LOCUS       NM_016654               4609 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens GA binding protein transcription factor subunit beta 1
            (GABPB1), transcript variant beta-2, mRNA.
ACCESSION   NM_016654
VERSION     NM_016654.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4609)
  AUTHORS   Pinho,S.A., Costa,C.F., Deus,C.M., Pinho,S.L.C., Miranda-Santos,I.,
            Afonso,G., Bagshaw,O., Stuart,J.A., Oliveira,P.J. and
            Cunha-Oliveira,T.
  TITLE     Mitochondrial and metabolic remodelling in human skin fibroblasts
            in response to glucose availability
  JOURNAL   FEBS J 289 (17), 5198-5217 (2022)
   PUBMED   35213938
REFERENCE   2  (bases 1 to 4609)
  AUTHORS   Xu,P., Xu,X., Liu,J., Hu,H., Shen,H. and Chen,C.
  TITLE     Association of single nucleotide polymorphisms in the nuclear
            respiratory factor-2 beta subunit-encoding the GABPB1 gene within
            the occupational environment
  JOURNAL   Toxicol Ind Health 38 (4), 193-200 (2022)
   PUBMED   35343317
  REMARK    GeneRIF: Association of single nucleotide polymorphisms in the
            nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene
            within the occupational environment.
REFERENCE   3  (bases 1 to 4609)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4609)
  AUTHORS   Amen,A.M., Fellmann,C., Soczek,K.M., Ren,S.M., Lew,R.J.,
            Knott,G.J., Park,J.E., McKinney,A.M., Mancini,A., Doudna,J.A. and
            Costello,J.F.
  TITLE     Cancer-specific loss of TERT activation sensitizes glioblastoma to
            DNA damage
  JOURNAL   Proc Natl Acad Sci U S A 118 (13) (2021)
   PUBMED   33758097
  REMARK    GeneRIF: Cancer-specific loss of TERT activation sensitizes
            glioblastoma to DNA damage.
REFERENCE   5  (bases 1 to 4609)
  AUTHORS   Guilherme,J.P.L.F., Souza-Junior,T.P. and Lancha Junior,A.H.
  TITLE     Association study of performance-related polymorphisms in Brazilian
            combat-sport athletes highlights variants in the GABPB1 gene
  JOURNAL   Physiol Genomics 53 (2), 47-50 (2021)
   PUBMED   33346691
  REMARK    GeneRIF: Association study of performance-related polymorphisms in
            Brazilian combat-sport athletes highlights variants in the GABPB1
            gene.
REFERENCE   6  (bases 1 to 4609)
  AUTHORS   Gugneja,S., Virbasius,J.V. and Scarpulla,R.C.
  TITLE     Four structurally distinct, non-DNA-binding subunits of human
            nuclear respiratory factor 2 share a conserved transcriptional
            activation domain
  JOURNAL   Mol Cell Biol 15 (1), 102-111 (1995)
   PUBMED   7799916
REFERENCE   7  (bases 1 to 4609)
  AUTHORS   Sawada,J., Goto,M., Watanabe,H., Handa,H. and Yoshida,M.C.
  TITLE     Regional mapping of two subunits of transcription factor E4TF1 to
            human chromosome
  JOURNAL   Jpn J Cancer Res 86 (1), 10-12 (1995)
   PUBMED   7737900
REFERENCE   8  (bases 1 to 4609)
  AUTHORS   de la Brousse,F.C., Birkenmeier,E.H., King,D.S., Rowe,L.B. and
            McKnight,S.L.
  TITLE     Molecular and genetic characterization of GABP beta
  JOURNAL   Genes Dev 8 (15), 1853-1865 (1994)
   PUBMED   7958862
REFERENCE   9  (bases 1 to 4609)
  AUTHORS   Watanabe,H., Sawada,J., Yano,K., Yamaguchi,K., Goto,M. and Handa,H.
  TITLE     cDNA cloning of transcription factor E4TF1 subunits with Ets and
            notch motifs
  JOURNAL   Mol Cell Biol 13 (3), 1385-1391 (1993)
   PUBMED   8441384
REFERENCE   10 (bases 1 to 4609)
  AUTHORS   Virbasius,J.V., Virbasius,C.A. and Scarpulla,R.C.
  TITLE     Identity of GABP with NRF-2, a multisubunit activator of cytochrome
            oxidase expression, reveals a cellular role for an ETS domain
            activator of viral promoters
  JOURNAL   Genes Dev 7 (3), 380-392 (1993)
   PUBMED   8383622
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA156248.1, D13317.1,
            BC036080.1, AI631183.1 and AC022087.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_016654.4.
            
            Summary: This gene encodes the GA-binding protein transcription
            factor, beta subunit. This protein forms a tetrameric complex with
            the alpha subunit, and stimulates transcription of target genes.
            The encoded protein may be involved in activation of cytochrome
            oxidase expression and nuclear control of mitochondrial function.
            The crystal structure of a similar protein in mouse has been
            resolved as a ternary protein complex. Multiple transcript variants
            encoding distinct isoforms have been identified for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (beta 2) lacks an alternate
            in-frame segment, compared to variant beta 1, resulting in a
            shorter isoform (beta 2) that lacks a 12-amino acid serine-rich
            region, compared to isoform beta 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1773950.1,
                                           SRR14038195.904683.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380877.8/ ENSP00000370259.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DA156248.1         211-238
            29-1561             D13317.1           20-1552
            1562-2741           BC036080.1         1566-2745
            2742-2806           AI631183.1         18-82               c
            2807-4609           AC022087.8         28720-30522         c
FEATURES             Location/Qualifiers
     source          1..4609
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..4609
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /note="GA binding protein transcription factor subunit
                     beta 1"
                     /db_xref="GeneID:2553"
                     /db_xref="HGNC:HGNC:4074"
                     /db_xref="MIM:600610"
     exon            1..214
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1366
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /EC_number="3.2.1.3"
                     /note="isoform beta 2 is encoded by transcript variant
                     beta-2; GABP subunit beta-2; transcription factor
                     E4TF1-47; transcription factor E4TF1-53; GA binding
                     protein transcription factor beta subunit 1; nuclear
                     respiratory factor 2"
                     /codon_start=1
                     /product="GA-binding protein subunit beta-1 isoform beta
                     2"
                     /protein_id="NP_057738.1"
                     /db_xref="CCDS:CCDS10135.1"
                     /db_xref="GeneID:2553"
                     /db_xref="HGNC:HGNC:4074"
                     /db_xref="MIM:600610"
                     /translation="MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHL
                     AAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDM
                     LKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAM
                     QNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAAL
                     AEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSI
                     PTSGIGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEE
                     REALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV"
     exon            215..322
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..490
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..685
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            686..797
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..911
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1097
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1213
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..4609
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2721..2726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /note="hexamer: ATTAAA"
     polyA_site      2741
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /note="major polyA site"
     regulatory      2784..2789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /note="hexamer: ATTAAA"
     polyA_site      2806
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
     regulatory      2927..2932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /note="hexamer: AATAAA"
     polyA_site      2950
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
     regulatory      3760..3765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /note="hexamer: AATAAA"
     polyA_site      3781
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
     regulatory      4588..4593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /note="hexamer: AATAAA"
     polyA_site      4609
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
ORIGIN      
        1 gcacaccatg tgtccctccg cgcgcagcac gggggacttt tcggtgggga ttttgggcgc
       61 cgaccagacg cggcattttc ggaaaatagc gccctgtgca gctgaagcgc tttgtgtgta
      121 gcggggccgc gtcagcccgg ccgggtacga ggcgcctcgg gtccccgcac cacctcctgc
      181 tgccttcccg tcgccgctcc cgaagctttt ccagatgtcc ctggtagatt tgggaaagaa
      241 gcttttagaa gcggcacgag caggtcaaga tgatgaagtt cgtattttga tggcaaatgg
      301 agctcccttt actacagact ggctgggaac ttctccactt catctagcag cacagtatgg
      361 tcattattcc accacagagg tactgctgcg agctggtgtg agcagagatg ccagaaccaa
      421 agtggaccga acaccattac atatggcagc ttctgagggc catgccagca tagtagaggt
      481 tttacttaag catggtgctg atgtcaatgc aaaggacatg ttaaagatga cagctctcca
      541 ttgggccaca gaacacaatc atcaagaggt ggtggaactt ttaatcaaat atggtgctga
      601 tgtacacacg caaagtaaat tttgtaaaac tgcatttgat atttcaatag acaatggaaa
      661 tgaagattta gcagagatat tacagattgc tatgcagaac caaatcaaca caaacccaga
      721 gagtcctgac actgtgacaa tacatgctgc aacaccacag tttatcattg gacctggagg
      781 ggtggtgaac ctaacagatg aaacgggtgt atctgctgtt cagtttggaa actcttctac
      841 atcagtatta gctacattag ctgccttagc tgaagcatct gctccattgt ccaattcttc
      901 agaaactcca gtagtggcca cagaagaagt agttactgca gaatctgtgg atggtgccat
      961 tcagcaagta gttagttcag ggggtcagca agtcatcaca atagttacag atggaattca
     1021 gcttggaaat ttgcactcta ttccaaccag tggaattggt cagcccatca ttgtgaccat
     1081 gccagatgga caacaagtat taacagtacc agcaacagac attgctgaag aaactgttat
     1141 aagtgaagaa ccaccagcta agagacaatg tatcgaaata attgaaaacc gggtggaatc
     1201 tgcagaaata gaagagagag aagctcttca gaaacagctg gatgaagcaa atcgagaagc
     1261 acaaaaatat cgacagcagc tcctaaagaa agaacaggaa gcagaggcct acagacagaa
     1321 gttggaagct atgactcgtc ttcagactaa taaagaagct gtttaattga aatgaacatg
     1381 tagtttgatt ttacttttgg tcaagaaaga atacaatctt gaactgtaca caacaaaggt
     1441 acagccatgg gaatacagaa tgatagaaga gactacagat ggataattgg acttaagcca
     1501 tgagctctga gttcttgtaa cataaaactt tactttagaa gttgtgaaat gtatttaaaa
     1561 ctgaattctg taaatagttt tttttttttt acagttccaa atgagttgat aaagattgtt
     1621 gaagagatcc aaaaccagaa taagccactg tttttgtgaa ttctttttga ttttagtaca
     1681 aaccttaatt tctcagaaac ggaacagttt taagggtgat cgttgttggt taggccaaat
     1741 gttgtgtaat aattatggtg gactgatgct ggaattactc ctgtaggtat aaacctctgt
     1801 atgaagagaa gatttctccc aggaaatctt tgtacagctt taagttgtgt cagattctct
     1861 gaaaacattt tttagaaagc aaaattttta tatttgttca atttcagcta tacccaagta
     1921 gatttacatg tatatgaagc aaatattttt aaaaatttct gtttgtacat attctgcatg
     1981 ttttataatt tcaaaatgca tcacttacat aggtatttct cccacagaaa tgatgaaagt
     2041 gaccagaaaa aaacaaaaac aaaacccctt tactctgtag gtcattgaaa cgaagtaagc
     2101 tggcagctgg ttttattgga atgacagtgt tctcggaagg agcagcctac aagataactt
     2161 gaatttgcca attctgcaaa atctgtgctt ttttgaaaat ttaagagtgg ggacgtgaaa
     2221 ctgtattctg tgccttccat catgatttcc acatgaaagc actttaaggc actgatttta
     2281 agataatgtt tttggaaaac ccaatgcata tgggtttctg aaatatttta tggacttatt
     2341 tctccccagg aaatgattct tacggaaaaa aattgctttt gtatgtagaa caggaacttt
     2401 ttgtattaca gtgatgcaat agacatgtct aatgtaactt ctacttttcc ttttgaaagc
     2461 tcagtgtctg tgctatgact tgctctcatc acaatattgt tgaattccac aatgtatgga
     2521 cattaaacac tggcagactg ttcacttttt cttttttttt tttggtaaaa tattacttca
     2581 aacccctttt tcttgcttta tttttcagtg ttttattgct ttatgaactg tttaaccctg
     2641 aaatccctct aggttatcta tactgtataa aaaagcaatt acccttaaaa ctgtactctg
     2701 gcctactttt ctattttgca attaaatatc tttttcacat atgttcattg tagacttatg
     2761 tttttatcac atcttattaa cacattaaaa atgttatcct actgcatatt tgagccacca
     2821 tatgaaaata ttttatactc tccacaacat gactttaaaa ttcctgaggt aactcttgag
     2881 aatttgttaa ctctttcact ggaattacca gtatatttgt taatgtaata aaggggtcta
     2941 tggtctgtca gcctgatggt tactattgga agcacttaaa aaagagttta gggcaaattg
     3001 aagaactctg taaggaagag gaaaaagatc tttttcaatt ttccactaaa tttgacatat
     3061 tttaagtgat ccaaaaacta gtttttaaaa atgccaggcc atattttcaa tagcatgaag
     3121 tgactttttc tgcagtcctg aaaagtcaat agagaatgtt gtttctggtt acttcggtac
     3181 attaatttgt catgttaggc agggtgctgg taccacagcc aggtaccctg acatgtggtg
     3241 ctggagcaga gaagggccag tgtcttcacc ccagagggca atcactgtag agttttgctt
     3301 tcagaccagg ctggccctga aaagactcaa gacagtgttg ggaacaagtt tgtgaaagct
     3361 aacttaatgt cgtctttgac ttccagtctc ctctcctgct ggagacttta cctggtgcaa
     3421 gaaataattt tgattcctaa taacaacagc tggcatagat gggagaaaat aattggtgct
     3481 taaaaggagt aagtctatga tagcatcagg tactcaggta tctgtggagg aagctcacct
     3541 ttttcagagt cattgttaca taacataatt tctcaatcat ttacatctga tttactgttc
     3601 tgtaaaatca ctacttagac aagaatttgt aattaaaact taaaatgggt gtcttcttcc
     3661 cttcacttat ttcatgctgt tttcaggtgg gctgtaaaag ctttgcattc tagtcattct
     3721 caatagtgct ctgaacagag gatttaaaga actgacaaaa ataaaagtat atgaaataaa
     3781 agttttcaga aatccacata attgtttcca ctacatagtg atggatttgt agttagcagt
     3841 catctggttg ccacatcact ggttaattgt ttccacatat gtgtgaacaa acacctggag
     3901 caacctttct caaccagggt tctgcaagac aagccattta gtgttatggt gtaatgaatt
     3961 attttctttc ctgtgcacct agaatcgttc ttgttacgta ctatccagac actgagttcg
     4021 ttaggcatct tgactgccca attactttat tcagatttaa cacttccctc tgtatagtcc
     4081 ctggacctct agaattataa attctagact gaatctgtga tgctttcaga aagcctcatc
     4141 tgagaagtag tatctgcagg gactgtgctt ctcaactaat tttcatttat tgttatttat
     4201 tttatttata tcttaattac ttcacaaaag gacttgtgat gtcatttgtt ttcgttggct
     4261 tttaggaatt attttcttaa catcaatctt ttgtgatatg aatggcagaa gagttctttt
     4321 actctgtcac tggattgctc tatttcttta tggtggtgga gggttgggaa gacaattaga
     4381 gagaaaagag gataaatggg aaatctcatg taatgaaagc tacacagatg gtccccaatt
     4441 tatgatgctt tgatttatga ttgtttgact ttacaatggg tttatcaggg tattaattgc
     4501 attttacatt tatgatattt ttgacttagg atgggtttat caggacataa ccccattgca
     4561 agccagagag catctgtact tgtttgtaat aaaaagatct gcttacaaa
//
