LOCUS       NM_003468               7039 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens frizzled class receptor 5 (FZD5), mRNA.
ACCESSION   NM_003468
VERSION     NM_003468.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7039)
  AUTHORS   He,J., Yu,K., Liang,G., Shen,W. and Tian,H.
  TITLE     circ_0000592 facilitates the progression of esophageal squamous
            cell carcinoma via miR-155-5p/FZD5 axis
  JOURNAL   J Biochem Mol Toxicol 38 (6), e23742 (2024)
   PUBMED   38780005
  REMARK    GeneRIF: circ_0000592 facilitates the progression of esophageal
            squamous cell carcinoma via miR-155-5p/FZD5 axis.
REFERENCE   2  (bases 1 to 7039)
  AUTHORS   Yang,A., Chidiac,R., Russo,E., Steenland,H., Pauli,Q., Bonin,R.,
            Blazer,L.L., Adams,J.J., Sidhu,S.S., Goeva,A., Salahpour,A. and
            Angers,S.
  TITLE     Exploiting spatiotemporal regulation of FZD5 during neural
            patterning for efficient ventral midbrain specification
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38358799
  REMARK    GeneRIF: Exploiting spatiotemporal regulation of FZD5 during neural
            patterning for efficient ventral midbrain specification.
REFERENCE   3  (bases 1 to 7039)
  AUTHORS   Lu,P., Yang,J., Li,M., Wen,S., Zhang,T., Yan,C., Liu,R., Xiao,Y.,
            Wang,X. and Jiang,W.
  TITLE     A desert lncRNA HIDEN regulates human endoderm differentiation via
            interacting with IMP1 and stabilizing FZD5 mRNA
  JOURNAL   Genome Biol 24 (1), 92 (2023)
   PUBMED   37095549
  REMARK    GeneRIF: A desert lncRNA HIDEN regulates human endoderm
            differentiation via interacting with IMP1 and stabilizing FZD5
            mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7039)
  AUTHORS   Chen,Y., Wu,C., Peng,S., Guo,D., Ouyang,H., Wei,Y., Ju,R., Ding,X.,
            Xie,Z. and Liu,C.
  TITLE     Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse
            and Human Persistent Fetal Vasculature (PFV)
  JOURNAL   Invest Ophthalmol Vis Sci 64 (3), 8 (2023)
   PUBMED   36867129
  REMARK    GeneRIF: Single-Cell Characterization of the Frizzled 5 (Fz5)
            Mutant Mouse and Human Persistent Fetal Vasculature (PFV).
REFERENCE   5  (bases 1 to 7039)
  AUTHORS   Hosseini-Abgir,A., Naghizadeh,M.M., Igder,S. and Miladpour,B.
  TITLE     Insilco prediction of the role of the FriZZled5 gene in colorectal
            cancer
  JOURNAL   Cancer Treat Res Commun 36, 100751 (2023)
   PUBMED   37595345
  REMARK    GeneRIF: Insilco prediction of the role of the FriZZled5 gene in
            colorectal cancer.
REFERENCE   6  (bases 1 to 7039)
  AUTHORS   Medina,A. and Steinbeisser,H.
  TITLE     Interaction of Frizzled 7 and Dishevelled in Xenopus
  JOURNAL   Dev Dyn 218 (4), 671-680 (2000)
   PUBMED   10906785
REFERENCE   7  (bases 1 to 7039)
  AUTHORS   Tanaka,S., Akiyoshi,T., Mori,M., Wands,J.R. and Sugimachi,K.
  TITLE     A novel frizzled gene identified in human esophageal carcinoma
            mediates APC/beta-catenin signals
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 10164-10169 (1998)
   PUBMED   9707618
REFERENCE   8  (bases 1 to 7039)
  AUTHORS   Finch,P.W., He,X., Kelley,M.J., Uren,A., Schaudies,R.P.,
            Popescu,N.C., Rudikoff,S., Aaronson,S.A., Varmus,H.E. and
            Rubin,J.S.
  TITLE     Purification and molecular cloning of a secreted, Frizzled-related
            antagonist of Wnt action
  JOURNAL   Proc Natl Acad Sci U S A 94 (13), 6770-6775 (1997)
   PUBMED   9192640
REFERENCE   9  (bases 1 to 7039)
  AUTHORS   He,X., Saint-Jeannet,J.P., Wang,Y., Nathans,J., Dawid,I. and
            Varmus,H.
  TITLE     A member of the Frizzled protein family mediating axis induction by
            Wnt-5A
  JOURNAL   Science 275 (5306), 1652-1654 (1997)
   PUBMED   9054360
REFERENCE   10 (bases 1 to 7039)
  AUTHORS   Wang,Y., Macke,J.P., Abella,B.S., Andreasson,K., Worley,P.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A large family of putative transmembrane receptors homologous to
            the product of the Drosophila tissue polarity gene frizzled
  JOURNAL   J Biol Chem 271 (8), 4468-4476 (1996)
   PUBMED   8626800
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096772.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_003468.3.
            
            Summary:  Members of the 'frizzled' gene family encode
            7-transmembrane domain proteins that are receptors for Wnt
            signaling proteins.  The FZD5 protein is believed to be the
            receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB043702.1, U43318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2153427
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295417.4/ ENSP00000354607.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-642               AC096772.3         90313-90954         c
            643-7039            AC096772.3         83646-90042         c
FEATURES             Location/Qualifiers
     source          1..7039
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.3"
     gene            1..7039
                     /gene="FZD5"
                     /gene_synonym="C2orf31; HFZ5; MCOPCB11"
                     /note="frizzled class receptor 5"
                     /db_xref="GeneID:7855"
                     /db_xref="HGNC:HGNC:4043"
                     /db_xref="MIM:601723"
     exon            1..642
                     /gene="FZD5"
                     /gene_synonym="C2orf31; HFZ5; MCOPCB11"
                     /inference="alignment:Splign:2.1.0"
     exon            643..7039
                     /gene="FZD5"
                     /gene_synonym="C2orf31; HFZ5; MCOPCB11"
                     /inference="alignment:Splign:2.1.0"
     CDS             898..2655
                     /gene="FZD5"
                     /gene_synonym="C2orf31; HFZ5; MCOPCB11"
                     /note="frizzled 5, seven transmembrane spanning receptor;
                     seven-transmembrane receptor frizzled-5; Wnt receptor;
                     fz-5; fzE5; frizzled family receptor 5"
                     /codon_start=1
                     /product="frizzled-5 precursor"
                     /protein_id="NP_003459.2"
                     /db_xref="CCDS:CCDS33366.1"
                     /db_xref="GeneID:7855"
                     /db_xref="HGNC:HGNC:4043"
                     /db_xref="MIM:601723"
                     /translation="MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGI
                     GYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPL
                     PPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPP
                     RPFPAKPTLPGPPGAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNC
                     AVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSA
                     CYLCVSLGFLVRLVVGHASVACSREHNHIHYETTGPALCTIVFLLVYFFGMASSIWWV
                     ILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYV
                     GNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRI
                     GIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGHDTGQPRAKPEYWVLMLKYF
                     MCLVVGITSGVWIWSGKTVESWRRFTSRCCCRPRRGHKSGGAMAAGDYPEASAALTGR
                     TGPPGPAATYHKQVSLSHV"
     regulatory      2994..2999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD5"
                     /gene_synonym="C2orf31; HFZ5; MCOPCB11"
                     /note="hexamer: AATGAA"
     polyA_site      3026
                     /gene="FZD5"
                     /gene_synonym="C2orf31; HFZ5; MCOPCB11"
                     /note="major polyA site"
     polyA_site      3095
                     /gene="FZD5"
                     /gene_synonym="C2orf31; HFZ5; MCOPCB11"
                     /note="major polyA site"
     polyA_site      3112
                     /gene="FZD5"
                     /gene_synonym="C2orf31; HFZ5; MCOPCB11"
     polyA_site      5642
                     /gene="FZD5"
                     /gene_synonym="C2orf31; HFZ5; MCOPCB11"
     regulatory      7012..7017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD5"
                     /gene_synonym="C2orf31; HFZ5; MCOPCB11"
                     /note="hexamer: ATTAAA"
     polyA_site      7039
                     /gene="FZD5"
                     /gene_synonym="C2orf31; HFZ5; MCOPCB11"
ORIGIN      
        1 agagggcagc cagcctgcgg ccgtgagtcc gctgtggtcg ccgccgcgcg cggttccgtg
       61 ctcgccagag gtgggcgaaa gggtgcgaga gcgcggggga ggagccgagc agggcacgtc
      121 ccgagagcgt cgccaccgcc cccaggagtc cactggagcg cggagccccc tgcaggggag
      181 gaggcgagcg gcgggcggga cgcggcggcc ggcgctcacc atgcagtccc ggcctggcca
      241 gcgccggctg ctcgcggtgc tgtgaggcgg cggggtccca cggcccccgc ctcccgcctt
      301 cctcccgccc aggtgctgcc aggcgcgctc gccctccgtc cggctcccgg ccccggggag
      361 aacgcacggc ctgcccctgc ccggctccgt ctggatcatg cggggggctc ccgaggagga
      421 gagggcgagt gaccggcctg cgccgcccct gttctggggg cgccccccac tctgagtcgc
      481 ccccacctgc tgccatgtgc cgctgccacg ggtacccagc ctgtcgctaa actttccggg
      541 cgccagcccg gctctgagtc gcgcttctca gcggagtgac ccagggacgg aggacccagg
      601 ctggctgggg actgtctgct cttctcggcg ggatccgtgg agagtccttt ccctggaatc
      661 cgagccctaa ccgtctctcc ccagccctat ccggcgagga gcggagcgct gccagcggag
      721 gcagcgcctt cccgaagcag tttatctttg gacggttttc tttaaaggaa aaagcaacca
      781 acaggttgcc agccccggcg ccacacacga gacgccggag ggagaagccc cggcccggat
      841 tcctctgcct gtgtgcgtcc ctcgcgggct gctggaggcg aggggaggga gggggcgatg
      901 gctcggcctg acccatccgc gccgccctcg ctgttgctgc tgctcctagc gcagctggtg
      961 ggccgggcgg ccgccgcgtc caaggccccg gtgtgccagg aaatcacggt gcccatgtgc
     1021 cgcggcatcg gctacaacct gacgcacatg cccaaccagt tcaaccacga cacgcaggac
     1081 gaggcgggcc tggaggtgca ccagttctgg ccgctggtgg agatccaatg ctcgccggac
     1141 ctgcgcttct tcctatgctc tatgtacacg cccatctgtc tgcccgacta ccacaagccg
     1201 ctgccgccct gccgctcggt gtgcgagcgc gccaaggccg gctgctcgcc gctgatgcgc
     1261 cagtacggct tcgcctggcc cgagcgcatg agctgcgacc gcctcccggt gctgggccgc
     1321 gacgccgagg tcctctgcat ggattacaac cgcagcgagg ccaccacggc gccccccagg
     1381 cctttcccag ccaagcccac ccttccaggc ccgccagggg cgccggcctc ggggggcgaa
     1441 tgccccgctg ggggcccgtt cgtgtgcaag tgtcgcgagc ccttcgtgcc cattctgaag
     1501 gagtcacacc cgctctacaa caaggtgcgg acgggccagg tgcccaactg cgcggtaccc
     1561 tgctaccagc cgtccttcag tgccgacgag cgcacgttcg ccaccttctg gataggcctg
     1621 tggtcggtgc tgtgcttcat ctccacgtcc accacagtgg ccaccttcct catcgacatg
     1681 gaacgcttcc gctatcctga gcgccccatc atcttcctgt cagcctgcta cctgtgcgtg
     1741 tcgctgggct tcctggtgcg tctggtcgtg ggccatgcca gcgtggcctg cagccgcgag
     1801 cacaaccaca tccactacga gaccacgggc cctgcactgt gcaccatcgt cttcctcctg
     1861 gtctacttct tcggcatggc cagctccatc tggtgggtca tcctgtcgct cacctggttc
     1921 ctggccgccg gcatgaagtg gggcaacgag gccatcgcgg gctacgcgca gtacttccac
     1981 ctggctgcgt ggctcatccc cagcgtcaag tccatcacgg cactggcgct gagctccgtg
     2041 gacggggacc cagtggccgg catctgctac gtgggcaacc agaacctgaa ctcgctgcgc
     2101 ggcttcgtgc tgggcccgct ggtgctctac ctgctggtgg gcacgctctt cctgctggcg
     2161 ggcttcgtgt cgctcttccg catccgcagc gtcatcaagc agggcggcac caagacggac
     2221 aagctggaga agctcatgat ccgcatcggc atcttcacgc tgctctacac ggtccccgcc
     2281 agcattgtgg tggcctgcta cctgtacgag cagcactacc gcgagagctg ggaggcggcg
     2341 ctcacctgcg cctgcccggg ccacgacacc ggccagccgc gcgccaagcc cgagtactgg
     2401 gtgctcatgc tcaagtactt catgtgcctg gtggtgggca tcacgtcggg cgtctggatc
     2461 tggtcgggca agacggtgga gtcgtggcgg cgtttcacca gccgctgctg ctgccgcccg
     2521 cggcgcggcc acaagagcgg gggcgccatg gccgcagggg actaccccga ggcgagcgcc
     2581 gcgctcacag gcaggaccgg gccgccgggc cccgccgcca cctaccacaa gcaggtgtcc
     2641 ctgtcgcacg tgtaggaggc tgccgccgag ggactcggcc ggagagctga ggggaggggg
     2701 gcgttttgtt tggtagtttt gccaaggtca cttccgttta ccttcatggt gctgttgccc
     2761 cctcccgcgg cgacttggag agagggaaga ggggcgtttt cgaggaagaa cctgtcccag
     2821 gtcttctcca aggggcccag ctcacgtgta ttctattttg cgtttcttac tgccttcttt
     2881 atgggaaccc tctttttaat ttatatgtat ttttcttaat ttgtaacttt gttgcatttt
     2941 ggcaacaatt tacctttgct ttgggggctt tacaatccta aggttggcgt tgtaatgaag
     3001 ttccacttgg ttcaggtttc tttgaactgt gtggtctcaa ttgggaaaat atatttccta
     3061 tacgtgtgtc tttaaaaaaa aatgtgaaca gtgaacgttt cggttgctgt gactgggaag
     3121 ttgttgggtg tgctttttca gccagcttct ccttccactg cttaaagtgt ccatgattct
     3181 ttaaggtgag ctgcagttta tagccccagg tcatacctag gaggggagca taatgagctc
     3241 agggcctccc caaagtgaca aggttaggga gtgcttagcg gttttgtgtt cagccttagc
     3301 tttgtttata gagggaggtt cagtttcttt tctgtagtgc ttgtaataat tctcactcct
     3361 aacagcacca tcgttgtgtc ttgaataagt tagaggtagc attatagagg atctggcata
     3421 aatatttgca gtagtgagag cctaagcgat ggtgattggt ggagcttgaa ttttaggctg
     3481 gtgagatggc agctttgtgc ctgagaggta gtgggtggtt cttaagcttc agtgatcccc
     3541 tttttttttt tttttttttt tttttaagga acttgtgtta taattttggt aaaagtataa
     3601 acccactccc tctggacaat acttagcgac agttgctaaa gggggctcct ttttaaatgt
     3661 aaggactgaa atggatatac ttctaataag taaatttcca acacttattt gctccacccc
     3721 ctcccccctc ccccctcccc ctttatcatg ttaaacagcc tttttgcttt tcttattcct
     3781 cctctcctgg agagctgtga ttagaaacca cacccaccct tgaatgaagt gcttgaactg
     3841 ggggagggag gctggctacc tgtgaacaaa cattggccca aataagggaa aataagtgtt
     3901 cctggacttt ggactagttt atagccagat attccaagag cagcaagacg ttgctctctg
     3961 ccgtctctga aaacaaaaga gatgcataac atgcttgcac aaccttttaa aatatagatc
     4021 agtatagtgc tacctctata gttttcttcc tcttctgaga aagcctgtat attgatgatc
     4081 acacacacac acactttgca attagagaat ttggtttgct ttactaatct gtttaactat
     4141 tccttcattc attatgaacg cttatattga tgaacataca cacagaggtt tctttgctat
     4201 tagaaaattc tgtttgcttt cctaatctgt ttaagcattc attcatgaag agtgtggggc
     4261 cattactggg gaaggggggt gacagtgcct cagccagcaa aataccaatg accaggattg
     4321 gggactaaat ttaggaagct aaaatggcca gagcaattaa catttgagaa aatcctgtct
     4381 aggaaaacaa cttgagtgta ggcatttgta attcacttat accaaagttg gaaaagtaaa
     4441 atttaagcct aggacaattt ttacttcatg gatgttaaat agacaaatgc atagttccca
     4501 gggggaattt aaacacttta ctggtgggaa gaaacctagt attaaagttg taaggactct
     4561 caaaaacttc acatttatta aaatgcactg ctcttaccca atttatcctc tgaattaaaa
     4621 tttcagtgga ttctacaaaa cctcgtacaa atagctacag aactttgtgc ctattttatt
     4681 cctctattta ttcttctagg aagaagcctc ttcctagaat cttgaaatag atcccttgac
     4741 tgaatgccaa ttcctctcct gtttttcaaa tgagagaacc ttttctgatc accttgacct
     4801 tttccctcat ttcatatgtc ttcccagaaa gtagacagac tgctctgctg ccttcagtca
     4861 ttgtgcctca tttgggttgt ccctccttct ttgtggagaa atctggaaat gatgcacagt
     4921 gtatccaaaa gttgtgggat gaagtggatg aaagtgattt aattcatttt tagaattttt
     4981 ttttgttttg ttttagcaac atgctgaaca actaatttac tttaaaaata agccagttaa
     5041 aacaaaggac gctaagccca agtggggggc aatattagtc aggatctttg gggtctaatt
     5101 ccagaccaac tttcagaagc acttctttgt ctctgttctc acctctgctg tccctctctt
     5161 ccctcatccc ctaagagaga caaagataaa agcccacctg catccctaag tcttactgag
     5221 atcagccacc ccaggggaga gaaactggat ctacttacag ccaccccctg tttccatcca
     5281 tatagttact tcccccaatt tgcatgtgat tatggaaaca agtcatgctc atgaaagcaa
     5341 ctgtaaaata aaaggttatg gagtagttca gcaacttctt cacagccagc tttgtggagc
     5401 tggggaggac ttagggccca ttggagtctc ttatgtgtac agcttcaggg ctgtcccttt
     5461 cagtttgatt ttaagcaatg cctcacttca tagcttaggg ggtaaggatt ccattcaggt
     5521 aggttgtcta aaggaactaa tgggacctct cagtgaatta gctgaccaga ttttaggaaa
     5581 tctttttaat ttctatgatt ttccttctca cattttgaaa tggtaaaatt gactggaaat
     5641 aatttttctt ggtgccttat tggttttcct tgcaaacctt tctcatattt tctcatgacc
     5701 attgccagtg accaaggccc atgtgtgtgt tgtgtgtaat tgtgggcatg tacaagctta
     5761 aataacgtgc cgacagcact gtttcaaagt tggtattcat taggctgttg cctcctgggc
     5821 tggagctgcg ctaatcctga caccggctgc caggagaaaa cctcatggat cacacaccaa
     5881 accttaataa cagcatccgt gacctgcact ctccagtaca gaatgggaac cccagagcta
     5941 ggaaatgtag ttgtatattt taatgaactg ctaccccagc caaagaagct tctttcactt
     6001 ttgtgctcta cagaaagccc aaggggggta ggagggacag agctttgaat aactgctttc
     6061 taacactaaa tgtggccaac aggacagagc acatcacacg tataggcagg tgtgagggac
     6121 agtggctaag aattgcctgc tccctctgca tgctctttct tgtttccaaa gtccaatcaa
     6181 gtgatcctgg gaaacaaatc tgtctggatt gcggagggtg gttctgaaag aactgccaag
     6241 acgttaaaga agggtgaaga gtaggcagaa tataagtagc taacctgagt caagactctc
     6301 aaaagctagc agcctgatga caataggatt tatttcagcc aggatagtgt ctgtctgtga
     6361 gtgcatcatt ttaagacagt atgacttcat gttgttacaa actatgtata gtatgtatgt
     6421 tttgtgggtt gtatatatac ataatatata ttatatatat atatgagaga tttggtgact
     6481 tttgatacgg gtttggtgca ggtgaattta ttactgagcc aaatgaggca cataccgagt
     6541 cagtagttga agtccagggc attcgatact gtttatgatt tccatatatg tatagtgcct
     6601 atcccatgct gtagtcactg ttatgttaaa tccagaagtt acactagagc cagcgatact
     6661 ttatttgtag acaatcaatt tgaatccata tgttattact ggcagatgat acatgattac
     6721 agttctgaat ctgtaacact tacaaaagga aacccagagc agcttgatga gtttttgttt
     6781 ctgcttcgtt cctgggagtc agtagaaaca gcagttgtat gtggttatgt tagtctcaag
     6841 atacttaatt tgttgacctt acttcagaaa aattttgtat gtattatatt tgtgggaagg
     6901 taaaataatc atttgagatt tttatcaaat atgaagatta gttatttatg aaaaacaaag
     6961 aaatgtctat ttttctttgt tcccaattaa tgtagataaa ttttaaaatg cattaaagta
     7021 atggtaaaga caataaaaa
//
