LOCUS       NM_001400012            4313 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens G3BP stress granule assembly factor 2 (G3BP2),
            transcript variant 11, mRNA.
ACCESSION   NM_001400012
VERSION     NM_001400012.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4313)
  AUTHORS   Si,W., Wei,H., Chen,W., Chen,B., Zhou,Y. and Zhang,H.
  TITLE     Exosomal microRNA-363 mediates the destructive effect of M1
            macrophages on chondrocytes by repressing G3BP2
  JOURNAL   Exp Cell Res 442 (2), 114276 (2024)
   PUBMED   39413984
  REMARK    GeneRIF: Exosomal microRNA-363 mediates the destructive effect of
            M1 macrophages on chondrocytes by repressing G3BP2.
REFERENCE   2  (bases 1 to 4313)
  AUTHORS   Sheng,Z., Wang,X., Ding,X., Zheng,Y., Guo,A., Cui,J., Ma,J.,
            Duan,W., Dong,H., Zhang,H., Cui,M., Su,W. and Zhang,B.
  TITLE     Exosomal miRNA-92a derived from cancer-associated fibroblasts
            promote invasion and metastasis in breast cancer by regulating
            G3BP2
  JOURNAL   Cell Signal 119, 111182 (2024)
   PUBMED   38640983
  REMARK    GeneRIF: Exosomal miRNA-92a derived from cancer-associated
            fibroblasts promote invasion and metastasis in breast cancer by
            regulating G3BP2.
REFERENCE   3  (bases 1 to 4313)
  AUTHORS   Xia,W., Chen,W., Ni,C., Meng,X., Wu,J., Yang,Q., Tang,H., Yuan,H.
            and Fang,S.
  TITLE     Chemotherapy-induced exosomal circBACH1 promotes breast cancer
            resistance and stemness via miR-217/G3BP2 signaling pathway
  JOURNAL   Breast Cancer Res 25 (1), 85 (2023)
   PUBMED   37461019
  REMARK    GeneRIF: Chemotherapy-induced exosomal circBACH1 promotes breast
            cancer resistance and stemness via miR-217/G3BP2 signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4313)
  AUTHORS   Wang,N., Li,T., Liu,W., Lin,J., Zhang,K., Li,Z., Huang,Y., Shi,Y.,
            Xu,M. and Liu,X.
  TITLE     USP7- and PRMT5-dependent G3BP2 stabilization drives de novo
            lipogenesis and tumorigenesis of HNSC
  JOURNAL   Cell Death Dis 14 (3), 182 (2023)
   PUBMED   36878903
  REMARK    GeneRIF: USP7- and PRMT5-dependent G3BP2 stabilization drives de
            novo lipogenesis and tumorigenesis of HNSC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4313)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   6  (bases 1 to 4313)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 4313)
  AUTHORS   Ong,S.E., Mittler,G. and Mann,M.
  TITLE     Identifying and quantifying in vivo methylation sites by heavy
            methyl SILAC
  JOURNAL   Nat Methods 1 (2), 119-126 (2004)
   PUBMED   15782174
REFERENCE   8  (bases 1 to 4313)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 4313)
  AUTHORS   Prigent,M., Barlat,I., Langen,H. and Dargemont,C.
  TITLE     IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in
            the cytoplasm through interaction with a novel partner, RasGAP
            SH3-binding protein 2
  JOURNAL   J Biol Chem 275 (46), 36441-36449 (2000)
   PUBMED   10969074
REFERENCE   10 (bases 1 to 4313)
  AUTHORS   Kennedy,D., Wood,S.A., Ramsdale,T., Tam,P.P., Steiner,K.A. and
            Mattick,J.S.
  TITLE     Identification of a mouse orthologue of the human
            ras-GAP-SH3-domain binding protein and structural confirmation that
            these proteins contain an RNA recognition motif
  JOURNAL   Biomed Pept Proteins Nucleic Acids 2 (3), 93-99 (1996)
   PUBMED   9575347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104828.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.110904.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC104828.4         83616-83811         c
            197-315             AC104828.4         73041-73159         c
            316-397             AC104828.4         69953-70034         c
            398-571             AC104828.4         68667-68840         c
            572-662             AC104828.4         68034-68124         c
            663-765             AC104828.4         66878-66980         c
            766-946             AC104828.4         66176-66356         c
            947-1045            AC104828.4         65093-65191         c
            1046-1148           AC104828.4         59749-59851         c
            1149-1277           AC104828.4         58139-58267         c
            1278-1396           AC104828.4         57448-57566         c
            1397-4313           AC104828.4         53896-56812         c
FEATURES             Location/Qualifiers
     source          1..4313
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..4313
                     /gene="G3BP2"
                     /note="G3BP stress granule assembly factor 2"
                     /db_xref="GeneID:9908"
                     /db_xref="HGNC:HGNC:30291"
                     /db_xref="MIM:620020"
     exon            1..196
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            197..315
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1669
                     /gene="G3BP2"
                     /note="isoform a is encoded by transcript variant 11;
                     Ras-GTPase activating protein SH3 domain-binding protein
                     2; GTPase activating protein (SH3 domain) binding protein
                     2; ras GTPase-activating protein-binding protein 2;
                     G3BP-2; GAP SH3 domain-binding protein 2"
                     /codon_start=1
                     /product="ras GTPase-activating protein-binding protein 2
                     isoform a"
                     /protein_id="NP_001386941.1"
                     /db_xref="CCDS:CCDS3571.1"
                     /db_xref="GeneID:9908"
                     /db_xref="HGNC:HGNC:30291"
                     /db_xref="MIM:620020"
                     /translation="MVMEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGG
                     VDASGKPQEAVYGQNDIHHKVLSLNFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSG
                     QPERKFMQTFVLAPEGSVPNKFYVHNDMFRYEDEVFGDSEPELDEESEDEVEEEQEER
                     QPSPEPVQENANSGYYEAHPVTNGIEEPLEESSHEPEPEPESETKTEELKPQVEEKNL
                     EELEEKSTTPPPAEPVSLPQEPPKAFSWASVTSKNLPPSGTVSSSGIPPHVKAPVSQP
                     RVEAKPEVQSQPPRVREQRPRERPGFPPRGPRPGRGDMEQNDSDNRRIIRYPDSHQLF
                     VGNLPHDIDENELKEFFMSFGNVVELRINTKGVGGKLPNFGFVVFDDSEPVQRILIAK
                     PIMFRGEVRLNVEEKKTRAARERETRGGGDDRRDIRRNDRGPGGPRGIVGGGMMRDRD
                     GRGPPPRGGMAQKLGSGRGTGQMEGRFTGQRR"
     exon            316..397
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            398..571
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..662
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..765
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..946
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1045
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1148
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1277
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1396
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..4313
                     /gene="G3BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4290..4295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G3BP2"
                     /note="hexamer: AATAAA"
     polyA_site      4313
                     /gene="G3BP2"
                     /note="major polyA site"
ORIGIN      
        1 gtgtcgacgg aggcagaagc gacgcagatg cgaaagtggc ggcctccggg caccatttct
       61 gtgcacggaa acagaatccg ggtttgaagg cagccgccgc ttcgcttacc cagtacctag
      121 tgttccgtcg tgtttgacca acccccctct ccctgccacc gcgggtttaa tccgaacgtg
      181 ttcggatact ggaactcatt tgacattgtg cagcaaagaa atggttatgg agaagcccag
      241 tccgctgctt gtagggcggg agtttgtgag gcaatattat actttgctga ataaagctcc
      301 ggaatattta cacaggtttt atggcaggaa ttcttcctat gttcatggtg gagtagatgc
      361 tagtggaaag ccccaggaag ctgtttatgg ccaaaatgat atacaccaca aagtattatc
      421 tctgaacttc agtgaatgtc atactaaaat tcgtcatgtg gatgctcatg caaccttgag
      481 tgatggagta gttgtccagg tcatgggttt gctgtctaac agtggacaac cagaaagaaa
      541 gtttatgcaa acctttgttc tggctcctga aggatctgtt ccaaataaat tttatgttca
      601 caatgatatg tttcgttatg aagatgaagt gtttggtgat tctgagcctg aacttgatga
      661 agaatcagaa gatgaagtag aagaggaaca agaagaaaga caaccatctc ctgaacctgt
      721 gcaagaaaat gctaacagtg gttactatga agctcaccct gtgactaatg gcatagagga
      781 gcctttggaa gaatcctctc atgaacctga acctgagcca gaatctgaaa caaagactga
      841 agagctgaaa ccacaagtgg aggagaagaa cttagaagaa ctagaggaga aatctactac
      901 tcctcctccg gcagaacctg tttctctgcc acaagaacca ccaaaggctt tctcctgggc
      961 ttcagtgacc agtaaaaacc tgcctcctag tggtactgtt tcttcctctg gaattccacc
     1021 ccatgttaaa gcaccagtct cacagccaag agtcgaagct aaaccagaag ttcaatctca
     1081 gccacctcgt gtgcgtgaac aacgacctag agaacgacct ggttttcctc ctagaggacc
     1141 aagaccaggc agaggagata tggaacagaa tgactctgac aaccgtagaa taattcgcta
     1201 tccagatagt catcaacttt ttgttggtaa cttgccacat gatattgatg aaaatgagct
     1261 aaaggaattc ttcatgagtt ttggaaacgt tgtggaactt cgcatcaata ccaagggtgt
     1321 tgggggaaag cttccaaatt ttggttttgt ggtttttgat gactctgaac cagttcagag
     1381 aatcttaatt gcaaaaccga ttatgtttcg aggggaagta cgtttaaatg tggaagagaa
     1441 aaaaacaaga gctgcaagag agcgagaaac cagaggtggt ggtgatgatc gcagggatat
     1501 taggcgcaat gatcgaggtc ccggtggtcc acgtggaatt gtgggtggtg gaatgatgcg
     1561 tgatcgtgat ggaagaggac ctcctccaag gggtggcatg gcacagaaac ttggctctgg
     1621 aagaggaacc gggcaaatgg agggccgctt cacaggacag cgtcgctgaa gctccactgt
     1681 tggcaaagtc ttggcagtgg tacattattc atcgtgtttg cattcttgtt aatttttttt
     1741 ttggctttgg aatgtgacac agcctttttg atcatttctt tgatgtgaaa agcatctttg
     1801 gttatcagtt aaattgaggt ggacattatt tccccaattt cacaacagga ttcacattgt
     1861 taatttataa atctagactt ggagaattaa ggactgagaa atgaccatat cttaaactat
     1921 ctacgacaaa gtgaacttaa aaggacatgc ccactgaatt caggtccttt gagtaaaaaa
     1981 aaaatcttct gctgcacatt ttgtttaagt gttactgttt ctgcctgtta atgctgggaa
     2041 cacaaatagt gcaatttgtg caattggaga atcttgcctt ttttcttggc tccccccaaa
     2101 aatacaaacc aacagaaact tgttatgcac tcatcaaaat gtactaatgg gtactctgaa
     2161 ctcattaaca ttgacatctg caacaggagg caacagggaa aaaatctcat cttcttttcc
     2221 agtagaaaat agtttgtgaa atgatgaggg cattttatct gcttgctgtg accagcgtgt
     2281 gtacacataa accttaacaa gactacaagt atattccaga aggaaatcat tttagttatg
     2341 aactaaataa taaaaattag aacttcaaat gcgatggtct tgactattag accagattta
     2401 gtagctccat atctaagatt tttctacctg cccctcttca gtacagggat ggctggctgc
     2461 tcaacacact cctcctcccc ttttttcctt tctttaagct gtgtacagtg aaaattgtct
     2521 ttactgtatt tttgttctct ggtaatgtaa taagcatgat ggtgccttct attaatacat
     2581 cattccagtc ttgctggtaa ttttgtacag tatagtgtat gaattgctgt gctgcaaagc
     2641 caaacagctg caaaatgttg aaaaatcatc gaaatgtata aaaattgcag tatctttaaa
     2701 atcagtaaaa tggactagca tattatttat cttgttcttc agttaacaac tttgtgttct
     2761 ctgtgggagg gagggagtcc tgtgtgtttg tggggagagg gaaggaggaa gtcagttatt
     2821 tgagtaagcc tctagttgac ttttctctta gcctgaatgt ggacgttgaa acatatcact
     2881 tcagggcttg gaaaagtcag tcaacttgac gtacattttt agtgacattt taaaagcagt
     2941 cagattctat aaatggcaag taagcctgaa gtgaggatac tgcaattttc ggagaaaaga
     3001 acagcagctc tttaagtgtt tgcattttct atttgggggg cagggaactg tcattcattt
     3061 tgcacaattc ttgaactgat gtcagcaccc gagtggctcc tgaatttaag tctgggacga
     3121 catcttttat ttttacatga atctttaaac aattctgtga gcaaagtttg tagctgctgg
     3181 attattgtct gtctttatag caagttccag taaaccacaa gtatggcaaa gcttatccaa
     3241 ttttatgctt ggagcagtca gtacatacca gtttctgatg tttcaggcag gagtggggta
     3301 aataagtgtg accacttaaa gctgctcgtt agcatggaag acttctccat tctatctttg
     3361 taaaacagac aagatatgca cttgacatag tagcaaattg gttctgaatt atgcaactgt
     3421 ttgctattta gtaaactagc aaatgatgca tgtattttgt ttttcatgta ctgggcaata
     3481 tgagtaaaat ctgtcccttt ttcccccttt gaatgaggtc ttccatgttt gagggaaagt
     3541 cttgcactat tgcatatatt ttggggacac agattttcat agtttccatt tttggggggc
     3601 ttaaggattt tttttttttc tgtttgaaac agttttatac tttctgatat agtacttgaa
     3661 attcttacca gaaaattact ttggagtttt gaagccttta ttaatactac ttttaaagaa
     3721 gcagttgttt tattgtcaat gttttttttc ccccaagcat attttcttgt atttctgttt
     3781 ccatatatat atatatatat ataatttcca attcaggata ttgccctgcc atccatgaaa
     3841 actgttctgg caccaaaagt aatgacaaat gttaagtgta ataatagaaa agtagagcaa
     3901 agagccattc agcttcagtc tttacatacc atgaataaaa cattaaaaca tcatatggag
     3961 aagtttacat ggtgattgtt cacctgcagt actgtggagt tttaacattt tgtcctcttt
     4021 tcagtgaaac agagtaaaaa tattcatcta ccattactgt tatttgctga ttttgtttta
     4081 ttttttgatg gtaatattct atccttatga cactattgca accaaattgg ctttaccatc
     4141 ttggctttag taggtataga agacaatgga ttaccatctt tattgctgta atgtgttaag
     4201 cattatatgc tagtagaatc tagtttaatt gtttcaggtg gaaagtattc tttgagtttc
     4261 catattgaat gtgtttggac taaacaaaca ataaactact gatgtctgca gca
//
