LOCUS       NM_080491               6110 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens GRB2 associated binding protein 2 (GAB2), transcript
            variant 1, mRNA.
ACCESSION   NM_080491
VERSION     NM_080491.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6110)
  AUTHORS   Abd-Elmawla,M.A., Elsabagh,Y.A. and Aborehab,N.M.
  TITLE     Association of XIST/miRNA155/Gab2/TAK1 cascade with the
            pathogenesis of anti-phospholipid syndrome and its effect on cell
            adhesion molecules and inflammatory mediators
  JOURNAL   Sci Rep 13 (1), 18790 (2023)
   PUBMED   37914735
  REMARK    GeneRIF: Association of XIST/miRNA155/Gab2/TAK1 cascade with the
            pathogenesis of anti-phospholipid syndrome and its effect on cell
            adhesion molecules and inflammatory mediators.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6110)
  AUTHORS   Yin,Y., Zhang,L., Li,Y., Zhang,C. and He,A.
  TITLE     Gab2 plays a carcinogenic role in ovarian cancer by regulating
            CrkII
  JOURNAL   J Ovarian Res 16 (1), 79 (2023)
   PUBMED   37085900
  REMARK    GeneRIF: Gab2 plays a carcinogenic role in ovarian cancer by
            regulating CrkII.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6110)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 6110)
  AUTHORS   Huang,L., Liu,R., Zhou,P., Tian,Y. and Lu,Z.
  TITLE     miR-9 and miR-181a Target Gab2 to Inhibit the Proliferation and
            Migration of Hepatocellular Carcinoma HepG2 Cells
  JOURNAL   Genes (Basel) 13 (11), 2152 (2022)
   PUBMED   36421826
  REMARK    GeneRIF: miR-9 and miR-181a Target Gab2 to Inhibit the
            Proliferation and Migration of Hepatocellular Carcinoma HepG2
            Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6110)
  AUTHORS   Gong,R., Li,H., Liu,Y., Wang,Y., Ge,L., Shi,L., Wu,G., Lyu,J.,
            Gu,H. and He,L.
  TITLE     Gab2 promotes acute myeloid leukemia growth and migration through
            the SHP2-Erk-CREB signaling pathway
  JOURNAL   J Leukoc Biol 112 (4), 669-677 (2022)
   PUBMED   35322464
  REMARK    GeneRIF: Gab2 promotes acute myeloid leukemia growth and migration
            through the SHP2-Erk-CREB signaling pathway.
REFERENCE   6  (bases 1 to 6110)
  AUTHORS   Hibi,M. and Hirano,T.
  TITLE     Gab-family adapter molecules in signal transduction of cytokine and
            growth factor receptors, and T and B cell antigen receptors
  JOURNAL   Leuk Lymphoma 37 (3-4), 299-307 (2000)
   PUBMED   10752981
  REMARK    Review article
REFERENCE   7  (bases 1 to 6110)
  AUTHORS   Bone,H. and Welham,M.J.
  TITLE     Shc associates with the IL-3 receptor beta subunit, SHIP and Gab2
            following IL-3 stimulation. Contribution of Shc PTB and SH2 domains
  JOURNAL   Cell Signal 12 (3), 183-194 (2000)
   PUBMED   10704825
REFERENCE   8  (bases 1 to 6110)
  AUTHORS   Wickrema,A., Uddin,S., Sharma,A., Chen,F., Alsayed,Y., Ahmad,S.,
            Sawyer,S.T., Krystal,G., Yi,T., Nishada,K., Hibi,M., Hirano,T. and
            Platanias,L.C.
  TITLE     Engagement of Gab1 and Gab2 in erythropoietin signaling
  JOURNAL   J Biol Chem 274 (35), 24469-24474 (1999)
   PUBMED   10455108
REFERENCE   9  (bases 1 to 6110)
  AUTHORS   Zhao,C., Yu,D.H., Shen,R. and Feng,G.S.
  TITLE     Gab2, a new pleckstrin homology domain-containing adapter protein,
            acts to uncouple signaling from ERK kinase to Elk-1
  JOURNAL   J Biol Chem 274 (28), 19649-19654 (1999)
   PUBMED   10391903
REFERENCE   10 (bases 1 to 6110)
  AUTHORS   Nishida,K., Yoshida,Y., Itoh,M., Fukada,T., Ohtani,T.,
            Shirogane,T., Atsumi,T., Takahashi-Tezuka,M., Ishihara,K., Hibi,M.
            and Hirano,T.
  TITLE     Gab-family adapter proteins act downstream of cytokine and growth
            factor receptors and T- and B-cell antigen receptors
  JOURNAL   Blood 93 (6), 1809-1816 (1999)
   PUBMED   10068651
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003086.2 and AP002985.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_080491.2.
            
            Summary: This gene is a member of the GRB2-associated binding
            protein (GAB) gene family. These proteins contain pleckstrin
            homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2
            adapter protein. They act as adapters for transmitting various
            signals in response to stimuli through cytokine and growth factor
            receptors, and T- and B-cell antigen receptors. The protein encoded
            by this gene is the principal activator of phosphatidylinositol-3
            kinase in response to activation of the high affinity IgE receptor.
            Two alternatively spliced transcripts encoding different isoforms
            have been described for this gene. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018413.1, BC131711.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361507.5/ ENSP00000354952.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AP003086.2         69843-70017         c
            176-476             AP002985.2         134965-135265       c
            477-720             AP002985.2         104521-104764       c
            721-1307            AP002985.2         80829-81415         c
            1308-1402           AP002985.2         79472-79566         c
            1403-1667           AP002985.2         77776-78040         c
            1668-1758           AP002985.2         76469-76559         c
            1759-1861           AP002985.2         76041-76143         c
            1862-1987           AP002985.2         74683-74808         c
            1988-6110           AP002985.2         69657-73779         c
FEATURES             Location/Qualifiers
     source          1..6110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..6110
                     /gene="GAB2"
                     /note="GRB2 associated binding protein 2"
                     /db_xref="GeneID:9846"
                     /db_xref="HGNC:HGNC:14458"
                     /db_xref="MIM:606203"
     exon            1..175
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2131
                     /gene="GAB2"
                     /note="isoform a is encoded by transcript variant 1;
                     Grb2-associated binder 2; growth factor receptor bound
                     protein 2-associated protein 2; pp100"
                     /codon_start=1
                     /product="GRB2-associated-binding protein 2 isoform a"
                     /protein_id="NP_536739.1"
                     /db_xref="CCDS:CCDS8259.1"
                     /db_xref="GeneID:9846"
                     /db_xref="HGNC:HGNC:14458"
                     /db_xref="MIM:606203"
                     /translation="MSGGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPD
                     VLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETE
                     EDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSA
                     PSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRAS
                     FLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHG
                     HTKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDK
                     NHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTL
                     PAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSED
                     NYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEI
                     QPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRP
                     ISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSP
                     SPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL"
     exon            176..476
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..720
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..1307
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1402
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1667
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1758
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1861
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1987
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..6110
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6081..6086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAB2"
                     /note="hexamer: AATAAA"
     polyA_site      6110
                     /gene="GAB2"
                     /note="major polyA site"
ORIGIN      
        1 ccctggcctc ccgcgagctg cgcaccgccg gccgctgccc cagctgcccg agcccgcgcc
       61 ctcgtccgcg cgacccggcg gggggctcca ggccggcagc atgagcggcg gcggcgacgt
      121 ggtgtgcacc ggctggctga ggaaatcgcc tcccgagaag aagttgaggc gctatgcctg
      181 gaagaaacgc tggtttatcc tgcggagtgg ccggatgagc ggtgacccag atgttctgga
      241 atactacaag aacgatcact ccaagaagcc tctgcggatc atcaacctga acttctgtga
      301 gcaggtagat gcaggcctga cctttaacaa gaaggagctg caggatagtt ttgtgtttga
      361 catcaagacc agtgaacgca ccttttacct ggtggctgag acagaagagg acatgaataa
      421 gtgggtccag agcatctgcc agatctgtgg cttcaatcag gctgaggaga gcacagactc
      481 cctgagaaat gtttcctcag ccggtcatgg cccccgctct tctccagctg agctcagcag
      541 ctctagccag caccttctcc gagagcgcaa gtcctcagcc ccatcacact ccagccagcc
      601 aactctgttc acgtttgaac cccctgtgtc aaaccacatg cagcccacct tgtccaccag
      661 cgcacctcag gagtatctct acttgcacca gtgcataagc cgaagagcag aaaatgcaag
      721 gagtgccagc ttctctcagg gcaccagagc ctcttttctc atgaggagtg acacagctgt
      781 acaaaaactt gcccagggca atggacactg tgtcaacggg atcagtggtc aagtccatgg
      841 cttctatagc cttcccaagc cgagccggca caatacagaa ttcagagaca gtacctacga
      901 cctcccccgc agcctggcct cccatggcca caccaagggc agcctcacag gctccgagac
      961 agataatgag gatgtgtaca ccttcaagac gcccagcaac accctgtgca gggagttcgg
     1021 ggacctcctg gtagacaata tggatgttcc ggccacccca ctctcagcct accagatccc
     1081 taggacattc actctggaca aaaaccacaa tgccatgaca gtggccactc ctggggactc
     1141 agccatagct cccccacccc gcccccccaa gccaagtcag gcagaaacac ctcgatgggg
     1201 cagtcctcag cagagaccgc caatcagtga aaatagcaga tctgtcgctg ccaccatccc
     1261 cagacgcaac accctccctg caatggacaa cagccgactt caccgagctt cttcctgtga
     1321 gacctacgag tacccacagc gtggtggaga gagtgcaggc cggtctgctg aatccatgag
     1381 tgatggagtt ggctctttcc tgccagggaa aatgattgtg ggccgatcgg acagcaccaa
     1441 ttctgaagac aactatgtgc ccatgaatcc aggttcttcc accctgttgg ccatggaacg
     1501 agcaggtgat aattcccaga gcgtctacat cccaatgagc ccaggggccc atcactttga
     1561 ctcacttggc tacccatcaa caacccttcc tgtgcaccga ggccccagca gaggaagtga
     1621 gattcagcca ccccctgtca accgcaacct caaacctgat cggaaagcaa agccaacacc
     1681 acttgacctg aggaacaaca ccgtcatcga tgaactcccc ttcaagtcac ctatcaccaa
     1741 gtcttggtct agggccaacc acaccttcaa ctccagctcc tcccagtact gccgccccat
     1801 ctccacccag agcatcacca gcacagactc aggagacagc gaagagaact atgtccctat
     1861 gcaaaaccca gtgtctgcat ctcccgttcc cagtggcacg aacagtcctg cccctaagaa
     1921 gagcaccggc agcgttgatt atctggccct ggacttccag ccgagctccc caagccccca
     1981 ccgcaagcca tctacttcat ccgtcacctc tgatgagaag gtggactacg ttcaggtgga
     2041 caaggagaag acccaggccc tgcagaacac catgcaggag tggacagacg tgcggcagtc
     2101 ctcagagcct tccaagggtg ccaagctgtg atgagagggc caccgcagag cccaggaggc
     2161 agcatctcca gagctggccc ttcccatctc ccctctcccc tctcccgttc ttcctcccat
     2221 ccacctcctc tctactctgc cagtctcagc cttcaaagca cttgacatca gggaccctga
     2281 acccttcccc tgggaggtga gggcctgatc aaggcacctc ctctgcccac tcggggccca
     2341 gctgtgattt ttatcagtaa tggccatgcc tccacccacc ttagttagga gctacttcca
     2401 aaaagcatcc ttcagcctct tcctgtcctt tagacctgac tctctaccag atgtttggag
     2461 ggaagggctg gggctctgag ccagattcca cacctcacgt tcagtcacag ccctcagcta
     2521 tcttccctcc ggccactggg ctacctctcc ttcagtccca gaagacaagt ctcaccaacc
     2581 cagggagtca aggaccagca aaccaaagtg gataatggac tttttcattc ctgtttttct
     2641 tggcaggaga gaagcaaggc cactaaaaga ggagatggtg gagacggagg ctcagcagtg
     2701 gtcttgaggg gtaaaggact tagatgccca gatgaagagg gaaagctgac atctgcaggg
     2761 aacccacttt gaggctgagg ccatggcagg acagctgctg tggggtgcag aggcagaaga
     2821 tgaaggacaa aaggaaggga aaactgatgg ccaacctaga gcagcaagga gcagggcttg
     2881 gagctcgggt ggtggagatg acaaggacac tgtggggtct gggtccccag aactctggag
     2941 ctacaggcca ctctaggccc aagggctagt cctcttcccc agtcccctca gaggcccccg
     3001 ccagccccac cttgaaagca gcatacaggg gaaggcttgg accaagctgg gcgaccaagc
     3061 acatggggca ggaacacatg gtaaaggggt ggggaatatg ggagggagtg tggtgtggat
     3121 gggggtgatg cagggactga ggggaaccct gggacaggca caggctgggc agaggcacag
     3181 ggcagtgcag gggactctgc agtggggtcg ggaagtgagt ttctttgcag tgagcagtgc
     3241 agtggaagtc gggcacagag gtagcagaca gatgtgaagc agtggtgaag gccatgtagc
     3301 aagtggggaa atacatccaa agggcctggg agttgggggg tgcccaacgc aatccttggg
     3361 ggtgcagggt ggagcagaaa gtgaaggagg gacacgtgca agagtggtgt gcatggtggt
     3421 gtgacatgag gaccgttcct aggatgggac agtgggtcag gcaggacaag gagaaagcag
     3481 ggcagaatga tgcctagagg accacatcag gcatggctga cagcttgtgc ccatgggctg
     3541 tggcgtatgt cagatcgcag ggtaggaacg agtctggcct ggtgccggcc cagtgtttcc
     3601 tcagctcatc cgccctctgt tgctccctag cattccagga gccatcttgg actctcctcc
     3661 ccaggtttga aaggccatca gattagcagg gacggggtgt agggcatcac ccaaggttcc
     3721 ttctcttaaa ctaagggtgg gggatctgaa tgtttttatg ttgactgttc ttgactaaat
     3781 tttcaagagt ttcagaagca acaggacaga ccagacgttt cattctaccc tggggcgaac
     3841 agaacttctt cctcccaaac aatgacttcc tgccatgttt gatggggaca gctaccactg
     3901 tcctctgccc ccattcccct ttcagctccc atgagcatgc atagttcacc agaccaatgg
     3961 cctagccatt ctctaagtcc catcctggaa gaagttattt cttcaagagc tgcacctctc
     4021 ctcctagcat tagtttagat caactcaagg agtatttatt aatggctgct gtctccagtt
     4081 tctggggtta agcactaagg acacaagaat caatcagacc ttctccctga acttaagata
     4141 gccacaatca gaaaaaggac aaggacatga gacagtggtg atggccatca gacagagact
     4201 tcaaatgctg atggagggca gaggaagtac ttagggaggt tggtgtcaga ggcaggagtg
     4261 ggggatcagg gaaggtggat tctaggaaaa gggagtgcct gaggtaggcc ttagaagggg
     4321 atgagtcaga tttttacaga ggaggagggc agggcttggg tccagtggag gaagaaggaa
     4381 ggagaggctt ggaaagcctt gtgtcttggg aacaaaaggc ctttgagcat atgggtccag
     4441 ccactcagaa gtgtaggggc catgccttgg tgttccaata agtgaatgga agcagtggtg
     4501 gtagctacac tgggcagagt tggcagggtg ctggttcact ctgcccagcc ctgaatgtgt
     4561 gccttaaagg ccccctacaa ggggccccat acgacagagc ttttaactgg tgccttccct
     4621 gtacccgcag cagccacaag tgggcccaga ctattgcagc ctcccataaa catgtgagca
     4681 tgttctgagt gtgccatgat gtgagtggac ctggctggaa tcttcggaga gcgactgagg
     4741 tgttcaaatc gaatctccca ggaggcttcc ttccagcccc ctattctggt aactaccagg
     4801 aggcttcctt ccagccccct attctggtaa ctaccaaaat ccctcgggtg caagtgtagg
     4861 ggtagagatg gaaggatgag aggtgaaatt gaccttttga aagcaaagct ctggctcaca
     4921 ggccccaaac taccagccgt atctagcata tccccaccct ccacccacta cctcctccaa
     4981 caaaggagtc aactcagttg aaaaaactgg tcctttggcc tatccatggg tcaaagtcca
     5041 cctctcctgg gggcctggag aggactgagc ctacggaaag gggatacctt cccactcagc
     5101 actgcttcac acaggccccc tgcctggggc tctccaagga gccttcttca cccacttcca
     5161 gctccacttc tgcaaggtta agtcaagtga gaacgatgag aaatagggag atggtgtctc
     5221 cttaagtcct tgatctgcct gtctgtggaa tgggaggttg gattagctgc gctgaggtcc
     5281 catccacagc tggtgctcag ctgcttgaag gggagactcc ctcctctgta acttctttct
     5341 gggggattgg ggtgggcagt acctatcccc agtcccctcc tagcttgact ttagtggttt
     5401 ccaatgtaga agttaacaaa gtatgcccca ttcctgtgac aaaagcacaa ccattctgaa
     5461 gttactggag catgggctca gctcatcctc cctctggccc cttctcccat ggggacatct
     5521 cggcccagca cccctatccc atttccagag ttcttccttc cccatctggg ccttcataaa
     5581 atgcagggga agccagactg gtctcaggag cgctaaagcc cttccgtggg gggtcgtctt
     5641 tctgggacta gccctgctgt ttaggacctg ggaccacaat ggggtacctg ccgagggggt
     5701 ccccaagaga tccaggctgt catgtgattt atggtggcat gtgttgtgta tttgttggct
     5761 acttgtgtct tgaaatctag aattatttca cgcagaattg tcactgtttg tcaggaagag
     5821 aaaatgggct agtggaagcc cagtcttgag ttcttgtctt gttaccattt aaaattgaca
     5881 tttaattttc aaatcactgt tggtgcctaa tcacttaagt tattaattta ttctgttgta
     5941 ttcttttttt taaattgtaa catatttatc cggtgggtgg gacaggagtg tgttcaagtg
     6001 ggtcatgttt ttgctgtggt gacacatggt acaggcttgg agcttgcagg tccctttcta
     6061 ctgtggtgtt ggagcaggac aataaagtcc actagaaatg caccccagaa
//
