LOCUS       NM_012193               7387 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens frizzled class receptor 4 (FZD4), mRNA.
ACCESSION   NM_012193
VERSION     NM_012193.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7387)
  AUTHORS   Bian,F., Goda,C., Wang,G., Lan,Y.W., Deng,Z., Gao,W., Acharya,A.,
            Reza,A.A., Gomez-Arroyo,J., Merjaneh,N., Ren,X., Goveia,J.,
            Carmeliet,P., Kalinichenko,V.V. and Kalin,T.V.
  TITLE     FOXF1 promotes tumor vessel normalization and prevents lung cancer
            progression through FZD4
  JOURNAL   EMBO Mol Med 16 (5), 1063-1090 (2024)
   PUBMED   38589650
  REMARK    GeneRIF: FOXF1 promotes tumor vessel normalization and prevents
            lung cancer progression through FZD4.
REFERENCE   2  (bases 1 to 7387)
  AUTHORS   Dai,E., Liu,M., Li,S., Zhang,X., Wang,S., Zhao,R., He,Y., Peng,L.,
            Lv,L., Xiao,H., Yang,M., Yang,Z. and Zhao,P.
  TITLE     Identification of Novel FZD4 Mutations in Familial Exudative
            Vitreoretinopathy and Investigating the Pathogenic Mechanisms of
            FZD4 Mutations
  JOURNAL   Invest Ophthalmol Vis Sci 65 (4), 1 (2024)
   PUBMED   38558095
  REMARK    GeneRIF: Identification of Novel FZD4 Mutations in Familial
            Exudative Vitreoretinopathy and Investigating the Pathogenic
            Mechanisms of FZD4 Mutations.
REFERENCE   3  (bases 1 to 7387)
  AUTHORS   Liu,M., Dai,E., Yang,M., Li,S., Fan,L., Liu,Y., Xiao,H., Zhao,P.
            and Yang,Z.
  TITLE     Investigating the Impact of Dimer Interface Mutations on Norrin's
            Secretion and Norrin/beta-Catenin Pathway Activation
  JOURNAL   Invest Ophthalmol Vis Sci 65 (3), 31 (2024)
   PUBMED   38517429
  REMARK    GeneRIF: Investigating the Impact of Dimer Interface Mutations on
            Norrin's Secretion and Norrin/beta-Catenin Pathway Activation.
REFERENCE   4  (bases 1 to 7387)
  AUTHORS   Yin,M., Wang,J., Ying,X., Fang,Z. and Zhang,X.
  TITLE     Long non coding RNA, C8orf49, a novel diagnostic and prognostic
            biomarker, enhances PTEN/FZD4-mediated cell growth and metastasis
            by sponging miR-1323 in endometriosis
  JOURNAL   Mol Cell Endocrinol 575, 112040 (2023)
   PUBMED   37557978
  REMARK    GeneRIF: Long non coding RNA, C8orf49, a novel diagnostic and
            prognostic biomarker, enhances PTEN/FZD4-mediated cell growth and
            metastasis by sponging miR-1323 in endometriosis.
REFERENCE   5  (bases 1 to 7387)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   6  (bases 1 to 7387)
  AUTHORS   Sagara,N., Kirikoshi,H., Terasaki,H., Yasuhiko,Y., Toda,G.,
            Shiokawa,K. and Katoh,M.
  TITLE     FZD4S, a splicing variant of frizzled-4, encodes a soluble-type
            positive regulator of the WNT signaling pathway
  JOURNAL   Biochem Biophys Res Commun 282 (3), 750-756 (2001)
   PUBMED   11401527
REFERENCE   7  (bases 1 to 7387)
  AUTHORS   Kirikoshi,H., Sagara,N., Koike,J., Tanaka,K., Sekihara,H., Hirai,M.
            and Katoh,M.
  TITLE     Molecular cloning and characterization of human Frizzled-4 on
            chromosome 11q14-q21
  JOURNAL   Biochem Biophys Res Commun 264 (3), 955-961 (1999)
   PUBMED   10544037
REFERENCE   8  (bases 1 to 7387)
  AUTHORS   Tanaka,S., Akiyoshi,T., Mori,M., Wands,J.R. and Sugimachi,K.
  TITLE     A novel frizzled gene identified in human esophageal carcinoma
            mediates APC/beta-catenin signals
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 10164-10169 (1998)
   PUBMED   9707618
REFERENCE   9  (bases 1 to 7387)
  AUTHORS   Toomes,C. and Downey,L.
  TITLE     Familial Exudative Vitreoretinopathy, Autosomal Dominant - RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301326
REFERENCE   10 (bases 1 to 7387)
  AUTHORS   Li,Y., Fuhrmann,C., Schwinger,E., Gal,A. and Laqua,H.
  TITLE     The gene for autosomal dominant familial exudative
            vitreoretinopathy (Criswick-Schepens) on the long arm of chromosome
            11
  JOURNAL   Am J Ophthalmol 113 (6), 712-713 (1992)
   PUBMED   1598965
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001528.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_012193.3.
            
            Summary: This gene is a member of the frizzled gene family. Members
            of this family encode seven-transmembrane domain proteins that are
            receptors for the Wingless type MMTV integration site family of
            signaling proteins. Most frizzled receptors are coupled to the
            beta-catenin canonical signaling pathway. This protein may play a
            role as a positive regulator of the Wingless type MMTV integration
            site signaling pathway. A transcript variant retaining intronic
            sequence and encoding a shorter isoform has been described,
            however, its expression is not supported by other experimental
            evidence. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032417.1, BC114527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148, SAMEA2467150
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: community standard
                                                (PMID:10544037)
            MANE Ensembl match               :: ENST00000531380.2/
                                                ENSP00000434034.1
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-595               AP001528.4         73314-73908         c
            596-7387            AP001528.4         64192-70983         c
FEATURES             Location/Qualifiers
     source          1..7387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.2"
     gene            1..7387
                     /gene="FZD4"
                     /gene_synonym="CD344; EVR1; FEVR; Fz-4; Fz4; FZD4S; FzE4;
                     GPCR; hFz4"
                     /note="frizzled class receptor 4"
                     /db_xref="GeneID:8322"
                     /db_xref="HGNC:HGNC:4042"
                     /db_xref="MIM:604579"
     exon            1..595
                     /gene="FZD4"
                     /gene_synonym="CD344; EVR1; FEVR; Fz-4; Fz4; FZD4S; FzE4;
                     GPCR; hFz4"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1924
                     /gene="FZD4"
                     /gene_synonym="CD344; EVR1; FEVR; Fz-4; Fz4; FZD4S; FzE4;
                     GPCR; hFz4"
                     /note="frizzled 4, seven transmembrane spanning receptor;
                     frizzled family receptor 4; WNT receptor frizzled-4;
                     frizzled homolog 4"
                     /codon_start=1
                     /product="frizzled-4 precursor"
                     /protein_id="NP_036325.2"
                     /db_xref="CCDS:CCDS8279.1"
                     /db_xref="GeneID:8322"
                     /db_xref="HGNC:HGNC:4042"
                     /db_xref="MIM:604579"
                     /translation="MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERR
                     CDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVY
                     VPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCME
                     GPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEF
                     TDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVG
                     RERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLK
                     WGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVV
                     APLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATC
                     VIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCS
                     NRLVNSGKVKREKRGNGWVKPGKGSETVV"
     exon            596..7387
                     /gene="FZD4"
                     /gene_synonym="CD344; EVR1; FEVR; Fz-4; Fz4; FZD4S; FzE4;
                     GPCR; hFz4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7369..7374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD4"
                     /gene_synonym="CD344; EVR1; FEVR; Fz-4; Fz4; FZD4S; FzE4;
                     GPCR; hFz4"
                     /note="hexamer: AATAAA"
     polyA_site      7387
                     /gene="FZD4"
                     /gene_synonym="CD344; EVR1; FEVR; Fz-4; Fz4; FZD4S; FzE4;
                     GPCR; hFz4"
                     /note="major polyA site"
ORIGIN      
        1 gagagctgcg cagcgctggc tgctggctgg cctcgcggag acgccgaacg gacgcggccg
       61 gcgccggctt gtgggctcgc cgcctgcagc catgaccctc gcagcctgtc cctcggcctc
      121 ggcccgggac gtctaaaatc ccacacagtc gcgcgcagct gctggagagc cggccgctgc
      181 cccctcgtcg ccgcatcaca ctcccgtccc gggagctggg agcagcgcgg gcagccggcg
      241 cccccgtgca aactgggggt gtctgccaga gcagccccag ccgctgccgc tgctaccccc
      301 gatgctggcc atggcctggc ggggcgcagg gccgagcgtc ccgggggcgc ccgggggcgt
      361 cggtctcagt ctggggttgc tcctgcagtt gctgctgctc ctggggccgg cgcggggctt
      421 cggggacgag gaagagcggc gctgcgaccc catccgcatc tccatgtgcc agaacctcgg
      481 ctacaacgtg accaagatgc ccaacctggt tgggcacgag ctgcagacgg acgccgagct
      541 gcagctgaca actttcacac cgctcatcca gtacggctgc tccagccagc tgcagttctt
      601 cctttgttct gtttatgtgc caatgtgcac agagaagatc aacatcccca ttggcccatg
      661 cggcggcatg tgtctttcag tcaagagacg ctgtgaaccc gtcctgaagg aatttggatt
      721 tgcctggcca gagagtctga actgcagcaa attcccacca cagaacgacc acaaccacat
      781 gtgcatggaa gggccaggtg atgaagaggt gcccttacct cacaaaaccc ccatccagcc
      841 tggggaagag tgtcactctg tgggaaccaa ttctgatcag tacatctggg tgaaaaggag
      901 cctgaactgt gtgctcaagt gtggctatga tgctggctta tacagccgct cagccaagga
      961 gttcactgat atctggatgg ctgtgtgggc cagcctgtgt ttcatctcca ctgccttcac
     1021 agtactgacc ttcctgatcg attcttctag gttttcctac cctgagcgcc ccatcatatt
     1081 tctcagtatg tgctataata tttatagcat tgcttatatt gtcaggctga ctgtaggccg
     1141 ggaaaggata tcctgtgatt ttgaagaggc agcagaacct gttctcatcc aagaaggact
     1201 taagaacaca ggatgtgcaa taattttctt gctgatgtac ttttttggaa tggccagctc
     1261 catttggtgg gttattctga cactcacttg gtttttggca gcaggactca aatggggtca
     1321 tgaagccatt gaaatgcaca gctcttattt ccacattgca gcctgggcca tccccgcagt
     1381 gaaaaccatt gtcatcttga ttatgagact ggtggatgca gatgaactga ctggcttgtg
     1441 ctatgttgga aaccaaaatc tcgatgccct caccgggttc gtggtggctc ccctctttac
     1501 ttatttggtc attggaactt tgttcattgc tgcaggtttg gtggccttgt tcaaaattcg
     1561 gtcaaatctt caaaaggatg ggacaaagac agacaagtta gaaagactga tggtcaagat
     1621 tggggtgttc tcagtactgt acacagttcc tgcaacgtgt gtgattgcct gttattttta
     1681 tgaaatctcc aactgggcac tttttcggta ttctgcagat gattccaaca tggctgttga
     1741 aatgttgaaa atttttatgt ctttgttggt gggcatcact tcaggcatgt ggatttggtc
     1801 tgccaaaact cttcacacgt ggcagaagtg ttccaacaga ttggtgaatt ctggaaaggt
     1861 aaagagagag aagagaggaa atggttgggt gaagcctgga aaaggcagtg agactgtggt
     1921 ataaggctag tcagcctcca tgctttcttc attttgaagg ggggaatgcc agcattttgg
     1981 aggaaattct actaaaagtt ttatgcagtg aatctcagtt tgaacaaact agcaacaatt
     2041 aagtgacccc cgtcaaccca ctgcctccca ccccgacccc agcatcaaaa aaccaatgat
     2101 tttgctgcag actttggaat gatccaaaat ggaaaagcca gttagaggct ttcaaagctg
     2161 tgaaaaatca aaacgttgat cactttagca ggttgcagct tggagcgtgg aggtcctgcc
     2221 tagattccag gaagtccagg gcgatactgt tttcccctgc agggtgggat ttgagctgtg
     2281 agttggtaac tagcagggag aaatattaac ttttttaacc ctttaccatt ttaaatacta
     2341 actgggtctt tcagatagca aagcaatcta taaacactgg aaacgctggg ttcagaaaag
     2401 tgttacaaga gttttatagt ttggctgatg taacataaac atcttctgtg gtgcgctgtc
     2461 tgctgtttag aactttgtgg actgcactcc caagaagtgg tgttagaatc tttcagtgcc
     2521 tttgtcataa aacagttatt tgaacaaaca aaagtactgt actcacacac ataaggtatc
     2581 cagtggattt ttcttctctg tcttcctctc ttaaatttca acatctctct tcttggctgc
     2641 tgctgttttc ttcattttat gttaatgact caaaaaaggt atttttatag aatttttgta
     2701 ctgcagcatg cttaaagagg ggaaaaggaa gggtgattca ctttctgaca atcacttaat
     2761 tcagaggaaa atgagattta ctaagttgac ttacctgacg gaccccagag acctattgca
     2821 ttgagcagtg gggacttaat atattttact tgtgtgattg catctatgca gacgccagtc
     2881 tggaagagct gaaatgttaa gtttcttggc aactttgcat tcacacagat tagctgtgta
     2941 atttttgtgt gtcaattaca attaaaagca cattgttgga ccatgacata gtatactcaa
     3001 ctgactttaa aactatggtc aacttcaact tgcattctca gaatgatagt gcctttaaaa
     3061 atttttttat tttttaaagc ataagaatgt tatcagaatc tggtctactt aggacaatgg
     3121 agactttttc agttttataa agggaactga ggacagctaa tccaactact tggtgcgtaa
     3181 ttgtttccta gtaattggca aaggctcctt gtaagatttc actggaggca gtgtggcctg
     3241 gagtatttat atggtgctta atgaatctcc agaatgccag ccagaagcct gattggttag
     3301 tagggaataa agtgtagacc atatgaaatg aactgcaaac tctaatagcc caggtcttaa
     3361 ttgcctttag cagaggtatc caaagctttt aaaatttatg catacgttct tcacaagggg
     3421 gtacccccag cagcctctcg aaaattgcac ttctcttaaa actgtaactg gcctttctct
     3481 taccttgcct taggcgttct aatcatgaga tcttggggac aaattgacta tgtcacaggt
     3541 tgctctcctt gtaactcata cctgtctgct tcagcaactg ctttgcaatg acatttattt
     3601 attaattcat gccttaaaaa aataggaagg gaagcttttt tttttctttt tttttttttc
     3661 aatcacactt tgtggaaaaa catttccagg gactcaaaat tccaaaaagg tggtcaaatt
     3721 ctggaagtaa gcatttcctc ttttttaaaa atttggtttg agccttatgc ccatagtttg
     3781 acatttccct ttcttctttc ctttttgttt ttgtgtggtt cttgagctct ctgacatcaa
     3841 gatgcatgta aagtcgattg tatgttttgg aaggcaaagt cttggctttt gagactgaag
     3901 ttaagtgggc acaggtggcc cctgctgctg tgcccagtct gagtaccttg gctagactct
     3961 aggtcaggct ccaggagcat gagaattgat ccccagaaga accattttaa ctccatctga
     4021 tactccattg cctatgaaat gtaaaatgtg aactccctgt gctgcttgta gacagttccc
     4081 ataactgtcc acggccctgg agcacgcacc caggggcaga gcctgccctt actcacgctc
     4141 tgctctggtg tcttgggagt tgtgcaggga ctctggccca ggcaggggaa ggaagaccag
     4201 gcggtagggg actggtcttg ctgttagagt atagaggttt gtaatgcagt tttcttcata
     4261 atgtgtcagt gattgtgtga ccaaggcagc atctagcaga aagccaggca tggagtaggt
     4321 gatcgatact tgtcaatgac taaataataa caataaaaga gcacttgggt gaatctgggc
     4381 acctgatttc tgagttttga gttctggagc tagtgttttg acaatgcttt gggttttgac
     4441 atgccttttc cacaaatctc ttgccttttc agggcaaagt gtatttgatc agaagtggcc
     4501 atttggatta gtagccttag caatgctaca gggttatagg cctctccttt cacattccag
     4561 acaatggaga gtgtttatgg tttcaggaaa agaactttgt ggctgagggg tcagttacca
     4621 gtgaccttca atcaactcca tcacttctta aatcggtatt tgttaaaaaa atcagttatt
     4681 ttatttattg agtgccgact gtagtaaagc cctgaaatag ataatctctg ttcttctaac
     4741 tgatctagga tggggacgca cccaggtctg ctgaacttta ctgttcctct gggaaaggag
     4801 cagggacctc tggaattccc atctgtttca ctgtctccat tccataaatc tcttcctgtg
     4861 tgagccacca cacccagcct gggtctctct acttttaaca catctctcat ccctttccca
     4921 ggattccttc caagtcagtt acaggtggtt ttaacagaaa gcatcagctc tgcttcgtga
     4981 cagtctctgg agaaatccct taggaagact atgagagtag gccacaagga catgggccca
     5041 cacatctgct ttggctttgc cggcaattca gggcttgggg tattccatgt gacttgtata
     5101 ggtatatttg aggacagcat cttgctagag aaaaggtgag ggttgttttt ctttctctga
     5161 aacctacagt aaatgggtat gattgtagct tcctcagaaa tcccttggcc tccagagatt
     5221 aaacatggtg caatggcacc tctgtccaac ctcctttctg gtagattcct ttctcctgct
     5281 tcatataggc caaacctcag ggcaagggaa catgggggta gagtggtgct ggccagaacc
     5341 atctgcttga gctacttggt tgattcatat cctctttcct ttatggagac ccatttcctg
     5401 atctctgaga ctgttgctga actggcaact tacttgggcc tgaaactgga gaaggggtga
     5461 cattttttta atttcagaga tgctttctga ttttcctctc ccaggtcact gtctcacctg
     5521 cactctccaa actcaggttc cgggaagctt gtgtgtctag atactgaatt gagattctgt
     5581 tcagcacctt ttagctctat actctctggc tcccctcatc ctcatggtca ctgaattaaa
     5641 tgcttattgt attgagaacc aagatgggac ctgaggacac aaagatgagc tcaacagtct
     5701 cagccctaga ggaatagact cagggatttc accaggtcgg tgcagtattt gatttctggt
     5761 gaggtgacca cagctgcagt tagggaaggg agccattgag cacagacttt ggaaggaacc
     5821 ttttttttgt tgtttgtttg tttgtttgtt tgtttgtttg tttgagacag ggtcttgctc
     5881 tgtcacccag gctggggcgc aatggcacga tcttggctca ctgcaacctc tgcctcctgg
     5941 gttcaagtga ttctcctgcc acagcctcct gaggagctgg gactacaggt gcgtgctacc
     6001 acgcccagct acttctgtat ttttagtaga gacggggttt cactgtgttg gccaggctgg
     6061 tctcgaactc ctgacctcat gatctgcccg cctcagcctc ccaaagtgct gggattacaa
     6121 gtgtgagcca ccacacctgg cctggaagga acctcttaaa atcagtttac gtcttgtatt
     6181 ttgttctgtg atggaggaca ctggagagag ttgctattcc agtcaatcat gtcgagtcac
     6241 tggactctga aaatcctatt ggttccttta ttttatttga gtttagagtt cccttctggg
     6301 tttgtattat gtctggcaaa tgacctgggt tatcactttt cctccagggt tagatcatag
     6361 atcttggaaa ctccttagag agcattttgc tcctaccaag gatcagatac tggagcccca
     6421 cataatagat ttcatttcac tctagcctac atagagcttt ctgttgctgt ctcttgccat
     6481 gcacttgtgc ggtgattaca cacttgacag taccaggaga caaatgactt acagatcccc
     6541 cgacatgcct cttccccttg gcaagctcag ttgccctgat agtagcatgt ttctgtttct
     6601 gatgtacctt ttttctcttc ttctttgcat cagccaattc ccagaatttc cccaggcaat
     6661 ttgtagagga cctttttggg gtcctatatg agccatgtcc tcaaagcttt taaacctcct
     6721 tgctctccta caatattcag tacatgacca ctgtcatcct agaaggcttc tgaaaagagg
     6781 ggcaagagcc actctgcgcc acaaaggttg ggtccatctt ctctccgagg ttgtgaaagt
     6841 tttcaaattg tactaatagg ctggggccct gacttggctg tgggctttgg gaggggtaag
     6901 ctgctttcta gatctctccc agtgaggcat ggaggtgttt ctgaattttg tctacctcac
     6961 agggatgttg tgaggcttga aaaggtcaaa aaatgatggc cccttgagct ctttgtaaga
     7021 aaggtagatg aaatatcgga tgtaatctga aaaaaagata aaatgtgact tcccctgctc
     7081 tgtgcagcag tcgggctgga tgctctgtgg cctttcttgg gtcctcatgc caccccacag
     7141 ctccaggaac cttgaagcca atctggggga ctttcagatg tttgacaaag aggtaccagg
     7201 caaacttcct gctacacatg ccctgaatga attgctaaat ttcaaaggaa atggaccctg
     7261 cttttaagga tgtacaaaag tatgtctgca tcgatgtctg tactgtaaat ttctaattta
     7321 tcactgtaca aagaaaaccc cttgctattt aattttgtat taaaggaaaa taaagttttg
     7381 tttgtta
//
