LOCUS       NM_003507               4587 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens frizzled class receptor 7 (FZD7), mRNA.
ACCESSION   NM_003507
VERSION     NM_003507.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4587)
  AUTHORS   Bous,J., Kinsolving,J., Gratz,L., Scharf,M.M., Voss,J.H.,
            Selcuk,B., Adebali,O. and Schulte,G.
  TITLE     Structural basis of frizzled 7 activation and allosteric regulation
  JOURNAL   Nat Commun 15 (1), 7422 (2024)
   PUBMED   39198452
  REMARK    GeneRIF: Structural basis of frizzled 7 activation and allosteric
            regulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4587)
  AUTHORS   Liu,Z., Yu,K., Chen,K., Liu,J., Dai,K. and Zhao,P.
  TITLE     HAS2 facilitates glioma cell malignancy and suppresses ferroptosis
            in an FZD7-dependent manner
  JOURNAL   Cancer Sci 115 (8), 2602-2616 (2024)
   PUBMED   38816349
  REMARK    GeneRIF: HAS2 facilitates glioma cell malignancy and suppresses
            ferroptosis in an FZD7-dependent manner.
REFERENCE   3  (bases 1 to 4587)
  AUTHORS   Huang,Q., Xiao,Y., Lan,T., Lu,Y., Huang,L. and Zheng,D.
  TITLE     WNT7A promotes tumorigenesis of head and neck squamous cell
            carcinoma via activating FZD7/JAK1/STAT3 signaling
  JOURNAL   Int J Oral Sci 16 (1), 7 (2024)
   PUBMED   38246919
  REMARK    GeneRIF: WNT7A promotes tumorigenesis of head and neck squamous
            cell carcinoma via activating FZD7/JAK1/STAT3 signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4587)
  AUTHORS   Zhang,J., Qin,X., Bi,Z., Niu,R., Zhang,K., Mei,X. and Guo,W.
  TITLE     Mechanism of miR-548b-5p down-regulating FZD7 to impede the
            migratory and invasive behavior of gastric carcinoma cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 143-149 (2023)
   PUBMED   38279460
  REMARK    GeneRIF: Mechanism of miR-548b-5p down-regulating FZD7 to impede
            the migratory and invasive behavior of gastric carcinoma cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4587)
  AUTHORS   Lan,S., Zhang,Z. and Li,Q.
  TITLE     FZD7: A potential biomarker for endometriosis
  JOURNAL   Medicine (Baltimore) 102 (40), e35406 (2023)
   PUBMED   37800830
  REMARK    GeneRIF: FZD7: A potential biomarker for endometriosis.
REFERENCE   6  (bases 1 to 4587)
  AUTHORS   Hering,H. and Sheng,M.
  TITLE     Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains
            of PSD-95
  JOURNAL   FEBS Lett 521 (1-3), 185-189 (2002)
   PUBMED   12067714
REFERENCE   7  (bases 1 to 4587)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   8  (bases 1 to 4587)
  AUTHORS   Sagara,N., Toda,G., Hirai,M., Terada,M. and Katoh,M.
  TITLE     Molecular cloning, differential expression, and chromosomal
            localization of human frizzled-1, frizzled-2, and frizzled-7
  JOURNAL   Biochem Biophys Res Commun 252 (1), 117-122 (1998)
   PUBMED   9813155
REFERENCE   9  (bases 1 to 4587)
  AUTHORS   Tanaka,S., Akiyoshi,T., Mori,M., Wands,J.R. and Sugimachi,K.
  TITLE     A novel frizzled gene identified in human esophageal carcinoma
            mediates APC/beta-catenin signals
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 10164-10169 (1998)
   PUBMED   9707618
REFERENCE   10 (bases 1 to 4587)
  AUTHORS   Finch,P.W., He,X., Kelley,M.J., Uren,A., Schaudies,R.P.,
            Popescu,N.C., Rudikoff,S., Aaronson,S.A., Varmus,H.E. and
            Rubin,J.S.
  TITLE     Purification and molecular cloning of a secreted, Frizzled-related
            antagonist of Wnt action
  JOURNAL   Proc Natl Acad Sci U S A 94 (13), 6770-6775 (1997)
   PUBMED   9192640
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069148.6 and AB017365.1.
            
            On Aug 11, 2020 this sequence version replaced NM_003507.1.
            
            Summary:  Members of the 'frizzled' gene family encode
            7-transmembrane domain proteins that are receptors for Wnt
            signaling proteins.  The FZD7 protein contains an N-terminal signal
            sequence, 10 cysteine residues typical of the cysteine-rich
            extracellular domain of Fz family members, 7 putative transmembrane
            domains, and an intracellular C-terminal tail with a PDZ
            domain-binding motif.  FZD7 gene expression may downregulate APC
            function and enhance beta-catenin-mediated signals in poorly
            differentiated human esophageal carcinomas. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB017365.1, BC015915.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286201.3/ ENSP00000286201.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-732               AC069148.6         2316-3047
            733-4583            AB017365.1         1-3851
            4584-4587           AC069148.6         6899-6902
FEATURES             Location/Qualifiers
     source          1..4587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..4587
                     /gene="FZD7"
                     /gene_synonym="FzE3"
                     /note="frizzled class receptor 7"
                     /db_xref="GeneID:8324"
                     /db_xref="HGNC:HGNC:4045"
                     /db_xref="MIM:603410"
     exon            1..4587
                     /gene="FZD7"
                     /gene_synonym="FzE3"
                     /inference="alignment:Splign:2.1.0"
     CDS             794..2518
                     /gene="FZD7"
                     /gene_synonym="FzE3"
                     /note="Frizzled, drosophila, homolog of, 7; frizzled 7,
                     seven transmembrane spanning receptor; frizzled-7; fz-7;
                     hFz7; frizzled homolog 7; frizzled family receptor 7"
                     /codon_start=1
                     /product="frizzled-7 precursor"
                     /protein_id="NP_003498.1"
                     /db_xref="CCDS:CCDS2351.1"
                     /db_xref="GeneID:8324"
                     /db_xref="HGNC:HGNC:4045"
                     /db_xref="MIM:603410"
                     /translation="MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVP
                     DHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFL
                     CSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEIC
                     VGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPP
                     YLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYL
                     VDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKE
                     GCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVK
                     TITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRI
                     RTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTC
                     KSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSH
                     SSKGETAV"
     regulatory      4565..4570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD7"
                     /gene_synonym="FzE3"
                     /note="hexamer: AATAAA"
     polyA_site      4587
                     /gene="FZD7"
                     /gene_synonym="FzE3"
                     /note="major polyA site"
ORIGIN      
        1 gttagtcggc gctcactccc ggcgggcggc ggcggcggcg gcggcggcgg gcgccaggac
       61 tcgctgctgg ggctgcgagg ggctggaggg gccggggcca ggccgcgggc acgagcgcct
      121 cgcggtttcg gacgcagtgt gactgggttt ccaaaaagaa ctcgccgtgc tcccgactcc
      181 ggggccgaga tcggactcag caagagccgg ccgtttggct gaaacttggg gccgagcttt
      241 tggggctgaa gaaggagcgg ggtgtggagg aggaggcgaa ggaggcggcg acgagcggag
      301 cctcgaggcc aggaggcggg gcagcaccgc ggaggcggcg gccggggcga gcgagcggcg
      361 gcggcagggg ttctcctagc ggggaccgga ccaggcgcgg ggggcgtgcg cgctgcggtg
      421 cgccgggggt ccagagtctt gggcaaactt tgaagggtgc cggagccgct tgttgctcct
      481 cgcggcggag ggagccgcac cgttacgtcc ccgcggggag agcgaggcgg ccctcctcgg
      541 cgcccccaac ccaggctgac gagttttggg cccccggcgg ccctgcgagt gcagggcggc
      601 ggcgtctgcg gcgccttcgc ggcgcgggca cccaggcggc agcgcccttt gctccacgcc
      661 gcccacggcc cggccccggc gccgtgagga ctctcatgcg tcgggcgcgg cggcgcctcc
      721 ccgcatccaa gcctctccca accgcctcgt cgcactcctc aggctgagag caccgctgca
      781 ctcgcggccg gcgatgcggg accccggcgc ggccgctccg ctttcgtccc tgggcctctg
      841 tgccctggtg ctggcgctgc tgggcgcact gtccgcgggc gccggggcgc agccgtacca
      901 cggagagaag ggcatctccg tgccggacca cggcttctgc cagcccatct ccatcccgct
      961 gtgcacggac atcgcctaca accagaccat cctgcccaac ctgctgggcc acacgaacca
     1021 agaggacgcg ggcctcgagg tgcaccagtt ctacccgctg gtgaaggtgc agtgttctcc
     1081 cgaactccgc tttttcttat gctccatgta tgcgcccgtg tgcaccgtgc tcgatcaggc
     1141 catcccgccg tgtcgttctc tgtgcgagcg cgcccgccag ggctgcgagg cgctcatgaa
     1201 caagttcggc ttccagtggc ccgagcggct gcgctgcgag aacttcccgg tgcacggtgc
     1261 gggcgagatc tgcgtgggcc agaacacgtc ggacggctcc gggggcccag gcggcggccc
     1321 cactgcctac cctaccgcgc cctacctgcc ggacctgccc ttcaccgcgc tgcccccggg
     1381 ggcctcagat ggcagggggc gtcccgcctt ccccttctca tgcccccgtc agctcaaggt
     1441 gcccccgtac ctgggctacc gcttcctggg tgagcgcgat tgtggcgccc cgtgcgaacc
     1501 gggccgtgcc aacggcctga tgtactttaa ggaggaggag aggcgcttcg cccgcctctg
     1561 ggtgggcgtg tggtccgtgc tgtgctgcgc ctcgacgctc tttaccgttc tcacctacct
     1621 ggtggacatg cggcgcttca gctacccaga gcggcccatc atcttcctgt cgggctgcta
     1681 cttcatggtg gccgtggcgc acgtggccgg cttccttcta gaggaccgcg ccgtgtgcgt
     1741 ggagcgcttc tcggacgatg gctaccgcac ggtggcgcag ggcaccaaga aggagggctg
     1801 caccatcctc ttcatggtgc tctacttctt cggcatggcc agctccatct ggtgggtcat
     1861 tctgtctctc acttggttcc tggcggccgg catgaagtgg ggccacgagg ccatcgaggc
     1921 caactcgcag tacttccacc tggccgcgtg ggccgtgccc gccgtcaaga ccatcactat
     1981 cctggccatg ggccaggtag acggggacct gctgagcggg gtgtgctacg ttggcctctc
     2041 cagtgtggac gcgctgcggg gcttcgtgct ggcgcctctg ttcgtctacc tcttcatagg
     2101 cacgtccttc ttgctggccg gcttcgtgtc cctcttccgt atccgcacca tcatgaaaca
     2161 cgacggcacc aagaccgaga agctggagaa gctcatggtg cgcatcggcg tcttcagcgt
     2221 gctctacaca gtgcccgcca ccatcgtcct ggcctgctac ttctacgagc aggccttccg
     2281 cgagcactgg gagcgcacct ggctcctgca gacgtgcaag agctatgccg tgccctgccc
     2341 gcccggccac ttcccgccca tgagccccga cttcaccgtc ttcatgatca agtacctgat
     2401 gaccatgatc gtcggcatca ccactggctt ctggatctgg tcgggcaaga ccctgcagtc
     2461 gtggcgccgc ttctaccaca gacttagcca cagcagcaag ggggagactg cggtatgagc
     2521 cccggcccct ccccaccttt cccaccccag ccctcttgca agaggagagg cacggtaggg
     2581 aaaagaactg ctgggtgggg gcctgtttct gtaactttct ccccctctac tgagaagtga
     2641 cctggaagtg agaagttctt tgcagatttg gggcgagggg tgatttggaa aagaagacct
     2701 gggtggaaag cggtttggat gaaaagattt caggcaaaga cttgcaggaa gatgatgata
     2761 acggcgatgt gaatcgtcaa aggtacgggc cagcttgtgc ctaatagaag gttgagacca
     2821 gcagagactg ctgtgagttt ctcccggctc cgaggctgaa cggggactgt gagcgatccc
     2881 cctgctgcag ggcgagtggc ctgtccagac ccctgtgagg ccccgggaaa ggtacagccc
     2941 tgtctgcggt ggctgctttg ttggaaagag ggagggcctc ctgcggtgtg cttgtcaagc
     3001 agtggtcaaa ccataatctc ttttcactgg ggccaaactg gagcccagat gggttaattt
     3061 ccagggtcag acattacggt ctctcctccc ctgccccctc ccgcctgttt ttcctcccgt
     3121 actgctttca ggtcttgtaa aataagcatt tggaagtctt gggaggcctg cctgctagaa
     3181 tcctaatgtg aggatgcaaa agaaatgatg ataacatttt gagataaggc caaggagacg
     3241 tggagtaggt atttttgcta ctttttcatt ttctggggaa ggcaggaggc agaaagacgg
     3301 gtgttttatt tggtctaata ccctgaaaag aagtgatgac ttgttgcttt tcaaaacagg
     3361 aatgcatttt tccccttgtc tttgttgtaa gagacaaaag aggaaacaaa agtgtctccc
     3421 tgtggaaagg cataactgtg acgaaagcaa cttttatagg caaagcagcg caaatctgag
     3481 gtttcccgtt ggttgttaat ttggttgaga taaacattcc tttttaagga aaagtgaaga
     3541 gcagtgtgct gtcacacacc gttaagccag aggttctgac ttcgctaaag gaaatgtaag
     3601 aggttttgtt gtctgtttta aataaattta attcggaaca catgatccaa cagactatgt
     3661 taaaatattc agggaaatct ctcccttcat ttactttttc ttgctataag cctatattta
     3721 ggtttctttt ctattttttt ctcccatttg gatcctttga ggtaaaaaaa cataatgtct
     3781 tcagcctcat aataaaggaa agttaattaa aaaaaaaaag caaagagcca ttttgtcctg
     3841 ttttcttggt tccatcaatc tgtttattaa acatcatcca tatgctgacc ctgtctctgt
     3901 gtggttgggt tgggaggcga tcagcagata ccatagtgaa cgaagaggaa ggtttgaacc
     3961 atgggcccca tctttaaaga aagtcattaa aagaaggtaa acttcaaagt gattctggag
     4021 ttctttgaaa tgtgctggaa gacttaaatt tattaatctt aaatcatgta ctttttttct
     4081 gtaatagaac tcggattctt ttgcatgatg gggtaaagct tagcagagaa tcatgggagc
     4141 taacctttat cccacctttg acactaccct ccaatcttgc aacactatcc tgtttctcag
     4201 aacagttttt aaatgccaat catagagggt actgtaaagt gtacaagtta ctttatatat
     4261 gtaatgttca cttgagtgga actgcttttt acattaaagt taaaatcgat cttgtgtttc
     4321 ttcaaccttc aaaactatct catctgtcag atttttaaaa ctccaacaca ggttttggca
     4381 tcttttgtgc tgtatctttt aagtgcatgt gaaatttgta aaatagagat aagtacagta
     4441 tgtatatttt gtaaatctcc catttttgta agaaaatata tattgtattt atacattttt
     4501 actttggatt tttgttttgt tggctttaaa ggtctacccc actttatcac atgtacagat
     4561 cacaaataaa tttttttaaa tacaaaa
//
