LOCUS       NM_031412               1883 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens GABA type A receptor associated protein like 1
            (GABARAPL1), transcript variant 2, mRNA.
ACCESSION   NM_031412
VERSION     NM_031412.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1883)
  AUTHORS   Kliche,J., Simonetti,L., Krystkowiak,I., Kuss,H., Diallo,M.,
            Rask,E., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Proteome-scale characterisation of motif-based interactome rewiring
            by disease mutations
  JOURNAL   Mol Syst Biol 20 (9), 1025-1048 (2024)
   PUBMED   39009827
REFERENCE   2  (bases 1 to 1883)
  AUTHORS   Hatanaka,A., Nakada,S., Matsumoto,G., Satoh,K., Aketa,I.,
            Watanabe,A., Hirakawa,T., Tsujita,T., Waku,T. and Kobayashi,A.
  TITLE     The transcription factor NRF1 (NFE2L1) activates aggrephagy by
            inducing p62 and GABARAPL1 after proteasome inhibition to maintain
            proteostasis
  JOURNAL   Sci Rep 13 (1), 14405 (2023)
   PUBMED   37658135
  REMARK    GeneRIF: The transcription factor NRF1 (NFE2L1) activates
            aggrephagy by inducing p62 and GABARAPL1 after proteasome
            inhibition to maintain proteostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1883)
  AUTHORS   Xu,L., Shi,Z., Pan,Z. and Wu,R.
  TITLE     METTL3 promotes hyperoxia-induced pyroptosis in neonatal
            bronchopulmonary dysplasia by inhibiting ATG8-mediated autophagy
  JOURNAL   Clinics (Sao Paulo) 78, 100253 (2023)
   PUBMED   37478627
  REMARK    GeneRIF: METTL3 promotes hyperoxia-induced pyroptosis in neonatal
            bronchopulmonary dysplasia by inhibiting ATG8-mediated autophagy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1883)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   5  (bases 1 to 1883)
  AUTHORS   Jimenez-Moreno,N., Kollareddy,M., Stathakos,P., Moss,J.J.,
            Anton,Z., Shoemark,D.K., Sessions,R.B., Witzgall,R., Caldwell,M.
            and Lane,J.D.
  TITLE     ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain
            dopaminergic neuronal resilience
  JOURNAL   J Cell Biol 222 (5) (2023)
   PUBMED   37014324
  REMARK    GeneRIF: ATG8-dependent LMX1B-autophagy crosstalk shapes human
            midbrain dopaminergic neuronal resilience.
REFERENCE   6  (bases 1 to 1883)
  AUTHORS   Xin,Y., Yu,L., Chen,Z., Zheng,L., Fu,Q., Jiang,J., Zhang,P.,
            Gong,R. and Zhao,S.
  TITLE     Cloning, expression patterns, and chromosome localization of three
            human and two mouse homologues of GABA(A) receptor-associated
            protein
  JOURNAL   Genomics 74 (3), 408-413 (2001)
   PUBMED   11414770
REFERENCE   7  (bases 1 to 1883)
  AUTHORS   Vernier-Magnin,S., Muller,S., Sallot,M., Radom,J., Musard,J.F.,
            Adami,P., Dulieu,P., Remy-Martin,J.P., Jouvenot,M. and Fraichard,A.
  TITLE     A novel early estrogen-regulated gene gec1 encodes a protein
            related to GABARAP
  JOURNAL   Biochem Biophys Res Commun 284 (1), 118-125 (2001)
   PUBMED   11374880
REFERENCE   8  (bases 1 to 1883)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 1883)
  AUTHORS   Wang,H., Bedford,F.K., Brandon,N.J., Moss,S.J. and Olsen,R.W.
  TITLE     GABA(A)-receptor-associated protein links GABA(A) receptors and the
            cytoskeleton
  JOURNAL   Nature 397 (6714), 69-72 (1999)
   PUBMED   9892355
REFERENCE   10 (bases 1 to 1883)
  AUTHORS   Pellerin,I., Vuillermoz,C., Jouvenot,M., Ordener,C., Royez,M. and
            Adessi,G.L.
  TITLE     Identification and characterization of an early estrogen-regulated
            RNA in cultured guinea-pig endometrial cells
  JOURNAL   Mol Cell Endocrinol 90 (2), R17-R21 (1993)
   PUBMED   8495796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115676.1 and BC028315.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031412.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087847.1, SRR3476690.521070.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266458.10/ ENSP00000266458.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC115676.1         40047-40059
            14-1883             BC028315.1         1-1870
FEATURES             Location/Qualifiers
     source          1..1883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1883
                     /gene="GABARAPL1"
                     /gene_synonym="APG8-LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1"
                     /note="GABA type A receptor associated protein like 1"
                     /db_xref="GeneID:23710"
                     /db_xref="HGNC:HGNC:4068"
                     /db_xref="MIM:607420"
     exon            1..343
                     /gene="GABARAPL1"
                     /gene_synonym="APG8-LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..607
                     /gene="GABARAPL1"
                     /gene_synonym="APG8-LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1"
                     /note="isoform 2 is encoded by transcript variant 2; early
                     estrogen-regulated protein; gamma-aminobutyric acid
                     receptor-associated protein-like 1; glandular epithelial
                     cell protein 1; GABA(A) receptor-associated protein-like
                     1"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor-associated
                     protein-like 1 isoform 2"
                     /protein_id="NP_113600.1"
                     /db_xref="CCDS:CCDS8620.1"
                     /db_xref="GeneID:23710"
                     /db_xref="HGNC:HGNC:4068"
                     /db_xref="MIM:607420"
                     /translation="MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDL
                     DKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEED
                     YFLYVAYSDESVYGK"
     exon            344..422
                     /gene="GABARAPL1"
                     /gene_synonym="APG8-LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..541
                     /gene="GABARAPL1"
                     /gene_synonym="APG8-LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..1883
                     /gene="GABARAPL1"
                     /gene_synonym="APG8-LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1863..1868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABARAPL1"
                     /gene_synonym="APG8-LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1"
                     /note="hexamer: AATAAT"
     polyA_site      1883
                     /gene="GABARAPL1"
                     /gene_synonym="APG8-LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1"
                     /note="major polyA site"
ORIGIN      
        1 gtttttgtgc tcccagctct agcgaaaagc cgccggtatt tctccatctg gctctcctct
       61 acctccaggc aggctcaccc gagatccccg ccccgaaccc cccctgcaca ctcggcccag
      121 cgctgttgcc cccggagcgg acgtttctgc agctattctg agcacacctt gacgtcggct
      181 gagggagcgg gacagggtca gcggcgaagg aggcaggccc cgcgcgggga tctcggaagc
      241 cctgcggtgc atcatgaagt tccagtacaa ggaggaccat ccctttgagt atcggaaaaa
      301 ggaaggagaa aagatccgga agaaatatcc ggacagggtc cccgtgattg tagagaaggc
      361 tccaaaagcc agggtgcctg atctggacaa gaggaagtac ctagtgccct ctgaccttac
      421 tgttggccag ttctacttct taatccggaa gagaatccac ctgagacctg aggacgcctt
      481 attcttcttt gtcaacaaca ccatccctcc caccagtgct accatgggcc aactgtatga
      541 ggacaatcat gaggaagact attttctgta tgtggcctac agtgatgaga gtgtctatgg
      601 gaaatgagtg gttggaagcc cagcagatgg gagcacctgg acttgggggt aggggagggg
      661 tgtgtgtgcg cgacatgggg aaagagggtg gctcccaccg caaggagaca gaaggtgaag
      721 acatctagaa acattacacc acacacaccg tcatcacatt ttcacatgct caattgatat
      781 tttttgctgc ttcctcggcc cagggagaaa gcatgtcagg acagagctgt tggattggct
      841 ttgatagagg aatggggatg atgtaagttt acagtattcc tggggtttaa ttgttgtgca
      901 gtttcataga tgggtcagga ggtggacaag ttggggccag agatgatggc agtccagcag
      961 caactccctg tgctcccttc tctttgggca gagattctat ttttgacatt tgcacaagac
     1021 aggtagggaa aggggacttg tggtagtgga ccatacctgg ggaccaaaag agacccactg
     1081 taattgatgc attgtggccc ctgatcttcc ctgtctcaca cttcttttct cccatcccgg
     1141 ttgcaatctc actcagacat cacagtacca ccccaggggt ggcagtagac aacaacccag
     1201 aaatttagac agggatctct tacctttgga aaataggggt taggcatgaa ggtggttgtg
     1261 attaagaaga tggttttgtt attaaatagc attaaactgg aattgacaag agtgttgagc
     1321 atccctgtct aacctgctct ttctctttgg tgccccttat ctcacccctt ccttggaatt
     1381 taataagtct caggcatttc caattgtaga ctaaaaccac tcttagcatc tcctctagta
     1441 ttttccatgt atcaggacag aggtgtctta tgtagggagg gggcaagtat gaagtaaggt
     1501 aattatatac tactctcatt caggattctt gctcccatgc tgctgtccct tcaggctcac
     1561 atgcacagga atgctacatg atggccagct gcttccctcc ttggttatca tccactgcag
     1621 ctgctagtta gaaaggtttg gagggatgac ttttagtaaa tcatggggat tttattgatt
     1681 tattttcact tttgggattt tgtggggtgg gagtggggag caggaattgc actcagacat
     1741 gacatttcaa ttcatctctg ctaatgaaaa gggttctttc tcttggggga aatgtgtgtg
     1801 tcagttctgt cagctgcaag ttcttgtata atgaagtcaa tgccatcagg ccaaggaaat
     1861 aaaataattg cttaccttaa aaa
//
