LOCUS       NM_016263               5178 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens fizzy and cell division cycle 20 related 1 (FZR1),
            transcript variant 2, mRNA.
ACCESSION   NM_016263
VERSION     NM_016263.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5178)
  AUTHORS   Peng,Y., Zhang,Y., Fang,R., Jiang,H., Lan,G., Xu,Z., Liu,Y.,
            Nie,Z., Ren,L., Wang,F., Zhang,S.D., Ma,Y., Yang,P., Ge,H.H.,
            Zhang,W.D., Luo,C., Li,A. and He,W.
  TITLE     Target Identification and Mechanistic Characterization of Indole
            Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential
            for Cdh1-Mediated Proteolysis of CENP-A
  JOURNAL   Adv Sci (Weinh) 11 (29), e2305593 (2024)
   PUBMED   38873820
  REMARK    GeneRIF: Target Identification and Mechanistic Characterization of
            Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is
            Essential for Cdh1-Mediated Proteolysis of CENP-A.
REFERENCE   2  (bases 1 to 5178)
  AUTHORS   Su,J., Li,R., Chen,Z., Liu,S., Zhao,H., Deng,S., Zeng,L., Xu,Z.,
            Zhao,S., Zhou,Y., Li,M., He,X., Liu,J., Xue,C., Bai,R., Zhuang,L.,
            Zhou,Q., Zhang,S., Chen,R., Huang,X., Lin,D., Zheng,J. and Zhang,J.
  TITLE     N 6-methyladenosine Modification of FZR1 mRNA Promotes Gemcitabine
            Resistance in Pancreatic Cancer
  JOURNAL   Cancer Res 83 (18), 3059-3076 (2023)
   PUBMED   37326469
  REMARK    GeneRIF: N 6-methyladenosine Modification of FZR1 mRNA Promotes
            Gemcitabine Resistance in Pancreatic Cancer.
REFERENCE   3  (bases 1 to 5178)
  AUTHORS   Awadia,S., Sitto,M., Ram,S., Ji,W., Liu,Y., Damani,R., Ray,D.,
            Lawrence,T.S., Galban,C.J., Cappell,S.D. and Rehemtulla,A.
  TITLE     The adapter protein FADD provides an alternate pathway for entry
            into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase
            activity
  JOURNAL   J Biol Chem 299 (6), 104786 (2023)
   PUBMED   37146968
  REMARK    GeneRIF: The adapter protein FADD provides an alternate pathway for
            entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin
            ligase activity.
REFERENCE   4  (bases 1 to 5178)
  AUTHORS   Zhang,S., You,X., Zheng,Y., Shen,Y., Xiong,X. and Sun,Y.
  TITLE     The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor
            cascade in lung cancer cells
  JOURNAL   J Clin Invest 133 (4), e162434 (2023)
   PUBMED   36548081
  REMARK    GeneRIF: The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor
            suppressor cascade in lung cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5178)
  AUTHORS   Bhattacharjee,D., Kaveti,S. and Jain,N.
  TITLE     APC/C CDH1 ubiquitinates STAT3 in mitosis
  JOURNAL   Int J Biochem Cell Biol 154, 106333 (2023)
   PUBMED   36400381
  REMARK    GeneRIF: APC/C CDH1 ubiquitinates STAT3 in mitosis.
REFERENCE   6  (bases 1 to 5178)
  AUTHORS   Kramer,E.R., Scheuringer,N., Podtelejnikov,A.V., Mann,M. and
            Peters,J.M.
  TITLE     Mitotic regulation of the APC activator proteins CDC20 and CDH1
  JOURNAL   Mol Biol Cell 11 (5), 1555-1569 (2000)
   PUBMED   10793135
REFERENCE   7  (bases 1 to 5178)
  AUTHORS   Lukas,C., Sorensen,C.S., Kramer,E., Santoni-Rugiu,E., Lindeneg,C.,
            Peters,J.M., Bartek,J. and Lukas,J.
  TITLE     Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
            rearrangement of the anaphase-promoting complex
  JOURNAL   Nature 401 (6755), 815-818 (1999)
   PUBMED   10548110
REFERENCE   8  (bases 1 to 5178)
  AUTHORS   Gieffers,C., Peters,B.H., Kramer,E.R., Dotti,C.G. and Peters,J.M.
  TITLE     Expression of the CDH1-associated form of the anaphase-promoting
            complex in postmitotic neurons
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11317-11322 (1999)
   PUBMED   10500174
REFERENCE   9  (bases 1 to 5178)
  AUTHORS   Kramer,E.R., Gieffers,C., Holzl,G., Hengstschlager,M. and
            Peters,J.M.
  TITLE     Activation of the human anaphase-promoting complex by proteins of
            the CDC20/Fizzy family
  JOURNAL   Curr Biol 8 (22), 1207-1210 (1998)
   PUBMED   9811605
REFERENCE   10 (bases 1 to 5178)
  AUTHORS   Fang,G., Yu,H. and Kirschner,M.W.
  TITLE     Direct binding of CDC20 protein family members activates the
            anaphase-promoting complex in mitosis and G1
  JOURNAL   Mol Cell 2 (2), 163-171 (1998)
   PUBMED   9734353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB462260.1, BC013413.2, AF083810.1, BC111760.1 and AC005787.1.
            
            On Jun 2, 2019 this sequence version replaced NM_016263.3.
            
            Transcript Variant: This variant (2) lacks a short in-frame segment
            in the 3' coding region compared to variant 1. The encoded protein
            (isoform 2) has a shorter C-terminus compared to isoform 1. This
            isoform is also known as isoform alpha.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF083810.1, SRR7410570.648852.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000441788.7/ ENSP00000410369.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DB462260.1         15-23
            10-1850             BC013413.2         1-1841
            1851-3038           AF083810.1         1792-2979
            3039-3601           BC111760.1         1356-1918
            3602-5178           AC005787.1         40073-41649
FEATURES             Location/Qualifiers
     source          1..5178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..5178
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /note="fizzy and cell division cycle 20 related 1"
                     /db_xref="GeneID:51343"
                     /db_xref="HGNC:HGNC:24824"
                     /db_xref="MIM:603619"
     exon            1..164
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            165..267
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1680
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /note="isoform 2 is encoded by transcript variant 2; CDC20
                     homolog 1; fizzy-related protein homolog; CDC20-like 1b;
                     cdh1/Hct1 homolog; CDC20-like protein 1; fizzy/cell
                     division cycle 20 related 1"
                     /codon_start=1
                     /product="fizzy-related protein homolog isoform 2"
                     /protein_id="NP_057347.2"
                     /db_xref="CCDS:CCDS12109.1"
                     /db_xref="GeneID:51343"
                     /db_xref="HGNC:HGNC:24824"
                     /db_xref="MIM:603619"
                     /translation="MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKH
                     GDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGA
                     GIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKL
                     LRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQ
                     VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGA
                     LAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGND
                     NKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQP
                     LQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLA
                     MSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR"
     exon            268..393
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..457
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..585
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..668
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..852
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..918
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1021
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1206
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1440
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1545
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1638
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..5178
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3038
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /note="major polyA site"
     regulatory      3577..3582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /note="hexamer: ATTAAA"
     polyA_site      3600
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
     regulatory      5152..5157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
                     /note="hexamer: AATACA"
     polyA_site      5178
                     /gene="FZR1"
                     /gene_synonym="CDC20C; CDH1; DEE109; FZR; FZR2; HCDH;
                     HCDH1"
ORIGIN      
        1 agcggaggag cgaccgccgc catattaggg accgcggagc ccgggatccc gtcagcggcg
       61 gccgcggccg ggcctgcggg agctgcggag gccggaggcg ggcgctgtgc ggtgccagga
      121 gaggcggggt cggcgggagc cagcgagcca cgggagcgag ccaggctaac cttgccgcgg
      181 gccgagccct gcctcgccat ggaccaggac tatgagcggc gcctgcttcg ccagatcgtc
      241 atccagaatg agaacacgat gccacgcgtc acagagatgc ggcggaccct gacgcctgcc
      301 agctccccag tgtcctcgcc cagcaagcac ggagaccgct tcatcccctc cagagccgga
      361 gccaactgga gcgtgaactt ccacaggatt aacgagaatg agaagtctcc cagtcagaac
      421 cggaaagcca aggacgccac ctcagacaac ggcaaagacg gcctggccta ctctgccctg
      481 ctcaagaatg agctgctggg tgccggcatc gagaaggtgc aggacccgca gactgaggac
      541 cgcaggctgc agccctccac gcctgagaag aagggtctgt tcacgtattc ccttagcacc
      601 aagcgctcca gccccgatga cggcaacgat gtgtctccct actccctgtc tcccgtcagc
      661 aacaagagcc agaagctgct ccggtccccc cggaaaccca cccgcaagat ctccaagatc
      721 cccttcaagg tgctggacgc gcccgagctg caggacgact tctacctcaa tctggtggac
      781 tggtcgtccc tcaatgtgct cagcgtgggg ctaggcacct gcgtgtacct gtggagtgcc
      841 tgtaccagcc aggtgacgcg gctctgtgac ctctcagtgg aaggggactc agtgacctcc
      901 gtgggctggt ctgagcgggg gaacctggtg gcggtgggca cacacaaggg cttcgtgcag
      961 atctgggacg cagccgcagg gaagaagctg tccatgttgg agggccacac ggcacgcgtc
     1021 ggggcgctgg cctggaatgc tgagcagctg tcgtccggga gccgcgaccg catgatcctg
     1081 cagagggaca tccgcacccc gccactgcag tcggagcggc ggctgcaggg ccaccggcag
     1141 gaggtgtgcg ggctcaagtg gtccacagac caccagctcc tcgcctcggg gggcaacgac
     1201 aacaagctgc tggtctggaa tcactcgagc ctgagccccg tgcagcagta cacggagcac
     1261 ctggcggccg tgaaggccat cgcctggtcc ccacatcagc acgggctgct ggcctcgggg
     1321 ggcggcacag ctgaccgctg tatccgcttc tggaacacgc tgacaggaca accactgcag
     1381 tgtatcgaca cgggctccca agtgtgcaat ctggcctggt ccaagcacgc caacgagctg
     1441 gtgagcacgc acggctactc acagaaccag atccttgtct ggaagtaccc ctccctgacc
     1501 caggtggcca agctgaccgg gcactcctac cgcgtgctgt acctggcaat gtcccctgat
     1561 ggggaggcca tcgtcactgg tgctggagac gagaccctga ggttctggaa cgtctttagc
     1621 aaaacccgtt cgacaaagga gtctgtgtct gtgctcaacc tcttcaccag gatccggtaa
     1681 acctgccggg caggaccgtg ccacaccagc tgtccagagt cggaggaccc cagctcctca
     1741 gcttgcatgg actctgcctt cccagcgctt gtcccccgag gaaggcggct gggcgggcgg
     1801 ggagctgggc ctggaggatc ctggagtctc attaaatgcc tgattgtgaa ccatgtccac
     1861 cagtatctgg ggtgggcacg tggtcgggga ccctcagcag caggggctct gtctcccttc
     1921 ccaaagggcg agaaccacat tggacggtcc cggctcagac cgtctgtact cagagcgacg
     1981 gatgccccct gggaccctca ctgcctccgt ctgttcatca cctgcccacc ggagccgcat
     2041 gctcttcctg gaactgccca cgtctgcaca gaacagacca ccagacgcca gggctgattg
     2101 gtgggggcct gagaccccgg ttgcccattc atggctgcac cccaccatgt caaacccaag
     2161 accagcccca aggccagacc aaggcatgta ggcctgggca ggtggctcgg ggccactggc
     2221 ggagccagcc tgtggatcca agagacagtc cccacctggg cttcacggca tccttgcagc
     2281 cacctctgct gtcactgctc gaagcagcag tctctctgga agcatctgtg tcatggccat
     2341 cgcccggcgg tcagtgggct tcagatgggc ctgtgcatcc tggccaagcg tcaccctcac
     2401 actggaggag gatgtctgct ctggacttat caccccagga gaactgaacc cggacctgct
     2461 cactgccctg gctggagagg agcacaacag atgccacgtc ttcgtgcatt cgccaacacg
     2521 tgccctcaca gggccagcgt cctccttccc tgcgcaagac ttgcgtcccc catgcctgct
     2581 gggtggctgg gtcctgtgga ggccagcagc ggtgtggccc ccgcccccag gctgcctgtg
     2641 tcttcacctg tcctgtccac cagcgccaac agccgtgggg aagccaagga gacccaaggg
     2701 gtccaggagg tgggcgccct ccatccttcg agaagcttcc caggctcctc tgcttctctg
     2761 tctcatgctc ccaggctgca cagcaggcag ggagggaggc aaggcagggg agtggggcct
     2821 gagctgagca ctgccccctc acccccccac caccccttcc catttcatcg gtggggacgt
     2881 ggagagggtg gggcgggctg gggttggagg gtcccaccca ccaccctgct gtgcttggga
     2941 acccccactc cccactcccc acatcccaac atcctggtgt ctgtccccag tggggttggc
     3001 gtgcatgtgt acatatgtat ttgtgacttt tctttggatt tgttttgtgt ttttgttgac
     3061 tagtcctgga aatgtttgag gctagacggg gaggggccag gacccaccca ctgctcctgg
     3121 gggatgaggt cctggtttta aagccccgtc atttcaagcg ggtcgatctt ccacattcac
     3181 tggagagact ctccccacct ctgtctgggt ggggcgcgga cccctcactg tgcgcctgtg
     3241 cagggggtgc tggtgcacgt ggcagtgtgg atttccagtg gtcacggtct tactgtttca
     3301 aggtttttaa ataagaaaac caaccctgcc ttcgcccatg cccgcccctg cccgcagttg
     3361 ccaaagagcc gccttgtcgc tgtgggcgtc agggcttggc tggctcagtg cacaacccac
     3421 agtggccttc agaggctcct cctgggactg ggaaccgccg cagggccagg cggacggcgt
     3481 gaggtttgtg ttggggctgg ttctgcccat gctagggggt gggggagctc ccaggacaga
     3541 ccagccttgt ttctcatgta atgcagtgac gctgtcatta aacacgtgga ttcatgtgtg
     3601 gccgggactg gctggctcta ggtccccggc tcgggtgggg tcacacggtc ctgccctaga
     3661 gtccccatct ggccctggag ctgcagaagc agcttctgag gggcttccca ggcctgcatt
     3721 tcacagatgg ggagctcagc cctcgaaggc cgcagagacg cctcccaggc ccgtctgcca
     3781 gggcgccggc cacaatcctg cagggccaag gactggactc caggcaagtc cctgcgctcc
     3841 agctggacgg ccctgttcca gggaggaggt gctcggttga caccatcagg gagggagggt
     3901 gggcactgct gggctgagtt cacccccagg gctggccaga tggggccagg agggacagag
     3961 caaggggggt gaaggccgtg gtgggagggt cccatgatga tgggccaggg ctcgtgtaga
     4021 aatgggggaa ttggttcccc atggcccagg acagctgaga ggaggtggag gggccccagg
     4081 ggagtgtacg tcaggctttg cggggcacgg gggccactca gcagcgctgg ggcaggtgcc
     4141 tctgctgtca gctccacccg acaggcagac gaaggccagt ggggccatcg cttcctgggg
     4201 cgaccctggc agtggttggg agacgcccag atggaggggg aggctgacca agggccccgc
     4261 agggcgggct gcaacttttc tgttgatcct ggaatgtagc tggtgcagtg agagggaaag
     4321 agaattgaaa aactcaggct gccataggtt ctgcgatgag aggtgcagga ggcaggagcc
     4381 tggcccaggg ggtgctggtg cctccccggg gtctgggcgg agagaacagg aggaatggct
     4441 gggaagtggc tgagggagcc aggaggccgg ggggccgggg gctgcagggg aggctgtggg
     4501 ggtcctggca gccaggaggc cccaggtggt tttgaggctc gctcttgcgc ggtgcctgag
     4561 aagagggtga aggagctggg gcaggcccca tcctgggcat tggagatgat gaaaccgagc
     4621 agacctggcc catgtggagc tggcatgggg gacacagccc agagacagag aagcttatga
     4681 ggaagtgagg aggtggcgtc acaagggtgg ggagggggcc ttggggaagg gcggccttgg
     4741 atcagaggct caccacaagc ctggcatttc agccagggct ggagaaggca gggacgcctg
     4801 ggtgagaggc aaagggcaca gccatgcaaa ggccctgggg caggacggca cctggtatgc
     4861 gggaggaaca gagtgaggag aggagggcag ggcgtgcagg gccttgtggg cctcagggag
     4921 gacttgggca cctacgccga gggagtggag ctcctgggtg cgtgtccaga tgggaaaggc
     4981 agggtcgtat ctgtggggac ctgacaaggg caggggaagc ggagaccagg gtgcaggctc
     5041 cgcccccacc caaggccggg cccagccaga ggaggggcag ggcagggcag gaggtttctg
     5101 gatgtttgtt gggtttggtt tggttttgtt ttgttttgtt tattgtggta aaatacaaaa
     5161 tctaccgtct tacagtga
//
