LOCUS       NM_012296               6095 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens GRB2 associated binding protein 2 (GAB2), transcript
            variant 2, mRNA.
ACCESSION   NM_012296
VERSION     NM_012296.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6095)
  AUTHORS   Abd-Elmawla,M.A., Elsabagh,Y.A. and Aborehab,N.M.
  TITLE     Association of XIST/miRNA155/Gab2/TAK1 cascade with the
            pathogenesis of anti-phospholipid syndrome and its effect on cell
            adhesion molecules and inflammatory mediators
  JOURNAL   Sci Rep 13 (1), 18790 (2023)
   PUBMED   37914735
  REMARK    GeneRIF: Association of XIST/miRNA155/Gab2/TAK1 cascade with the
            pathogenesis of anti-phospholipid syndrome and its effect on cell
            adhesion molecules and inflammatory mediators.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6095)
  AUTHORS   Yin,Y., Zhang,L., Li,Y., Zhang,C. and He,A.
  TITLE     Gab2 plays a carcinogenic role in ovarian cancer by regulating
            CrkII
  JOURNAL   J Ovarian Res 16 (1), 79 (2023)
   PUBMED   37085900
  REMARK    GeneRIF: Gab2 plays a carcinogenic role in ovarian cancer by
            regulating CrkII.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6095)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 6095)
  AUTHORS   Huang,L., Liu,R., Zhou,P., Tian,Y. and Lu,Z.
  TITLE     miR-9 and miR-181a Target Gab2 to Inhibit the Proliferation and
            Migration of Hepatocellular Carcinoma HepG2 Cells
  JOURNAL   Genes (Basel) 13 (11), 2152 (2022)
   PUBMED   36421826
  REMARK    GeneRIF: miR-9 and miR-181a Target Gab2 to Inhibit the
            Proliferation and Migration of Hepatocellular Carcinoma HepG2
            Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6095)
  AUTHORS   Gong,R., Li,H., Liu,Y., Wang,Y., Ge,L., Shi,L., Wu,G., Lyu,J.,
            Gu,H. and He,L.
  TITLE     Gab2 promotes acute myeloid leukemia growth and migration through
            the SHP2-Erk-CREB signaling pathway
  JOURNAL   J Leukoc Biol 112 (4), 669-677 (2022)
   PUBMED   35322464
  REMARK    GeneRIF: Gab2 promotes acute myeloid leukemia growth and migration
            through the SHP2-Erk-CREB signaling pathway.
REFERENCE   6  (bases 1 to 6095)
  AUTHORS   Hibi,M. and Hirano,T.
  TITLE     Gab-family adapter molecules in signal transduction of cytokine and
            growth factor receptors, and T and B cell antigen receptors
  JOURNAL   Leuk Lymphoma 37 (3-4), 299-307 (2000)
   PUBMED   10752981
  REMARK    Review article
REFERENCE   7  (bases 1 to 6095)
  AUTHORS   Bone,H. and Welham,M.J.
  TITLE     Shc associates with the IL-3 receptor beta subunit, SHIP and Gab2
            following IL-3 stimulation. Contribution of Shc PTB and SH2 domains
  JOURNAL   Cell Signal 12 (3), 183-194 (2000)
   PUBMED   10704825
REFERENCE   8  (bases 1 to 6095)
  AUTHORS   Wickrema,A., Uddin,S., Sharma,A., Chen,F., Alsayed,Y., Ahmad,S.,
            Sawyer,S.T., Krystal,G., Yi,T., Nishada,K., Hibi,M., Hirano,T. and
            Platanias,L.C.
  TITLE     Engagement of Gab1 and Gab2 in erythropoietin signaling
  JOURNAL   J Biol Chem 274 (35), 24469-24474 (1999)
   PUBMED   10455108
REFERENCE   9  (bases 1 to 6095)
  AUTHORS   Zhao,C., Yu,D.H., Shen,R. and Feng,G.S.
  TITLE     Gab2, a new pleckstrin homology domain-containing adapter protein,
            acts to uncouple signaling from ERK kinase to Elk-1
  JOURNAL   J Biol Chem 274 (28), 19649-19654 (1999)
   PUBMED   10391903
REFERENCE   10 (bases 1 to 6095)
  AUTHORS   Nishida,K., Yoshida,Y., Itoh,M., Fukada,T., Ohtani,T.,
            Shirogane,T., Atsumi,T., Takahashi-Tezuka,M., Ishihara,K., Hibi,M.
            and Hirano,T.
  TITLE     Gab-family adapter proteins act downstream of cytokine and growth
            factor receptors and T- and B-cell antigen receptors
  JOURNAL   Blood 93 (6), 1809-1816 (1999)
   PUBMED   10068651
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002985.2.
            
            On Aug 13, 2020 this sequence version replaced NM_012296.3.
            
            Summary: This gene is a member of the GRB2-associated binding
            protein (GAB) gene family. These proteins contain pleckstrin
            homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2
            adapter protein. They act as adapters for transmitting various
            signals in response to stimuli through cytokine and growth factor
            receptors, and T- and B-cell antigen receptors. The protein encoded
            by this gene is the principal activator of phosphatidylinositol-3
            kinase in response to activation of the high affinity IgE receptor.
            Two alternatively spliced transcripts encoding different isoforms
            have been described for this gene. [provided by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (b) is shorter at the N-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC152459.1, AB011143.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AP002985.2         196124-196283       c
            161-461             AP002985.2         134965-135265       c
            462-705             AP002985.2         104521-104764       c
            706-1292            AP002985.2         80829-81415         c
            1293-1387           AP002985.2         79472-79566         c
            1388-1652           AP002985.2         77776-78040         c
            1653-1743           AP002985.2         76469-76559         c
            1744-1846           AP002985.2         76041-76143         c
            1847-1972           AP002985.2         74683-74808         c
            1973-6095           AP002985.2         69657-73779         c
FEATURES             Location/Qualifiers
     source          1..6095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..6095
                     /gene="GAB2"
                     /note="GRB2 associated binding protein 2"
                     /db_xref="GeneID:9846"
                     /db_xref="HGNC:HGNC:14458"
                     /db_xref="MIM:606203"
     exon            1..160
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            161..461
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2116
                     /gene="GAB2"
                     /note="isoform b is encoded by transcript variant 2;
                     Grb2-associated binder 2; growth factor receptor bound
                     protein 2-associated protein 2; pp100"
                     /codon_start=1
                     /product="GRB2-associated-binding protein 2 isoform b"
                     /protein_id="NP_036428.1"
                     /db_xref="CCDS:CCDS8260.1"
                     /db_xref="GeneID:9846"
                     /db_xref="HGNC:HGNC:14458"
                     /db_xref="MIM:606203"
                     /translation="MSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQD
                     SFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRS
                     SPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQC
                     ISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSR
                     HNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNM
                     DVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQR
                     PPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGV
                     GSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDS
                     LGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPIT
                     KSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPA
                     PKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWT
                     DVRQSSEPSKGAKL"
     exon            462..705
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1292
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1387
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1652
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1743
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1846
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1972
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..6095
                     /gene="GAB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6066..6071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GAB2"
                     /note="hexamer: AATAAA"
     polyA_site      6095
                     /gene="GAB2"
                     /note="major polyA site"
ORIGIN      
        1 aaacattgca cttagccatt cagatgataa cttggatcag aaattttgag aagtggtggg
       61 atgaagaaga tccctgaaga gaggagtaac tgagacaaag gcgaggctag caatagagag
      121 acaagtgagg gaattagacc tttggtatca tcatgaaaag gcctggaaga aacgctggtt
      181 tatcctgcgg agtggccgga tgagcggtga cccagatgtt ctggaatact acaagaacga
      241 tcactccaag aagcctctgc ggatcatcaa cctgaacttc tgtgagcagg tagatgcagg
      301 cctgaccttt aacaagaagg agctgcagga tagttttgtg tttgacatca agaccagtga
      361 acgcaccttt tacctggtgg ctgagacaga agaggacatg aataagtggg tccagagcat
      421 ctgccagatc tgtggcttca atcaggctga ggagagcaca gactccctga gaaatgtttc
      481 ctcagccggt catggccccc gctcttctcc agctgagctc agcagctcta gccagcacct
      541 tctccgagag cgcaagtcct cagccccatc acactccagc cagccaactc tgttcacgtt
      601 tgaaccccct gtgtcaaacc acatgcagcc caccttgtcc accagcgcac ctcaggagta
      661 tctctacttg caccagtgca taagccgaag agcagaaaat gcaaggagtg ccagcttctc
      721 tcagggcacc agagcctctt ttctcatgag gagtgacaca gctgtacaaa aacttgccca
      781 gggcaatgga cactgtgtca acgggatcag tggtcaagtc catggcttct atagccttcc
      841 caagccgagc cggcacaata cagaattcag agacagtacc tacgacctcc cccgcagcct
      901 ggcctcccat ggccacacca agggcagcct cacaggctcc gagacagata atgaggatgt
      961 gtacaccttc aagacgccca gcaacaccct gtgcagggag ttcggggacc tcctggtaga
     1021 caatatggat gttccggcca ccccactctc agcctaccag atccctagga cattcactct
     1081 ggacaaaaac cacaatgcca tgacagtggc cactcctggg gactcagcca tagctccccc
     1141 accccgcccc cccaagccaa gtcaggcaga aacacctcga tggggcagtc ctcagcagag
     1201 accgccaatc agtgaaaata gcagatctgt cgctgccacc atccccagac gcaacaccct
     1261 ccctgcaatg gacaacagcc gacttcaccg agcttcttcc tgtgagacct acgagtaccc
     1321 acagcgtggt ggagagagtg caggccggtc tgctgaatcc atgagtgatg gagttggctc
     1381 tttcctgcca gggaaaatga ttgtgggccg atcggacagc accaattctg aagacaacta
     1441 tgtgcccatg aatccaggtt cttccaccct gttggccatg gaacgagcag gtgataattc
     1501 ccagagcgtc tacatcccaa tgagcccagg ggcccatcac tttgactcac ttggctaccc
     1561 atcaacaacc cttcctgtgc accgaggccc cagcagagga agtgagattc agccaccccc
     1621 tgtcaaccgc aacctcaaac ctgatcggaa agcaaagcca acaccacttg acctgaggaa
     1681 caacaccgtc atcgatgaac tccccttcaa gtcacctatc accaagtctt ggtctagggc
     1741 caaccacacc ttcaactcca gctcctccca gtactgccgc cccatctcca cccagagcat
     1801 caccagcaca gactcaggag acagcgaaga gaactatgtc cctatgcaaa acccagtgtc
     1861 tgcatctccc gttcccagtg gcacgaacag tcctgcccct aagaagagca ccggcagcgt
     1921 tgattatctg gccctggact tccagccgag ctccccaagc ccccaccgca agccatctac
     1981 ttcatccgtc acctctgatg agaaggtgga ctacgttcag gtggacaagg agaagaccca
     2041 ggccctgcag aacaccatgc aggagtggac agacgtgcgg cagtcctcag agccttccaa
     2101 gggtgccaag ctgtgatgag agggccaccg cagagcccag gaggcagcat ctccagagct
     2161 ggcccttccc atctcccctc tcccctctcc cgttcttcct cccatccacc tcctctctac
     2221 tctgccagtc tcagccttca aagcacttga catcagggac cctgaaccct tcccctggga
     2281 ggtgagggcc tgatcaaggc acctcctctg cccactcggg gcccagctgt gatttttatc
     2341 agtaatggcc atgcctccac ccaccttagt taggagctac ttccaaaaag catccttcag
     2401 cctcttcctg tcctttagac ctgactctct accagatgtt tggagggaag ggctggggct
     2461 ctgagccaga ttccacacct cacgttcagt cacagccctc agctatcttc cctccggcca
     2521 ctgggctacc tctccttcag tcccagaaga caagtctcac caacccaggg agtcaaggac
     2581 cagcaaacca aagtggataa tggacttttt cattcctgtt tttcttggca ggagagaagc
     2641 aaggccacta aaagaggaga tggtggagac ggaggctcag cagtggtctt gaggggtaaa
     2701 ggacttagat gcccagatga agagggaaag ctgacatctg cagggaaccc actttgaggc
     2761 tgaggccatg gcaggacagc tgctgtgggg tgcagaggca gaagatgaag gacaaaagga
     2821 agggaaaact gatggccaac ctagagcagc aaggagcagg gcttggagct cgggtggtgg
     2881 agatgacaag gacactgtgg ggtctgggtc cccagaactc tggagctaca ggccactcta
     2941 ggcccaaggg ctagtcctct tccccagtcc cctcagaggc ccccgccagc cccaccttga
     3001 aagcagcata caggggaagg cttggaccaa gctgggcgac caagcacatg gggcaggaac
     3061 acatggtaaa ggggtgggga atatgggagg gagtgtggtg tggatggggg tgatgcaggg
     3121 actgagggga accctgggac aggcacaggc tgggcagagg cacagggcag tgcaggggac
     3181 tctgcagtgg ggtcgggaag tgagtttctt tgcagtgagc agtgcagtgg aagtcgggca
     3241 cagaggtagc agacagatgt gaagcagtgg tgaaggccat gtagcaagtg gggaaataca
     3301 tccaaagggc ctgggagttg gggggtgccc aacgcaatcc ttgggggtgc agggtggagc
     3361 agaaagtgaa ggagggacac gtgcaagagt ggtgtgcatg gtggtgtgac atgaggaccg
     3421 ttcctaggat gggacagtgg gtcaggcagg acaaggagaa agcagggcag aatgatgcct
     3481 agaggaccac atcaggcatg gctgacagct tgtgcccatg ggctgtggcg tatgtcagat
     3541 cgcagggtag gaacgagtct ggcctggtgc cggcccagtg tttcctcagc tcatccgccc
     3601 tctgttgctc cctagcattc caggagccat cttggactct cctccccagg tttgaaaggc
     3661 catcagatta gcagggacgg ggtgtagggc atcacccaag gttccttctc ttaaactaag
     3721 ggtgggggat ctgaatgttt ttatgttgac tgttcttgac taaattttca agagtttcag
     3781 aagcaacagg acagaccaga cgtttcattc taccctgggg cgaacagaac ttcttcctcc
     3841 caaacaatga cttcctgcca tgtttgatgg ggacagctac cactgtcctc tgcccccatt
     3901 cccctttcag ctcccatgag catgcatagt tcaccagacc aatggcctag ccattctcta
     3961 agtcccatcc tggaagaagt tatttcttca agagctgcac ctctcctcct agcattagtt
     4021 tagatcaact caaggagtat ttattaatgg ctgctgtctc cagtttctgg ggttaagcac
     4081 taaggacaca agaatcaatc agaccttctc cctgaactta agatagccac aatcagaaaa
     4141 aggacaagga catgagacag tggtgatggc catcagacag agacttcaaa tgctgatgga
     4201 gggcagagga agtacttagg gaggttggtg tcagaggcag gagtggggga tcagggaagg
     4261 tggattctag gaaaagggag tgcctgaggt aggccttaga aggggatgag tcagattttt
     4321 acagaggagg agggcagggc ttgggtccag tggaggaaga aggaaggaga ggcttggaaa
     4381 gccttgtgtc ttgggaacaa aaggcctttg agcatatggg tccagccact cagaagtgta
     4441 ggggccatgc cttggtgttc caataagtga atggaagcag tggtggtagc tacactgggc
     4501 agagttggca gggtgctggt tcactctgcc cagccctgaa tgtgtgcctt aaaggccccc
     4561 tacaaggggc cccatacgac agagctttta actggtgcct tccctgtacc cgcagcagcc
     4621 acaagtgggc ccagactatt gcagcctccc ataaacatgt gagcatgttc tgagtgtgcc
     4681 atgatgtgag tggacctggc tggaatcttc ggagagcgac tgaggtgttc aaatcgaatc
     4741 tcccaggagg cttccttcca gccccctatt ctggtaacta ccaggaggct tccttccagc
     4801 cccctattct ggtaactacc aaaatccctc gggtgcaagt gtaggggtag agatggaagg
     4861 atgagaggtg aaattgacct tttgaaagca aagctctggc tcacaggccc caaactacca
     4921 gccgtatcta gcatatcccc accctccacc cactacctcc tccaacaaag gagtcaactc
     4981 agttgaaaaa actggtcctt tggcctatcc atgggtcaaa gtccacctct cctgggggcc
     5041 tggagaggac tgagcctacg gaaaggggat accttcccac tcagcactgc ttcacacagg
     5101 ccccctgcct ggggctctcc aaggagcctt cttcacccac ttccagctcc acttctgcaa
     5161 ggttaagtca agtgagaacg atgagaaata gggagatggt gtctccttaa gtccttgatc
     5221 tgcctgtctg tggaatggga ggttggatta gctgcgctga ggtcccatcc acagctggtg
     5281 ctcagctgct tgaaggggag actccctcct ctgtaacttc tttctggggg attggggtgg
     5341 gcagtaccta tccccagtcc cctcctagct tgactttagt ggtttccaat gtagaagtta
     5401 acaaagtatg ccccattcct gtgacaaaag cacaaccatt ctgaagttac tggagcatgg
     5461 gctcagctca tcctccctct ggccccttct cccatgggga catctcggcc cagcacccct
     5521 atcccatttc cagagttctt ccttccccat ctgggccttc ataaaatgca ggggaagcca
     5581 gactggtctc aggagcgcta aagcccttcc gtggggggtc gtctttctgg gactagccct
     5641 gctgtttagg acctgggacc acaatggggt acctgccgag ggggtcccca agagatccag
     5701 gctgtcatgt gatttatggt ggcatgtgtt gtgtatttgt tggctacttg tgtcttgaaa
     5761 tctagaatta tttcacgcag aattgtcact gtttgtcagg aagagaaaat gggctagtgg
     5821 aagcccagtc ttgagttctt gtcttgttac catttaaaat tgacatttaa ttttcaaatc
     5881 actgttggtg cctaatcact taagttatta atttattctg ttgtattctt ttttttaaat
     5941 tgtaacatat ttatccggtg ggtgggacag gagtgtgttc aagtgggtca tgtttttgct
     6001 gtggtgacac atggtacagg cttggagctt gcaggtccct ttctactgtg gtgttggagc
     6061 aggacaataa agtccactag aaatgcaccc cagaa
//
