LOCUS       NM_001037814            2630 bp    mRNA    linear   PRI 04-JUN-2024
DEFINITION  Homo sapiens GRB2 associated binding protein family member 4
            (GAB4), transcript variant 1, mRNA.
ACCESSION   NM_001037814 XM_927961 XM_937472
VERSION     NM_001037814.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2630)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB076978.1.
            
            On or before Mar 4, 2006 this sequence version replaced
            XM_927961.1, XM_937472.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB076978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400588.5/ ENSP00000383431.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.1"
     gene            1..2630
                     /gene="GAB4"
                     /note="GRB2 associated binding protein family member 4"
                     /db_xref="GeneID:128954"
                     /db_xref="HGNC:HGNC:18325"
     exon            1..282
                     /gene="GAB4"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1833
                     /gene="GAB4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GRB2-associated binder 2-like protein;
                     GRB2-associated-binding protein 4; GRB2-associated binder
                     4; growth factor receptor bound protein 2-associated
                     protein 4"
                     /codon_start=1
                     /product="GRB2-associated-binding protein 4 isoform 1"
                     /protein_id="NP_001032903.1"
                     /db_xref="CCDS:CCDS42976.1"
                     /db_xref="GeneID:128954"
                     /db_xref="HGNC:HGNC:18325"
                     /translation="MSLPSPSPSRELCPPDPAFAPLSSWPGSGPAGGSTRSGHVLYSG
                     WLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINLNLCEQL
                     DVDVTLNFNKKEIQKGYMFDIKTSERTFYLVAETREDMNEWVQSICQICGFRQEESTG
                     FLGNISSASHGLCSSPAEPSCSHQHLPQEQEPTSEPPVSHCVPPTWPIPAPPGCLRSH
                     QHASQRAEHARSASFSQGSEAPFIMRRNTAMQNLAQHSGYSVDGVSGHIHGFHSLSKP
                     SQHNAEFRGSTHRIPWSLASHGHTRGSLTGSEADNEASSGKYTQHGGGNASRPAESMH
                     EGVCSFLPGRTLVGLSDSIASEGSCVPMNPGSPTLPAVKQAGDDSQGVCIPVGSCLVR
                     FDLLGSPLTELSMHQDLSQGHEVQLPPVNRSLKPNQKANPTPPNLRNNRVINELSFKP
                     PVTEPWSGTSHTFDSSSSQHPISTQSITNTDSEDSGERYLFPNPASAFPVSGGTSSSA
                     PPRSTGNIHYAALDFQPSKPSIGSVTSGKKVDYVQVDLEKTQALQKTMHEQMCLRQSS
                     EPPRGAKL"
     exon            283..586
                     /gene="GAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            587..794
                     /gene="GAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1045
                     /gene="GAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1131
                     /gene="GAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1396
                     /gene="GAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1487
                     /gene="GAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1584
                     /gene="GAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1689
                     /gene="GAB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..2630
                     /gene="GAB4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttctacc ccgcagtccc agggtatcgc aagccgtccc tcacacccca cctccagcaa
       61 cgccctctcg ccctgtctcc cccaccttca ctgtgagctg cagcccccat gtccctgccg
      121 tccccctcac cctcccggga gctgtgccca cctgacccgg catttgcgcc tttgtcttcg
      181 tggcccggaa gtggccccgc cggcggaagc acgagaagtg gccacgtgct gtacagcggc
      241 tggctgagga agtcgccccc cgagaagaag ctgaggctct ttgcctggag gaaacgctgg
      301 tttatcctgc ggaggggcca gactagcagt gacccagatg ttctggaata ctacaagaat
      361 gatggctcca agaagcccct gcgcaccatc aacctgaacc tctgtgagca gctggatgtt
      421 gatgtgactc tgaacttcaa caagaaggag attcagaagg gctatatgtt tgacatcaag
      481 accagtgagc gtacctttta cctggtggct gagaccaggg aggacatgaa tgagtgggtc
      541 cagagcatct gtcagatctg tggcttcagg caggaggaaa gcacaggctt cctgggaaac
      601 atttcctcag ccagtcacgg cctctgctct tctccagctg agcccagctg ctcccatcag
      661 cacctccccc aagaacaaga acccacatct gagcccccgg tgtctcactg tgtgccgccc
      721 acctggccca tccctgcacc tccggggtgt ctccgctcgc accagcacgc cagccagaga
      781 gcagaacatg caaggagtgc cagcttctcc cagggttctg aggccccatt catcatgagg
      841 agaaacacag ccatgcaaaa tcttgcccag cacagtggat acagtgttga tggggtcagc
      901 ggtcacatcc atggcttcca tagcctttcc aagcccagcc agcacaatgc agaattcaga
      961 ggcagcaccc acagaatccc ctggagcctg gcctcccatg gccacaccag aggcagcctc
     1021 acaggctctg aggcggataa tgaggcttcc tccggcaagt acacccagca tggtggaggg
     1081 aatgccagcc ggcctgctga gtccatgcat gagggagtct gttctttcct gccaggaaga
     1141 acgcttgtgg gcctgtcaga cagcattgct tctgagggca gctgtgtgcc catgaaccca
     1201 ggctccccta ccctgccggc tgtgaagcaa gcaggcgatg attcccaggg tgtctgcatc
     1261 cctgtgggct catgtcttgt tcgctttgac ctgcttggct ccccactcac agagctttct
     1321 atgcaccaag acctcagcca gggacatgag gtccagctgc cccctgtcaa ccgcagcctc
     1381 aagcctaacc agaaggccaa cccaacaccg cccaacctga gaaacaacag ggtcatcaat
     1441 gagctctcct tcaagccacc tgtcacagag ccctggtctg ggaccagcca cacctttgac
     1501 tccagctcct cccaacaccc catctccacg cagagcatca ccaacacaga ctcagaagac
     1561 agtggagaga ggtatctttt cccgaacccg gcatctgcat ttcctgtttc cggtggcacc
     1621 agcagttcag ccccgccgag gagcactggt aacatccact acgcggccct ggacttccag
     1681 ccgagcaagc catccatagg ctctgtcacg tccggcaaga aggtggacta tgtccaggtg
     1741 gatctggaga agacccaggc cctgcagaag accatgcatg aacagatgtg cctgcggcag
     1801 tcctcagagc ctcccagggg cgccaagctg tgactcgggc caccaaaacc agagtggggc
     1861 caggacagtg cctcagagct gctccgccac actctaaagc tctgtaatat cagggaccgc
     1921 atcccttaca tagagagcag aggcctgatc aatatacatc ctttgcctgc ttggggccca
     1981 cctgtgcctt tggctggcca tggtccccac cttcaccccc ttgctaggag cagttgccag
     2041 caagcatcct cagtctcttc ctgcccctca gacccgggct cccaacagat ttccactctc
     2101 acacttactc atggtcctca gcctcttcct tctagcctct gggctgtttc cctcaatcct
     2161 ggaacatgag gagctacctt gctgacccgg ggacccaagg cccacaggcc acagtggaca
     2221 tggacctttt cagccctggc attttttggt caggggagag gcaaggccat caaacgttgg
     2281 aatagttgag aaggaaggtt aaaggtggtc ttgagaagca aaggaattag atccttagac
     2341 cagcagggca gctgatacct gcaagggctc ccactttcag actgaggcca gagtatggca
     2401 gctgctcccg ggtgggagag gcagagaggg aagggcaaaa ggaagggaaa acatgaagac
     2461 gaacagccga aagccacaag aagcagggct ggagctccag agactggggt gacaaggacc
     2521 agggtcaggg ccccagaaat ccggagctgc aggctggctc tgctgctctt tgctgatgcc
     2581 ccttgggggg cccttgcctg cctaagaagg cttgatctga gctgggcaaa
//
