LOCUS       XM_006714167            7628 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens GRB2 associated binding protein 1 (GAB1),
            transcript variant X11, mRNA.
ACCESSION   XM_006714167
VERSION     XM_006714167.5
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000004.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_006714167.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            1..7628
                     /gene="GAB1"
                     /gene_synonym="DFNB26"
                     /note="GRB2 associated binding protein 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 mRNAs, 18 ESTs, 699 long SRA reads, 1 Protein, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 18 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:2549"
                     /db_xref="HGNC:HGNC:4066"
                     /db_xref="MIM:604439"
     CDS             306..2252
                     /gene="GAB1"
                     /gene_synonym="DFNB26"
                     /codon_start=1
                     /product="GRB2-associated-binding protein 1 isoform X5"
                     /protein_id="XP_006714230.1"
                     /db_xref="GeneID:2549"
                     /db_xref="HGNC:HGNC:4066"
                     /db_xref="MIM:604439"
                     /translation="MNKWVRCICDICGFNPTEEDPVKPPGSSLQAPADLPLAINTAPP
                     STQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTSQGSSFVS
                     EEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFF
                     QQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTS
                     SVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAH
                     DRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPR
                     AFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQ
                     EANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
                     RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPIT
                     RSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGG
                     SSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLAL
                     KSTREAWTDGRQSTESETPAKSVK"
ORIGIN      
        1 agtcatgaac aggatgttgg aagtcagagg tacagagaag ctgccttttt aggccgctca
       61 catgaaaggc atggaagagg agatggttcg tgttacgcag tggccgttta actggagatc
      121 cagatgtttt ggaatattac aaaaatgatc atgccaagaa gcctattcgt attattgatt
      181 taaatttatg tcaacaagta gatgctggat tgacatttaa caaaaaagag tttgaaaaca
      241 gctacatttt tgatatcaac actattgacc ggattttcta cttggtagca gacagcgagg
      301 aggagatgaa taagtgggtt cgttgtattt gtgacatctg tgggtttaat ccaacagaag
      361 aagatcctgt gaagccacct ggcagctctt tacaagcacc agctgattta cctttagcta
      421 taaatacagc accaccatcc acccaggcag attcatcctc tgctactcta cctcctccat
      481 atcagctaat caatgttcca ccacacctgg aaactcttgg cattcaggag gatcctcaag
      541 actacctgtt gctcatcaac tgtcaaagca agaagcccga acccaccagc caagggtcat
      601 cttttgtttc tgaagaagga gaggaatacc ttctactaga agattttgaa agcaaaacga
      661 ttccattgca aacgcatgct gattctgcaa aatccacctc ttctgaaaca gactgcaatg
      721 ataacgtccc ttctcataaa aatcctgctt cctcccagag caaacatgga atgaatggct
      781 tttttcagca gcaaatgata tacgactctc caccttcacg tgccccatct gcttcagttg
      841 actccagcct ttataacctg cccaggagtt attcccatga tgttttacca aaggtgtctc
      901 catcaagtac tgaagcagat ggagaactct atgtttttaa taccccatct gggacatcga
      961 gtgtagagac tcaaatgagg catgtatcta ttagttatga cattcctcca acacctggta
     1021 atacttatca gattccacga acatttccag aaggaacctt gggacagaca tcaaagctag
     1081 acactattcc agatattcct ccacctcggc caccgaaacc acatccagct catgaccgat
     1141 ctcctgtgga aacgtgtagt atcccacgca ccgcctcaga cactgacagt agttactgta
     1201 tccctacagc agggatgtcg ccttcacgta gtaataccat ttccactgtg gatttaaaca
     1261 aattgcgaaa agatgctagt tctcaagact gctatgatat tccacgagca tttccaagtg
     1321 atagatctag ttcacttgaa ggcttccata accactttaa agtcaaaaat gtgttgacag
     1381 tgggaagtgt ttcaagtgaa gaactggatg aaaattacgt cccaatgaat cccaattcac
     1441 caccacgaca acattccagc agttttacag aaccaattca ggaagcaaat tatgtgccaa
     1501 tgactccagg aacatttgat ttttcctcat ttggaatgca agttcctcct cctgctcata
     1561 tgggcttcag gtccagccca aaaacccctc ccagaaggcc agttcctgtt gcagactgtg
     1621 aaccaccccc cgtggatagg aacctcaagc cagacagaaa aggtcaaagt cctaaaattt
     1681 taagactcaa accccatggt ttagagcgaa ctgattcaca aaccataggt gactttgcta
     1741 caagaagaaa ggtcaagcca gcgcctttag aaataaaacc tttgccagaa tgggaagaat
     1801 tacaagcccc agttagatct cccatcacta ggagttttgc tcgagactct tccaggtttc
     1861 ccatgtcccc ccgaccagat tcagtgcata gcacaacttc aagcagtgac tcacacgaca
     1921 gtgaagagaa ttatgttccc atgaacccaa acctgtccag tgaagaccca aatctctttg
     1981 gcagtaacag tcttgatgga ggaagcagcc ctatgatcaa gcccaaagga gacaaacagg
     2041 tggaatactt agatctcgac ttagattctg ggaaatccac accaccacgt aagcaaaaga
     2101 gcagtggctc aggcagcagt gtagcagatg agagagtgga ttatgttgtt gttgaccaac
     2161 agaagacctt ggctctaaag agtacccggg aagcctggac agatgggaga cagtccacag
     2221 aatcagaaac gccagcgaag agtgtgaaat gaaaatattg ccttgccatt tctgaacaaa
     2281 agaaaactga attgtaaaga taaatccctt ttgaagaatg acttgacact tccactctag
     2341 gtagatcctc aaatgagtag agttgaagtc aaaggacctt tctgacataa tcaagcaatt
     2401 tagacttaag tggtgctttg tggtatctga acaattcata acatgtaaat aatgtgggaa
     2461 aatagtattg tttagctccc agagaaacat ttgttccaca gttaacacac tcgtagtatt
     2521 actgtattta tgcacttttt catctaaaac attgttctgg gttttcccaa tgtaccttac
     2581 cataattcct ttgggagttc ttgttttttg tcacactact ttatataaca atactaagtc
     2641 aactaagcta cttttagatt tggaaattgc tgtttacagt ctaacaacat taaaatgaga
     2701 ggtagattca caagttagct ttctacctga agcttcaggt gataaccatt agcttatact
     2761 tggactcatc atttgttgcc ttccaaaatg ctgaggataa tgtatgtact ggtgtcagga
     2821 cctagttctc tggttaatgt acatttagtt tttaatggtg gaactttgtt atattttgtt
     2881 aattacagtg tttttggttc attgagtgaa gattctgccg ggtgggatct tgcacctttg
     2941 aaagactgaa taattacact accaagtaag cctgcaaatc attgatggca tgcagtgatg
     3001 atgtgctctt acacttgtta acatgtatta agtgttattt gcaaaaggta gattatgtaa
     3061 ccaatcaggt acgtaccagg cagtgatgtg ctaatacact gatcaggttt agacaatgag
     3121 ctttggttgt gttcttgtta gtcctaatat tggttttcag tttggaatta ataaagcagt
     3181 tgacattcac tgttagttac agcaacatac tgtgattttt aattagatag taattcagat
     3241 ttattactct atgaaattct gtcttttgac accatagtgc cctttctatg atttttttta
     3301 cttaatattc ttcttggcct tatatttaat tccctatgca attaatattt tatatctgca
     3361 tttttttaaa aaaaatagat gttatataag tgattctcgt atgtagcacc tgttgctttt
     3421 ccactgaaag aattacggat tttgtactgt gatttatatt cactgcccca attcaagaaa
     3481 tattggagcc ttgctacaat gtgaaatgtt atagtcatgg actccttcca accagatttc
     3541 tgaaaacacc agagggatgg tataattctg tctcacctat aacatggtcc tgtgacatag
     3601 atattaagac cacaagttgt agtgaggcta caattatatt cgtctgtctt ggctttgcaa
     3661 cataatttag aaagcacgta tagttgtttt ttaaccaagt tacatacaat ctcatgtact
     3721 gatttgagac ttataacaat ttttggaggg ggcatagaga aaggagtgcc cacagttgag
     3781 gcatgacccc ctccattcag acctctaact gttgcctgag tacacagatg tgccctgatt
     3841 tctggcccat tggccatagt actgtgccta atcaatgtaa taggtttatt ttcccaatcc
     3901 tcaaactaaa aatgttcata acaagatgaa ttgtagacta gtaacatttg atgcttttaa
     3961 atatttgctt ctttttaaac aaaaactaaa acccagaagt gaatttttag gtggattttt
     4021 aaataaaaaa gattgattga gtttggtgtg caagctgttt tataatgaaa caacaaaatg
     4081 aaatctaaaa tcctgaaatg tgcctaaact atcaaaacac acgatacagc taatgtgtaa
     4141 agatgctaaa ttctgttact tggaggatga atatatttaa gatttaaaac acaataataa
     4201 atacatgatt aattcaaaaa taaaaatctt tacagctgcc tatcaagggt ctaaagcact
     4261 taatgaatgt ttttagtcta acttatcatt aactttttac aagtcaccat atttgaagat
     4321 ctgtagcact ctgattttca gaaaattttt cattctgaat aatttaaaaa tggtgatgta
     4381 ttagaaaggc agtttgcttt agaaaactaa atcacattga acattgtatt agagaattaa
     4441 attaaaagtt tcttacagag cagtattttc caaacatttt tagcactaga atctttttag
     4501 atgaaatttt atgtataacc ccaatacata aagcctgaaa actcaatttt atcaatataa
     4561 atgtattttg ggttcacatt tatgcttatt cattttggct cattactaag cataataaga
     4621 ttctgagtta tttctgaata acacaaatgt ggagttatac atagttgatg aaaccagcag
     4681 ccaatttata gctatgccct gttttatttg tatactatca agaaaatttt gattcacaca
     4741 aatgtaagca aaaataatag gttttaaaca tacatctcag gaaattcttt aattagagat
     4801 agctaaagtt attcaaggtc tatacaaaaa taagttatcc tggtagtgga agttaataca
     4861 taagcagtct ccagtgtggt aaagtagggt atgtaacaca tcagaatgtg cgtttttatt
     4921 aggttttaaa atatgcacgt ataaaaacta aatttgaatc aaaccctttt aactcacctc
     4981 caagaagcta gactttggcc aggaatgggc taaaaaccac tggttaacga tgtgacagtt
     5041 atgatcttgg agattggaaa tctttcttcc acattagagt tctttacctt aattccttat
     5101 tctgaaaaat tgtaagattt tatgaaggtt tgaatactga agcacagttc tgctttcaaa
     5161 aattaaaatt caaacttgaa aaagctgttt aacccatgga agatatcatt tagtaagatg
     5221 taaaagattt tttaaatcta cacttcagtt tatacatctt tatcattatc aatactatat
     5281 aagttactgt gagcatttta gagaattcca taaaggtact atgagtgtgt ctgtatgtgt
     5341 gtgtatatat agcattgtat ttaatcatag actaaattta atttgatata gaaatactac
     5401 tttacttgta cattaaggtc ataatttctg ctggactctt ttatatttaa ttaatgggga
     5461 ttatagtctt ccttcataaa tgcatttaaa cctgaaattg aacaccagtg tttttctttt
     5521 tctacttatg ggaagttgtc tgcttccccc tttagagaaa acagtatttt tatattttgt
     5581 taaaatatta actactttat gcctacacac tatgctgtag atactgatca taattcttgg
     5641 gtgttcacaa acactcctag tgcctctttt ttggcccgtt gaaagtgttg gtattactac
     5701 tttcactaca gagcctttgg ccctctaata atgctgaggt gggctgatcc ttcccatttc
     5761 tgtcttcggg tcattctggt aggtcttctc ctccactgtc aagtaagcaa tcaggtccgt
     5821 gacagggatt ggacatatga acaaattaag tggatacaca cagtgagaaa gatacatgca
     5881 ttctatggta acaactactg tcaataacat ctgatgttac atgcacattt atatatatat
     5941 aattttaaaa actgaactat gagaagccat ggtataaatg aatattgtgg acatcatgga
     6001 cttgatatga tagaaatcaa ttgtcagctt gagaaagttg tttttaatct gtctaaatag
     6061 ttcatgcatt actacagtta aaaatagttt catttgtctt ctatagactt aattttattc
     6121 cggttcagta taatctctgt taacagagtt tcagcaaact gattggtcaa ggtattaaca
     6181 tagcttctac ttcctttact taaaaagatg tggttttatg taagttcttg attactgatg
     6241 atcatcccaa attttgacaa caaaatcata tgtataaatt tatttctccc ctcttgttca
     6301 tcatcttttg taaaggtccc attgtagatc ttttctgcta ccaaataaaa cttttcaaac
     6361 aatttggttt caagacctta aatagacaag ttggatacta agattgtgaa ctgataagga
     6421 catataaatt tatatttcca gcccttcctt agagtcttta tctgcatcaa aaacccaatt
     6481 ctgccattaa ctgtgcttcc cagtcccacc tctatatgtc actcattttc tgcaacaaag
     6541 atctcactaa atcatgttga aacacaagtc atgatcctct ctaagtaaat agaaaaagct
     6601 ccctggaaaa actctgttgc cacatgcacg tgccctgtta ctcctccagc cagccagtgc
     6661 tgccagcatt ttattgtgta aaagtccaaa taaataaggg cctgcatgca acctttatct
     6721 tcagaaacta ggttttatat gtaaaatgtg acttgggaaa tgattctgtt tattaactgg
     6781 ctgggatttt tcatttctat gaaagtttca aacatctcca gtactttata aaatcccaac
     6841 aattgctgta agtcagcact ttggtccact cagcccaccc agcccacttg caactctgac
     6901 tcttcactga atcatatttg ggaagtttgg gtagggtgag gctatcttct tcaagattat
     6961 tttctcatat gtctgtctgt caccttgtaa accatgagac tcctgggtat ttgcatgtaa
     7021 cttctttgag gaagttacca ccatctctga tatagacaca ctttttgagt tgcagtttct
     7081 gttagaattt tttggagact aacttgccaa ttctgtgaat gttattgaat atttaaaaag
     7141 ctgggtctgt aatgggaggc attttattag ctgttgtgat tgggtaacat gtccccttag
     7201 atttcctgat ttaaaattat acaaaattac tatttttgat aaaataaagg aacacctaca
     7261 gaaaattaag tttctaagat gtttctatac ttcattagaa aagattttat tactattact
     7321 tatggttatt ggtgattaac acttaatgcg tctcctctga ttttgtgttc catgaggtgc
     7381 ttggaacatt tggagtgctc tgtgcgaggg acatacagtg atataggaaa tttaaaaatt
     7441 aaaataatac ccaaaaccca ctttatcaga tatggtattg tgatggttaa tattatgtgt
     7501 caacttggtg aggctatggc gcccatgtgt ttggtcaaac actagcctag atgttgctgt
     7561 gaatatattt tgtagatgtg attaacattt acaatcagtt gattttaagt aaagcagatt
     7621 ctcatcca
//
