LOCUS       NM_031866               4050 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens frizzled class receptor 8 (FZD8), mRNA.
ACCESSION   NM_031866
VERSION     NM_031866.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4050)
  AUTHORS   Liu,Y., Zhang,K. and Yang,X.
  TITLE     CircMCTP2 enhances the progression of bladder cancer by regulating
            the miR-99a-5p/FZD8 axis
  JOURNAL   J Egypt Natl Canc Inst 36 (1), 8 (2024)
   PUBMED   38494582
  REMARK    GeneRIF: CircMCTP2 enhances the progression of bladder cancer by
            regulating the miR-99a-5p/FZD8 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4050)
  AUTHORS   Demirci,U., Orenay-Boyacioglu,S., Kasap,E., Gerceker,E., Bilgic,F.,
            Yuceyar,H., Yildirim,H., Baykan,A.R., Ellidokuz,E.B. and Korkmaz,M.
  TITLE     Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes
            enhance gastric cancer development in the presence of Helicobacter
            pylori
  JOURNAL   Arab J Gastroenterol 24 (2), 91-97 (2023)
   PUBMED   36720664
  REMARK    GeneRIF: Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5
            genes enhance gastric cancer development in the presence of
            Helicobacter pylori.
REFERENCE   3  (bases 1 to 4050)
  AUTHORS   Wang,Y., Zheng,X., Luo,D., Xu,W. and Zhou,X.
  TITLE     MiR-99a alleviates apoptosis and extracellular matrix degradation
            in experimentally induced spine osteoarthritis by targeting FZD8
  JOURNAL   BMC Musculoskelet Disord 23 (1), 872 (2022)
   PUBMED   36127685
  REMARK    GeneRIF: MiR-99a alleviates apoptosis and extracellular matrix
            degradation in experimentally induced spine osteoarthritis by
            targeting FZD8.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4050)
  AUTHORS   Kushwaha,P., Kim,S., Foxa,G.E., Michalski,M.N., Williams,B.O.,
            Tomlinson,R.E. and Riddle,R.C.
  TITLE     Frizzled-4 is required for normal bone acquisition despite
            compensation by Frizzled-8
  JOURNAL   J Cell Physiol 235 (10), 6673-6683 (2020)
   PUBMED   31985040
  REMARK    GeneRIF: Frizzled-4 is required for normal bone acquisition despite
            compensation by Frizzled-8.
REFERENCE   5  (bases 1 to 4050)
  AUTHORS   Chen,W., Liu,Z., Mai,W., Xiao,Y., You,X. and Qin,L.
  TITLE     FZD8 Indicates a Poor Prognosis and Promotes Gastric Cancer
            Invasion and Metastasis via B-Catenin Signaling Pathway
  JOURNAL   Ann Clin Lab Sci 50 (1), 13-23 (2020)
   PUBMED   32161008
  REMARK    GeneRIF: FZD8 Indicates a Poor Prognosis and Promotes Gastric
            Cancer Invasion and Metastasis via B-Catenin Signaling Pathway.
REFERENCE   6  (bases 1 to 4050)
  AUTHORS   Dann,C.E., Hsieh,J.C., Rattner,A., Sharma,D., Nathans,J. and
            Leahy,D.J.
  TITLE     Insights into Wnt binding and signalling from the structures of two
            Frizzled cysteine-rich domains
  JOURNAL   Nature 412 (6842), 86-90 (2001)
   PUBMED   11452312
REFERENCE   7  (bases 1 to 4050)
  AUTHORS   Semenov,M.V., Tamai,K., Brott,B.K., Kuhl,M., Sokol,S. and He,X.
  TITLE     Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
  JOURNAL   Curr Biol 11 (12), 951-961 (2001)
   PUBMED   11448771
REFERENCE   8  (bases 1 to 4050)
  AUTHORS   Saitoh,T., Hirai,M. and Katoh,M.
  TITLE     Molecular cloning and characterization of human Frizzled-8 gene on
            chromosome 10p11.2
  JOURNAL   Int J Oncol 18 (5), 991-996 (2001)
   PUBMED   11295046
REFERENCE   9  (bases 1 to 4050)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   10 (bases 1 to 4050)
  AUTHORS   Finch,P.W., He,X., Kelley,M.J., Uren,A., Schaudies,R.P.,
            Popescu,N.C., Rudikoff,S., Aaronson,S.A., Varmus,H.E. and
            Rubin,J.S.
  TITLE     Purification and molecular cloning of a secreted, Frizzled-related
            antagonist of Wnt action
  JOURNAL   Proc Natl Acad Sci U S A 94 (13), 6770-6775 (1997)
   PUBMED   9192640
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121749.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 5, 2020 this sequence version replaced NM_031866.2.
            
            Summary: This intronless gene is a member of the frizzled gene
            family. Members of this family encode seven-transmembrane domain
            proteins that are receptors for the Wingless type MMTV integration
            site family of signaling proteins. Most frizzled receptors are
            coupled to the beta-catenin canonical signaling pathway. This gene
            is highly expressed in two human cancer cell lines, indicating that
            it may play a role in several types of cancer. The crystal
            structure of the extracellular cysteine-rich domain of a similar
            mouse protein has been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB043703.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374694.3/ ENSP00000363826.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4050              AL121749.14        128420-132469       c
FEATURES             Location/Qualifiers
     source          1..4050
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.21"
     gene            1..4050
                     /gene="FZD8"
                     /gene_synonym="FZ-8; hFZ8"
                     /note="frizzled class receptor 8"
                     /db_xref="GeneID:8325"
                     /db_xref="HGNC:HGNC:4046"
                     /db_xref="MIM:606146"
     exon            1..4050
                     /gene="FZD8"
                     /gene_synonym="FZ-8; hFZ8"
                     /inference="alignment:Splign:2.1.0"
     CDS             868..2952
                     /gene="FZD8"
                     /gene_synonym="FZ-8; hFZ8"
                     /note="frizzled 8, seven transmembrane spanning receptor;
                     frizzled homolog 8; frizzled family receptor 8"
                     /codon_start=1
                     /product="frizzled-8 precursor"
                     /protein_id="NP_114072.1"
                     /db_xref="CCDS:CCDS7192.1"
                     /db_xref="GeneID:8325"
                     /db_xref="HGNC:HGNC:4046"
                     /db_xref="MIM:606146"
                     /translation="MEWGYLLEVTSLLAALALLQRSSGAAAASAKELACQEITVPLCK
                     GIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKK
                     PLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAA
                     PSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGKA
                     RPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAF
                     TVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAG
                     HEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGRGEYEELGAVEQHVRYETTG
                     PALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPS
                     VKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLF
                     RIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHN
                     CPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRSLCTRCCWAS
                     KGAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGGGGGSLYSDVSTGLTWRSGTASS
                     VSYPKQMPLSQV"
     regulatory      3660..3665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD8"
                     /gene_synonym="FZ-8; hFZ8"
                     /note="hexamer: AATAAA"
     polyA_site      3683
                     /gene="FZD8"
                     /gene_synonym="FZ-8; hFZ8"
                     /note="major polyA site"
     regulatory      3847..3852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD8"
                     /gene_synonym="FZ-8; hFZ8"
                     /note="hexamer: AGTAAA"
     polyA_site      3871
                     /gene="FZD8"
                     /gene_synonym="FZ-8; hFZ8"
     regulatory      4028..4033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD8"
                     /gene_synonym="FZ-8; hFZ8"
                     /note="hexamer: ACTAAA"
     polyA_site      4050
                     /gene="FZD8"
                     /gene_synonym="FZ-8; hFZ8"
ORIGIN      
        1 gcgagcgggg ctggagccgg gaagttgggc taagggcgct gctcccgccg aggaggaggc
       61 ggcggctggg cgcgggccgc gccactcagg tgtccgctcc gccttccggt ctggatttgc
      121 tcctgggtgt ccagcaggaa ggagactgtg tgcacctcgc ccgactgcgg ccggagcgcg
      181 gcgctgactt ttccaggcgg cgggggtccg tctgtcccgg cggcggacgg acgaaggacg
      241 gacgccggag aaagagggcg gcggcctggg ccgaggcggg tccccaactc cggcggcggc
      301 ggcggcggct tggccttggg ggcgggcatg agcccccggg ggccgagtgg tggccgccag
      361 ggctgacccg gcgcggcaag cggcccggcc cagccatctt gactgcgcac cgcggcccca
      421 gaggaaactt gcggcgcctc cgccctctct gtccggcgga gtcaccgccg cccggcgcgg
      481 cggggagaag tggtcgggcg cgcggagagg aggcgagcga gcgcgggacg atgagccgag
      541 gcccggccgc tctgcgccgc gagggctgag cgcgacccgg ggccagcaga gcggacctac
      601 ggactgtggc gcgcgcctgc agccgccttc aaacccccgg agcggcggaa aggagtgcgg
      661 aagggccctg cccaggctgc gggccgcgcc gctgcggacg cgcccctaga aggggttaga
      721 ttatcggcag acccccctcc cgggcgaagc ataagggaga ccccagatca cccgctgtac
      781 ccgtctgcgg ctctctcgtg ggcccccccc ccggcacccc tctgcgcgcc gcctggaggg
      841 cgagggcacc gggccgaggc gcacagcatg gagtggggtt acctgttgga agtgacctcg
      901 ctgctggccg ccttggcgct gctgcagcgc tctagcggcg ctgcggccgc ctcggccaag
      961 gagctggcat gccaagagat caccgtgccg ctgtgtaagg gcatcggcta caactacacc
     1021 tacatgccca atcagttcaa ccacgacacg caagacgagg cgggcctgga ggtgcaccag
     1081 ttctggccgc tggtggagat ccagtgctcg cccgatctca agttcttcct gtgcagcatg
     1141 tacacgccca tctgcctaga ggactacaag aagccgctgc cgccctgccg ctcggtgtgc
     1201 gagcgcgcca aggccggctg cgcgccgctc atgcgccagt acggcttcgc ctggcccgac
     1261 cgcatgcgct gcgaccggct gcccgagcaa ggcaaccctg acacgctgtg catggactac
     1321 aaccgcaccg acctaaccac cgccgcgccc agcccgccgc gccgcctgcc gccgccgccg
     1381 cccggcgagc agccgccttc gggcagcggc cacggccgcc cgccgggggc caggcccccg
     1441 caccgcggcg gcggcagggg cggtggcggc ggggacgcgg cggcgccccc agctcgcggc
     1501 ggcggcggtg gcgggaaggc gcggccccct ggcggcggcg cggctccctg cgagcccggg
     1561 tgccagtgcc gcgcgcctat ggtgagcgtg tccagcgagc gccacccgct ctacaaccgc
     1621 gtcaagacag gccagatcgc taactgcgcg ctgccctgcc acaacccctt tttcagccag
     1681 gacgagcgcg ccttcaccgt cttctggatc ggcctgtggt cggtgctctg cttcgtgtcc
     1741 accttcgcca ccgtctccac cttccttatc gacatggagc gcttcaagta cccggagcgg
     1801 cccattatct tcctctcggc ctgctacctc ttcgtgtcgg tgggctacct agtgcgcctg
     1861 gtggcgggcc acgagaaggt ggcgtgcagc ggtggcgcgc cgggcgcggg gggcgctggg
     1921 ggcgcgggcg gcgcggcggc gggcgcgggc gcggcgggcg cgggcgcggg cggcccgggc
     1981 gggcgcggcg agtacgagga gctgggcgcg gtggagcagc acgtgcgcta cgagaccacc
     2041 ggccccgcgc tgtgcaccgt ggtcttcttg ctggtctact tcttcggcat ggccagctcc
     2101 atctggtggg tgatcttgtc gctcacatgg ttcctggcgg ccggtatgaa gtggggcaac
     2161 gaagccatcg ccggctactc gcagtacttc cacctggccg cgtggcttgt gcccagcgtc
     2221 aagtccatcg cggtgctggc gctcagctcg gtggacggcg acccggtggc gggcatctgc
     2281 tacgtgggca accagagcct ggacaacctg cgcggcttcg tgctggcgcc gctggtcatc
     2341 tacctcttca tcggcaccat gttcctgctg gccggcttcg tgtccctctt ccgcatccgc
     2401 tcggtcatca agcaacagga cggccccacc aagacgcaca agctggagaa gctgatgatc
     2461 cgcctgggcc tgttcaccgt gctctacacc gtgcccgccg cggtggtggt cgcctgcctc
     2521 ttctacgagc agcacaaccg cccgcgctgg gaggccacgc acaactgccc gtgcctgcgg
     2581 gacctgcagc ccgaccaggc acgcaggccc gactacgccg tcttcatgct caagtacttc
     2641 atgtgcctag tggtgggcat cacctcgggc gtgtgggtct ggtccggcaa gacgctggag
     2701 tcctggcgct ccctgtgcac ccgctgctgc tgggccagca agggcgccgc ggtgggcggg
     2761 ggcgcgggcg ccacggccgc ggggggtggc ggcgggccgg ggggcggcgg cggcggggga
     2821 cccggcggcg gcggggggcc gggcggcggc gggggctccc tctacagcga cgtcagcact
     2881 ggcctgacgt ggcggtcggg cacggcgagc tccgtgtctt atccaaagca gatgccattg
     2941 tcccaggtct gagcggaggg gagggggcgc ccaggagggg tggggagggg ggcgaggaga
     3001 gccaagtgca gcgaagggac acttgatggg ctgaggttcc caccccttca cagtgttgat
     3061 tgctattagc atgataatga actcttaatg gtatccatta gctgggactt aaatgactca
     3121 cttagaacaa agtacctggc attgaagcct cccagaccca gccccttttc ctccattgat
     3181 gtgcggggag ctcctcccgc cacgcgttaa tttctgttgg ctgaggaggg tggactctgc
     3241 ggcgtttcca gaacccgaga tttggagccc tccctggctg cacttggctg ggtttgcagt
     3301 cagatacaca gatttcacct gggagaacct ctttttctcc ctcgactctt cctacgtaaa
     3361 ctcccacccc tgacttaccc tggaggaggg gtgaccgcca cctgatggga ttgcacggtt
     3421 tgggtattct taatgaccag gcaaatgcct taagtaaaca aacaagaaat gtcttaatta
     3481 tacaccccac gtaaatacgg gtttcttaca ttagaggatg tatttatata attatttgtt
     3541 aaattgtaaa aaaaaaagtg taaaatatgt atatatccaa agatatagtg tgtacatttt
     3601 tttgtaaaaa gtttagaggc ttacccctgt aagaacagat ataagtattc tattttgtca
     3661 ataaaatgac ttttgataaa tgatttaacc attgccctct cccccgcctc ttctgagctg
     3721 tcacctttaa agtgcttgct aaggacgcat ggggaaaatg gacattttct ggcttgtcat
     3781 tctgtacact gaccttaggc atggagaaaa ttacttgtta aactctagtt cttaagttgt
     3841 tagccaagta aatatcattg ttgaactgaa atcaaaattg agtttttgca ccttccccaa
     3901 agacggtgtt tttcatggga gctcttttct gatccatgga taacaactct cactttagtg
     3961 gatgtaaatg gaacttctgc aaggcagtaa ttccccttag gccttgttat ttatcctgca
     4021 tggtatcact aaaggtttca aaaccctgca
//
