LOCUS       NM_017769               5770 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens G2/M-phase specific E3 ubiquitin protein ligase
            (G2E3), transcript variant 1, mRNA.
ACCESSION   NM_017769
VERSION     NM_017769.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5770)
  AUTHORS   Shen,Y., Xue,J., Yu,J., Jiang,Y., Bu,J., Zhu,T., Gu,X. and Zhu,X.
  TITLE     Comprehensive analysis of the expression, prognostic significance,
            and regulation pathway of G2E3 in breast cancer
  JOURNAL   World J Surg Oncol 20 (1), 398 (2022)
   PUBMED   36517818
  REMARK    GeneRIF: Comprehensive analysis of the expression, prognostic
            significance, and regulation pathway of G2E3 in breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5770)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5770)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 5770)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 5770)
  AUTHORS   Schmidt,F., Kunze,M., Loock,A.C. and Dobbelstein,M.
  TITLE     Screening analysis of ubiquitin ligases reveals G2E3 as a potential
            target for chemosensitizing cancer cells
  JOURNAL   Oncotarget 6 (2), 617-632 (2015)
   PUBMED   25593194
  REMARK    GeneRIF: Results suggest that G2E3 is a molecular determinant of
            the DDR and cell survival.
REFERENCE   6  (bases 1 to 5770)
  AUTHORS   Brooks,W.S., Helton,E.S., Banerjee,S., Venable,M., Johnson,L.,
            Schoeb,T.R., Kesterson,R.A. and Crawford,D.F.
  TITLE     G2E3 is a dual function ubiquitin ligase required for early
            embryonic development
  JOURNAL   J Biol Chem 283 (32), 22304-22315 (2008)
   PUBMED   18511420
REFERENCE   7  (bases 1 to 5770)
  AUTHORS   Brooks,W.S., Banerjee,S. and Crawford,D.F.
  TITLE     G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage
            responsive localization
  JOURNAL   Exp Cell Res 313 (4), 665-676 (2007)
   PUBMED   17239372
  REMARK    GeneRIF: Cell cycle phase-specific expression and highly regulated
            subcellular localization of G2E3 suggest a possible role in cell
            cycle regulation and the cellular response to DNA damage.
REFERENCE   8  (bases 1 to 5770)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   9  (bases 1 to 5770)
  AUTHORS   Crawford,D.F. and Piwnica-Worms,H.
  TITLE     The G(2) DNA damage checkpoint delays expression of genes encoding
            mitotic regulators
  JOURNAL   J Biol Chem 276 (40), 37166-37177 (2001)
   PUBMED   11483598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA491192.1, AB037754.1, AI432917.1 and BM993069.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017769.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000340.1, SRR1660805.82939.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000206595.11/ ENSP00000206595.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA491192.1         36-48
            14-2972             AB037754.1         1-2959
            2973-5341           AB037754.1         2961-5329
            5342-5351           AI432917.1         191-200             c
            5352-5546           AB037754.1         5340-5534
            5547-5770           BM993069.1         14-237              c
FEATURES             Location/Qualifiers
     source          1..5770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..5770
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /note="G2/M-phase specific E3 ubiquitin protein ligase"
                     /db_xref="GeneID:55632"
                     /db_xref="HGNC:HGNC:20338"
                     /db_xref="MIM:611299"
     exon            1..115
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            116..156
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2240
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /EC_number="2.3.2.26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     G2/M-phase specific E3 ubiquitin ligase; PHD finger
                     protein 7B; G2/M phase-specific HECT-type E3 ubiquitin
                     transferase"
                     /codon_start=1
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase
                     isoform 1"
                     /protein_id="NP_060239.2"
                     /db_xref="CCDS:CCDS9638.1"
                     /db_xref="GeneID:55632"
                     /db_xref="HGNC:HGNC:20338"
                     /db_xref="MIM:611299"
                     /translation="MNESKPGDSQNLACVFCRKHDDCPNKYGEKKTKEKWNLTVHYYC
                     LLMSSGIWQRGKEEEGVYGFLIEDIRKEVNRASKLKCCVCKKNGASIGCVAPRCKRSY
                     HFPCGLQRECIFQFTGNFASFCWDHRPVQIITSNNYRESLPCTICLEFIEPIPSYNIL
                     RSPCCKNAWFHRDCLQVQAINAGVFFFRCTICNNSDIFQKEMLRMGIHIPEKDASWEL
                     EENAYQELLQHYERCDVRRCRCKEGRDYNAPDSKWEIKRCQCCGSSGTHLACSSLRSW
                     EQNWECLECRGIIYNSGEFQKAKKHVLPNSNNVGITDCLLEESSPKLPRQSPGSQSKD
                     LLRQGSKFRRNVSTLLIELGFQIKKKTKRLYINKANIWNSALDAFRNRNFNPSYAIEV
                     AYVIENDNFGSEHPGSKQEFLSLLMQHLENSSLFEGSLSKNLSLNSQALKENLYYEAG
                     KMLAISLVHGGPSPGFFSKTLFNCLVYGPENTQPILDDVSDFDVAQIIIRINTATTVA
                     DLKSIINECYNYLELIGCLRLITTLSDKYMLVKDILGYHVIQRVHTPFESFKQGLKTL
                     GVLEKIQAYPEAFCSILCHKPESLSAKILSELFTVHTLPDVKALGFWNSYLQAVEDGK
                     STTTMEDILIFATGCSSIPPAGFKPTPSIECLHVDFPVGNKCNNCLAIPITNTYKEFQ
                     ENMDFTIRNTLRLEKEESSHYIGH"
     exon            157..254
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            255..356
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            357..481
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            482..647
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            648..754
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            755..871
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            872..996
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1129
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1437
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1619
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1792
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1983
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..5770
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2489..2494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /note="hexamer: TATAAA"
     polyA_site      2505
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /note="major polyA site"
     regulatory      3918..3923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /note="hexamer: ATTAAA"
     polyA_site      3940
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /note="major polyA site"
     regulatory      4913..4918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /note="hexamer: AGTAAA"
     polyA_site      4938
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
     regulatory      5195..5200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /note="hexamer: ATTAAA"
     polyA_site      5227
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
     regulatory      5516..5521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /note="hexamer: AATAAA"
     regulatory      5520..5525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /note="hexamer: AATAAA"
     polyA_site      5538
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
     polyA_site      5549
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
     regulatory      5749..5754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /note="hexamer: AATAAA"
     polyA_site      5770
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
ORIGIN      
        1 gaatttgaat cctgtgggcc gttgaatgtg gctgctcgcg gtcggcgtgc cccgacgtac
       61 agcgggccgg gaaaagtggc actgaggctc tggaacttct gcccagctct ccttgtaaaa
      121 tgaatgaaag taaacctggt gactcacaga accttgcttg tgttttctgt cgaaaacatg
      181 atgactgtcc taataaatac ggagaaaaga aaactaagga gaaatggaat ctcactgtac
      241 attactactg tttgttgatg tcaagtggaa tttggcagag aggcaaagaa gaagaaggag
      301 tttatggttt tctaatagaa gatatcagga aggaagtgaa tagagcttct aaactgaaat
      361 gctgtgtttg caagaaaaat ggtgcttcaa ttggatgtgt tgcaccccga tgtaaacgaa
      421 gttatcattt cccatgtgga cttcagagag aatgtatttt ccagtttact ggcaattttg
      481 cgtcattttg ttgggaccat cgacctgttc aaataattac atctaataat tatagagagt
      541 ccttaccatg caccatttgc ttggaattta ttgagcctat tccaagttat aacatattac
      601 gaagtccttg ttgtaagaac gcttggtttc atagagactg tttacaggtt caagcaataa
      661 atgcgggagt gtttttcttt aggtgtacaa tatgcaataa tagtgacatc tttcagaaag
      721 agatgttgag aatgggaatt catattcctg aaaaagatgc ttcctgggaa ttagaggaaa
      781 acgcttatca agagcttctg cagcactatg agcgttgtga tgttcgaaga tgtcgttgca
      841 aagaagggcg agactataat gcacctgata gcaaatggga aataaagcgc tgtcagtgtt
      901 gtggttccag tggcacacat ttagcctgct cctcattacg gtcatgggag caaaattggg
      961 agtgtttgga atgtaggggt attatctaca attcaggaga gttccaaaaa gccaaaaaac
     1021 atgtattacc caattctaat aatgtgggga ttacagattg tttgttggaa gagtcatcac
     1081 ctaaattacc cagacagtca cctggatccc agagtaaaga tctactgagg caaggcagca
     1141 aatttagaag aaatgtatca acactattaa tagagttagg attccaaatt aaaaaaaaaa
     1201 ctaaaagatt gtatatcaac aaagccaata tctggaatag tgccttagat gcattcagaa
     1261 atcgaaactt taatccttca tatgcaattg aagtagcata tgttattgaa aatgataatt
     1321 ttggaagtga gcatcctgga tcaaagcaag aatttctgag tctcttaatg caacatcttg
     1381 agaactcatc attgtttgaa gggtccttgt caaagaactt gtctctaaat tctcaagctc
     1441 tgaaagagaa tctttactat gaagctggca aaatgcttgc catttcttta gttcacggtg
     1501 gtccttcacc tggtttcttt tctaaaacct tgtttaactg ccttgtttat ggaccagaaa
     1561 atacccagcc aattttagat gatgtttcag actttgatgt ggcacagatt ataatcagga
     1621 taaatactgc aacaactgta gctgacttaa agtcaataat aaatgaatgc tataactacc
     1681 ttgagttaat tggatgtctc agacttataa cgacattaag tgataaatat atgttagtaa
     1741 aagacatact tggctaccat gtaattcaga gagtccacac accctttgaa agttttaagc
     1801 agggtctgaa aacccttggt gttttggaga aaattcaggc ttatccagaa gcattttgta
     1861 gcatcctgtg tcataaacct gagagtcttt ctgcaaaaat ccttagtgag ctttttacag
     1921 tacacacatt acctgatgtg aaagctttgg ggttttggaa cagttactta caggctgttg
     1981 aagatggtaa atctacaaca acaatggaag acattcttat ttttgcaact ggttgcagtt
     2041 ccattcctcc agctggattt aaacccactc cttcaattga gtgtctgcat gtggattttc
     2101 ctgttggaaa caagtgtaat aactgtttag caattcccat caccaataca tataaagagt
     2161 ttcaagaaaa tatggacttc accataagaa acactctaag actagaaaag gaagaaagtt
     2221 ctcattacat tggacattaa aatgtttcct tgaacaaaga gaagcttctt taaaagctgc
     2281 tattgataac tctcttttat ttcactaacc ttttcatcat cactttgaac aaactagtta
     2341 gcttcttgac ctaataaaat ttatgatatg aatataaagg aatattatag ccacttaggc
     2401 taaaaaaagg ttttttttgt taaagcatac tagtcaaaat tggtgataat ttctcatttt
     2461 cttgatatag atacttcata aacctcaata taaatactct caaaatggtt gtatggattt
     2521 tatttaggta tggtagcatg gttaataaaa gtaaaaactg ttttactcac attttttgta
     2581 aattaggatt acatatagaa tgccacaatt tctctaggtt tattcaattt tcaaattatt
     2641 cctcatttta ttttaaagca ttaaatagaa aagctaattg gttaaatttt gttatataaa
     2701 tcagagtcat atattctggg atttgtgtta ctatgcatac ttttctagga tgtcaccaaa
     2761 ttagttgttt aaaatgtttt tagattactg atttatatta agatgaccca cactgcaatt
     2821 agattatgcc tagtgggaag tattatataa aaagcagaat taagctgggc acatgtgctt
     2881 gtaatctcag ttataaggga ggctgaggtg ggagaatcga gatactcagc cagcctggca
     2941 atgtagcaaa gactccatct caaaaaaaaa aacagaattg cacaaatttt ctggaatcta
     3001 tggacattcc atgagcttaa acacttttga ggtggataac atttagttga aaatacctaa
     3061 gaaagtgtgt cttctttaaa gccttggctt taatcatggg aaattgttgt tgttgttgtt
     3121 gttgtttgta tcctatgttt ggtattctgt atgtctgatc cataatcatt ttagatattt
     3181 gaatgatctc tgtggattgg taggtttggc catttgacca ttatttatta tcaagttggt
     3241 tgtatgctaa ggtaagttga cgccatagca ttatacagtt atcttcattg ctcttgaatg
     3301 atatctgtta tataagcaat gtataaataa agtaaaaagg atagaatgaa aaacccattc
     3361 taatgtcacc actcagagat aagtaccgta tttctgtgta tccttctata aactctttac
     3421 ttctgtttcc tttatttttt aactttaata atgctactaa aagacaatac ctaaaagtaa
     3481 ctgtactaac aaagtgctaa caatgtgaaa atatatagtc ccatagtcat gtccccatat
     3541 ttatactccc acagaagaaa aaattggaaa acaaagtctg atgtccttaa tctattaaca
     3601 tatttaaatg atataatggt tcagttttcc atgaaagtaa atcattatgg gaagtaaaat
     3661 gttttaacca tatttttctt aatacacaaa gcaggtgtca gctgttgtat tctcaccctt
     3721 cttaagaaaa atcattacat tattgatatt ttttaagtaa cagaatagat ttgaaagaga
     3781 taatatatct cttaatacca aaggaaaact aaaacataat tctagtgtac ttttctttgt
     3841 tccctcatgt ctttttcaat ctgtacacta acatacctag caaatttgtt ttactttaac
     3901 ttgaaatatt taagaacatt aaacaagaca tttctttggc tttggttgaa tttttttgtc
     3961 tcaccaatag taattgaaag atcaattatc aaagagtttg aatagctaat ataaacccca
     4021 aagtcaccat acagttttta ttccaaatat gttgataaaa agatatttgt ttctttatcc
     4081 accttatttt tattacagct aaaaaccaat acaaaccaat aaaacctagt taaagctatt
     4141 ttctggtttt tagttgcaat taatttcccc tagggtagaa attaaagctg attaagtcac
     4201 acacacatac tttgttgggg tgggggtggc aggtggagag gcagtgtact tgggttagct
     4261 acaattaaaa acagtatttc aattcctcat ttgacttatt ttatatatag acagggcctt
     4321 agtgataaga tggtgtaaat aatttaggat attcatgttt taaagtgaag cataaatatt
     4381 tattttgcaa aatgttttct agtttgaagg atgttccatt attaccattt ttagattaat
     4441 ctgtatggtc aaggaatatc agagaaacct gtaggttatt tattttctgc agtgtcattt
     4501 tgtcaaatgg ttggtattat aattgttctt ttcttattaa ttttataacc agtgcataat
     4561 tcttacatta gattttaaaa aagaattatg ctataaatct ttataaatgt gtacatatat
     4621 ttcttaaata ttgcaattgc ctaaatgttg tatattttaa ggctgttttc tcttgctctt
     4681 aatgttgagg aaaactataa attgatctat aatgcatcta ctgttaatgg ttttggttag
     4741 tttgatattc attgttttta aacactttcc aatatggaaa ctttaacacc ttttatacaa
     4801 ttctctacta ttcaagatat tctttaaaat atctcaccag aaacttacaa ttttatactt
     4861 tgtaattttt agtttctgta atttgaggaa gtgacttttt ttgtttgggt taagtaaaaa
     4921 gcctttgatt gattaccagc atgagaattc accttggttt ctattttatg catttgtaaa
     4981 tttttcccct aattatatgg aagctattgg aacttttgta ttcagtgcta aatactaagt
     5041 caaggggagt atattaggta agttttttca gtgactgtgc ctttagcatt cagtcattat
     5101 aagaaaatga tcagaacaaa atcattacat tataaacatg taattctttt atatagtgat
     5161 tatcatgtac tgcattgtta ctttaaaata agctattaaa ctagttttta tggttcaagt
     5221 aatgcaatac aaagtttcat gcttcaagta atgcaataca aaacataacc catttaatga
     5281 tgaattactt gaatgtatat tatctgtggt ttaggaaaat ttggattgtc ttgaagagac
     5341 tcagttttca agttctgatt ttgaccatta tctcttctaa ttcataaaca tatcccagta
     5401 cctacactat gccaggtatt atgctaggtg atcgtttata tgtcagccta tttccccccc
     5461 ttttaaagac tgccagatta accaaaaagc gtgacattta taacaatgtt ttataaataa
     5521 ataaatgtgt ttatgccact aaaggtaaac tgcctattta aactaagtaa ttttttggga
     5581 tttaataaga ttaagattct gacgaaactg aaagatacaa gattccttta ctctccacat
     5641 ttgagagatc ctataagcaa gcagttagtg tctgacaccc aggaacctat agaaatgagg
     5701 gaatctgtgt taaaactatg tatcctctaa tgtaaaatag cttaccagaa taaattattt
     5761 aagccaaaaa
//
