LOCUS       NM_001470               4525 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens gamma-aminobutyric acid type B receptor subunit 1
            (GABBR1), transcript variant 1, mRNA.
ACCESSION   NM_001470
VERSION     NM_001470.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4525)
  AUTHORS   Cediel,M.L., Stawarski,M., Blanc,X., Noskova,L., Magner,M.,
            Platzer,K., Gburek-Augustat,J., Baldridge,D., Constantino,J.N.,
            Ranza,E., Bettler,B. and Antonarakis,S.E.
  TITLE     GABBR1 monoallelic de novo variants linked to neurodevelopmental
            delay and epilepsy
  JOURNAL   Am J Hum Genet 109 (10), 1885-1893 (2022)
   PUBMED   36103875
  REMARK    GeneRIF: GABBR1 monoallelic de novo variants linked to
            neurodevelopmental delay and epilepsy.
REFERENCE   2  (bases 1 to 4525)
  AUTHORS   Bekic,M., Vasiljevic,M., Stojanovic,D., Kokol,V., Mihajlovic,D.,
            Vucevic,D., Uskokovic,P., Colic,M. and Tomic,S.
  TITLE     Phosphonate-Modified Cellulose Nanocrystals Potentiate the Th1
            Polarising Capacity of Monocyte-Derived Dendritic Cells via GABA-B
            Receptor
  JOURNAL   Int J Nanomedicine 17, 3191-3216 (2022)
   PUBMED   35909813
  REMARK    GeneRIF: Phosphonate-Modified Cellulose Nanocrystals Potentiate the
            Th1 Polarising Capacity of Monocyte-Derived Dendritic Cells via
            GABA-B Receptor.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4525)
  AUTHORS   Guo,M., Li,D., Feng,Y., Li,M. and Yang,B.
  TITLE     Adipose-derived stem cell-derived extracellular vesicles inhibit
            neuroblastoma growth by regulating GABBR1 activity through
            LINC00622-mediated transcription factor AR
  JOURNAL   J Leukoc Biol 111 (1), 19-32 (2022)
   PUBMED   34448502
  REMARK    GeneRIF: Adipose-derived stem cell-derived extracellular vesicles
            inhibit neuroblastoma growth by regulating GABBR1 activity through
            LINC00622-mediated transcription factor AR.
REFERENCE   4  (bases 1 to 4525)
  AUTHORS   Lee,C., Mayfield,R.D. and Harris,R.A.
  TITLE     Intron 4 containing novel GABAB1 isoforms impair GABAB receptor
            function
  JOURNAL   PLoS One 5 (11), e14044 (2010)
   PUBMED   21124972
  REMARK    GeneRIF: Data suggest that the GABAB1 intron 4 containing
            N-terminal truncation is necessary for the inhibitory action of the
            new splice variants.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4525)
  AUTHORS   Schwarz,D.A., Barry,G., Eliasof,S.D., Petroski,R.E., Conlon,P.J.
            and Maki,R.A.
  TITLE     Characterization of gamma-aminobutyric acid receptor GABAB(1e), a
            GABAB(1) splice variant encoding a truncated receptor
  JOURNAL   J Biol Chem 275 (41), 32174-32181 (2000)
   PUBMED   10906333
  REMARK    Erratum:[J Biol Chem 2001 Mar 23;276(12):9582]
REFERENCE   6  (bases 1 to 4525)
  AUTHORS   Kaupmann,K., Schuler,V., Mosbacher,J., Bischoff,S., Bittiger,H.,
            Heid,J., Froestl,W., Leonhard,S., Pfaff,T., Karschin,A. and
            Bettler,B.
  TITLE     Human gamma-aminobutyric acid type B receptors are differentially
            expressed and regulate inwardly rectifying K+ channels
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14991-14996 (1998)
   PUBMED   9844003
REFERENCE   7  (bases 1 to 4525)
  AUTHORS   Peters,H.C., Kammer,G., Volz,A., Kaupmann,K., Ziegler,A.,
            Bettler,B., Epplen,J.T., Sander,T. and Riess,O.
  TITLE     Mapping, genomic structure, and polymorphisms of the human GABABR1
            receptor gene: evaluation of its involvement in idiopathic
            generalized epilepsy
  JOURNAL   Neurogenetics 2 (1), 47-54 (1998)
   PUBMED   9933300
REFERENCE   8  (bases 1 to 4525)
  AUTHORS   Goei,V.L., Choi,J., Ahn,J., Bowlus,C.L., Raha-Chowdhury,R. and
            Gruen,J.R.
  TITLE     Human gamma-aminobutyric acid B receptor gene: complementary DNA
            cloning, expression, chromosomal location, and genomic organization
  JOURNAL   Biol Psychiatry 44 (8), 659-666 (1998)
   PUBMED   9798068
REFERENCE   9  (bases 1 to 4525)
  AUTHORS   Bittiger,H., Froestl,W., Mickel,S. and Olpe,H.R.
  TITLE     GABAB receptor antagonists: from synthesis to therapeutic
            applications
  JOURNAL   Trends Pharmacol Sci 14 (11), 391-394 (1993)
   PUBMED   7905214
  REMARK    Review article
REFERENCE   10 (bases 1 to 4525)
  AUTHORS   Inoue,M. and Enomoto,S.
  TITLE     [Methylation of phenols using metal-salt catalysts (author's
            transl)]
  JOURNAL   Yakugaku Zasshi 96 (7), 923-926 (1976)
   PUBMED   987231
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645936.5, AL539611.3,
            AJ225028.1 and AB208790.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001470.3.
            
            Summary: This gene encodes a receptor for gamma-aminobutyric acid
            (GABA), which is the main inhibitory neurotransmitter in the
            mammalian central nervous system. This receptor functions as a
            heterodimer with GABA(B) receptor 2. Defects in this gene may
            underlie brain disorders such as schizophrenia and epilepsy.
            Alternative splicing generates multiple transcript variants, but
            the full-length nature of some of these variants has not been
            determined. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ225028.1, SRR1803611.79076.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377034.9/ ENSP00000366233.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AL645936.5         84122-84169         c
            49-100              AL539611.3         1-52
            101-249             AJ225028.1         1-149
            250-350             AB208790.1         1-101
            351-4525            AJ225028.1         251-4425
FEATURES             Location/Qualifiers
     source          1..4525
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..4525
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /note="gamma-aminobutyric acid type B receptor subunit 1"
                     /db_xref="GeneID:2550"
                     /db_xref="HGNC:HGNC:4070"
                     /db_xref="MIM:603540"
     exon            1..334
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..3220
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; seven transmembrane helix receptor; GABA-B
                     receptor, R1 subunit; gamma-aminobutyric acid (GABA) B
                     receptor, 1"
                     /codon_start=1
                     /product="gamma-aminobutyric acid type B receptor subunit
                     1 isoform a precursor"
                     /protein_id="NP_001461.1"
                     /db_xref="CCDS:CCDS4663.1"
                     /db_xref="GeneID:2550"
                     /db_xref="HGNC:HGNC:4070"
                     /db_xref="MIM:603540"
                     /translation="MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYR
                     GLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSK
                     SYLTLENGKVFLTGGDLPALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVN
                     RTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDS
                     KCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSN
                     RQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAG
                     IEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFL
                     IGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKL
                     TKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQ
                     IYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTD
                     KWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQN
                     SQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMF
                     TKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIET
                     FAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEK
                     INDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPK
                     MRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRH
                     QLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK"
     exon            335..419
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            420..623
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            624..809
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            810..830
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            831..991
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1126
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1297
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1399
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1465
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1657
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1900
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1964
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2042
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2193
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2326
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2443
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2551
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2645
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2773
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2902
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3046
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..4525
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4507..4512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /note="hexamer: AATAAA"
     polyA_site      4525
                     /gene="GABBR1"
                     /gene_synonym="GABABR1; GABBR1-3; GB1; GPRC3A; NEDLC"
                     /note="major polyA site"
ORIGIN      
        1 ctctcttccc cccgccctgc cttcccttgc accctccttc ttccctccgc ccgggagctc
       61 tccctggtcc ccggcgccgc ctccttccct cccggctccc cgctccccgc tcccgtggct
      121 gccgccgccc cggggaagaa gagacagggg tggggtttgg gggaagcgag agaggagggg
      181 agagaccctg gccaggctgg agcctggatt cgaggggagg agggacggga ggaggagaaa
      241 ggtggaggag aagggagggg ggagcgggga ggagcggccg ggcctggggc cttgaggccc
      301 ggggagagcc ggggagccgg gcccgcgcgc cgagatgttg ctgctgctgc tactggcgcc
      361 actcttcctc cgccccccgg gcgcgggcgg ggcgcagacc cccaacgcca cctcagaagg
      421 ttgccagatc atacacccgc cctgggaagg gggcatcagg taccggggcc tgactcggga
      481 ccaggtgaag gctatcaact tcctgccagt ggactatgag attgagtatg tgtgccgggg
      541 ggagcgcgag gtggtggggc ccaaggtccg caagtgcctg gccaacggct cctggacaga
      601 tatggacaca cccagccgct gtgtccgaat ctgctccaag tcttatttga ccctggaaaa
      661 tgggaaggtt ttcctgacgg gtggggacct cccagctctg gacggagccc gggtggattt
      721 ccggtgtgac cccgacttcc atctggtggg cagctcccgg agcatctgta gtcagggcca
      781 gtggagcacc cccaagcccc actgccaggt gaatcgaacg ccacactcag aacggcgcgc
      841 agtgtacatc ggggcactgt ttcccatgag cgggggctgg ccagggggcc aggcctgcca
      901 gcccgcggtg gagatggcgc tggaggacgt gaatagccgc agggacatcc tgccggacta
      961 tgagctcaag ctcatccacc acgacagcaa gtgtgatcca ggccaagcca ccaagtacct
     1021 atatgagctg ctctacaacg accctatcaa gatcatcctt atgcctggct gcagctctgt
     1081 ctccacgctg gtggctgagg ctgctaggat gtggaacctc attgtgcttt cctatggctc
     1141 cagctcacca gccctgtcaa accggcagcg tttccccact ttcttccgaa cgcacccatc
     1201 agccacactc cacaacccta cccgcgtgaa actctttgaa aagtggggct ggaagaagat
     1261 tgctaccatc cagcagacca ctgaggtctt cacttcgact ctggacgacc tggaggaacg
     1321 agtgaaggag gctggaattg agattacttt ccgccagagt ttcttctcag atccagctgt
     1381 gcccgtcaaa aacctgaagc gccaggatgc ccgaatcatc gtgggacttt tctatgagac
     1441 tgaagcccgg aaagtttttt gtgaggtgta caaggagcgt ctctttggga agaagtacgt
     1501 ctggttcctc attgggtggt atgctgacaa ttggttcaag atctacgacc cttctatcaa
     1561 ctgcacagtg gatgagatga ctgaggcggt ggagggccac atcacaactg agattgtcat
     1621 gctgaatcct gccaataccc gcagcatttc caacatgaca tcccaggaat ttgtggagaa
     1681 actaaccaag cgactgaaaa gacaccctga ggagacagga ggcttccagg aggcaccgct
     1741 ggcctatgat gccatctggg ccttggcact ggccctgaac aagacatctg gaggaggcgg
     1801 ccgttctggt gtgcgcctgg aggacttcaa ctacaacaac cagaccatta ccgaccaaat
     1861 ctaccgggca atgaactctt cgtcctttga gggtgtctct ggccatgtgg tgtttgatgc
     1921 cagcggctct cggatggcat ggacgcttat cgagcagctt cagggtggca gctacaagaa
     1981 gattggctac tatgacagca ccaaggatga tctttcctgg tccaaaacag ataaatggat
     2041 tggagggtcc cccccagctg accagaccct ggtcatcaag acattccgct tcctgtcaca
     2101 gaaactcttt atctccgtct cagttctctc cagcctgggc attgtcctag ctgttgtctg
     2161 tctgtccttt aacatctaca actcacatgt ccgttatatc cagaactcac agcccaacct
     2221 gaacaacctg actgctgtgg gctgctcact ggctttagct gctgtcttcc ccctggggct
     2281 cgatggttac cacattggga ggaaccagtt tcctttcgtc tgccaggccc gcctctggct
     2341 cctgggcctg ggctttagtc tgggctacgg ttccatgttc accaagattt ggtgggtcca
     2401 cacggtcttc acaaagaagg aagaaaagaa ggagtggagg aagactctgg aaccctggaa
     2461 gctgtatgcc acagtgggcc tgctggtggg catggatgtc ctcactctcg ccatctggca
     2521 gatcgtggac cctctgcacc ggaccattga gacatttgcc aaggaggaac ctaaggaaga
     2581 tattgacgtc tctattctgc cccagctgga gcattgcagc tccaggaaga tgaatacatg
     2641 gcttggcatt ttctatggtt acaaggggct gctgctgctg ctgggaatct tccttgctta
     2701 tgagaccaag agtgtgtcca ctgagaagat caatgatcac cgggctgtgg gcatggctat
     2761 ctacaatgtg gcagtcctgt gcctcatcac tgctcctgtc accatgattc tgtccagcca
     2821 gcaggatgca gcctttgcct ttgcctctct tgccatagtt ttctcctcct atatcactct
     2881 tgttgtgctc tttgtgccca agatgcgcag gctgatcacc cgaggggaat ggcagtcgga
     2941 ggcgcaggac accatgaaga cagggtcatc gaccaacaac aacgaggagg agaagtcccg
     3001 gctgttggag aaggagaacc gtgaactgga aaagatcatt gctgagaaag aggagcgtgt
     3061 ctctgaactg cgccatcaac tccagtctcg gcagcagctc cgctcccggc gccacccacc
     3121 gacaccccca gaaccctctg ggggcctgcc caggggaccc cctgagcccc ccgaccggct
     3181 tagctgtgat gggagtcgag tgcatttgct ttataagtga gggtagggtg agggaggaca
     3241 ggccagtagg gggagggaaa gggagagggg aagggcaggg gactcaggaa gcagggggtc
     3301 cccatcccca gctgggaaga acatgctatc caatctcatc tcttgtaaat acatgtcccc
     3361 ctgtgagttc tgggctgatt tgggtctctc atacctctgg gaaacagacc tttttctctc
     3421 ttactgcttc atgtaatttt gtatcacctc ttcacaattt agttcgtacc tggcttgaag
     3481 ctgctcactg ctcacacgct gcctcctcag cagcctcact gcatctttct cttcccatgc
     3541 aacaccctct tctagttacc acggcaaccc ctgcagctcc tctgcctttg tgctctgttc
     3601 ctgtccagca ggggtctccc aacaagtgct ctttccaccc caaaggggcc tctccttttc
     3661 tccactgtca taatctcttt ccatcttact tgcccttcta tactttctca catgtggctc
     3721 cccctgaatt ttgcttcctt tgggagctca ttcttttcgc caaggctcac atgctccttg
     3781 cctctgctct gtgcactcac gctcagcaca catgcatcct cccctctcct gcgtgtgccc
     3841 actgaacatg ctcatgtgta cacacgcttt tcccgtatgc tttcttcatg ttcagtcaca
     3901 tgtgctctcg ggtgccctgc attcacagct acgtgtgccc ctctcatggt catgggtctg
     3961 cccttgagcg tgtttgggta ggcatgtgca atttgtctag catgctgagt catgtctttc
     4021 ctatttgcac acgtccatgt ttatccatgt actttccctg tgtaccctcc atgtaccttg
     4081 tgtactttct tcccttaaat catggtattc ttctgacaga gccatatgta ccctaccctg
     4141 cacattgtta tgcacttttc cccaattcat gtttggtggg gccatccaca ccctctcctt
     4201 gtcacagaat ctccatttct gctcagattc cccccatctc cattgcattc atgtactacc
     4261 ctcagtctac actcacaatc atcttctccc aagactgctc ccttttgttt tgtgtttttt
     4321 tgaggggaat taaggaaaaa taagtggggg caggtttgga gagctgcttc cagtggatag
     4381 ttgatgagaa tcctgaccaa aggaaggcac ccttgactgt tgggatagac agatggacct
     4441 atggggtggg aggtggtgtc cctttcacac tgtggtgtct cttggggaag gatctccccg
     4501 aatctcaata aaccagtgaa cagtg
//
