LOCUS       NM_007285                974 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens GABA type A receptor associated protein like 2
            (GABARAPL2), mRNA.
ACCESSION   NM_007285 NM_173722
VERSION     NM_007285.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 974)
  AUTHORS   Jimenez-Moreno,N. and Lane,J.D.
  TITLE     ATG8 proteins are co-factors for human dopaminergic neuronal
            transcriptional control: implications for neuronal resilience in
            Parkinson disease
  JOURNAL   Autophagy 20 (4), 955-957 (2024)
   PUBMED   37312406
  REMARK    GeneRIF: ATG8 proteins are co-factors for human dopaminergic
            neuronal transcriptional control: implications for neuronal
            resilience in Parkinson disease.
REFERENCE   2  (bases 1 to 974)
  AUTHORS   Lee,C.Y., Hubrich,D., Varga,J.K., Schafer,C., Welzel,M.,
            Schumbera,E., Djokic,M., Strom,J.M., Schonfeld,J., Geist,J.L.,
            Polat,F., Gibson,T.J., Keller Valsecchi,C.I., Kumar,M.,
            Schueler-Furman,O. and Luck,K.
  TITLE     Systematic discovery of protein interaction interfaces using
            AlphaFold and experimental validation
  JOURNAL   Mol Syst Biol 20 (2), 75-97 (2024)
   PUBMED   38225382
REFERENCE   3  (bases 1 to 974)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   4  (bases 1 to 974)
  AUTHORS   Toth,V., Vadaszi,H., Ravasz,L., Mittli,D., Matyas,D., Molnar,T.,
            Micsonai,A., Szaniszlo,T., Lorincz,P., Kovacs,R.A., Juhasz,T.,
            Beke-Somfai,T., Juhasz,G., Gyorffy,B.A., Kekesi,K.A. and Kardos,J.
  TITLE     Neuronal-specific septin-3 binds Atg8/LC3B, accumulates and
            localizes to autophagosomes during induced autophagy
  JOURNAL   Cell Mol Life Sci 79 (9), 471 (2022)
   PUBMED   35932293
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 974)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 974)
  AUTHORS   Xin,Y., Yu,L., Chen,Z., Zheng,L., Fu,Q., Jiang,J., Zhang,P.,
            Gong,R. and Zhao,S.
  TITLE     Cloning, expression patterns, and chromosome localization of three
            human and two mouse homologues of GABA(A) receptor-associated
            protein
  JOURNAL   Genomics 74 (3), 408-413 (2001)
   PUBMED   11414770
REFERENCE   7  (bases 1 to 974)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Ueno,T. and Kominami,E.
  TITLE     The human homolog of Saccharomyces cerevisiae Apg7p is a
            Protein-activating enzyme for multiple substrates including human
            Apg12p, GATE-16, GABARAP, and MAP-LC3
  JOURNAL   J Biol Chem 276 (3), 1701-1706 (2001)
   PUBMED   11096062
REFERENCE   8  (bases 1 to 974)
  AUTHORS   Okazaki,N., Yan,J., Yuasa,S., Ueno,T., Kominami,E., Masuho,Y.,
            Koga,H. and Muramatsu,M.
  TITLE     Interaction of the Unc-51-like kinase and microtubule-associated
            protein light chain 3 related proteins in the brain: possible role
            of vesicular transport in axonal elongation
  JOURNAL   Brain Res Mol Brain Res 85 (1-2), 1-12 (2000)
   PUBMED   11146101
REFERENCE   9  (bases 1 to 974)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 974)
  AUTHORS   Sagiv,Y., Legesse-Miller,A., Porat,A. and Elazar,Z.
  TITLE     GATE-16, a membrane transport modulator, interacts with NSF and the
            Golgi v-SNARE GOS-28
  JOURNAL   EMBO J 19 (7), 1494-1504 (2000)
   PUBMED   10747018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB030710.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007285.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.178644.1, BC029601.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000037243.7/ ENSP00000037243.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-974               AB030710.1         29-1002
FEATURES             Location/Qualifiers
     source          1..974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..974
                     /gene="GABARAPL2"
                     /gene_synonym="ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2"
                     /note="GABA type A receptor associated protein like 2"
                     /db_xref="GeneID:11345"
                     /db_xref="HGNC:HGNC:13291"
                     /db_xref="MIM:607452"
     exon            1..142
                     /gene="GABARAPL2"
                     /gene_synonym="ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..462
                     /gene="GABARAPL2"
                     /gene_synonym="ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2"
                     /note="ganglioside expression factor 2; MAP1 light chain 3
                     related protein; general protein transport factor p16;
                     golgi-associated ATPase enhancer of 16 kDa; GABA(A)
                     receptor-associated protein-like 2"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor-associated
                     protein-like 2"
                     /protein_id="NP_009216.1"
                     /db_xref="CCDS:CCDS10921.1"
                     /db_xref="GeneID:11345"
                     /db_xref="HGNC:HGNC:13291"
                     /db_xref="MIM:607452"
                     /translation="MKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDI
                     DKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDED
                     GFLYVAYSGENTFGF"
     exon            143..198
                     /gene="GABARAPL2"
                     /gene_synonym="ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            199..371
                     /gene="GABARAPL2"
                     /gene_synonym="ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            372..974
                     /gene="GABARAPL2"
                     /gene_synonym="ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      951..956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABARAPL2"
                     /gene_synonym="ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2"
                     /note="hexamer: AATAAA"
     polyA_site      974
                     /gene="GABARAPL2"
                     /gene_synonym="ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2"
                     /note="major polyA site"
ORIGIN      
        1 agtcgccgcc gtcgctgccg ctgccgctgc cgccgtcgtt gttgttgtgc tcggtgcgct
       61 gagctccgcg gctccgcgag ccggttccgt ccccttcccg ccgccgccat gaagtggatg
      121 ttcaaggagg accactcgct ggaacacaga tgcgtggagt ccgcgaagat tcgagcgaaa
      181 tatcccgaca gggttccggt gattgtggaa aaggtctcag gctctcagat tgttgacatt
      241 gacaaacgga agtacttggt tccatctgat atcactgtgg ctcagttcat gtggatcatc
      301 aggaaaagga tccagcttcc ttctgaaaag gcgatcttcc tgtttgtgga taagacagtc
      361 ccacagtcca gcctaactat gggacagctt tacgagaagg aaaaagatga agatggattc
      421 ttatatgtgg cctacagcgg agagaacact tttggcttct gagggccatt gctgggctag
      481 gtgcaccgta actgcttgtg tatcttgtaa atagccagcc attttcagtt attataccag
      541 aacctcttca catagaccta ttagtgcatt tgtaactgga tttatttctt aatatattgg
      601 aaggttttgt ttccttagac tagtaaatta tcatacagag ttttattttg agtttttctt
      661 tttgtgcatt gtcctcatgc ctgtattctc caggaaactt gtccttctgg aaatcatatt
      721 gaatgatatt tctatatcga agtgaggtag gtgcggtatt aaagtgaaag ggaaggtgat
      781 gcatttattc tgggttatgc ttgaagtgtt agatggctaa gtattaaaat tatccaaatt
      841 aaatccttag cagtcagaac acttgcttca ctagaatatg ccaactgcca atcatgttgg
      901 actgagctaa tttgttcctc tttctgaaac tattaaggta aataattaac aataaaaatt
      961 ctcttataaa ggca
//
