LOCUS       NM_002040               5226 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens GA binding protein transcription factor subunit alpha
            (GABPA), transcript variant 1, mRNA.
ACCESSION   NM_002040
VERSION     NM_002040.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5226)
  AUTHORS   Wu,Y., Wu,Z., Yao,M., Liu,L., Song,Y., Ma,L. and Liu,C.
  TITLE     GABPA inhibits tumorigenesis in clear cell renal cell carcinoma by
            regulating ferroptosis through ACSL4
  JOURNAL   Sci Rep 14 (1), 26521 (2024)
   PUBMED   39489850
  REMARK    GeneRIF: GABPA inhibits tumorigenesis in clear cell renal cell
            carcinoma by regulating ferroptosis through ACSL4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5226)
  AUTHORS   Pinho,S.A., Costa,C.F., Deus,C.M., Pinho,S.L.C., Miranda-Santos,I.,
            Afonso,G., Bagshaw,O., Stuart,J.A., Oliveira,P.J. and
            Cunha-Oliveira,T.
  TITLE     Mitochondrial and metabolic remodelling in human skin fibroblasts
            in response to glucose availability
  JOURNAL   FEBS J 289 (17), 5198-5217 (2022)
   PUBMED   35213938
REFERENCE   3  (bases 1 to 5226)
  AUTHORS   Fang,Z., Zhang,N., Yuan,X., Xing,X., Li,X., Qin,X., Liu,Z., Neo,S.,
            Liu,C., Kong,F., Bjorkholm,M., Fan,Y. and Xu,D.
  TITLE     GABPA-activated TGFBR2 transcription inhibits aggressiveness but is
            epigenetically erased by oncometabolites in renal cell carcinoma
  JOURNAL   J Exp Clin Cancer Res 41 (1), 173 (2022)
   PUBMED   35549739
  REMARK    GeneRIF: GABPA-activated TGFBR2 transcription inhibits
            aggressiveness but is epigenetically erased by oncometabolites in
            renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5226)
  AUTHORS   Ma,X., Lin,Q., Cui,G., Zhao,J., Wei,X., Li,R., Mao,H., Ma,Y.,
            Liu,P. and Pang,Y.
  TITLE     GABPA Expression in Endometrial Carcinoma: A Prognostic Marker
  JOURNAL   Dis Markers 2021, 5552614 (2021)
   PUBMED   34306255
  REMARK    GeneRIF: GABPA Expression in Endometrial Carcinoma: A Prognostic
            Marker.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5226)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5226)
  AUTHORS   Goto,M., Shimizu,T., Sawada,J., Sawa,C., Watanabe,H., Ichikawa,H.,
            Ohira,M., Ohki,M. and Handa,H.
  TITLE     Assignment of the E4TF1-60 gene to human chromosome 21q21.2-q21.3
  JOURNAL   Gene 166 (2), 337-338 (1995)
   PUBMED   8543189
REFERENCE   7  (bases 1 to 5226)
  AUTHORS   Chrast,R., Chen,H., Morris,M.A. and Antonarakis,S.E.
  TITLE     Mapping of the human transcription factor GABPA (E4TF1-60) gene to
            chromosome 21
  JOURNAL   Genomics 28 (1), 119-122 (1995)
   PUBMED   7590737
REFERENCE   8  (bases 1 to 5226)
  AUTHORS   Gugneja,S., Virbasius,J.V. and Scarpulla,R.C.
  TITLE     Four structurally distinct, non-DNA-binding subunits of human
            nuclear respiratory factor 2 share a conserved transcriptional
            activation domain
  JOURNAL   Mol Cell Biol 15 (1), 102-111 (1995)
   PUBMED   7799916
REFERENCE   9  (bases 1 to 5226)
  AUTHORS   Sawada,J., Goto,M., Watanabe,H., Handa,H. and Yoshida,M.C.
  TITLE     Regional mapping of two subunits of transcription factor E4TF1 to
            human chromosome
  JOURNAL   Jpn J Cancer Res 86 (1), 10-12 (1995)
   PUBMED   7737900
REFERENCE   10 (bases 1 to 5226)
  AUTHORS   Watanabe,H., Sawada,J., Yano,K., Yamaguchi,K., Goto,M. and Handa,H.
  TITLE     cDNA cloning of transcription factor E4TF1 subunits with Ets and
            notch motifs
  JOURNAL   Mol Cell Biol 13 (3), 1385-1391 (1993)
   PUBMED   8441384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000226.2, CD674081.1, BC035031.2, BX647755.1, CV575645.1,
            BG542623.1, CB132898.1, BX117934.1 and AI917898.1.
            
            On Jun 2, 2019 this sequence version replaced NM_002040.3.
            
            Summary: This gene encodes one of three GA-binding protein
            transcription factor subunits which functions as a DNA-binding
            subunit. Since this subunit shares identity with a subunit encoding
            the nuclear respiratory factor 2 gene, it is likely involved in
            activation of cytochrome oxidase expression and nuclear control of
            mitochondrial function. This subunit also shares identity with a
            subunit constituting the transcription factor E4TF1, responsible
            for expression of the adenovirus E4 gene. Because of its
            chromosomal localization and ability to form heterodimers with
            other polypeptides, this gene may play a role in the Down Syndrome
            phenotype. Two transcript variants encoding the same protein have
            been found for this gene. [provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.147144.1,
                                           SRR1660807.54866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400075.4/ ENSP00000382948.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AP000226.2         32845-32890
            47-416              CD674081.1         72-441              c
            417-1962            BC035031.2         4-1549
            1963-3871           BX647755.1         1858-3766
            3872-4117           CV575645.1         4-249
            4118-4158           BG542623.1         149-189
            4159-4671           CB132898.1         28-540
            4672-5094           BX117934.1         52-474
            5095-5226           AI917898.1         3-134               c
FEATURES             Location/Qualifiers
     source          1..5226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.3"
     gene            1..5226
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /note="GA binding protein transcription factor subunit
                     alpha"
                     /db_xref="GeneID:2551"
                     /db_xref="HGNC:HGNC:4071"
                     /db_xref="MIM:600609"
     exon            1..607
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /inference="alignment:Splign:2.1.0"
     exon            608..710
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /inference="alignment:Splign:2.1.0"
     CDS             634..1998
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /note="human nuclear respiratory factor-2 subunit alpha;
                     nuclear respiratory factor 2 alpha subunit; GABP subunit
                     alpha; transcription factor E4TF1-60; nuclear respiratory
                     factor 2 subunit alpha; GA binding protein transcription
                     factor alpha subunit 60kDa"
                     /codon_start=1
                     /product="GA-binding protein alpha chain"
                     /protein_id="NP_002031.2"
                     /db_xref="CCDS:CCDS13575.1"
                     /db_xref="GeneID:2551"
                     /db_xref="HGNC:HGNC:4071"
                     /db_xref="MIM:600609"
                     /translation="MTKREAEELIEIEIDGTEKAECTEESIVEQTYAPAECVSQAIDI
                     NEPIGNLKKLLEPRLQCSLDAHEICLQDIQLDPERSLFDQGVKTDGTVQLSVQVISYQ
                     GIEPKLNILEIVKPADTVEVVIDPDAHHAESEAHLVEEAQVITLDGTKHITTISDETS
                     EQVTRWAAALEGYRKEQERLGIPYDPIQWSTDQVLHWVVWVMKEFSMTDIDLTTLNIS
                     GRELCSLNQEDFFQRVPRGEILWSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASV
                     QSATPTTIKVINSSAKAAKVQRAPRISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKD
                     ARDCISWVGDEGEFKLNQPELVAQKWGQRKNKPTMNYEKLSRALRYYYDGDMICKVQG
                     KRFVYKFVCDLKTLIGYSAAELNRLVTECEQKKLAKMQLHGIAQPVTAVALATASLQT
                     EKDN"
     exon            711..855
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /inference="alignment:Splign:2.1.0"
     exon            856..940
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1186
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1381
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1435
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1576
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1769
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..5226
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /note="hexamer: AATGAA"
     polyA_site      2352
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /note="major polyA site"
     regulatory      2725..2730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /note="hexamer: AATAAA"
     polyA_site      2749
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /note="major polyA site"
     regulatory      2814..2819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /note="hexamer: AATAAA"
     polyA_site      2834
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
     regulatory      5207..5212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
                     /note="hexamer: AATAAA"
     polyA_site      5226
                     /gene="GABPA"
                     /gene_synonym="E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A;
                     RCH04A07"
ORIGIN      
        1 agtcggtcga cgctcaccgg acaggaagcg tctcggagac agtctgcgac cggacgggtc
       61 taggtgagac agaagccaaa caggaggagg aagtggaggg taagtgcttc cgggtcccct
      121 ggcacagcct ccgccatctt ttcttcgcct aatttgaccc gttctttttc ccctccttga
      181 aaccttgctc tgtacgcatg cgctctttga gtggcctttc ccctagttca agctcccctc
      241 cgagtcagcg tcctgttcgt tagggttatc gaagtgtata aaggtgcagg gaaagtgaga
      301 ctgtgtaaaa caaagcggat tggggcgttg tgcttccttg tacctcgtga gcctccgttg
      361 ccttgggcgg tcgttttgcg caccctgccg ggagttgtag tcctggaccc gaaggtgcct
      421 gggaggcggg aggggggttg gggcttctca gcgccgattc cgcgggaagg gccctgggac
      481 ctcacacttc tagtcgcggg agctgcaggt cttacccgga gagacgctgc acgtggagcc
      541 ctcgccgctg ccgttctcag ccggctctgg agtgcgggcg ggggcgacag ggccgattcc
      601 ggagtgggac tgatcctttg aaatactcca gccatgacta aaagagaagc agaggagctg
      661 atagaaattg agattgatgg aacagagaaa gcagagtgca cagaagaaag cattgtagaa
      721 caaacctacg cgccagctga atgtgtaagc caggccatag acatcaatga accaataggc
      781 aatttaaaga aactgctaga accaagacta cagtgttctt tggatgctca tgaaatttgt
      841 ctgcaagata tccagctgga tccagaacga agtttatttg accaaggagt aaaaacagat
      901 ggaactgtac agcttagtgt acaggtaatt tcttaccaag gaattgaacc aaagttaaac
      961 atccttgaaa ttgttaaacc tgcggacact gttgaggttg ttattgatcc agatgcccac
     1021 catgctgaat cagaagcaca tcttgttgaa gaagctcaag tgataactct tgatggcaca
     1081 aaacacatca caaccatttc agatgaaact tcagaacaag tgacaagatg ggctgctgca
     1141 ctggaaggct ataggaaaga acaagaacgc cttgggatac cctatgatcc catacagtgg
     1201 tccacagacc aagtcctgca ttgggtggtt tgggtaatga aggaattcag catgaccgat
     1261 atagacctca ccacactcaa catttcgggg agagaattat gtagtctcaa ccaagaagat
     1321 ttttttcagc gggttcctcg gggagaaatt ctctggagtc atctggaact tctccgaaaa
     1381 tatgtattgg caagtcaaga acaacagatg aatgaaatag ttacaattga tcaacctgtg
     1441 caaattattc cagcatcagt gcaatctgct acacctacta ccattaaagt tataaatagt
     1501 agtgcgaaag cagccaaagt acaaagagcg ccgaggattt caggagaaga tagaagctca
     1561 cctgggaaca gaacaggaaa caatggccaa atccaactat ggcagttttt gctagaactt
     1621 cttactgata aggacgctcg agactgcatt tcttgggttg gtgatgaagg tgaatttaag
     1681 ctaaatcagc ctgaactggt tgcacagaaa tggggacagc gtaaaaataa gcctacgatg
     1741 aactatgaga aactcagtcg tgcattaaga tattattacg atggggacat gatttgtaaa
     1801 gttcaaggca agagatttgt gtacaagttt gtctgtgact tgaagactct tattggatac
     1861 agtgcagcgg agttgaaccg tttggtcaca gaatgtgaac agaagaaact tgcaaagatg
     1921 cagctccatg gaattgccca gccagtcaca gcagtagctc tggctactgc ttctctgcaa
     1981 acggaaaagg ataattgagc cccaggacat tctgagactc caaagtcttt cttaaaatgt
     2041 ttagagcaag tatagctctt acctttatta ctgaatttga atcttctttt atttctaggc
     2101 tgtacagtct gatgcatgat ttttttataa atatttcata ctcttgtgaa tttggatctt
     2161 tttactttga gcatatattt tagaatatgt gtatgttaaa ggatctccac aatgtctgca
     2221 gtgtgaaggc aggttcattg tggaatagtt taacagtcag gaaggctaaa ctggtcagta
     2281 ttaatgtgta gccctaccaa aaatagccag tagtatctga aaatgaaaaa taaatgaagt
     2341 atctctagga aacagtctgg cttaactatt tttgaaaata taactgtttc ccctctctgc
     2401 tgctttagat gttgctttac atagaaccag aaaatggaat ttctcagcta aagcatgtgt
     2461 gcctgtttca tctaatcaag cagagctaaa atgttcatac cgaataaatt tatattaata
     2521 aattactaaa ctaagagtat caggttattt atatatttgc aagcaaagga cagtaagaag
     2581 ttgactggca aaagagcagt gctgaaggag gagatccagg tttaaatctg gcttattaac
     2641 tcaagccaat tttaaggatt ttctgtatag attactcatg tcagaccaag aatttaaatt
     2701 attttgagag aggcatttaa ttctaataaa ccagctgtta taaaaattat aaaatgatct
     2761 ctgtttttcc tgtcagagat ttaaaaaact gaaaaggtat acctcaaccc aaaaataaag
     2821 gtttgttttg gtttgttatg gcttcctttt ttaaaaaatt accctgtagt gccagtttat
     2881 tatgcaaagc agcttatatt cctttgtttc tgataaaatg aagactttaa atcagtcagt
     2941 agtactttac ctttcaaggc attagtaaat tacttgcaaa tagttttaaa aggaaaatac
     3001 gacctttgtt ataggcagtc ttctctttaa gacaatactt ttccacttgt tttccttttc
     3061 catattatat atgtgtattc atatagctgt atacatattc agttgatcat tttataaaca
     3121 tatgaaggca taaagatata cagaagaaaa attattaaac aactcatttt aagattcaaa
     3181 ttaactaatt cctgcatata tgacattcct tacataagcg aacactaaac aaaaatggct
     3241 agaaatgtct ttttctttct tttctctctt tgttgtttaa ggtattaagc acgaattatt
     3301 acatgagact ggcagatagc tattaatcct cttacagatt tgagaaagtt gattctcaaa
     3361 tatttatgca ccttctcctt cattgttttc tttaaatctg tcctcttaaa aagcttctta
     3421 agagctcagt taatgctttt gacttaacta ggagaaaaag gcatgataat acaggcaaga
     3481 tggcattgtt agcaattctg gtagtggttt ggaatgaatc ctaagaggca gggatcttaa
     3541 ggacaaggaa gagaagagag agagggaggg atctttgatc tctttctctg gtaatcttaa
     3601 tgcataattt tactaaaaca tgttctcaat tcattcatat tattaagctc ttcctgcagt
     3661 tgatatctga gcagagtaag atttgtattt ccatttttac ttttttgaaa gagaatatat
     3721 ggacagatta ttagtacaat ttgggcactg tggttttaag aatatctgag taaaataaca
     3781 atatgaaata ataaacagaa gctctaacgt caggtaacaa atagacagca agaaaggttt
     3841 tgcaccatcc tcttacggcc tagagagttg acaagttgct tgtagtttta aaaaaataat
     3901 aaagtatacc cttctggtat atcatcaaga gcttaagaat cttggctttc atatttaaaa
     3961 tgcttttggg gagacatata ttaaaatttt agccaagatg atagacatgt ctcaattata
     4021 tatgtgtgtg tatgttttta aagctaaaaa cattactttt agatccctag aatgaaaatt
     4081 tttttctcat ctatgcaatt cccatatggt ttttttttaa atcatatttt attcattttc
     4141 tccctttagc aattttcatt ttatttctca taatttgaac agagacagtt ctcatacatg
     4201 atcagatgct ttttttttct tcttaccatc atttatgcat gacataggta atgtgactaa
     4261 tttctccagt tgattcaaga aactcattac tttgcctcaa attatatgta aaatatttgt
     4321 tttacttagg ttacagttat cagaaaggta gtttttttct tctattaaaa tataacattg
     4381 tgaaagaaaa taaaatttat gctattcttt gctttgtttt tataaatgaa tttttcatag
     4441 aatttacagt atattcaaag gaagaaagat aaaattattg gtcatcattt gtaccttaga
     4501 agtacaagaa tttaagtaaa agaaatgttc atttttgttt taaaatttgt tttccatgtg
     4561 aagtttttat tgagccaact ttcatacata tcttgctagc ctaaagtcta aatatttgtg
     4621 ttggcatcag aaaaacaaat gaggcagaat tgctatgtgt ggttgatctt cagataaatt
     4681 gactgatcac agttattttt gtatcagtct atgttattag gaaaaattgt ttagttgttt
     4741 tctcccctga ttaatggtga tattcaagta tgatacaaaa agaattgtac caccaaatat
     4801 ttttgtgagg tctgctgttt tccatattca ttttatgcta ctgcctttaa gaaagaacta
     4861 gtgtatcctt gaaatagcac aaaaatgttt taaaattcat aattgcaaaa caaatctgtg
     4921 actaacttaa tgtcttcaga tctaaagggt gtaaaaatat tgatacttca atatttcact
     4981 tgctgccagg aaaaacaaaa ttctcaatct tttgtaaatg ggaggaggac ttttgcatac
     5041 atttttactc tttaaataac gacaacgaca cttatactgt cataataaca attatgtatt
     5101 tctttgtggt tttaattttt tttgtaattt tacataaaac agttattttc tatttttacg
     5161 cagataaata tttgtgcata aaatgtaaaa atagtaaaat gagaaaaata aaactattat
     5221 acagta
//
