LOCUS       NM_203505               4321 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens G3BP stress granule assembly factor 2 (G3BP2),
            transcript variant 1, mRNA.
ACCESSION   NM_203505
VERSION     NM_203505.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4321)
  AUTHORS   Si,W., Wei,H., Chen,W., Chen,B., Zhou,Y. and Zhang,H.
  TITLE     Exosomal microRNA-363 mediates the destructive effect of M1
            macrophages on chondrocytes by repressing G3BP2
  JOURNAL   Exp Cell Res 442 (2), 114276 (2024)
   PUBMED   39413984
  REMARK    GeneRIF: Exosomal microRNA-363 mediates the destructive effect of
            M1 macrophages on chondrocytes by repressing G3BP2.
REFERENCE   2  (bases 1 to 4321)
  AUTHORS   Sheng,Z., Wang,X., Ding,X., Zheng,Y., Guo,A., Cui,J., Ma,J.,
            Duan,W., Dong,H., Zhang,H., Cui,M., Su,W. and Zhang,B.
  TITLE     Exosomal miRNA-92a derived from cancer-associated fibroblasts
            promote invasion and metastasis in breast cancer by regulating
            G3BP2
  JOURNAL   Cell Signal 119, 111182 (2024)
   PUBMED   38640983
  REMARK    GeneRIF: Exosomal miRNA-92a derived from cancer-associated
            fibroblasts promote invasion and metastasis in breast cancer by
            regulating G3BP2.
REFERENCE   3  (bases 1 to 4321)
  AUTHORS   Xia,W., Chen,W., Ni,C., Meng,X., Wu,J., Yang,Q., Tang,H., Yuan,H.
            and Fang,S.
  TITLE     Chemotherapy-induced exosomal circBACH1 promotes breast cancer
            resistance and stemness via miR-217/G3BP2 signaling pathway
  JOURNAL   Breast Cancer Res 25 (1), 85 (2023)
   PUBMED   37461019
  REMARK    GeneRIF: Chemotherapy-induced exosomal circBACH1 promotes breast
            cancer resistance and stemness via miR-217/G3BP2 signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4321)
  AUTHORS   Wang,N., Li,T., Liu,W., Lin,J., Zhang,K., Li,Z., Huang,Y., Shi,Y.,
            Xu,M. and Liu,X.
  TITLE     USP7- and PRMT5-dependent G3BP2 stabilization drives de novo
            lipogenesis and tumorigenesis of HNSC
  JOURNAL   Cell Death Dis 14 (3), 182 (2023)
   PUBMED   36878903
  REMARK    GeneRIF: USP7- and PRMT5-dependent G3BP2 stabilization drives de
            novo lipogenesis and tumorigenesis of HNSC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4321)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   6  (bases 1 to 4321)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 4321)
  AUTHORS   Ong,S.E., Mittler,G. and Mann,M.
  TITLE     Identifying and quantifying in vivo methylation sites by heavy
            methyl SILAC
  JOURNAL   Nat Methods 1 (2), 119-126 (2004)
   PUBMED   15782174
REFERENCE   8  (bases 1 to 4321)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 4321)
  AUTHORS   Prigent,M., Barlat,I., Langen,H. and Dargemont,C.
  TITLE     IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in
            the cytoplasm through interaction with a novel partner, RasGAP
            SH3-binding protein 2
  JOURNAL   J Biol Chem 275 (46), 36441-36449 (2000)
   PUBMED   10969074
REFERENCE   10 (bases 1 to 4321)
  AUTHORS   Kennedy,D., Wood,S.A., Ramsdale,T., Tam,P.P., Steiner,K.A. and
            Mattick,J.S.
  TITLE     Identification of a mouse orthologue of the human
            ras-GAP-SH3-domain binding protein and structural confirmation that
            these proteins contain an RNA recognition motif
  JOURNAL   Biomed Pept Proteins Nucleic Acids 2 (3), 93-99 (1996)
   PUBMED   9575347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB241424.1, AF145284.1, AB014560.1, BM744299.1 and AI913597.1.
            
            On May 7, 2020 this sequence version replaced NM_203505.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.22901.1,
                                           SRR14038192.3838584.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359707.9/ ENSP00000352738.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               DB241424.1         182-356
            176-1026            AF145284.1         143-993
            1027-3809           AB014560.1         919-3701
            3810-3829           BM744299.1         10-29
            3830-4321           AI913597.1         19-510              c
FEATURES             Location/Qualifiers
     source          1..4321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..4321
                     /gene="G3BP2"
                     /note="G3BP stress granule assembly factor 2"
                     /db_xref="GeneID:9908"
                     /db_xref="HGNC:HGNC:30291"
                     /db_xref="MIM:620020"
     exon            1..204
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            205..323
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1677
                     /gene="G3BP2"
                     /note="isoform a is encoded by transcript variant 1;
                     Ras-GTPase activating protein SH3 domain-binding protein
                     2; GTPase activating protein (SH3 domain) binding protein
                     2; ras GTPase-activating protein-binding protein 2;
                     G3BP-2; GAP SH3 domain-binding protein 2"
                     /codon_start=1
                     /product="ras GTPase-activating protein-binding protein 2
                     isoform a"
                     /protein_id="NP_987101.1"
                     /db_xref="CCDS:CCDS3571.1"
                     /db_xref="GeneID:9908"
                     /db_xref="HGNC:HGNC:30291"
                     /db_xref="MIM:620020"
                     /translation="MVMEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGG
                     VDASGKPQEAVYGQNDIHHKVLSLNFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSG
                     QPERKFMQTFVLAPEGSVPNKFYVHNDMFRYEDEVFGDSEPELDEESEDEVEEEQEER
                     QPSPEPVQENANSGYYEAHPVTNGIEEPLEESSHEPEPEPESETKTEELKPQVEEKNL
                     EELEEKSTTPPPAEPVSLPQEPPKAFSWASVTSKNLPPSGTVSSSGIPPHVKAPVSQP
                     RVEAKPEVQSQPPRVREQRPRERPGFPPRGPRPGRGDMEQNDSDNRRIIRYPDSHQLF
                     VGNLPHDIDENELKEFFMSFGNVVELRINTKGVGGKLPNFGFVVFDDSEPVQRILIAK
                     PIMFRGEVRLNVEEKKTRAARERETRGGGDDRRDIRRNDRGPGGPRGIVGGGMMRDRD
                     GRGPPPRGGMAQKLGSGRGTGQMEGRFTGQRR"
     exon            324..405
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            406..579
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            580..670
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            671..773
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            774..954
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1053
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1156
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1285
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1404
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..4321
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4298..4303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G3BP2"
                     /note="hexamer: AATAAA"
     polyA_site      4321
                     /gene="G3BP2"
                     /note="major polyA site"
ORIGIN      
        1 cgtccgtggt ccttgtcgca cgtcgcagcg cctggcgccc gggaagaggt ggttgtgagg
       61 cagacgaact cgcggctctc cggcttccga ggcttccgag ttgtcggagg aagggggcgg
      121 cgagcaataa gaacccgccg cacccggtcc tcagcgactc ttctgacctc cgcgcgacgt
      181 acccgccgcc gccgttggct ggagcatttg acattgtgca gcaaagaaat ggttatggag
      241 aagcccagtc cgctgcttgt agggcgggag tttgtgaggc aatattatac tttgctgaat
      301 aaagctccgg aatatttaca caggttttat ggcaggaatt cttcctatgt tcatggtgga
      361 gtagatgcta gtggaaagcc ccaggaagct gtttatggcc aaaatgatat acaccacaaa
      421 gtattatctc tgaacttcag tgaatgtcat actaaaattc gtcatgtgga tgctcatgca
      481 accttgagtg atggagtagt tgtccaggtc atgggtttgc tgtctaacag tggacaacca
      541 gaaagaaagt ttatgcaaac ctttgttctg gctcctgaag gatctgttcc aaataaattt
      601 tatgttcaca atgatatgtt tcgttatgaa gatgaagtgt ttggtgattc tgagcctgaa
      661 cttgatgaag aatcagaaga tgaagtagaa gaggaacaag aagaaagaca accatctcct
      721 gaacctgtgc aagaaaatgc taacagtggt tactatgaag ctcaccctgt gactaatggc
      781 atagaggagc ctttggaaga atcctctcat gaacctgaac ctgagccaga atctgaaaca
      841 aagactgaag agctgaaacc acaagtggag gagaagaact tagaagaact agaggagaaa
      901 tctactactc ctcctccggc agaacctgtt tctctgccac aagaaccacc aaaggctttc
      961 tcctgggctt cagtgaccag taaaaacctg cctcctagtg gtactgtttc ttcctctgga
     1021 attccacccc atgttaaagc accagtctca cagccaagag tcgaagctaa accagaagtt
     1081 caatctcagc cacctcgtgt gcgtgaacaa cgacctagag aacgacctgg ttttcctcct
     1141 agaggaccaa gaccaggcag aggagatatg gaacagaatg actctgacaa ccgtagaata
     1201 attcgctatc cagatagtca tcaacttttt gttggtaact tgccacatga tattgatgaa
     1261 aatgagctaa aggaattctt catgagtttt ggaaacgttg tggaacttcg catcaatacc
     1321 aagggtgttg ggggaaagct tccaaatttt ggttttgtgg tttttgatga ctctgaacca
     1381 gttcagagaa tcttaattgc aaaaccgatt atgtttcgag gggaagtacg tttaaatgtg
     1441 gaagagaaaa aaacaagagc tgcaagagag cgagaaacca gaggtggtgg tgatgatcgc
     1501 agggatatta ggcgcaatga tcgaggtccc ggtggtccac gtggaattgt gggtggtgga
     1561 atgatgcgtg atcgtgatgg aagaggacct cctccaaggg gtggcatggc acagaaactt
     1621 ggctctggaa gaggaaccgg gcaaatggag ggccgcttca caggacagcg tcgctgaagc
     1681 tccactgttg gcaaagtctt ggcagtggta cattattcat cgtgtttgca ttcttgttaa
     1741 tttttttttt ggctttggaa tgtgacacag cctttttgat catttctttg atgtgaaaag
     1801 catctttggt tatcagttaa attgaggtgg acattatttc cccaatttca caacaggatt
     1861 cacattgtta atttataaat ctagacttgg agaattaagg actgagaaat gaccatatct
     1921 taaactatct acgacaaagt gaacttaaaa ggacatgccc actgaattca ggtcctttga
     1981 gtaaaaaaaa aatcttctgc tgcacatttt gtttaagtgt tactgtttct gcctgttaat
     2041 gctgggaaca caaatagtgc aatttgtgca attggagaat cttgcctttt ttcttggctc
     2101 cccccaaaaa tacaaaccaa cagaaacttg ttatgcactc atcaaaatgt actaatgggt
     2161 actctgaact cattaacatt gacatctgca acaggaggca acagggaaaa aatctcatct
     2221 tcttttccag tagaaaatag tttgtgaaat gatgagggca ttttatctgc ttgctgtgac
     2281 cagcgtgtgt acacataaac cttaacaaga ctacaagtat attccagaag gaaatcattt
     2341 tagttatgaa ctaaataata aaaattagaa cttcaaatgc gatggtcttg actattagac
     2401 cagatttagt agctccatat ctaagatttt tctacctgcc cctcttcagt acagggatgg
     2461 ctggctgctc aacacactcc tcctcccctt ttttcctttc tttaagctgt gtacagtgaa
     2521 aattgtcttt actgtatttt tgttctctgg taatgtaata agcatgatgg tgccttctat
     2581 taatacatca ttccagtctt gctggtaatt ttgtacagta tagtgtatga attgctgtgc
     2641 tgcaaagcca aacagctgca aaatgttgaa aaatcatcga aatgtataaa aattgcagta
     2701 tctttaaaat cagtaaaatg gactagcata ttatttatct tgttcttcag ttaacaactt
     2761 tgtgttctct gtgggaggga gggagtcctg tgtgtttgtg gggagaggga aggaggaagt
     2821 cagttatttg agtaagcctc tagttgactt ttctcttagc ctgaatgtgg acgttgaaac
     2881 atatcacttc agggcttgga aaagtcagtc aacttgacgt acatttttag tgacatttta
     2941 aaagcagtca gattctataa atggcaagta agcctgaagt gaggatactg caattttcgg
     3001 agaaaagaac agcagctctt taagtgtttg cattttctat ttggggggca gggaactgtc
     3061 attcattttg cacaattctt gaactgatgt cagcacccga gtggctcctg aatttaagtc
     3121 tgggacgaca tcttttattt ttacatgaat ctttaaacaa ttctgtgagc aaagtttgta
     3181 gctgctggat tattgtctgt ctttatagca agttccagta aaccacaagt atggcaaagc
     3241 ttatccaatt ttatgcttgg agcagtcagt acataccagt ttctgatgtt tcaggcagga
     3301 gtggggtaaa taagtgtgac cacttaaagc tgctcgttag catggaagac ttctccattc
     3361 tatctttgta aaacagacaa gatatgcact tgacatagta gcaaattggt tctgaattat
     3421 gcaactgttt gctatttagt aaactagcaa atgatgcatg tattttgttt ttcatgtact
     3481 gggcaatatg agtaaaatct gtcccttttt ccccctttga atgaggtctt ccatgtttga
     3541 gggaaagtct tgcactattg catatatttt ggggacacag attttcatag tttccatttt
     3601 tggggggctt aaggattttt tttttttctg tttgaaacag ttttatactt tctgatatag
     3661 tacttgaaat tcttaccaga aaattacttt ggagttttga agcctttatt aatactactt
     3721 ttaaagaagc agttgtttta ttgtcaatgt tttttttccc ccaagcatat tttcttgtat
     3781 ttctgtttcc atatatatat atatatatat aatttccaat tcaggatatt gccctgccat
     3841 ccatgaaaac tgttctggca ccaaaagtaa tgacaaatgt taagtgtaat aatagaaaag
     3901 tagagcaaag agccattcag cttcagtctt tacataccat gaataaaaca ttaaaacatc
     3961 atatggagaa gtttacatgg tgattgttca cctgcagtac tgtggagttt taacattttg
     4021 tcctcttttc agtgaaacag agtaaaaata ttcatctacc attactgtta tttgctgatt
     4081 ttgttttatt ttttgatggt aatattctat ccttatgaca ctattgcaac caaattggct
     4141 ttaccatctt ggctttagta ggtatagaag acaatggatt accatcttta ttgctgtaat
     4201 gtgttaagca ttatatgcta gtagaatcta gtttaattgt ttcaggtgga aagtattctt
     4261 tgagtttcca tattgaatgt gtttggacta aacaaacaat aaactactga tgtctgcagc
     4321 a
//
