatgac aagaaaaaag aaaaggcttc cgttatgata cagaacaacg
     1501 cttatgcagt ggctgttgcc aattatgccc cgaatctttc aaaagatcca gttctctcca
     1561 ccatctccaa gagtgcaacc acgccagaac ccaacaagaa gccagaaaac aagccagctg
     1621 aagcaaagaa aactttcaac agtgttagca aaattgacag aatgtccaga atagtttttc
     1681 cagttttgtt tggtaccttt aatttagttt actgggctac atatttaaac agagaacctg
     1741 tattaggggt cagtccttga attgagaccc atgttatctt tgggatgtat agcaacatta
     1801 aatttggttt gttttgctat gtacagtctg actaataact gctaatttgt gatccaacat
     1861 gtacagtatg tatatagtga catagcttac cagtagacct ttaatggaga catgcatttg
     1921 ctaactcatg gaactgcaga cagaaagcac tccatgcgaa aacagccatt gcctttttta
     1981 aagatttacc ctaggacctg atttaaagtg aatttcaagt gacctgatta atttcctatt
     2041 cttccaaatg agatgaaaat ggggatcctg tacaaccctt tgtggaccct tttggtttag
     2101 ctcttaagta ggggtatttt ctactgttgc ttaattatga tggaagataa cattgtcatt
     2161 cctagatgaa tcctttgaag taacaaacat tgtatctgac atcagctctg ttcatgagtg
     2221 ctcagagtcc ctgctaatgt aattggaagc ttggtacaca taagaaaaac tagagatttg
     2281 aaatcagcta tgaattactc tatatagtat ctatagccat gtacatatta cagcatgaca
     2341 agctcaaata attatgagtc agcccgaaag gatgttaatt atgcctacga tgtaataact
     2401 attggaatgt catggtcatt acatttttag cttcagagtt tatttgaaag taataattga
     2461 aatcctacaa tttattttaa tcattggaaa ctaccttaat taaaaaaaaa gaaaagaaat
     2521 gtgtcttaac atttccaggt atgtgttgta ttgaaattga tcagctaaat tttacgggtg
     2581 ctggagactg gaaaaagcat ccagtttggt tgctgtggag caacatgcat attggattag
     2641 aaaattgtgc caaaaactcc cactgatgag aattcatagg tgccccacac tatgacaaac
     2701 acttatatga ttctcctctt tcctgtttac tgcaaattct gccttaaggc ttcttttcaa
     2761 gactcagaag ccactaatta taaaggaaag ggcagttaat tggcacattt ttctcttgtg
     2821 aaagcagttc tttcagataa gaattaatgt aaatctgctt ttgtaaattg caactttaaa
     2881 tttcgctgac tcaaatttac aacagctttg tataccagaa gaggttttgg taagggttga
     2941 acatttttac actgcaactt taaaacatca ccaatagatt gtggattatt tcacgtgcac
     3001 aaacatacac acacacacac acacacacac acatacacag ctaaattaga aaacacaatt
     3061 ttaaatttta tataattact agttattaat gggtaaaatt catttttctt ttaatatctt
     3121 aaaatattat ttatgccccg aaatatgcta ataaaagtta aagattgtgt attatgccta
     3181 gattcaaagt ttttggcaaa cttcaaatac ttttgattga catgtacatt agcagttatt
     3241 agttgacttt tactaaaaca tgcaccttta cgatggtgtt tttgtagaaa cataagtagt
     3301 caaatagtaa catttattgc agttttgtac agtatttgag tatagtgcat aaataggtat
     3361 gttcataaaa tcaataaaag gagtatctat ggaaataagc aaaatatcag caaaaattgc
     3421 tattcctttg cctcatttaa tttttaaaat ttctttgttt ccatgtgatt ctattatatg
     3481 ctttgcatgc ttgtataaaa ccaaggtcac aaatgcaact tattaacgga atttgccaag
     3541 aagacagcct tgacattaaa aattccctca caagaggtaa tccataatcc ttaataaaat
     3601 aaaattgtta catgagccaa taaatgtatt tctttaattc ccttccagta acactttctt
     3661 tgtcacctag ttttaaaatg tgcactttat tcatacattg aaatagaaga tatcctattt
     3721 tcttatacat ttaaatatag catagctctt ctgtatagtt tagggatgtg tgcaattgta
     3781 taaggaagta cacaatgcca gaaggcaagc aatgaaattg ctctatatgg tatgcattat
     3841 tagatacttt aagaatattt gtcttgtaaa gtccgcattg cccccttaat gtctgactat
     3901 aagttataaa tttataaata tgtgtatatg taaaaacagt tgtaaataac agtttctgta
     3961 tgacaacaga aaaggcttat ctatactttg ggcaaagagc tgctactata ttgatggcac
     4021 cagtattatt agcatttatg gcagattgac cagaaaactt atcactgtta ttcttatttt
     4081 aaatttcatg tggtaaaatt ttatttgagt gcaatgacat tctggcagtt cagatttttc
     4141 agtgctaggg atcagaattc tttgttattt ctttaaactt tgatgtactt tttacatatt
     4201 tcttcttctt ttaatgttta aataaatcaa aaggagcttc ttctcttgtg gggagactag
     4261 ggatgctccg tggaaattgc ttttaaatta tagaacaaga ttcgtaacaa ttataatcct
     4321 ttccatgaac caatttaaaa acaaatttaa aaggatttta atttatcaca ataaggccaa
     4381 tttttcagaa aatacatttt atatatacta acactgatct ctttggccca taagattata
     4441 cctattttat gcagttgtac aatgacataa agagttatgg tatgtacaaa atgtagataa
     4501 atacatgtac atatatagag atataatctc attattttat agctactact ctgatttaac
     4561 taatatttat tcaaaaatat tttttacctc ctgtgccatg ccctgtaatt ggtgttaaaa
     4621 tcactcatgt cacacccact gaatttagtt gaaattttaa gtgcatctca ttcttataat
     4681 gacttgaaat taaagactat ataaaacatg taaattaatt tagtactggg agttctttaa
     4741 tgagctatga tgccactagt gtgctaggat aggtggctgt ttttctcttt tctcctgttc
     4801 atgttcccat gtgtttgatt ataaaatgga agaaatataa ccatttaata tatatttttt
     4861 aaattttaat gattttatta agtgccaatc ttaatgttta gaaatctttt caggtatctc
     4921 tctattttga atttatctca ggtttggata agtgatcccc ttgagccatg tttctaaatt
     4981 ttttttctta aatagttcat agtttatttt taaaaacaac ccagaatcta ttattttact
     5041 ctcattattt ggtaagtata atttgcattt atgtggctct ttttgaattc ctggttgagg
     5101 gacacaaacc ctgccatgat ataatcatgg attccagaag agcaccaaag tacttttctt
     5161 tggcatggcc ggtcatcatt ccaatgaaag aagaaaggaa gtagctcaag tcaccttctg
     5221 cattatcatg gttctttggc atccattaat aatttgttta atgtattcta tgcctgatgc
     5281 cctcagacac atgtctgtga aacacagaca tatttattat ttacttggaa atatgaggtt
     5341 atgttaatag atttactaaa cagattatta ttgttattag tctcctggca cactgacatt
     5401 catctgcatg tttttgaagc aatgaccaaa ttttttatca tatgaaaaca ttcagaattt
     5461 taaggggatt actacctgac tcattgctac cctatagtgc cattcatttt ccttttaatt
     5521 gaggtcccat aggcacctcg tgcttccctt ttattaattt aaagtatgca gaagtgtaaa
     5581 attttaactg gggaggggtg cagttatttt tgacatctgc atgcttgaga aacatggaca
     5641 ctataccaaa accacttgta acagtgtgga gaagacaagt catattttta tctactgaat
     5701 tcatgctcta aaaattaaag taaatattta acataattat ttaatatcca taatattttg
     5761 ctgttaaaat ttatattaaa gatattaata ttttccatca gtatttaaga gctcagaatt
     5821 actgaaaaga agaaaccaca ggaaacagga gactgttgtt aattaaacca agtgaagcat
     5881 ttttcccttt ttaacttccg agaaagtaga taaattatac atatgtagac acacaaatat
     5941 tttaagagtc gttattctat catagtaagc atcataacta aaatactaaa gtagagaaag
     6001 ttcatgtgaa agtcatttgg gaaggtaaat tattcaatat ctacttataa atattatata
     6061 tcataatttt gtttttttgc taaaattctt aattatcaac atatctagac cactgtgtct
     6121 tccatcttgt taagttgaaa tattctattt ttgtttgttt atatatgaag aaatacttat
     6181 aaaggtggtt atacgtccca cctcaaacta ctcaatgatg tatttaatac ataacattac
     6241 ctaatattgc caatagtaaa gaacaattta caggtttatg tttcagctta cagtaatgtt
     6301 cccaaagatc ttttaatagg gtcttagctg tgtgtgtcag tgatgtgtgt atgtttgcga
     6361 gtgtgtatgt gtgtaattcc taggtatgta tggaataatg ttttgagaaa ttcagataaa
     6421 tttatgatat ctaaacaatt tgttttatta atggatctta tcacaaattc agctcttatt
     6481 aaactagcaa ttaacttgca cactagaaca catttttcag taaatccata acaaacttat
     6541 taattagaat taggtttgag ttatgcatat ggttaaaaat atcttttcta tgttggtgta
     6601 aactttttcg aatgtatttc tagttttttt ttaaaaaaag attaaattca aaatgatctt
     6661 gcaattctgc ttcatgagat agaatagaaa catctttgaa tgccaggttt ctcaacggag
     6721 gcttgtgtaa gctcttctaa aagttaaata tctggttatt tacaaataca aagttatgta
     6781 tattcattac tgatttgttt cataccttac tttttgaatt ggaatgattc agagtataat
     6841 tcttacagag agcccatcac atactagtca acgttctaag ttttttatgc atattagttc
     6901 attcagtcct cacagcagcc atcatcactg tgtgattctt gaagctctgg aaatctagga
     6961 tttctatata gtacaccaac ataccagttt acatatatta taggaaaggt aaacgaaaca
     7021 aacaaacaaa aaaacaaaaa acaacaaaaa aaccaaaaac ctgtgttttt tctttgcttt
     7081 aattcaaatt tatattcatg ccttttgggg aatattcatt caataaggga gccattacat
     7141 ggttttctac ataacaaaac aaacaagtaa aaagcaaaca ctcaacaata aaactgtact
     7201 gtacagtaag caatacccgt ttttgtgatg ctagctattt actaacttct ttggtacaat
     7261 ttagtttctg ggaatatatt gcagttttct tttttggttc acaagtaatg atcacgtatt
     7321 aaaaatgatt aatgttgatt aagcaaaagt aagcacttcc ttcatttcct tttttttcta
     7381 attttgccag ttttattagt ggttggagag atgtgttttc atttgtcata ttgttcgttt
     7441 cataacattt aatcccattg ggcttcaagg attatgtatt gatttcatca aatattttgt
     7501 tgtaagttac cgtttataga atgacgcctg aattgatccc aagggatgcc accggtggga
     7561 ttgcaattgc tgaattagct tactaggttt gaaaatgtca gttttccatg cttcttttta
     7621 gaagactttg ccataacatg atgccaaaag gcaaactatg ttgcattggc tatataaact
     7681 gtattattgg ctatacatga atatttccaa caaagtttat ttgtaaaaac aactgatgct
     7741 aagaaagcaa gagttagttg cagaattact ttagaaatag tactgataga tttgttcaga
     7801 atttattttt aacatattcg acatagtcgt tgaagcaatt gattgtgctt taaactgatc
     7861 ataatgtgta aaaaggtgta acgtataatt agaaagacat aagtaaaact caattattga
     7921 gccacaattc tcatgaatta aactttacca tccacagtta agtccttatt gcttgttaat
     7981 cttgggtgcc tgcactacac ttgattttaa aattgttggt cttctataaa ttttcaagat
     8041 tttcctgagc agatacaaat tcaggttttg atgtgcttca aactaaggaa catcaccttt
     8101 catgaaatgt ttccagtaga tgtgatgtga gtgaaaactt taaaaaatgt catacttatt
     8161 gctacatttg aatagaaaat aaaaggaata aagtattttt cctttgctac aaattaataa
     8221 tacgatcaca tgcagagaga atgtgaggaa ccttcaacac taaactttga tagtcacatt
     8281 atgtgaaatt tgaaattttc tgggtgacag tatacttatt ggtaggtttt ctggttcatg
     8341 aaaataactc aagaactaat atttgtaatt gtgaccttgt tgtaattggg aaaggccact
     8401 agttgatcat atgaccttta ttgaatatgt catgcttgct gtttaaaaaa ttcctaacta
     8461 atcacatgca aattaatgct aaacaacttt tttgtattta ttaaaaatga tttaaatata
//
