LOCUS       NM_005458               5499 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens gamma-aminobutyric acid type B receptor subunit 2
            (GABBR2), mRNA.
ACCESSION   NM_005458
VERSION     NM_005458.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5499)
  AUTHORS   Elahi Najafi,M.A., Yasui,M., Teramoto,Y., Tatenuma,T., Jiang,G. and
            Miyamoto,H.
  TITLE     GABBR2 as a Downstream Effector of the Androgen Receptor Induces
            Cisplatin Resistance in Bladder Cancer
  JOURNAL   Int J Mol Sci 24 (18), 13733 (2023)
   PUBMED   37762034
  REMARK    GeneRIF: GABBR2 as a Downstream Effector of the Androgen Receptor
            Induces Cisplatin Resistance in Bladder Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5499)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5499)
  AUTHORS   Miyazawa,A., Kanahara,N., Kogure,M., Otsuka,I., Okazaki,S.,
            Watanabe,Y., Yamasaki,F., Nakata,Y., Oda,Y., Hishimoto,A. and
            Iyo,M.
  TITLE     A preliminary genetic association study of GAD1 and GABAB receptor
            genes in patients with treatment-resistant schizophrenia
  JOURNAL   Mol Biol Rep 49 (3), 2015-2024 (2022)
   PUBMED   34845648
  REMARK    GeneRIF: A preliminary genetic association study of GAD1 and GABAB
            receptor genes in patients with treatment-resistant schizophrenia.
REFERENCE   4  (bases 1 to 5499)
  AUTHORS   Kim,Y., Jeong,E., Jeong,J.H., Kim,Y. and Cho,Y.
  TITLE     Structural Basis for Activation of the Heterodimeric GABAB Receptor
  JOURNAL   J Mol Biol 432 (22), 5966-5984 (2020)
   PUBMED   33058878
  REMARK    GeneRIF: Structural Basis for Activation of the Heterodimeric GABAB
            Receptor.
REFERENCE   5  (bases 1 to 5499)
  AUTHORS   Park,J., Fu,Z., Frangaj,A., Liu,J., Mosyak,L., Shen,T.,
            Slavkovich,V.N., Ray,K.M., Taura,J., Cao,B., Geng,Y., Zuo,H.,
            Kou,Y., Grassucci,R., Chen,S., Liu,Z., Lin,X., Williams,J.P.,
            Rice,W.J., Eng,E.T., Huang,R.K., Soni,R.K., Kloss,B., Yu,Z.,
            Javitch,J.A., Hendrickson,W.A., Slesinger,P.A., Quick,M.,
            Graziano,J., Yu,H., Fiehn,O., Clarke,O.B., Frank,J. and Fan,Q.R.
  TITLE     Structure of human GABAB receptor in an inactive state
  JOURNAL   Nature 584 (7820), 304-309 (2020)
   PUBMED   32581365
  REMARK    GeneRIF: Structure of human GABAB receptor in an inactive state.
            Erratum:[Nature. 2020 Jul;583(7818):E29. doi:
            10.1038/s41586-020-2543-y.. PMID: 32665714]
REFERENCE   6  (bases 1 to 5499)
  AUTHORS   Kaupmann,K., Malitschek,B., Schuler,V., Heid,J., Froestl,W.,
            Beck,P., Mosbacher,J., Bischoff,S., Kulik,A., Shigemoto,R.,
            Karschin,A. and Bettler,B.
  TITLE     GABA(B)-receptor subtypes assemble into functional heteromeric
            complexes
  JOURNAL   Nature 396 (6712), 683-687 (1998)
   PUBMED   9872317
REFERENCE   7  (bases 1 to 5499)
  AUTHORS   White,J.H., Wise,A., Main,M.J., Green,A., Fraser,N.J., Disney,G.H.,
            Barnes,A.A., Emson,P., Foord,S.M. and Marshall,F.H.
  TITLE     Heterodimerization is required for the formation of a functional
            GABA(B) receptor
  JOURNAL   Nature 396 (6712), 679-682 (1998)
   PUBMED   9872316
REFERENCE   8  (bases 1 to 5499)
  AUTHORS   Kerr,D.I. and Ong,J.
  TITLE     GABAB receptors
  JOURNAL   Pharmacol Ther 67 (2), 187-246 (1995)
   PUBMED   7494864
  REMARK    Review article
REFERENCE   9  (bases 1 to 5499)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
REFERENCE   10 (bases 1 to 5499)
  AUTHORS   Inoue,M. and Enomoto,S.
  TITLE     [Methylation of phenols using metal-salt catalysts (author's
            transl)]
  JOURNAL   Yakugaku Zasshi 96 (7), 923-926 (1976)
   PUBMED   987231
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF056085.1, DB474482.1,
            AJ012188.1, AF099033.1, BC055425.1, BX420187.2 and BX452140.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005458.7.
            
            Summary: The multi-pass membrane protein encoded by this gene
            belongs to the G-protein coupled receptor 3 family and GABA-B
            receptor subfamily. The GABA-B receptors inhibit neuronal activity
            through G protein-coupled second-messenger systems, which regulate
            the release of neurotransmitters, and the activity of ion channels
            and adenylyl cyclase. This receptor subunit forms an active
            heterodimeric complex with GABA-B receptor subunit 1, neither of
            which is effective on its own. Allelic variants of this gene have
            been associated with nicotine dependence.[provided by RefSeq, Jan
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF056085.1, AF099033.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259455.4/ ENSP00000259455.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AF056085.1         263-299
            38-288              DB474482.1         27-277
            289-3024            AJ012188.1         91-2826
            3025-3329           AF099033.1         2827-3131
            3330-3970           BC055425.1         142-782
            3971-4654           BX420187.2         242-925
            4655-5259           BX452140.1         123-727
            5260-5499           BC055425.1         2070-2309
FEATURES             Location/Qualifiers
     source          1..5499
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..5499
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /note="gamma-aminobutyric acid type B receptor subunit 2"
                     /db_xref="GeneID:9568"
                     /db_xref="HGNC:HGNC:4507"
                     /db_xref="MIM:607340"
     exon            1..519
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..3024
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /note="GABA-B receptor, R2 subunit; gb2; GABA-BR2;
                     GABA-B-R2; GABA-B receptor 2; G-protein coupled receptor
                     51; gamma-aminobutyric acid B receptor 2;
                     gamma-aminobutyric acid (GABA) B receptor, 2"
                     /codon_start=1
                     /product="gamma-aminobutyric acid type B receptor subunit
                     2 precursor"
                     /protein_id="NP_005449.5"
                     /db_xref="CCDS:CCDS6736.1"
                     /db_xref="GeneID:9568"
                     /db_xref="HGNC:HGNC:4507"
                     /db_xref="MIM:607340"
                     /translation="MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWAR
                     GAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLR
                     LYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATT
                     PVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGV
                     LYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSK
                     YQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKT
                     PQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTD
                     HTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLE
                     IINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRN
                     QKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTT
                     AFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRT
                     VEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVS
                     IPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVF
                     VPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRL
                     RMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKN
                     HLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASC
                     VSPCVSPTASPRHRHVPPSFRVMVSGL"
     exon            520..657
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            658..828
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            829..930
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            931..996
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1197
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1434
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1495
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1576
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1727
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1860
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1968
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2091
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2202
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2427
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2610
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2740
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2858
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..5499
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5470..5475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /note="hexamer: AATAAA"
     polyA_site      5499
                     /gene="GABBR2"
                     /gene_synonym="DEE59; EIEE59; GABABR2; GPR51; GPRC3B;
                     HG20; HRIHFB2099; NDPLHS"
                     /note="major polyA site"
ORIGIN      
        1 gatccgtcac gggcgccgcc gctgccgccg ccgccgccgc ggccgttctg agccgagccg
       61 gaaccctagc ccgagacgga gccggggccc gggccggcgc cattgcgcgg gcgccgcggg
      121 aagaccttgg cgcggggcgg cgggccgggc caggccatgc gggccgagtg agccggcgcc
      181 cgcagcccgc ggcgcggcat ggcttccccg cggagctccg ggcagcccgg gccgccgccg
      241 ccgccgccac cgccgcccgc gcgcctgcta ctgctactgc tgctgccgct gctgctgcct
      301 ctggcgcccg gggcctgggg ctgggcgcgg ggcgcccccc ggccgccgcc cagcagcccg
      361 ccgctctcca tcatgggcct catgccgctc accaaggagg tggccaaggg cagcatcggg
      421 cgcggtgtgc tccccgccgt ggaactggcc atcgagcaga tccgcaacga gtcactcctg
      481 cgcccctact tcctcgacct gcggctctat gacacggagt gcgacaacgc aaaagggttg
      541 aaagccttct acgatgcaat aaaatacggg cctaaccact tgatggtgtt tggaggcgtc
      601 tgtccatccg tcacatccat cattgcagag tccctccaag gctggaatct ggtgcagctt
      661 tcttttgctg caaccacgcc tgttctagcc gataagaaaa aataccctta tttctttcgg
      721 accgtcccat cagacaatgc ggtgaatcca gccattctga agttgctcaa gcactaccag
      781 tggaagcgcg tgggcacgct gacgcaagac gttcagaggt tctctgaggt gcggaatgac
      841 ctgactggag ttctgtatgg cgaggacatt gagatttcag acaccgagag cttctccaac
      901 gatccctgta ccagtgtcaa aaagctgaag gggaatgatg tgcggatcat ccttggccag
      961 tttgaccaga atatggcagc aaaagtgttc tgttgtgcat acgaggagaa catgtatggt
     1021 agtaaatatc agtggatcat tccgggctgg tacgagcctt cttggtggga gcaggtgcac
     1081 acggaagcca actcatcccg ctgcctccgg aagaatctgc ttgctgccat ggagggctac
     1141 attggcgtgg atttcgagcc cctgagctcc aagcagatca agaccatctc aggaaagact
     1201 ccacagcagt atgagagaga gtacaacaac aagcggtcag gcgtggggcc cagcaagttc
     1261 cacgggtacg cctacgatgg catctgggtc atcgccaaga cactgcagag ggccatggag
     1321 acactgcatg ccagcagccg gcaccagcgg atccaggact tcaactacac ggaccacacg
     1381 ctgggcagga tcatcctcaa tgccatgaac gagaccaact tcttcggggt cacgggtcaa
     1441 gttgtattcc ggaatgggga gagaatgggg accattaaat ttactcaatt tcaagacagc
     1501 agggaggtga aggtgggaga gtacaacgct gtggccgaca cactggagat catcaatgac
     1561 accatcaggt tccaaggatc cgaaccacca aaagacaaga ccatcatcct ggagcagctg
     1621 cggaagatct ccctacctct ctacagcatc ctctctgccc tcaccatcct cgggatgatc
     1681 atggccagtg cttttctctt cttcaacatc aagaaccgga atcagaagct cataaagatg
     1741 tcgagtccat acatgaacaa ccttatcatc cttggaggga tgctctccta tgcttccata
     1801 tttctctttg gccttgatgg atcctttgtc tctgaaaaga cctttgaaac actttgcacc
     1861 gtcaggacct ggattctcac cgtgggctac acgaccgctt ttggggccat gtttgcaaag
     1921 acctggagag tccacgccat cttcaaaaat gtgaaaatga agaagaagat catcaaggac
     1981 cagaaactgc ttgtgatcgt ggggggcatg ctgctgatcg acctgtgtat cctgatctgc
     2041 tggcaggctg tggaccccct gcgaaggaca gtggagaagt acagcatgga gccggaccca
     2101 gcaggacggg atatctccat ccgccctctc ctggagcact gtgagaacac ccatatgacc
     2161 atctggcttg gcatcgtcta tgcctacaag ggacttctca tgttgttcgg ttgtttctta
     2221 gcttgggaga cccgcaacgt cagcatcccc gcactcaacg acagcaagta catcgggatg
     2281 agtgtctaca acgtggggat catgtgcatc atcggggccg ctgtctcctt cctgacccgg
     2341 gaccagccca atgtgcagtt ctgcatcgtg gctctggtca tcatcttctg cagcaccatc
     2401 accctctgcc tggtattcgt gccgaagctc atcaccctga gaacaaaccc agatgcagca
     2461 acgcagaaca ggcgattcca gttcactcag aatcagaaga aagaagattc taaaacgtcc
     2521 acctcggtca ccagtgtgaa ccaagccagc acatcccgcc tggagggcct acagtcagaa
     2581 aaccatcgcc tgcgaatgaa gatcacagag ctggataaag acttggaaga ggtcaccatg
     2641 cagctgcagg acacaccaga aaagaccacc tacattaaac agaaccacta ccaagagctc
     2701 aatgacatcc tcaacctggg aaacttcact gagagcacag atggaggaaa ggccatttta
     2761 aaaaatcacc tcgatcaaaa tccccagcta cagtggaaca caacagagcc ctctcgaaca
     2821 tgcaaagatc ctatagaaga tataaactct ccagaacaca tccagcgtcg gctgtccctc
     2881 cagctcccca tcctccacca cgcctacctc ccatccatcg gaggcgtgga cgccagctgt
     2941 gtcagcccct gcgtcagccc caccgccagc ccccgccaca gacatgtgcc accctccttc
     3001 cgagtcatgg tctcgggcct gtaagggtgg gaggcctggg cccggggcct cccccgtgac
     3061 agaaccacac tgggcagagg ggtctgctgc agaaacactg tcggctctgg ctgcggagaa
     3121 gctgggcacc atggctggcc tctcaggacc actcggatgg cactcaggtg gacaggacgg
     3181 ggcaggggga gacttggcac ctgacctcga gccttatttg tgaagtcctt atttcttcac
     3241 aaagaagagg aacggaaatg ggacgtcttc cttaacatct gcaaacaagg aggcgctggg
     3301 atatcaaact tgcaaaaaaa aaaaaaaaaa aaaaaaaaca aaaaaactag acaaggagag
     3361 aggcactaga actccagctg gaagtcacgg agtggctcga gcagccttgg gaagaggcaa
     3421 ggagcttctg aagaaactgc ctctgcacac acatcactgg ctgtgacccc tcaggctagc
     3481 ccttctccac tctgggggag gaggtgggaa gggccaccag gcccccagct gccaggccag
     3541 ctgaccccag ccttcctgga acagggagtc tgcaggagcg cagacaggca cagccctgga
     3601 gcaggcaggc cgagggctgc ggcactggag caggctgact tacatgctcc acatgggacc
     3661 tgtgtcaccc aatgagatgt ttgttactct ggtaaatgcc acacgttaac acaataacac
     3721 ccattcctgg gaccgtgggg atttagggca cgtcactgca gacacgctct gcagcattca
     3781 ccgacagtct gtcatgcacc caccacgttg gccatgtcct tgtgttccta tcggatgctc
     3841 ccagtaacca gggggaccac ccgagctaat catggaatgt ctgttcccag caaacacgat
     3901 aaagaaagat tgtgcacttt aacctctctc atcagggccc aagggctggc tgggattttt
     3961 tttttttttt tcccactaac tttgtttctg accaaagtga attggaggca ctctgctaaa
     4021 agacatcccc gtagacatag gggagagagt tgctggctga gggcttccct tggcttccag
     4081 aaggcagcct tccatccaga caagccagtg agctctcccc ttgggatcac tggggtgatc
     4141 agtcagcaga ttgattctca ttcataagat cattcctccc tttaaattga gcccctaaga
     4201 gcactggcct gggagtcaga cagacctggg ttcaagtcct cagtcccctg cccactccct
     4261 acgtgacttt gatcaggtca ctagtgtctc tctgagcctc agtttcccct ctgtaacttg
     4321 gggttgaact aaaacacctg tcctgcctac ctcacaaggt cactctgagg attgaaactt
     4381 gatcttgtcc aggaaagctt tgtaccaaac agtgaagccg ccctgatccg tgaggtatga
     4441 gtatgactct gaccttcagc cctccctaca gccgggggtg tggcccagag aagcttccag
     4501 cacagccctc tacccagaac atccgggctg gagggaggct cccagtgact tttctgacat
     4561 tcctagacag gttcattctt tgctcaagaa aggcctgaat gacaatgtcc aggatgtctg
     4621 cacaactgag cagctcgctc actccctaaa gaaacctatt ggcagcttca acaggcaggc
     4681 aataatctct tcccagaacc actgcagtca ggaataaact gttttctcca ccaggctttg
     4741 acaaaagggc ccacaggaat cttaccaatg ccaacatttc aaagcaccct atttcacgta
     4801 gcatagcttt ctgctcccct tccccaaaga gaggttatgg aggtactgta gcttttaggg
     4861 aaaaaaaaat gttaacacat cacaggtcaa gttgaagtca ttctctgttt aggcactaaa
     4921 aatcggtgtt gtcactcact gtgtattacc agtatttact tgctttcttg atttcaccaa
     4981 aaccaaattt aatttaaagg accacattaa tttttcaaag ggaaagagac aattaattgt
     5041 acataatgta tacacacaca caaaaaaaaa tacctgtaga aatattattc cagcatagca
     5101 ggaaaacaaa caaaagtatt ggactgtcgg aggtgagcct gtgcgtctgt aaccctttgt
     5161 gactcctgag cgtgcgctgt cttctaggtt aactcacgaa gtacattctc tgtcttactg
     5221 atactgtagg ttcacccatt tttttttaat ttcctcgcaa ataacaagac ccacagaagt
     5281 gactctagct acttaatggt tctgttcttt tatatgcagc aaacacaccg tccatttctg
     5341 aagaggcttc ggcctgaagg cattttccaa tgatgttagt gcacaaaacg ctttaaatta
     5401 gactggaact gccagaatca aatgtaaatg aggaatttct cgtaccccta ctgcatggta
     5461 tcgattttta ataaattgtt gcaaatttgt ttttatgaa
//
