LOCUS       NM_007278               1319 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens GABA type A receptor-associated protein (GABARAP),
            mRNA.
ACCESSION   NM_007278
VERSION     NM_007278.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1319)
  AUTHORS   Ogura,M., Kaminishi,T., Shima,T., Torigata,M., Bekku,N., Tabata,K.,
            Minami,S., Nishino,K., Nezu,A., Hamasaki,M., Kosako,H.,
            Yoshimori,T. and Nakamura,S.
  TITLE     Microautophagy regulated by STK38 and GABARAPs is essential to
            repair lysosomes and prevent aging
  JOURNAL   EMBO Rep 24 (12), e57300 (2023)
   PUBMED   37987447
  REMARK    GeneRIF: Microautophagy regulated by STK38 and GABARAPs is
            essential to repair lysosomes and prevent aging.
REFERENCE   2  (bases 1 to 1319)
  AUTHORS   Xie,W., Zhang,C., Wang,Z., Chen,H., Gu,T., Zhou,T., Wu,Y., Xia,F.,
            Li,M., Wang,J., Jiao,R., Cui,J. and Jin,S.
  TITLE     ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic
            degradation of TBK1
  JOURNAL   Autophagy 19 (11), 2853-2868 (2023)
   PUBMED   37434364
  REMARK    GeneRIF: ATG4B antagonizes antiviral immunity by GABARAP-directed
            autophagic degradation of TBK1.
REFERENCE   3  (bases 1 to 1319)
  AUTHORS   Xu,L., Shi,Z., Pan,Z. and Wu,R.
  TITLE     METTL3 promotes hyperoxia-induced pyroptosis in neonatal
            bronchopulmonary dysplasia by inhibiting ATG8-mediated autophagy
  JOURNAL   Clinics (Sao Paulo) 78, 100253 (2023)
   PUBMED   37478627
  REMARK    GeneRIF: METTL3 promotes hyperoxia-induced pyroptosis in neonatal
            bronchopulmonary dysplasia by inhibiting ATG8-mediated autophagy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1319)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   5  (bases 1 to 1319)
  AUTHORS   Farnung,J., Muhar,M., Liang,J.R., Tolmachova,K.A., Benoit,R.M.,
            Corn,J.E. and Bode,J.W.
  TITLE     Semisynthetic LC3 Probes for Autophagy Pathways Reveal a
            Noncanonical LC3 Interacting Region Motif Crucial for the Enzymatic
            Activity of Human ATG3
  JOURNAL   ACS Cent Sci 9 (5), 1025-1034 (2023)
   PUBMED   37252361
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1319)
  AUTHORS   Paz,Y., Elazar,Z. and Fass,D.
  TITLE     Structure of GATE-16, membrane transport modulator and mammalian
            ortholog of autophagocytosis factor Aut7p
  JOURNAL   J Biol Chem 275 (33), 25445-25450 (2000)
   PUBMED   10856287
REFERENCE   7  (bases 1 to 1319)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   8  (bases 1 to 1319)
  AUTHORS   Wang,H. and Olsen,R.W.
  TITLE     Binding of the GABA(A) receptor-associated protein (GABARAP) to
            microtubules and microfilaments suggests involvement of the
            cytoskeleton in GABARAPGABA(A) receptor interaction
  JOURNAL   J Neurochem 75 (2), 644-655 (2000)
   PUBMED   10899939
REFERENCE   9  (bases 1 to 1319)
  AUTHORS   Kneussel,M., Haverkamp,S., Fuhrmann,J.C., Wang,H., Wassle,H.,
            Olsen,R.W. and Betz,H.
  TITLE     The gamma-aminobutyric acid type A receptor (GABAAR)-associated
            protein GABARAP interacts with gephyrin but is not involved in
            receptor anchoring at the synapse
  JOURNAL   Proc Natl Acad Sci U S A 97 (15), 8594-8599 (2000)
   PUBMED   10900017
REFERENCE   10 (bases 1 to 1319)
  AUTHORS   Wang,H., Bedford,F.K., Brandon,N.J., Moss,S.J. and Olsen,R.W.
  TITLE     GABA(A)-receptor-associated protein links GABA(A) receptors and the
            cytoskeleton
  JOURNAL   Nature 397 (6714), 69-72 (1999)
   PUBMED   9892355
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120057.9 and AF067171.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007278.1.
            
            Summary: Gamma-aminobutyric acid A receptors [GABA(A) receptors]
            are ligand-gated chloride channels that mediate inhibitory
            neurotransmission. This gene encodes GABA(A) receptor-associated
            protein, which is highly positively charged in its N-terminus and
            shares sequence similarity with light chain-3 of
            microtubule-associated proteins 1A and 1B. This protein clusters
            neurotransmitter receptors by mediating interaction with the
            cytoskeleton. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.187949.1,
                                           SRR1660803.379622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302386.10/ ENSP00000306866.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC120057.9         196581-196595       c
            16-908              AF067171.1         1-893
            909-1319            AC120057.9         194154-194564       c
FEATURES             Location/Qualifiers
     source          1..1319
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1319
                     /gene="GABARAP"
                     /gene_synonym="ATG8A; GABARAP-a; MM46"
                     /note="GABA type A receptor-associated protein"
                     /db_xref="GeneID:11337"
                     /db_xref="HGNC:HGNC:4067"
                     /db_xref="MIM:605125"
     exon            1..209
                     /gene="GABARAP"
                     /gene_synonym="ATG8A; GABARAP-a; MM46"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..473
                     /gene="GABARAP"
                     /gene_synonym="ATG8A; GABARAP-a; MM46"
                     /note="GABA(A) receptor-associated protein; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="gamma-aminobutyric acid receptor-associated
                     protein"
                     /protein_id="NP_009209.1"
                     /db_xref="CCDS:CCDS11092.1"
                     /db_xref="GeneID:11337"
                     /db_xref="HGNC:HGNC:4067"
                     /db_xref="MIM:605125"
                     /translation="MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDL
                     DKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEED
                     FFLYIAYSDESVYGL"
     exon            210..288
                     /gene="GABARAP"
                     /gene_synonym="ATG8A; GABARAP-a; MM46"
                     /inference="alignment:Splign:2.1.0"
     exon            289..407
                     /gene="GABARAP"
                     /gene_synonym="ATG8A; GABARAP-a; MM46"
                     /inference="alignment:Splign:2.1.0"
     exon            408..1319
                     /gene="GABARAP"
                     /gene_synonym="ATG8A; GABARAP-a; MM46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      883..888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABARAP"
                     /gene_synonym="ATG8A; GABARAP-a; MM46"
                     /note="hexamer: AATAAA"
     polyA_site      908
                     /gene="GABARAP"
                     /gene_synonym="ATG8A; GABARAP-a; MM46"
                     /note="major polyA site"
     regulatory      1295..1300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GABARAP"
                     /gene_synonym="ATG8A; GABARAP-a; MM46"
                     /note="hexamer: AGTAAA"
     polyA_site      1319
                     /gene="GABARAP"
                     /gene_synonym="ATG8A; GABARAP-a; MM46"
ORIGIN      
        1 gcaaattcgt ggatcgctcc gctgaatccg cccgcgcgtc gccgccgtcg tcgccgcccc
       61 ccgtcccggc ccccctgggt tccctcagcc cagccctgtc cagcccggtt cccgggagga
      121 tgaagttcgt gtacaaagaa gagcatccgt tcgagaagcg ccgctctgag ggcgagaaga
      181 tccgaaagaa atacccggac cgggtgccgg tgatagtaga aaaggctccc aaagctcgga
      241 taggagacct ggacaaaaag aaatacctgg tgccttctga tctcacagtt ggtcagttct
      301 acttcttgat ccggaagcga attcatctcc gagctgagga tgccttgttt ttctttgtca
      361 acaatgtcat tccacccacc agtgccacaa tgggtcagct gtaccaggaa caccatgaag
      421 aagacttctt tctctacatt gcctacagtg acgaaagtgt ctacggtctg tgaagctgct
      481 gcccctgagc tggagggggg tctcattcta caaagagaga ggtggccccc ctttcttgac
      541 ctcctcctcc ttcaagctca aacaccacct cccttattca ggaccggcac ttcttaatgt
      601 ttgtggcttt ctctccagcc tctcttagga ggggtaatgg tggagttggc atcttgtaac
      661 tctcctttct cctttcttcc cctttctctg cccgcctttc ccatcctgct gtagacttct
      721 tgattgtcag tctgtgtcac atccagtgat tgttttggtt tctgttccct ttctgactgc
      781 ccaaggggct cagaacccca gcaatccctt cctttcacta ccttcttttt tgggggtagt
      841 tggaagggac tgaaattgtg gggggaaggt aggaggcaca tcaataaaga ggaaaccacc
      901 aagctgaact gaattttgcc ttgtgttgct cccctcgtcc cgctgatttt aagtctttcc
      961 aaggtgtcag tgggtttcag tggtggggaa agaagagtac tgggtacaag ctggagggat
     1021 agaagtatat tttggtttat tctgttcatg ttgggctttt ccctgtctgc aaaaagaggg
     1081 tgcttttgtt gtgatggaat ggaatactga ggattatttc ttgaaacttt agttttataa
     1141 cacgcatgtg aaactaaatg ttaaaaatgc tcatgtaaaa aaaaattttt ttttactgtg
     1201 ggttcctgtg gagaaagttc cgaagtacct gctttaggtg aacatccaca tttgctagaa
     1261 cattctaact aagatatttt catgtgtgca agctagtaaa acggctgttc tcagttgca
//
