LOCUS       NM_144618               8807 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens GA binding protein transcription factor subunit beta 2
            (GABPB2), transcript variant 1, mRNA.
ACCESSION   NM_144618
VERSION     NM_144618.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8807)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8807)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 8807)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 8807)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 8807)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 8807)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8807)
  AUTHORS   Du,K., Leu,J.I., Peng,Y. and Taub,R.
  TITLE     Transcriptional up-regulation of the delayed early gene HRS/SRp40
            during liver regeneration. Interactions among YY1, GA-binding
            proteins, and mitogenic signals
  JOURNAL   J Biol Chem 273 (52), 35208-35215 (1998)
   PUBMED   9857059
REFERENCE   8  (bases 1 to 8807)
  AUTHORS   de la Brousse,F.C., Birkenmeier,E.H., King,D.S., Rowe,L.B. and
            McKnight,S.L.
  TITLE     Molecular and genetic characterization of GABP beta
  JOURNAL   Genes Dev 8 (15), 1853-1865 (1994)
   PUBMED   7958862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC027033.1 and AL592424.13.
            
            On Nov 23, 2018 this sequence version replaced NM_144618.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027033.1, AK092230.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368918.8/ ENSP00000357914.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1796              BC027033.1         158-1953
            1797-8807           AL592424.13        12635-19645
FEATURES             Location/Qualifiers
     source          1..8807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..8807
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /note="GA binding protein transcription factor subunit
                     beta 2"
                     /db_xref="GeneID:126626"
                     /db_xref="HGNC:HGNC:28441"
     exon            1..174
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1521
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /EC_number="3.2.1.3"
                     /note="isoform a is encoded by transcript variant 1;
                     GA-binding protein subunit beta-2; GABP subunit beta-2; GA
                     binding protein transcription factor beta subunit 2"
                     /codon_start=1
                     /product="GA-binding protein subunit beta-2 isoform a"
                     /protein_id="NP_653219.1"
                     /db_xref="CCDS:CCDS983.1"
                     /db_xref="GeneID:126626"
                     /db_xref="HGNC:HGNC:28441"
                     /translation="MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHL
                     AAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDM
                     LKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAM
                     QNQVNVNPERANPVTDPVSMAAPFIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFS
                     NSTTSVLATLAALAEASVPLSNSHRATANTEEIIEGNSVDSSIQQVMGSGGQRVITIV
                     TDGVPLGNIQTSIPTGGIGQPFIVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTK
                     KPRIGEKTNSVEESKEGNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAI
                     ARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTRVSMATVSS"
     exon            175..282
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            283..450
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            451..645
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..796
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..910
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1096
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1221
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..8807
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1729..1734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /note="hexamer: AATAAA"
     polyA_site      1754
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
     regulatory      8789..8794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /note="hexamer: AATAAA"
     polyA_site      8807
                     /gene="GABPB2"
                     /gene_synonym="GABPB-2"
                     /note="major polyA site"
ORIGIN      
        1 gccattttgt tgcctctgtt tctccacgag ggggggttaa aggcccccaa aacatgcaca
       61 catgaaaagg gcaaaaagta accgtccttg acagggagtc ttaactagag aaggaaacgg
      121 gactaaactg gcgggctccg tggaagcgtg gccggcagcg tcccggacga ggagatgtct
      181 ttggtggact tgggaaagag gttgctagaa gcagcaagaa aaggccaaga tgatgaagtg
      241 agaacgttga tggcaaatgg cgccccattc accacagact ggcttggaac atcacccctc
      301 caccttgcag ctcaatatgg tcattattcc acagcagaag tactccttcg agcaggtgtt
      361 agcagggatg cccggactaa agtagacagg acccccttgc acatggctgc agccgatgga
      421 catgcgcaca tcgtggaact gcttgttcgg aatggtgcag atgtgaatgc caaggacatg
      481 ctgaagatga cagctttgca ttgggccaca gagcgccacc atcgagatgt cgtagagtta
      541 cttatcaaat atggagctga tgtccatgct ttcagcaaat ttgataaatc agcctttgac
      601 atagctctgg agaaaaacaa tgctgagatt ttggtcatcc tccaggaagc aatgcagaat
      661 caggtgaatg ttaatccaga gagagccaac cctgtgactg accctgtgag tatggctgct
      721 ccattcatct tcacgtcggg tgaggttgtt aacctcgcaa gccttatttc ttcaaccaac
      781 accaaaacaa cctcaggtga cccccatgcc tcaacagtac agttttcaaa ttctaccacc
      841 tcagtgctgg ctacccttgc agctcttgct gaggcatcag tccccctctc caactcacac
      901 agagccacag ccaatacaga ggaaattata gaaggaaatt ccgttgactc atcaatccag
      961 caagtaatgg ggagtggagg ccagagggtc atcaccatag tgactgatgg agtccctctg
     1021 ggtaatatcc aaacttcaat ccctactgga ggcattggcc agccatttat tgtaactgtg
     1081 caagatggac agcaagttct aactgtacct gctggtaagg ttgcagagga gactgtaatt
     1141 aaagaggaag aagaagagaa gttgccacta acaaagaaac caaggatagg agagaagaca
     1201 aacagtgtgg aggaaagcaa ggaaggcaat gaaagagagc tactacagca acaactccag
     1261 gaggccaatc gaagagccca ggaataccga caccagctcc taaagaaaga gcaggaagca
     1321 gaacagtacc gtcttaagct ggaggccata gcccgacagc agcccaatgg agttgatttc
     1381 accatggttg aagaggtggc tgaggtagat gctgtagtag tcacagaggg ggagttggaa
     1441 gagagagaga caaaagtgac tgggtcagca gggaccacag agcctcacac tagagtttcc
     1501 atggcaactg tttcatctta atatgcaagg gccacaattt gcactgtgtt catattaatc
     1561 ctcttttaaa aaaggaaata tacagaagac aaacattgta taaaaactaa gagtgtcttt
     1621 aagaagaaaa ctatagcagg gtacaatgct tgggctcagg aagtttctct gtgcaactag
     1681 aaaattcaaa gccatattta gggaacattt tttctgaggg gccaaaagaa taaaggacca
     1741 aatttcttag ctcatatcat tgctttaaac atagaagtaa aagaatactg catgttgtgg
     1801 gttgattttt tttttttaaa taactgactt tctcacaaaa gattttaaga taacatttct
     1861 aatatatatg caccaatata tatgccttta ataattatac catcaagtga cctgaaaatg
     1921 ccccttagat ttatgatgcg tatctgttgg aaaaaccaat tggaagggaa gttagacaag
     1981 ctttggggaa gagaaaagga atatagtcca tttccaaagg agcaggaact cccaacctta
     2041 agttaatttc actgaagaga attttccctt tttttttttt tttttgagac acggtctgac
     2101 tctgtcaccc aggctagagt acagtggtgc aatcttggct cactgcaacc tccgcctcca
     2161 gggcgcagcc tcctgagtag ctgggaggac aggcatatgc caccacatca ctgagaagaa
     2221 atttttgatt gtctgacaga tacttatcca ttatgtgtct atagttcaga tgcttgtgta
     2281 agaaactgaa ataagctgcg tgtggtggct cacacctgta atcccaacac tttgggacgt
     2341 tgaaatggga gaattgcttg agtccaggag tttgagatgc gcctgggcaa catagaaacc
     2401 tgtgtctaca aaaaatttaa aaattagcca agtatggtga caggcaccta tggttccagc
     2461 tactcaggag gctgaggtgg gaggatcgct tgtgccttgg aggtcaaaac tgcagtgagc
     2521 catggttgca ccactgctct ccaggcttga gtgacagagc aagactgtat ctcaaaggaa
     2581 aaaggaaact aggccaggcg tggtggctca cgcctgtaat cccaacactt tgggaggccg
     2641 aggcgggcgg atcacgaggt cagatcaaga acatcctggc taacacggtg aaactccatc
     2701 tctactaaaa atacaaaaaa ttggccgggc gcagcggctc acgcctgtaa tcccagcact
     2761 ttcggaggca gaggcaggcg gatcacaagg tcaagagatt aagatcatcc tggccaacat
     2821 ggtgacaccc cgtctctact aaaaatacaa aaattaccca ggcatagtgg cacacgcctg
     2881 tagtcccagt tacttgggag gctgaggcag gagaattgct tgaacctggg aggtggaggt
     2941 tgcagtgagc caagatcgtg ccactgcact ccagcctggc gacacagtga gactctgtct
     3001 caaaaaaaca aaacaaacaa acaaaaatac aaaaaattag ccgggcgtgg tggcacctgc
     3061 ctgtaatccc agctacttgg gaggctgagg caggagaatc gcttgaaccc gggaggcgga
     3121 ggttgcagtg agctgagatc gcaccattac actccagcct gggcaacaga gccagactct
     3181 gtctcaaaaa aaaaaaaaaa ggaaattgaa atagagtttt taaaaactga actggaaagc
     3241 cgaggcgagc ggatcacctg aggccaggag ttccagacca gcctgaccaa catggagaaa
     3301 ccctgtctct actaaaaata caaaattagg gccagacccg gcagctcatg cctgtaatcc
     3361 cagcactttg ggaggctgag gtgggtggat catgaggtca ggagttcaag accagcctgg
     3421 ccgagatggt gaaaccctac taaaaataca aaaattcacc tggcgaggtg gcaggcacct
     3481 ggaatcccag ctactcggga ggctgaggcg gtagaatcac ttgaacccag gtgacagagg
     3541 ttgcagtgat ccaagatcat gccactgcac tccagcctgg gcgatagagt gagactctgt
     3601 ctcaaacaaa caaaacaaaa caaaattagc tgggtgtggt ggcacatgcc tgtaatccca
     3661 gctactcagg aggctgaggc aggagaatcg cttgaacccg ggaggcggca gttgcaatga
     3721 gccgagatgg caccattgca ctccaacctg ggcaacaaga gtgaaactca attaaaaaaa
     3781 aaatagaaaa gaaagaaaac ttgtttatgt gggaggagta tatataaaac caaaatccag
     3841 gctgtgtttc cacagtgctg ggaagtggcc agaaaaaggc ttataggggc tatgaaactc
     3901 tggtcttgac atataaactt tgctctgact ggatttcata aaattacagt gaggagggta
     3961 gtctcttgtc agaaaaactt gtttccaaac atttatgtaa tgtcaagctc agtctctctt
     4021 tttttttttt ttttttttga gacggagtct tgctcttgtt gcccaggctg gagtgcaatg
     4081 gtgtgatctc aactcaccgc aacttccacc tcccggtttc aagctattct cctgcctcag
     4141 cctcccgagt agctgggatt acaggcacgc gccaccacgc ccggctaatt ttgtatattc
     4201 agtagagaca gggtttctct atgttggtca ggctggtctg gaactcctgg cctcaggtga
     4261 tccacccgcc ttggcctccc aaaatgctga gattacaggc gtgagccacc ccgcgcacag
     4321 cctagactct aattttataa aactttgttg aattttctaa gtgtcattta ggacatattg
     4381 tgcttttctg tggagcttat atcttatcct cttatgtgca acaaaaaggg ggtcggaggt
     4441 aaatgctgat gatgttgttt agttttattt ccttttgatc tggcatgagt aaattgctct
     4501 gtttccttaa gcttgggtct gttacagagc tttgtgcctt atagggtgct cagtgtgtgt
     4561 tgacaaaggg aataagaact gtcagtgcca taaagaacca aagattctgg ctactttgtc
     4621 ttcttccttt ctctcccact atgcctacac ttcctctgcc cagacacttt tggaaagtgt
     4681 ttaactgctg ggttttcttt ttctttttct tttttttttt gagacggagt ttcactcttg
     4741 ttgcccaggc tggagtgcaa tggcgtgatc ttggctcacc gcaacctcta cctcctgggt
     4801 tcaagtgatt ctcctgcctc agcctcccga gtagctggga ctacaggcat gcgccacaat
     4861 gcctggctaa ttttgtattt ttagtagaga tggggtttct ccatgttagt cgggctggtc
     4921 ttgaactcct gacctcaggt gatccacctg tctcgacctc ccaaagtgct gggattatag
     4981 gcgtgagcca ctgcgcctga ccacctacct gctgggtttt ctttgtatgt cagcatggag
     5041 tttttcccaa agaaagggaa tatggatgga gagagagagg ttatgaacag gttatgttac
     5101 agaggttatt gcctttgaaa ctgggccctc atcattctag acttgcttgc tttgttataa
     5161 attagaagaa accagaggga gatgtgccaa gtaaacattc gaatgactgt ttagaatatg
     5221 gttttcttaa ttagcagtca tggggaaaac atgcattttt aatttggaaa aaacctgaca
     5281 gttaacatgg ttctgtttac cttgattagt gaagtaattt gctgcagtgt tacagaggag
     5341 cagaatcact tgggtctcaa aatagactga aaatttaact ccccaaacca aatttaacaa
     5401 acagaattgg ttattagaga tttataggca aaaatatcag tttggaaatt aaccttggct
     5461 actggccacc ttagctaggt tttctccaca gatctgtttt ctccacagat ctgagtactt
     5521 aacacttccc agatgattgg agaatattct gggctgttgg ggatgacagg aaaatgtgag
     5581 ggggagtagc ctaggtaagg gtgatgatga aattgttcta tctgctgtca aataatcttt
     5641 tcctgtttgc aatgttttta ttttttctga gtccctttgg gaaccaggtg ctaacaagaa
     5701 gctgttatgt gtgggatttc ggagccttac tttaacgata gaggaaccaa gtatcatttt
     5761 agatatcttt tatttatgtt ctcggtgcat atgttgactt taatccctct tcccccacac
     5821 ctcgcccatt aaggggaagg aggttaactc tgcagatgat attcaggccc aaccagctca
     5881 ctctctgggg tggctactga ctaaaggcag agaatgtcca tccaacatgc ccttctgact
     5941 atacagtcac cacttttttg ggggaattct ttagcagatc ttattgttct ttctgcagaa
     6001 gctatcattc ctacctcccc aacccccaaa atctctaata caggccaagt cattttttat
     6061 gatgggtctc tgagataggg cagtttgtta gaggagaggc tagggtagag agggagagaa
     6121 tggaggtatc tgaaaataag taagaaaaag gcattgattt ttatttactc ggaacggtcc
     6181 tcttggcatc ccagataagg gaaataggat ttgatctcca attgtattgc catggagaga
     6241 atggcaggtg aggatgcttt gaagtagtta gaaattaaat attgaataca ttaatggcaa
     6301 taccatttca tgactttgca tatctttctg gattagtcat ggaagttggg gaaatattgc
     6361 ttagatcttc tgggttagag gattccaact gtttattggc aaggttggat tattaagaat
     6421 caaatagcag acaaaaatgg ctgggcacgg tggctcacgc ctgtaatccc agcactttga
     6481 gaggctgagg tgggtagatc acttgaggtg aggagttcga gaccagcctg gccgacatgg
     6541 caaaaccctg tctctaccaa aatacaaaaa ttagttgggc atgatggcat acgcctgtag
     6601 tcccagctac tctggaggct gaaacaggag aattgcttga acccaaaagg tggagtttac
     6661 agtgagctga gattgtgcca ctgcactcca gcctgggcaa tagagcgaga ctctgtctca
     6721 aaaaaaaaaa aaaaagaagg aaagaaagaa aaaacagaca aatggatcag aattggtgct
     6781 tgagcaagag aaacttcgag cttaggatgg ttgtctactt taaaataaag ctgctggccg
     6841 ggcacagtgg ctcacgcctg taacctcagc actttgggag gccaaggcag gtggatcacg
     6901 aggtcaggag attgagacca tcctggctaa cacagtgaaa ccctggccct actaaaaata
     6961 caaaaaatta gccgggcgtg gtggtgggtg cctgtagtcc cagctactcg ggaggctgag
     7021 gcaggagaat gacgtgaacc caggaggcag agcttgcagt gagctgagat cgccccactg
     7081 caacagatcg cctgggcaac agaatgagac tcggtctcaa aaaataaaat aaaataaaat
     7141 aaaataaaat aagtaaagct gctggccaga catggtggct cacgcctgta atcccagcac
     7201 tttgggaggc cgagatggga ggatcacttg aggccaggcc agcgtggtga aactcagtct
     7261 ctactaaaaa tacaaaaatt agccgggggt ggtggcgcat catcatactg gtgagaaaaa
     7321 aaaaaaaaaa aaagaggccg ggcgcggtgg ctcacaaaaa aaaaaaaaag aaagaaaaag
     7381 gaaaaaaaga aatatcagtt tgagaaatga tttttttttc ttttttcttt tctttttttt
     7441 tttttaaaca gagtctctct ctgtcaccca ggctggagcg cagtggcatg atcttggctc
     7501 attgcaacct ctgtctcccg ggttcaagcg attcttctgc ctcagcctct gaagtagctg
     7561 ggattacagg cacgcgctaa tttttgtatt tttagtacag acgggatttc accatattgg
     7621 ccaggctggt ctcgaactcc tgacctcgtg atccaccctc cttggcctcc caaagtgctg
     7681 ggattacagg tgtgagccac cacgcccagc ctcttttttt tttttttttt ctcaccagta
     7741 tgatgatgac cattttaaga aagcttgtgt ggctctctcc tatcattaca gacctccaga
     7801 gctggaaaat ttgatgcatt tactgaactc ttcctgaaag tttaatatgg agtgggaatc
     7861 agtttttgtc ctaatttatt agagaaggct tcctcttctc tactccttgt gcaaacccat
     7921 ctctggatag ctagaaaagg aacttcagaa tggactatat gtgatgacca cctgtatgca
     7981 ctctaggctc ttatctgtct ctattttatg tggtgactat atctcagaag tactacccct
     8041 tctgagtagt actattattt cctatgccaa ttttttttaa gtctctgatg ctgccctttt
     8101 taaatttttg tcttattttt tagcctcttt agtattaggg ggtgaggtga cattcctaga
     8161 ctctacagta gcagtttggc atgttagtga caggaaattg tgattcccta tctccccctc
     8221 ctcctacctt ttctgctttt gtgattccat tgttcctatc tcattgaggc tttcccaggc
     8281 attcgaattt agttagtagg tcatttctaa tctctgggcc ttgtcttttc tctctccgtt
     8341 cccctccttc cctaccacat attttttgtt tattctgagg tggtttgttt ctgaaagtta
     8401 atctaggtca ccttctatat cctgtgcttt ctagttggct ttagacatct tgttctagca
     8461 acaatgatgg tagcagctct ctccctgacc ttgccccatg tgctgtcctt ctgtcaaggc
     8521 catttgtgtg tgtactgcgg caggtgtgtg tgtgggggga tgcgcccaga ctgttctcac
     8581 aatgtcctca gtttttcagg ttgtctgaca gctttatgta cagcgtattt ttagaaaaac
     8641 ttaaatatac ttctttattt agggttttat tctgatgagc aagtttgtgt gtatatgtgt
     8701 gtatgagcat ttgtatgtat atatacttat acagatctat attatatata cagtttttgt
     8761 actatcattt aaaataaaaa tgtttctcaa taaaatgtca aagccga
//
