LOCUS       NM_015714                876 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G0/G1 switch 2 (G0S2), mRNA.
ACCESSION   NM_015714
VERSION     NM_015714.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 876)
  AUTHORS   Rong,B., Chen,X., Xie,G., Han,L., Chen,H., Sun,Q. and Zhou,Y.
  TITLE     Gastric Cancer Growth Modulated by circSNTB2/miR-6938-5p/G0S2 and
            PDCD4
  JOURNAL   Comb Chem High Throughput Screen 26 (11), 1990-2002 (2023)
   PUBMED   36366842
  REMARK    GeneRIF: Gastric Cancer Growth Modulated by
            circSNTB2/miR-6938-5p/G0S2 and PDCD4.
REFERENCE   2  (bases 1 to 876)
  AUTHORS   Gonzalez,M.A., Olivas,I.M., Bencomo-Alvarez,A.E., Rubio,A.J.,
            Barreto-Vargas,C., Lopez,J.L., Dang,S.K., Solecki,J.P., McCall,E.,
            Astudillo,G., Velazquez,V.V., Schenkel,K., Reffell,K., Perkins,M.,
            Nguyen,N., Apaflo,J.N., Alvidrez,E., Young,J.E., Lara,J.J., Yan,D.,
            Senina,A., Ahmann,J., Varley,K.E., Mason,C.C., Eide,C.A.,
            Druker,B.J., Nurunnabi,M., Padilla,O., Bajpeyi,S. and Eiring,A.M.
  TITLE     Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and
            drug resistance in chronic myeloid leukaemia (CML) by disrupting
            glycerophospholipid metabolism
  JOURNAL   Clin Transl Med 12 (12), e1146 (2022)
   PUBMED   36536477
  REMARK    GeneRIF: Loss of G0/G1 switch gene 2 (G0S2) promotes disease
            progression and drug resistance in chronic myeloid leukaemia (CML)
            by disrupting glycerophospholipid metabolism.
REFERENCE   3  (bases 1 to 876)
  AUTHORS   Wang,X., Meng,H., Ruan,J., Chen,W. and Meng,F.
  TITLE     Low G0S2 gene expression levels in peripheral blood may be a
            genetic marker of acute myocardial infarction in patients with
            stable coronary atherosclerotic disease: A retrospective clinical
            study
  JOURNAL   Medicine (Baltimore) 100 (3), e23468 (2021)
   PUBMED   33545927
  REMARK    GeneRIF: Low G0S2 gene expression levels in peripheral blood may be
            a genetic marker of acute myocardial infarction in patients with
            stable coronary atherosclerotic disease: A retrospective clinical
            study.
REFERENCE   4  (bases 1 to 876)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 876)
  AUTHORS   Logue,M.W., Miller,M.W., Wolf,E.J., Huber,B.R., Morrison,F.G.,
            Zhou,Z., Zheng,Y., Smith,A.K., Daskalakis,N.P.,
            Ratanatharathorn,A., Uddin,M., Nievergelt,C.M., Ashley-Koch,A.E.,
            Baker,D.G., Beckham,J.C., Garrett,M.E., Boks,M.P., Geuze,E.,
            Grant,G.A., Hauser,M.A., Kessler,R.C., Kimbrel,N.A., Maihofer,A.X.,
            Marx,C.E., Qin,X.J., Risbrough,V.B., Rutten,B.P.F., Stein,M.B.,
            Ursano,R.J., Vermetten,E., Vinkers,C.H., Ware,E.B., Stone,A.,
            Schichman,S.A., McGlinchey,R.E., Milberg,W.P., Hayes,J.P. and
            Verfaellie,M.
  CONSRTM   Traumatic Stress Brain Study Group
  TITLE     An epigenome-wide association study of posttraumatic stress
            disorder in US veterans implicates several new DNA methylation loci
  JOURNAL   Clin Epigenetics 12 (1), 46 (2020)
   PUBMED   32171335
  REMARK    GeneRIF: An epigenome-wide association study of posttraumatic
            stress disorder in US veterans implicates several new DNA
            methylation loci.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 876)
  AUTHORS   Zandbergen,F., Mandard,S., Escher,P., Tan,N.S., Patsouris,D.,
            Jatkoe,T., Rojas-Caro,S., Madore,S., Wahli,W., Tafuri,S., Muller,M.
            and Kersten,S.
  TITLE     The G0/G1 switch gene 2 is a novel PPAR target gene
  JOURNAL   Biochem J 392 (Pt 2), 313-324 (2005)
   PUBMED   16086669
  REMARK    GeneRIF: A novel putative target gene of PPARalpha, G0S2 (G0/G1
            switch gene 2) was identified and characterized.
REFERENCE   7  (bases 1 to 876)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 876)
  AUTHORS   Schutte,B.C., Bjork,B.C., Coppage,K.B., Malik,M.I., Gregory,S.G.,
            Scott,D.J., Brentzell,L.M., Watanabe,Y., Dixon,M.J. and Murray,J.C.
  TITLE     A preliminary gene map for the Van der Woude syndrome critical
            region derived from 900 kb of genomic sequence at 1q32-q41
  JOURNAL   Genome Res 10 (1), 81-94 (2000)
   PUBMED   10645953
REFERENCE   9  (bases 1 to 876)
  AUTHORS   Cristillo,A.D., Heximer,S.P., Russell,L. and Forsdyke,D.R.
  TITLE     Cyclosporin A inhibits early mRNA expression of G0/G1 switch gene 2
            (G0S2) in cultured human blood mononuclear cells
  JOURNAL   DNA Cell Biol 16 (12), 1449-1458 (1997)
   PUBMED   9428793
REFERENCE   10 (bases 1 to 876)
  AUTHORS   Russell,L. and Forsdyke,D.R.
  TITLE     A human putative lymphocyte G0/G1 switch gene containing a CpG-rich
            island encodes a small basic protein with the potential to be
            phosphorylated
  JOURNAL   DNA Cell Biol 10 (8), 581-591 (1991)
   PUBMED   1930693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM788126.1 and AV709160.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015714.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.34592.1,
                                           SRR5189664.41709.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367029.5/ ENSP00000355996.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               BM788126.1         89-600
            513-876             AV709160.1         15-378
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..876
                     /gene="G0S2"
                     /note="G0/G1 switch 2"
                     /db_xref="GeneID:50486"
                     /db_xref="HGNC:HGNC:30229"
                     /db_xref="MIM:614447"
     exon            1..138
                     /gene="G0S2"
                     /inference="alignment:Splign:2.1.0"
     exon            139..876
                     /gene="G0S2"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..482
                     /gene="G0S2"
                     /note="G0/G1 switch regulatory protein 2; G0/G1switch 2"
                     /codon_start=1
                     /product="G0/G1 switch protein 2"
                     /protein_id="NP_056529.1"
                     /db_xref="CCDS:CCDS1488.1"
                     /db_xref="GeneID:50486"
                     /db_xref="HGNC:HGNC:30229"
                     /db_xref="MIM:614447"
                     /translation="METVQELIPLAKEMMAQKRKGKMVKLYVLGSVLALFGVVLGLME
                     TVCSPFTAARRLRDQEAAVAELQAALERQALQKQALQEKGKQQDTVLGGRALSNRQHA
                     S"
     regulatory      853..858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G0S2"
                     /note="hexamer: AATAAA"
     polyA_site      876
                     /gene="G0S2"
                     /note="major polyA site"
ORIGIN      
        1 tgccagcggc ggagtctcca actgggagag ctgcagctgc cgagaggagg agaacgctga
       61 ggtcggtcgg accaacggac gcgctgaccg ctgccaactg cagctcgcgc tgcctcctgc
      121 tcgcgccgtg ccactaaggt cattcccgcc tccgagagcc cagagccgag atggaaacgg
      181 tccaggagct gatccccctg gccaaggaga tgatggccca gaagcgcaag gggaagatgg
      241 tgaagctgta cgtgctgggc agcgtgctgg ccctcttcgg cgtggtgctc ggcctgatgg
      301 agactgtgtg cagccccttc acggccgcca gacgtctgcg ggaccaggag gcagccgtgg
      361 cggagctgca ggccgccctg gagcgacagg ctctccagaa gcaagccctg caggagaaag
      421 gcaagcagca ggacacggtc ctcggcggcc gggccctgtc caaccggcag cacgcctcct
      481 aggaactgtg ggagaccagc ggagtgggag ggagacgcag tagacagaga cagaccgaga
      541 gaggaatgga gagacagagg gggcgcgcgc acaggagcct gactccgctg ggagagtgca
      601 ggagcacgtg ctgtttttta tttggactta acttcagaga aaccgctgac atctagaact
      661 gacctaccac aagcatccac caaaggagtt tgggattgag ttttgctgct gtgcagcact
      721 gcattgtcat gacatttcca acactgtgtg aattatctaa atgcgtctac cattttgcac
      781 tagggaggaa ggataaatgc tttttatgtt attattatta attattacaa tgaccaccat
      841 tttgcatttt gaaataaaaa aactttttat accata
//
