LOCUS       NM_001081573            4745 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens GRB2 associated binding protein 3 (GAB3), transcript
            variant 1, mRNA.
ACCESSION   NM_001081573
VERSION     NM_001081573.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4745)
  AUTHORS   Li,C., Ye,Z., Wang,Y., Wang,G., Zhang,Q. and Zhang,C.
  TITLE     High expression of GRB2 associated binding protein 3 mRNA predicts
            positive prognosis in melanoma
  JOURNAL   Melanoma Res 33 (1), 27-37 (2023)
   PUBMED   36545920
  REMARK    GeneRIF: High expression of GRB2 associated binding protein 3 mRNA
            predicts positive prognosis in melanoma.
REFERENCE   2  (bases 1 to 4745)
  AUTHORS   Wang,N., Zhou,X., Wang,X. and Zhu,X.
  TITLE     Identification of Grb2-associated binding protein 3 expression to
            predict clinical outcomes and immunotherapeutic responses in lung
            adenocarcinoma
  JOURNAL   J Biochem Mol Toxicol 36 (10), e23166 (2022)
   PUBMED   35822560
  REMARK    GeneRIF: Identification of Grb2-associated binding protein 3
            expression to predict clinical outcomes and immunotherapeutic
            responses in lung adenocarcinoma.
REFERENCE   3  (bases 1 to 4745)
  AUTHORS   Xiang,S., Wang,N., Hui,P. and Ma,J.
  TITLE     Gab3 is required for human colorectal cancer cell proliferation
  JOURNAL   Biochem Biophys Res Commun 484 (4), 719-725 (2017)
   PUBMED   28115166
  REMARK    GeneRIF: Together, our results suggest that Gab3 expression in CRC
            cells is important for Akt-Erk activation and cell proliferation.
REFERENCE   4  (bases 1 to 4745)
  AUTHORS   Jia,P., Li,F., Gu,W., Zhang,W. and Cai,Y.
  TITLE     Gab3 overexpression in human glioma mediates Akt activation and
            tumor cell proliferation
  JOURNAL   PLoS One 12 (3), e0173473 (2017)
   PUBMED   28291820
  REMARK    GeneRIF: we conclude that Gab3 overexpression in human glioma
            mediates Akt activation and cancer cell proliferation
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4745)
  AUTHORS   Nakaoka,Y. and Komuro,I.
  TITLE     Gab docking proteins in cardiovascular disease, cancer, and
            inflammation
  JOURNAL   Int J Inflam 2013, 141068 (2013)
   PUBMED   23431498
REFERENCE   6  (bases 1 to 4745)
  AUTHORS   Sarmay,G., Angyal,A., Kertesz,A., Maus,M. and Medgyesi,D.
  TITLE     The multiple function of Grb2 associated binder (Gab)
            adaptor/scaffolding protein in immune cell signaling
  JOURNAL   Immunol Lett 104 (1-2), 76-82 (2006)
   PUBMED   16386802
  REMARK    Review article
REFERENCE   7  (bases 1 to 4745)
  AUTHORS   Seiffert,M., Custodio,J.M., Wolf,I., Harkey,M., Liu,Y.,
            Blattman,J.N., Greenberg,P.D. and Rohrschneider,L.R.
  TITLE     Gab3-deficient mice exhibit normal development and hematopoiesis
            and are immunocompetent
  JOURNAL   Mol Cell Biol 23 (7), 2415-2424 (2003)
   PUBMED   12640125
  REMARK    GeneRIF: Hematopoiesis in mice lacking Gab3 is not impaired,
            macrophages develop in normal numbers and exhibit normal function,
            and there is no major immune deficiency in T- and B-lymphocyte
            responses to protein antigens or during viral infection.
REFERENCE   8  (bases 1 to 4745)
  AUTHORS   Bourgin,C., Bourette,R.P., Arnaud,S., Liu,Y., Rohrschneider,L.R.
            and Mouchiroud,G.
  TITLE     Induced expression and association of the Mona/Gads adapter and
            Gab3 scaffolding protein during monocyte/macrophage differentiation
  JOURNAL   Mol Cell Biol 22 (11), 3744-3756 (2002)
   PUBMED   11997510
  REMARK    GeneRIF: The carboxy-terminal SH3 domain of the adapter protein
            Mona interacts with the atypical proline-rich domain of Gab3 to
            mediate late signaling of the macrophage colony-stimulating factor
            receptor.
REFERENCE   9  (bases 1 to 4745)
  AUTHORS   Liu,Y. and Rohrschneider,L.R.
  TITLE     The gift of Gab
  JOURNAL   FEBS Lett 515 (1-3), 1-7 (2002)
   PUBMED   11943184
  REMARK    Review article
REFERENCE   10 (bases 1 to 4745)
  AUTHORS   Wolf,I., Jenkins,B.J., Liu,Y., Seiffert,M., Custodio,J.M., Young,P.
            and Rohrschneider,L.R.
  TITLE     Gab3, a new DOS/Gab family member, facilitates macrophage
            differentiation
  JOURNAL   Mol Cell Biol 22 (1), 231-244 (2002)
   PUBMED   11739737
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK307927.1, AK126283.1,
            AY057989.1, AC244107.3 and AA808085.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001081573.2.
            
            Summary: This gene is a member of the GRB2-associated binding
            protein gene family. These proteins are scaffolding/docking
            proteins that are involved in several growth factor and cytokine
            signaling pathways, and they contain a pleckstrin homology domain,
            and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The
            protein encoded by this gene facilitates macrophage
            differentiation. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK307927.1, DRR138524.1295072.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424127.3/ ENSP00000399588.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1815              AK307927.1         1-1815
            1816-3590           AK126283.1         1670-3444
            3591-3797           AY057989.1         3568-3774
            3798-3798           AC244107.3         190662-190662       c
            3799-4741           AY057989.1         3776-4718
            4742-4745           AA808085.1         14-17               c
FEATURES             Location/Qualifiers
     source          1..4745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..4745
                     /gene="GAB3"
                     /note="GRB2 associated binding protein 3"
                     /db_xref="GeneID:139716"
                     /db_xref="HGNC:HGNC:17515"
                     /db_xref="MIM:300482"
     exon            1..124
                     /gene="GAB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1816
                     /gene="GAB3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DOS/Gab family member 3; Gab3 scaffolding protein;
                     GRB2-associated binder 3; growth factor receptor bound
                     protein 2-associated protein 3"
                     /codon_start=1
                     /product="GRB2-associated-binding protein 3 isoform 1"
                     /protein_id="NP_001075042.1"
                     /db_xref="CCDS:CCDS48198.1"
                     /db_xref="GeneID:139716"
                     /db_xref="HGNC:HGNC:17515"
                     /db_xref="MIM:300482"
                     /translation="MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDV
                     LEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTE
                     QEMQVWVHSISQVCNLGHLEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRD
                     DPNTNAVATEETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQAS
                     FDDVFVDCLQPLPSSHLVHPSCHGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPL
                     LESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKK
                     PECTLVPRRISLSGLDNMRTWKADVEGQSLRHRDKRLSLNLPCRFSPMYPTASASIED
                     SYVPMSPQAGASGLGPHCSPDDYIPMNSGSISSPLPELPANLEPPPVNRDLKPQRKSR
                     PPPLDLRNLSIIREHASLTRTRTVPCSRTSFLSPERNGINSARFFANPVSREDEESYI
                     EMEEHRTASSLSSGALTWTKKFSLDYLALDFNSASPAPMQQKLLLSEEQRVDYVQVDE
                     QKTQALQSTKQEWTDERQSKV"
     exon            125..428
                     /gene="GAB3"
                     /inference="alignment:Splign:2.1.0"
     exon            429..648
                     /gene="GAB3"
                     /inference="alignment:Splign:2.1.0"
     exon            649..1121
                     /gene="GAB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1177
                     /gene="GAB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1397
                     /gene="GAB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1479
                     /gene="GAB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1582
                     /gene="GAB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1699
                     /gene="GAB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..4745
                     /gene="GAB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4723..4728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAB3"
                     /note="hexamer: AATAAA"
     polyA_site      4745
                     /gene="GAB3"
                     /note="major polyA site"
ORIGIN      
        1 cttctgccgc gggcggctgg cccagctgga ggaagcggcg gcggcggcca cgatgagtgc
       61 gggcgacgca gtgtgcaccg gctggctcgt taagtcgccc cccgagagga agctacagcg
      121 ctacgcctgg cgcaagcgct ggtttgtcct ccggcgaggc cgcatgagcg gcaaccccga
      181 tgtcttggag tactacagga acaagcactc cagcaagccc atccgggtga tagacctcag
      241 cgagtgtgca gtgtggaagc atgtgggccc cagctttgtt cggaaggaat ttcagaataa
      301 tttcgtgttc attgtcaaga ctacttcccg tacattctac ctggtggcca aaactgagca
      361 agaaatgcag gtgtgggtgc acagcatcag tcaggtctgc aaccttggcc acctggagga
      421 tggtgcagca gattccatgg agagcctctc ttacacgccc tcctccctgc agccatcctc
      481 tgccagctcc cttcttaccg cccatgctgc cagctcctct ttgccaagag atgacccaaa
      541 cactaatgcc gtagccactg aggaaaccag aagtgagtca gagcttctct tccttccaga
      601 ttatctggtt ttgtccaact gcgagactgg aagactgcac cataccagtc tacccaccag
      661 atgtgatagc tggtcaaact cagaccgttc attggaacag gcttcatttg atgatgtttt
      721 tgttgactgc ctgcagccgc tcccctccag tcatttggtc cacccctcat gccatggcag
      781 tggagctcag gaggtgccat cctcgaggcc tcaggctgcc ctgatctgga gtagagaaat
      841 caatgggcca cccagggacc acttgtcttc ttcaccattg ctggaaagtt ccttaagttc
      901 caccattcag gtagataaaa atcaaggttc cttaccctgt ggagcaaaag aactagacat
      961 tatgtccaac actccacctc cccgcccccc taagccaagc catctgtctg aacggcgcca
     1021 agaggagtgg agtacacaca gtggtagcaa gaagccagaa tgcactctgg ttccaagaag
     1081 aatctccctc tctggtttag acaacatgag aacctggaaa gctgatgtag aaggccaatc
     1141 cttaagacac cgagacaagc ggcttagttt gaatttgcca tgcaggttct ccccgatgta
     1201 ccccacagct tcagccagta tcgaagacag ctatgtgccc atgagccccc aggctggtgc
     1261 ctctggtctt ggaccccact gcagccctga tgactacatt ccaatgaact caggaagcat
     1321 ctcaagcccg ttgcctgagc tgcctgcaaa cctggaacct cccccagtga atagagatct
     1381 caagcctcag aggaaatcac ggccacctcc tctggacctg agaaacctct cgatcatccg
     1441 ggaacatgca tctcttacca ggacccgcac tgtgccttgc agtcgaacca gctttctctc
     1501 tccagaaaga aatggtatta attctgcaag attttttgct aatcctgttt ccagagaaga
     1561 cgaagaaagc tacatcgaaa tggaggagca ccgaacagcc agttccctga gcagtggtgc
     1621 ccttacgtgg acaaagaaat tcagcctaga ttatttggcc ctggacttca attcagcatc
     1681 accagccccc atgcagcaga aacttctcct ttcagaagaa caaagagtag actatgtcca
     1741 agtggatgag cagaagacac aggctctcca gagcacaaaa caggagtgga cggatgaaag
     1801 gcaatccaaa gtatgagagg tgcgggcttg tgccatgtgt gaaacaggga agcttggggc
     1861 tcagtttgag ttttttcttt tttttttttt tttgtccact aaaaacacac tgatggtcaa
     1921 cacaggtcaa aaccaagaga gaatgtgtag ttttcaaggt cttggccaga acctttagga
     1981 aagaagacct gtttatacat tgaaggaaga aaagaaggaa gcagttgcct tccggagggg
     2041 gctctgagag aatctagcct cccctctgtc ctattggagc aaagattgga gtgagtgttg
     2101 ccaccaacag gattttatcg tttgactcca atacctgaaa ttctgacttc tctcctgtgc
     2161 ttcaatgaga atgataaatt atcctagcaa aggggcctct ggagaccatc ttgttccagc
     2221 ctctgaagac agttgaggag atcaagccca gcaatggtgg cagaatctta ctccacagac
     2281 ttcagcagac tagtcatttc aatacccaaa gaaagacaag tgacaggggc aatggatctc
     2341 aggctctgag ataagtatat cagatgacac tggtggctct aaggatattg caattaagca
     2401 gctacctgta gccaggtatt ctgctgctct tggccttttc ccacgcatcg tctcgtgtct
     2461 tctccgaaag accttggaag ataggcctgg aagagactgt tgatgccact ttgaagaaaa
     2521 gaacactgag aactagagga gggaacactt tgcccaagat tactcacaaa gccaagaccc
     2581 agagtccagc ttagagaata gagttgttca ggctgccaat tgcaagctca ttcctctacc
     2641 tcatacttcc tctgaggatt ttgacaaaat ggattaattg ggtgagcctt ggagacatgt
     2701 gggaaacacc tgcagacaca aaatgagtag tcatcctgtc tccctttcaa tagggatctg
     2761 aacaggtgtt ttgatacttg aaagatgtgc atgtcaagtg agggtttctt tctgcgatgt
     2821 tcaactggaa ctctcccatc agtagttaca attagaaata cctactgatg gttagtctga
     2881 aggccattct catggtcacc tatacagtgt gtttccctgt gagctagcag acacaatgac
     2941 caggaaaaaa cctatgaatt ccattcttag gtttcccagc caattgctcc cttctgcttt
     3001 agaagtgact aggtactgag agtacaaaca ctcccacttt ataatgaagg cgtcatgtca
     3061 ccccttcctt tacaggtcct ggggtccagg agacccagaa tgaaggtgtc agttgggcat
     3121 gaagtgttat ttagtgtcca ttcttgatcc ttctgagcac ctacagctgg aaactaagca
     3181 gatactggtc ctgcattctg actgagattg tgtcttcttt atgaggatag atcaaattgg
     3241 cagtcaggcc catgatagtc agtgcagttg gggcagttgt agactttgct acaggatttc
     3301 agggtttcca atcaccccac aggtaagtga atgccaaagt cttctttttt cagaccatac
     3361 aagaagtcat tttgattttc aaagaagccg ttttgatttt caaagaagca ggttctggtg
     3421 acattatttt cttccttgga caaagtgggg ggaaatttct aagtatttta actgagttca
     3481 gggtccttag tgagcctgga cagagcaagg agagggctcc ccactcccta agccccacag
     3541 ccagctctgc atcaccacac acagccagag cctgtgagga gctgccttct tccccatgtg
     3601 acttgcaaag agtctcaggc aagaaaccag ggcttcaaac tgctagttcc catggagggt
     3661 agttccctcg tgtggagcac ttgtgttagg atcactgatt atctgacaaa ggctggtgca
     3721 gaaaaaaaat tgtaggccca agtgtcaaga accacaccag attggagata gaaaagaata
     3781 gctgaaatta tgtcagtagt gaaatgtcac tccattgacc caccgaaaaa agaaaagaaa
     3841 tctgtttcta ccaaacattt ccagaaacgt atttatagca tgaagaaaca cacatgggta
     3901 gtgtgacctg tttggatgtg attacttaaa aatggaatgc tctgaatagg cactctctac
     3961 attaaaggta tggaaggcga taggggtcag aattttaaaa atttaatttt gaaaaaggtg
     4021 actcacccct catttccaga gtgtaggcaa ttatgtcctg ctttgataaa actgctagag
     4081 gatggctatg caaaagcata acgattcaag gaaacaaagt acaggtagtt tttgagctga
     4141 cagcagcaaa ggcaccataa gtcaaaatat tggttttggt ggagatgatc gatgtgtgtg
     4201 tgtgagagag agctatgttt ctaaccaagg gcctaatgtt tgttacagaa atgatcccag
     4261 agacctacaa gatgtgggaa tcagcataac agggcaatgc agcaattaac cccacatcgt
     4321 tttctgtagt tcctttttgt ttcattttct tctgtctcac ctcgttagaa aattcctccc
     4381 agtcaggggt cgtccagtgc aggacggggg acccaagggt ctcaagcctg caagtccaga
     4441 aggtgacaaa cccaggagca ctgggagtta agctttcctt ggggagggaa gagccttgat
     4501 gtccagcaca cagcctggct ataaagacac gaagcgacct acccactgta cagtccactt
     4561 cacaggatca gctgaatcat gacctttaaa agttccgagt tgaaactgaa ggctctcctc
     4621 agacctggct ttttcctcag tccctgttca taccatctct gcacccacaa tcacactgat
     4681 ttttcaaatt cattttgttt ttgctgtttc atttctggca ttaataaaag tcttataagg
     4741 agaaa
//
