LOCUS       NM_003506               3728 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens frizzled class receptor 6 (FZD6), transcript variant
            1, mRNA.
ACCESSION   NM_003506
VERSION     NM_003506.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3728)
  AUTHORS   Lanvin,P.L., Lebreton,L., Lasseaux,E., Creveaux,I.,
            Leaute-Labreze,C., Boralevi,F. and Morice-Picard,F.
  TITLE     A novel pathogenic variant in the FZD6 gene causes recessive nail
            dysplasia in a Moroccan family
  JOURNAL   Clin Exp Dermatol 48 (12), 1414-1417 (2023)
   PUBMED   37401642
  REMARK    GeneRIF: A novel pathogenic variant in the FZD6 gene causes
            recessive nail dysplasia in a Moroccan family.
REFERENCE   2  (bases 1 to 3728)
  AUTHORS   Dong,B., Simonson,L., Vold,S., Oldham,E., Barten,L., Ahmad,N. and
            Chang,H.
  TITLE     FZD6 Promotes Melanoma Cell Invasion but Not Proliferation by
            Regulating Canonical Wnt Signaling and Epithelial-Mesenchymal
            Transition
  JOURNAL   J Invest Dermatol 143 (4), 621-629 (2023)
   PUBMED   36368445
  REMARK    GeneRIF: FZD6 Promotes Melanoma Cell Invasion but Not Proliferation
            by Regulating Canonical Wnt Signaling and Epithelial-Mesenchymal
            Transition.
REFERENCE   3  (bases 1 to 3728)
  AUTHORS   Cassaro,A., Grillo,G., Notaro,M., Gliozzo,J., Esposito,I., Reda,G.,
            Trojani,A., Valentini,G., Di Camillo,B., Cairoli,R. and Beghini,A.
  TITLE     FZD6 triggers Wnt-signalling driven by WNT10BIVS1 expression and
            highlights new targets in T-cell acute lymphoblastic leukemia
  JOURNAL   Hematol Oncol 39 (3), 364-379 (2021)
   PUBMED   33497493
  REMARK    GeneRIF: FZD6 triggers Wnt-signalling driven by WNT10B(IVS1)
            expression and highlights new targets in T-cell acute lymphoblastic
            leukemia.
REFERENCE   4  (bases 1 to 3728)
  AUTHORS   Sun,S., Wang,J., Liu,J., Yin,F., Xin,C., Zeng,X., Li,J. and Chen,Q.
  TITLE     MiR-302b Suppresses Tumor Metastasis by Targeting Frizzled 6 in
            OSCC
  JOURNAL   J Dent Res 100 (7), 739-745 (2021)
   PUBMED   33478325
  REMARK    GeneRIF: MiR-302b Suppresses Tumor Metastasis by Targeting Frizzled
            6 in OSCC.
REFERENCE   5  (bases 1 to 3728)
  AUTHORS   Lyons,J.P., Mueller,U.W., Ji,H., Everett,C., Fang,X., Hsieh,J.C.,
            Barth,A.M. and McCrea,P.D.
  TITLE     Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and
            binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin
            activity in kidney epithelial cells
  JOURNAL   Exp Cell Res 298 (2), 369-387 (2004)
   PUBMED   15265686
REFERENCE   6  (bases 1 to 3728)
  AUTHORS   Golan,T., Yaniv,A., Bafico,A., Liu,G. and Gazit,A.
  TITLE     The human Frizzled 6 (HFz6) acts as a negative regulator of the
            canonical Wnt. beta-catenin signaling cascade
  JOURNAL   J Biol Chem 279 (15), 14879-14888 (2004)
   PUBMED   14747478
  REMARK    GeneRIF: Frizzled 6 (HFz6) has a role as a negative regulator of
            the canonical Wnt. beta-catenin signaling cascade
REFERENCE   7  (bases 1 to 3728)
  AUTHORS   Bafico,A., Gazit,A., Pramila,T., Finch,P.W., Yaniv,A. and
            Aaronson,S.A.
  TITLE     Interaction of frizzled related protein (FRP) with Wnt ligands and
            the frizzled receptor suggests alternative mechanisms for FRP
            inhibition of Wnt signaling
  JOURNAL   J Biol Chem 274 (23), 16180-16187 (1999)
   PUBMED   10347172
REFERENCE   8  (bases 1 to 3728)
  AUTHORS   Tokuhara,M., Hirai,M., Atomi,Y., Terada,M. and Katoh,M.
  TITLE     Molecular cloning of human Frizzled-6
  JOURNAL   Biochem Biophys Res Commun 243 (2), 622-627 (1998)
   PUBMED   9480858
  REMARK    Erratum:[Biochem Biophys Res Commun 1998 Jun 29;247(3):910]
REFERENCE   9  (bases 1 to 3728)
  AUTHORS   Wang,Y., Macke,J.P., Abella,B.S., Andreasson,K., Worley,P.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A large family of putative transmembrane receptors homologous to
            the product of the Drosophila tissue polarity gene frizzled
  JOURNAL   J Biol Chem 271 (8), 4468-4476 (1996)
   PUBMED   8626800
REFERENCE   10 (bases 1 to 3728)
  AUTHORS   Leung,A.K. and Robson,W.L.
  TITLE     Urinary tract infection in infancy and childhood
  JOURNAL   Adv Pediatr 38, 257-285 (1991)
   PUBMED   1927703
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025370.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_003506.3.
            
            Summary: This gene represents a member of the 'frizzled' gene
            family, which encode 7-transmembrane domain proteins that are
            receptors for Wnt signaling proteins. The protein encoded by this
            family member contains a signal peptide, a cysteine-rich domain in
            the N-terminal extracellular region, and seven transmembrane
            domains, but unlike other family members, this protein does not
            contain a C-terminal PDZ domain-binding motif. This protein
            functions as a negative regulator of the canonical Wnt/beta-catenin
            signaling cascade, thereby inhibiting the processes that trigger
            oncogenic transformation, cell proliferation, and inhibition of
            apoptosis. Alternative splicing results in multiple transcript
            variants, some of which do not encode a protein with a predicted
            signal peptide.[provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Both variants 1 and
            2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060836.1, SRR1660803.14963.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358755.5/ ENSP00000351605.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC025370.12        38779-38876         c
            99-427              AC025370.12        37490-37818         c
            428-624             AC025370.12        18988-19184         c
            625-1642            AC025370.12        12276-13293         c
            1643-1791           AC025370.12        9358-9506           c
            1792-2202           AC025370.12        7709-8119           c
            2203-3728           AC025370.12        4908-6433           c
FEATURES             Location/Qualifiers
     source          1..3728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..3728
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
                     /note="frizzled class receptor 6"
                     /db_xref="GeneID:8323"
                     /db_xref="HGNC:HGNC:4044"
                     /db_xref="MIM:603409"
     exon            1..98
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
                     /inference="alignment:Splign:2.1.0"
     exon            99..427
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..2371
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; frizzled 6, seven transmembrane spanning
                     receptor; seven transmembrane helix receptor; frizzled
                     homolog 6; frizzled family receptor 6"
                     /codon_start=1
                     /product="frizzled-6 isoform a precursor"
                     /protein_id="NP_003497.2"
                     /db_xref="CCDS:CCDS6298.1"
                     /db_xref="GeneID:8323"
                     /db_xref="HGNC:HGNC:4044"
                     /db_xref="MIM:603409"
                     /translation="MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPN
                     LMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKV
                     YSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFW
                     CPRHLKTSGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFL
                     TFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLG
                     SQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGT
                     PGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIIS
                     LNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWV
                     SDHCRQYHIPCPYQAKAKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFK
                     RNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGTSTGATA
                     NHGTSAVAITSHDYLGQETLTEIQTSPETSMREVKADGASTPRLREQDCGEPASPAAS
                     ISRLSGEQVDGKGQAGSVSESARSEGRISPKSDITDTGLAQSNNLQVPSSSEPSSLKG
                     STSLLVHPVSGVRKEQGGGCHSDT"
     exon            428..624
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
                     /inference="alignment:Splign:2.1.0"
     exon            625..1642
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1791
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2202
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..3728
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3679
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
                     /note="major polyA site"
     regulatory      3705..3710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
                     /note="hexamer: AATAAA"
     polyA_site      3728
                     /gene="FZD6"
                     /gene_synonym="FZ-6; FZ6; HFZ6; NDNC1; NDNC10"
ORIGIN      
        1 agtcccggac gcaaccccgg agccgtctca ggtccctggg gggaacggtg ggttagacgg
       61 ggacgggaag ggacagcggc cttcgaccgc cccccgagta attgacccag gactcatttt
      121 caggaaagcc tgaaaatgag taaaatagtg aaatgaggaa tttgaacatt ttatctttgg
      181 atggggatct tctgaggatg caaagagtga ttcatccaag ccatgtggta aaatcaggaa
      241 tttgaagaaa atggaaatgt ttacattttt gttgacgtgt atttttctac ccctcctaag
      301 agggcacagt ctcttcacct gtgaaccaat tactgttccc agatgtatga aaatggccta
      361 caacatgacg tttttcccta atctgatggg tcattatgac cagagtattg ccgcggtgga
      421 aatggagcat tttcttcctc tcgcaaatct ggaatgttca ccaaacattg aaactttcct
      481 ctgcaaagca tttgtaccaa cctgcataga acaaattcat gtggttccac cttgtcgtaa
      541 actttgtgag aaagtatatt ctgattgcaa aaaattaatt gacacttttg ggatccgatg
      601 gcctgaggag cttgaatgtg acagattaca atactgtgat gagactgttc ctgtaacttt
      661 tgatccacac acagaatttc ttggtcctca gaagaaaaca gaacaagtcc aaagagacat
      721 tggattttgg tgtccaaggc atcttaagac ttctggggga caaggatata agtttctggg
      781 aattgaccag tgtgcgcctc catgccccaa catgtatttt aaaagtgatg agctagagtt
      841 tgcaaaaagt tttattggaa cagtttcaat attttgtctt tgtgcaactc tgttcacatt
      901 ccttactttt ttaattgatg ttagaagatt cagataccca gagagaccaa ttatatatta
      961 ctctgtctgt tacagcattg tatctcttat gtacttcatt ggatttttgc taggcgatag
     1021 cacagcctgc aataaggcag atgagaagct agaacttggt gacactgttg tcctaggctc
     1081 tcaaaataag gcttgcaccg ttttgttcat gcttttgtat tttttcacaa tggctggcac
     1141 tgtgtggtgg gtgattctta ccattacttg gttcttagct gcaggaagaa aatggagttg
     1201 tgaagccatc gagcaaaaag cagtgtggtt tcatgctgtt gcatggggaa caccaggttt
     1261 cctgactgtt atgcttcttg ctatgaacaa agttgaagga gacaacatta gtggagtttg
     1321 ctttgttggc ctttatgacc tggatgcttc tcgctacttt gtactcttgc cactgtgcct
     1381 ttgtgtgttt gttgggctct ctcttctttt agctggcatt atttccttaa atcatgttcg
     1441 acaagtcata caacatgatg gccggaacca agaaaaacta aagaaattta tgattcgaat
     1501 tggagtcttc agcggcttgt atcttgtgcc attagtgaca cttctcggat gttacgtcta
     1561 tgagcaagtg aacaggatta cctgggagat aacttgggtc tctgatcatt gtcgtcagta
     1621 ccatatccca tgtccttatc aggcaaaagc aaaagctcga ccagaattgg ctttatttat
     1681 gataaaatac ctgatgacat taattgttgg catctctgct gtcttctggg ttggaagcaa
     1741 aaagacatgc acagaatggg ctgggttttt taaacgaaat cgcaagagag atccaatcag
     1801 tgaaagtcga agagtactac aggaatcatg tgagtttttc ttaaagcaca attctaaagt
     1861 taaacacaaa aagaagcact ataaaccaag ttcacacaag ctgaaggtca tttccaaatc
     1921 catgggaacc agcacaggag ctacagcaaa tcatggcact tctgcagtag caattactag
     1981 ccatgattac ctaggacaag aaactttgac agaaatccaa acctcaccag aaacatcaat
     2041 gagagaggtg aaagcggacg gagctagcac ccccaggtta agagaacagg actgtggtga
     2101 acctgcctcg ccagcagcat ccatctccag actctctggg gaacaggtcg acgggaaggg
     2161 ccaggcaggc agtgtatctg aaagtgcgcg gagtgaagga aggattagtc caaagagtga
     2221 tattactgac actggcctgg cacagagcaa caatttgcag gtccccagtt cttcagaacc
     2281 aagcagcctc aaaggttcca catctctgct tgttcacccg gtttcaggag tgagaaaaga
     2341 gcagggaggt ggttgtcatt cagatacttg aagaacattt tctctcgtta ctcagaagca
     2401 aatttgtgtt acactggaag tgacctatgc actgttttgt aagaatcact gttacattct
     2461 tcttttgcac ttaaagttgc attgcctact gttatactgg aaaaaataga gttcaagaat
     2521 aatatgactc atttcacaca aaggttaatg acaacaatat acctgaaaac agaaaatgtg
     2581 caggttaata atattttttt aatagtgtgg gaggacagag ttagaggaat cttccttttc
     2641 tatttatgaa gattctactc ttggtaagag tattttaaga tgtactatgc tattttactt
     2701 ttttgatata aaatcaagat atttctttgc tgaagtattt aaatcttatc cttgtatctt
     2761 tttatacata tttgaaaata agcttatatg tatttgaact tttttgaaat cctattcaag
     2821 tatttttatc atgctattgt gatattttag cactttggta gcttttacac tgaatttcta
     2881 agaaaattgt aaaatagtct tcttttatac tgtaaaaaaa gatataccaa aaagtcttat
     2941 aataggaatt taactttaaa aacccactta ttgatacctt accatctaaa atgtgtgatt
     3001 tttatagtct cgttttagga atttcacaga tctaaattat gtaactgaaa taaggtgctt
     3061 actcaaagag tgtccactat tgattgtatt atgctgctca ctgatccttc tgcatattta
     3121 aaataaaatg tcctaaaggg ttagtagaca aaatgttagt cttttgtata ttaggccaag
     3181 tgcaattgac ttcccttttt taatgtttca tgaccaccca ttgattgtat tataaccact
     3241 tacagttgct tatatttttt gttttaactt ttgtttttta acatttagaa tattacattt
     3301 tgtattatac agtacctttc tcagacattt tgtagaattc atttcggcag ctcactagga
     3361 ttttgctgaa cattaaaaag tgtgatagcg atattagtgc caatcaaatg gaaaaaaggt
     3421 agttttaata aacaagacac aacgttttta tacaacatac tttaaaatat taaggagttt
     3481 tcttaatttt gtttcctatt aagtattatt ctttgggcaa gattttctga tgcttttgat
     3541 tttctctcaa tttagcattt gcttttggtt tttttctcta tttagcattc tgttaaggca
     3601 caaaaactat gtactgtatg ggaaatgttg taaatattac cttttccaca ttttaaacag
     3661 acaactttga atacaaaaac tttgttttgt gtgatctttt cattaataaa attatctttg
     3721 tataagaa
//
