LOCUS       NM_017412              13770 bp    mRNA    linear   PRI 14-NOV-2024
DEFINITION  Homo sapiens frizzled class receptor 3 (FZD3), transcript variant
            1, mRNA.
ACCESSION   NM_017412
VERSION     NM_017412.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13770)
  AUTHORS   Zhao,H., Wu,G., Luo,Y., Xie,Y., Han,Y., Zhang,D., Han,Q., Zhao,X.,
            Qin,Y., Li,Q. and Wang,E.
  TITLE     WNT5B promotes the malignant phenotype of non-small cell lung
            cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway
  JOURNAL   Cell Signal 122, 111330 (2024)
   PUBMED   39094673
  REMARK    GeneRIF: WNT5B promotes the malignant phenotype of non-small cell
            lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.
REFERENCE   2  (bases 1 to 13770)
  AUTHORS   Li,J., Zhang,J., Chu,Z., Han,H. and Zhang,Y.
  TITLE     FZD3 regulates the viability, apoptosis, and extracellular matrix
            degradation of vaginal wall fibroblasts in pelvic organ prolapse
            via the Wnt signaling pathway
  JOURNAL   J Biochem Mol Toxicol 38 (2), e23654 (2024)
   PUBMED   38348712
  REMARK    GeneRIF: FZD3 regulates the viability, apoptosis, and extracellular
            matrix degradation of vaginal wall fibroblasts in pelvic organ
            prolapse via the Wnt signaling pathway.
REFERENCE   3  (bases 1 to 13770)
  AUTHORS   Meng,Z., Liu,Q., Liu,Y., Yang,Y., Shao,C. and Zhang,S.
  TITLE     Frizzled-3 suppression overcomes multidrug chemoresistance by
            Wnt/beta-catenin signaling pathway inhibition in hepatocellular
            carcinoma cells
  JOURNAL   J Chemother 35 (7), 653-661 (2023)
   PUBMED   36843499
  REMARK    GeneRIF: Frizzled-3 suppression overcomes multidrug chemoresistance
            by Wnt/beta-catenin signaling pathway inhibition in hepatocellular
            carcinoma cells.
REFERENCE   4  (bases 1 to 13770)
  AUTHORS   Xiang,M., Huang,Y., Dai,C. and Zou,G.
  TITLE     MiR-340 regulates the growth and metabolism of renal cell carcinoma
            cells by targeting frizzled class receptor 3
  JOURNAL   Arch Pharm Res 44 (2), 219-229 (2021)
   PUBMED   33609235
  REMARK    GeneRIF: MiR-340 regulates the growth and metabolism of renal cell
            carcinoma cells by targeting frizzled class receptor 3.
REFERENCE   5  (bases 1 to 13770)
  AUTHORS   Blue,E.E., Thornton,T.A., Kooperberg,C., Liu,S.,
            Wactawski-Wende,J., Manson,J., Kuller,L., Hayden,K. and Reiner,A.P.
  TITLE     Non-coding variants in MYH11, FZD3, and SORCS3 are associated with
            dementia in women
  JOURNAL   Alzheimers Dement 17 (2), 215-225 (2021)
   PUBMED   32966694
  REMARK    GeneRIF: Non-coding variants in MYH11, FZD3, and SORCS3 are
            associated with dementia in women.
REFERENCE   6  (bases 1 to 13770)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 13770)
  AUTHORS   Katsu,T., Ujike,H., Nakano,T., Tanaka,Y., Nomura,A., Nakata,K.,
            Takaki,M., Sakai,A., Uchida,N., Imamura,T. and Kuroda,S.
  TITLE     The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor
            gene for Wnt ligands, is associated with the susceptibility to
            schizophrenia
  JOURNAL   Neurosci Lett 353 (1), 53-56 (2003)
   PUBMED   14642436
  REMARK    GeneRIF: This study found a significant association between
            schizophrenia and the FZD3 gene in single nucleotide polymorphisms
            and haplotype analyses.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 13770)
  AUTHORS   Hung,B.S., Wang,X.Q., Cam,G.R. and Rothnagel,J.A.
  TITLE     Characterization of mouse Frizzled-3 expression in hair follicle
            development and identification of the human homolog in
            keratinocytes
  JOURNAL   J Invest Dermatol 116 (6), 940-946 (2001)
   PUBMED   11407985
REFERENCE   9  (bases 1 to 13770)
  AUTHORS   Sala,C.F., Formenti,E., Terstappen,G.C. and Caricasole,A.
  TITLE     Identification, gene structure, and expression of human frizzled-3
            (FZD3)
  JOURNAL   Biochem Biophys Res Commun 273 (1), 27-34 (2000)
   PUBMED   10873558
REFERENCE   10 (bases 1 to 13770)
  AUTHORS   Kirikoshi,H., Koike,J., Sagara,N., Saitoh,T., Tokuhara,M.,
            Tanaka,K., Sekihara,H., Hirai,M. and Katoh,M.
  TITLE     Molecular cloning and genomic structure of human frizzled-3 at
            chromosome 8p21
  JOURNAL   Biochem Biophys Res Commun 271 (1), 8-14 (2000)
   PUBMED   10777673
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA250029.1, AB039723.1,
            AC011132.15 and BU676090.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017412.3.
            
            Summary: This gene is a member of the frizzled gene family. Members
            of this family encode seven-transmembrane domain proteins that are
            receptors for the wingless type MMTV integration site family of
            signaling proteins. Most frizzled receptors are coupled to the
            beta-catenin canonical signaling pathway. The function of this
            protein is unknown, although it may play a role in mammalian hair
            follicle development. Alternative splicing results in multiple
            transcript variants. This gene is a susceptibility locus for
            schizophrenia. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.275442.1,
                                           SRR1803616.25154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240093.8/ ENSP00000240093.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                DA250029.1         8-51
            45-102              AB039723.1         1-58
            103-2604            AB039723.1         61-2562
            2605-2605           AC011132.15        24642-24642         c
            2606-3418           AB039723.1         2563-3375
            3419-13134          AC011132.15        14113-23828         c
            13135-13770         BU676090.1         28-663              c
FEATURES             Location/Qualifiers
     source          1..13770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..13770
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /note="frizzled class receptor 3"
                     /db_xref="GeneID:7976"
                     /db_xref="HGNC:HGNC:4041"
                     /db_xref="MIM:606143"
     exon            1..132
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /inference="alignment:Splign:2.1.0"
     exon            133..178
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /inference="alignment:Splign:2.1.0"
     exon            179..711
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             523..2523
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; frizzled 3, seven transmembrane spanning
                     receptor; frizzled homolog 3; frizzled family receptor 3"
                     /codon_start=1
                     /product="frizzled-3 isoform 1 precursor"
                     /protein_id="NP_059108.1"
                     /db_xref="CCDS:CCDS6069.1"
                     /db_xref="GeneID:7976"
                     /db_xref="HGNC:HGNC:4041"
                     /db_xref="MIM:606143"
                     /translation="MAMTWIVFSLWPLTVFMGHIGGHSLFSCEPITLRMCQDLPYNTT
                     FMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRL
                     CQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQRD
                     YGFWCPRELKIDPDLGYSFLHVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATL
                     FTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKAST
                     VTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAS
                     AWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLA
                     GIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWE
                     TTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWA
                     SFFHGRRKKEIVNESRQVLQEPDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLA
                     MVDDQRSKAGSIHSKVSSYHGSLHRSRDGRYTPCSYRGMEERLPHGSMSRLTDHSRHS
                     SSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIEEDGTSA"
     exon            712..908
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1926
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2075
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2309
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..13770
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11396..11401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /note="hexamer: ATTAAA"
     polyA_site      11418
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
     regulatory      13751..13756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /note="hexamer: AATAAA"
     polyA_site      13770
                     /gene="FZD3"
                     /gene_synonym="Fz-3"
                     /note="major polyA site"
ORIGIN      
        1 gcgaaagctc gctgtcgctg ggaggcgcgc gccggcgttc ctcggccgct ccgggtacct
       61 gagggacgcg cggccgcccg cggcaggcgg tgcagccccc ccaccccttg gagccaggcg
      121 ccggggtctg aggatagcat ttctcaagac ctgacttatg gagcacttgt aacctgagat
      181 atttcagttg aaggaagaaa tagctcttct cctaagatgg aatctgtggt ttgggaatgt
      241 ggttgatcaa cttgatatgt tggccaaatg tgccccatgt aataaaatga aaagaagaga
      301 caagatgatg tcattttccc atattgtgaa accaaaaaca aacgcctttt gtgagaccaa
      361 gctaacaaac ctctgacggt gcgaagagta tttaactgtt tgaagaattt aacagtaaga
      421 tacagaagaa gtaccttcga gctgagacct gcaggtgtat aaatatctaa aatacatatt
      481 gaataggcct gatcatctga atctccttca gacccaggaa ggatggctat gacttggatt
      541 gtcttctctc tttggccctt gactgtgttc atggggcata taggtgggca cagtttgttt
      601 tcttgtgaac ctattacctt gaggatgtgc caagatttgc cttataatac taccttcatg
      661 cctaatcttc tgaatcatta tgaccaacag acagcagctt tggcaatgga gccattccac
      721 cctatggtga atctggattg ttctcgggat ttccggcctt ttctttgtgc actctacgct
      781 cctatttgta tggaatatgg acgtgtcaca cttccctgtc gtaggctgtg tcagcgggct
      841 tacagtgagt gttcgaagct catggagatg tttggtgttc cttggcctga agatatggaa
      901 tgcagtaggt tcccagattg tgatgagcca tatcctcgac ttgtggatct gaatttagct
      961 ggagaaccaa ctgaaggagc cccagtggca gtgcagagag actatggttt ttggtgtccc
     1021 cgagagttaa aaattgatcc tgatctgggt tattcttttc tgcatgtgcg tgattgttca
     1081 cctccttgtc caaatatgta cttcagaaga gaagaactgt catttgctcg ctatttcata
     1141 ggattgattt caatcatttg cctctcggcc acattgttta cttttttaac ttttttgatt
     1201 gatgtcacaa gattccgtta tcctgaaagg cctattatat tttatgcagt ctgctacatg
     1261 atggtatcct taattttctt cattggattt ttgcttgaag atcgagtagc ctgcaatgca
     1321 tccatccctg cacaatataa ggcttccaca gtgacacaag gatctcataa taaagcctgt
     1381 accatgcttt ttatgatact ctattttttt actatggctg gcagtgtatg gtgggtaatt
     1441 cttaccatca catggttttt agcagctgtg ccaaagtggg gtagtgaagc tattgagaag
     1501 aaagcattgc tgtttcacgc cagtgcatgg ggcatccccg gaactctaac catcatcctt
     1561 ttagcgatga ataaaattga aggtgacaat attagtggcg tgtgttttgt tggcctctac
     1621 gatgttgatg cattgagata ttttgttctt gctcccctct gcctgtatgt ggtagttggg
     1681 gtttctctcc tcttagctgg cattatatcc ctaaacagag ttcgaattga gattccatta
     1741 gaaaaggaga accaagataa attagtgaag tttatgatcc ggatcggtgt tttcagcatt
     1801 ctttatctcg taccactctt ggttgtaatt ggatgctact tttatgagca agcttaccgg
     1861 ggcatctggg aaacaacgtg gatacaagaa cgctgcagag aatatcacat tccatgtcca
     1921 tatcaggtta ctcaaatgag tcgtccagac ttgattctct ttctgatgaa atacctgatg
     1981 gctctcatag ttggcattcc ctctgtattt tgggttggaa gcaaaaagac atgctttgaa
     2041 tgggccagtt tttttcatgg tcgtaggaaa aaagagatag tgaatgagag ccgacaggta
     2101 ctccaggaac ctgattttgc tcagtctctc ctgagggatc caaatactcc tatcataaga
     2161 aagtcaaggg gaacttccac tcaaggaaca tccacccatg cttcttcaac tcagctggct
     2221 atggtggatg atcaaagaag caaagcagga agcatccaca gcaaagtgag cagctaccac
     2281 ggcagcctcc acagatcacg tgatggcagg tacacgccct gcagttacag aggaatggag
     2341 gagagactac ctcatggcag catgtcacga ctaacagatc actccaggca tagtagttct
     2401 catcggctca atgaacagtc acgacatagc agcatcagag atctcagtaa taatcccatg
     2461 actcatatca cacatggcac cagcatgaat cgggttattg aagaagatgg aaccagtgct
     2521 taatttgtct tgtctaaggt ggaaatcttg tgctgtttaa aaagcagatt ttattctttg
     2581 ccttttgcat gactgatagc tgtaactcac agttaacatg ctttcagtca agtacagatt
     2641 gtgtccactg gaaaggtaaa tgattgcttt tttatattgc atcaaacttg gaacatcaag
     2701 gcatccaaaa cactaagaat tctatcatca caaaaataat tcgtctttct aggttatgaa
     2761 gagataatta tttgtctggt aagcattttt ataaacccac tcattttata tttagaaaaa
     2821 tcctaaatgt gtggtgactg ctttgtagtg aactttcata tactataaac tagttgtgag
     2881 ataacattct ggtagctcag ttaataaaac aatttcagaa ttaaagaaat tttctatgca
     2941 aggtttactt ctcagatgaa cagtaggact ttgtagtttt atttccacta agtgaaaaaa
     3001 gaactgtgtt tttaaactgt aggagaattt aataaatcag caagggtatt ttagctaata
     3061 gaataaaagt gcaacagaag aatttgatta gtctatgaaa ggttctctta aaattctatc
     3121 gaaataatct tcatgcagag atattcaggg tttggattag cagtggaata aagagatggg
     3181 cattgtttcc cctataattg tgctgttttt ataacttttg taaatattac tttttctggc
     3241 tgtgttttta taacttatcc atatgcatga tggaaaaatt ttaatttgta gccatctttt
     3301 cccatgtaat agtattgatt catagagaac ttaatgttca aaatttgctt tgtggaggca
     3361 tgtaataaga taaacatcat acattataag gtaaccacaa ttacaaaatg gcaaaacatt
     3421 ttctctgtat tcattgttgt atttttctac agtgagatgt gatcttgcca aagccaccag
     3481 accttggctt ccaggccctc ctgtagtgag ttgattgtct gcacttgcct tgcccaatag
     3541 ccagtaggct acagcttttg ccccacaccc ttattttcag attctggatc attcttgttt
     3601 acaactgaaa tatatataac ctcagtccaa agtggtgatt gatttgagta tttgaaaatt
     3661 gttgtagcta aatgaagcat gattagtctt agtatgaata tcatttaatc tttaaaaaat
     3721 caagtaaaaa tgtttatctg ataatgttta aataatttac aatataaact gtaaaactta
     3781 ttaggcatga aatcaatcag aagagaaaga aaaatgctgg aacatgcttg atgtattatg
     3841 taaaaagcat atttaaacaa gggtcctcaa ccctgactgc agataagaat cacttgggtt
     3901 acttcagatg cctaacacct tcctctcata caaataagaa ttggtagctt tcttaaaaaa
     3961 aaaaaaaaaa aaaaaaagcg ctccaggtga ttctaatctg cagcctggct tgaaactcac
     4021 tactttaact tgcccctgat gatctgtcgg catcatatat cacatgaaca tccacatgga
     4081 ttctgtcttt cgcttttata tcattatcta atattcagtt gttctgcacc tgatgccaaa
     4141 ttctgggctg tactcctaga gagacttact cagtaaggcc aaagtgatag gactttaaaa
     4201 tctgtagtta taaaaatacc gcaggtgatt cttacggagg taatccaaga atcatacttt
     4261 gaagaattat tctagactct gaagaggcct ggctctgcct tatgctatta tagtttatga
     4321 cctttaacaa tttaactctc cgagcctcag ttcccttgtt tgtaaatgaa gatagaagat
     4381 aaatacgtac tctacctacc tcacaaagct gtcagattaa gatcaagtga aaaaaattat
     4441 gtgaaagctc tttgaaaact gtaaagcatt atgaatgata agggattagg ttattgtgga
     4501 tttaagaggt gtgaggactg ctatagtaca ttccttgacg tgtgttgaat tcatgtatac
     4561 tttctttctt accctttaaa acaaactgcc aagaaattag gtgttgaaaa agaatattct
     4621 catcaggcag caaagtcagt tttctgatag taataatttg tctattatgt tatatatttc
     4681 aaagtacatg tatgataata tgacttattc ttcatgagag atatttgaat atttggccca
     4741 aaatgttttt catttttctc tgtgttcatt gcctttctcc ttggagctgg agttaatgct
     4801 caaagcaggc aggtctgaat tccctcataa ccgacaatta gtaaacattt tctctgaaag
     4861 ccaaacatat aacaacttat ttatcaataa ttcatgaagc ttttgtctga gaatctctcc
     4921 tgcaaacagc atgagagaac taaaacaaac attcacaaac aaaaataagt taaaatagaa
     4981 ggtaccagtt tgggctcgaa gatgttgtca tccattgcca tctgcattat attatcaact
     5041 gccaaaatgt taattggttt tcttttacaa gtgggccaag tatagacagt taagtgaaca
     5101 tcactatgaa aatcttaact ttgtgcttct agatttttag ataatcattt gtattttctc
     5161 tattaaattg tgggtatgta tgggaatact atattgactt ttcagttact ttcagtaagt
     5221 atcttaattt tgtcccacaa aatttatgta atattaatcc atggttttaa acaacagtat
     5281 tcagtttggg cagcagtttt aagtctaact agcttaaacc aatctgaata agtctggaca
     5341 gttttcctac catatgttta actttgattg gcatatgata atgtttagtg ttttcttttt
     5401 tcagttgaca actgagaaaa taatagttct ctctaacatg ttaatatatt atcaaaaggt
     5461 tttcaaaaag tactttgatt tcagcaactt tttttattca ataactagac aaaagatcta
     5521 agataatatt aaactcaaaa cagtttgttt caaagaacaa ttggttaata actcagctgg
     5581 cacagggatt catacacagt ttttcaataa atatttaaat gaacaattca tgtcacacaa
     5641 cttgctttta ccctagtact gagtctcaca tcaaagaaat ttgaaagatc tataacctat
     5701 gtgaaatgaa gtctctgctt taccagaata atatgtggca ggtaataaat atgtaaagta
     5761 caccaaatga aacatatttt gcatagataa cagtccatat cactattata attaaagaaa
     5821 tatatgtaca gacatgtacc aatcctttta attaatttta gaagatgaac agtgattctt
     5881 agaagtgagt aattagactc cttttagtct tatgctgtta gatctttgtg gaccagctga
     5941 gtaaatgaat cttcaaatca acctttcttt ttctgctgct cttagagcag atttataaaa
     6001 atcctaagaa tgtcttcaaa ttagaaaaat ttactacatt ttaacctacc tcatcagttt
     6061 ctttgtgata atagctgaaa ataactcaaa ctgtacccat cttagttagg ctatatctct
     6121 gtgaaatgaa aggaaccact taattttttt tatataaatt agtgaatcat ttgctggagc
     6181 ttagaaaata ttaacatacc aaaatttcat tatgatgata tttatattgc tttttgacat
     6241 gccaaaggta catttacata ttaccatatt tggatgactt acatagtctg gtgtaatgaa
     6301 aattcccctg ggattggaat tttaagactc atgatgtcaa ctgggctggt cattttattt
     6361 ctctgagtct ttgtttcttc aatgtaaaat gtggataagg taatttttgg ttttagcctc
     6421 cctcactgga tattgtaagg atcaaatgaa atagtattta ttataatgct ctgtaaccca
     6481 taaattattc tacttaaaaa aattttttat agagacaggg tcttgctctg tcacacaggc
     6541 tggagagcag tggcataatc atagttcatt ataaccttga actcctaggc tcaagcagtc
     6601 ctccagcttc agcctcccaa gtagctaaga ctgtaggcat gcaccactac acctggctaa
     6661 ttttaatttt tttttctttt tttgagacgg agtctggctt tgttgcccag gctggagtgc
     6721 agtggcacaa tctcagctca ctgcaacctc cacctcccag gttcaagtga ttcttctgtc
     6781 tcagcctccc gagtaactgg gactacaggt gcgtgccacc acatccagct agtttttgta
     6841 tttttagtgg agatggagtt ttgccatgtt ggtctcaaac tcctgacctc aagtgatctg
     6901 cccacctcag cctcccaaag tgctaggatt acaggcatga gtcactgcac ctggcttaat
     6961 tttaattttt ttaatttttt gtagagatga gtctcactat gttgaccagg ctggtcttga
     7021 actcctggcc tcctaaagca ctgggattac aagcatgagc caccatgcct gatccataaa
     7081 ttgttctact gataccattt ggttttgtta gaatttgggg gggctataga aaacaaggtt
     7141 acagtcttca ttagtatttc tttttagcaa taacaacaaa ataggcaatt agaccagtgt
     7201 tcatttggta cagtctttaa atcggtcatc caattaacct ttaaaaagta ggttatgctc
     7261 ttaaattgta ttggttcttt aatatgtgtt ataccagagt atgcctcaaa ttttatgtag
     7321 ttgaatttgt agaacaaatt tggggatatt cattttattt ttccttttat atgaaattgt
     7381 ataagtacat tagcttgact taaattataa aaaaaaatat atatgaagaa gaatgtagac
     7441 cctataatgt tttttgtctt tgactttttg gcttttatgt acctcatttt ttctgattga
     7501 gaaaaagttt tgaaaaagtg attcacttgt tggttttcat tgtggcaaaa ctttaaattt
     7561 taagtcatca cactatgaga attgtttgta cacatttata atttttttaa agtatgtaaa
     7621 gtaaggattt tttctccatt cttcactcac aaaggatagc atttttatgg aacctagatt
     7681 tacaaaggaa cttgtgattc ttttcaatgc ttttgtgtcg ttttacagct gattaagaaa
     7741 aaatgtttac atttaattca gctgtatttc ctagtagctg tataatctta cacattattc
     7801 ttatataatt ttgacctatt ttatatgaaa ataattgtat tggcatctct tcataattta
     7861 attctcttct ctccttcttt tgttccgatt agatgaattt gggaaaggag taggaagact
     7921 aggtatcgca tgccttccgt ctgattgtaa tcagtctcct gggtttttta ctaatttaat
     7981 cttaatcctg tgcttcttta gtcatcaaat tgatatagga ttacaatttt ctctcaggat
     8041 ccaagtcttc taagaatgaa aatgttgaag tctacccaga accagccatc cttgtagaca
     8101 tttctatttg gttgatttat aaagatttaa tatataaaga tttaatatga gttaaacatg
     8161 tttcttattc tgtgatctct aattagaaag taaaattctg ttgccataaa tataaaagaa
     8221 agttttcact tatattttag tcaaacacca aaccactgca ttacttactt cctataagac
     8281 acagtagttc aatctgttga aaggcattga aggataattt ccttcagatt actttttaaa
     8341 tcatcatctg cctcaggaaa ttctttcttg aatttttttg ttggtgtgaa agcgttgctt
     8401 atactttatg ctcattttat tggtcactgt caccagtttt tcccgataaa gattaaaaat
     8461 gttttttacc ttgaaataat tcagattttg aagattcact gtttcattat tttgctaatt
     8521 accattaact agtaaagtta gtttttaaag tttttttaag gttgatattt tatcatattc
     8581 ctggagtagg atggattact ttattattat tgtagcttta aggttttttg ttgtataagt
     8641 cagcttgttt gtatatgcta aattgcagat atttctttgt gttgtgctta ttggtttttt
     8701 tttttaactt agagcttaat aatttctatt ttctatcctg gagtctaaaa ttaaacaaaa
     8761 aaatctattt tctaaattgg caggattttt ttaatgatta gtaaaactgt attattttat
     8821 ttttaaaaat acaataggat tttgagtcag gaaacttgac ttctactctt gcctctcttt
     8881 tgcagttagc tgtgtaactt tggataaggc attttatctc gtggtgcctc catttttctc
     8941 attctctagg gaacaagaga attagtttag gtagcgtcta aaattccgcc cagctctcat
     9001 ttggttctca tttgaccatt ttataatcat tattttggtc tcatttttat tcttcttatt
     9061 catcccatga actagatcaa cttgtattat tttactagat caacctgtat tattaacgtc
     9121 atttacatgt aaattgatgg gattcagata ttttatcaac tgtttttcca ttagtgattt
     9181 taagtaattt taaagaagga aaattatatt acagataata aaaatgaaag aaagttataa
     9241 atattggaca tggctttttt aaatgggaaa gtcttcttaa gcaccaatat aagcacctta
     9301 aattgataca tagaaaagaa tgacataacg ttttgtggtc tttgttctct taaatatgaa
     9361 tatagctagt tagcctaaaa tttacacaaa atgtattcaa gatcaaatta gtgaacaaag
     9421 caatggttcg tatggctaat ttaaaagcaa ttcaatttac caatattaaa ataattataa
     9481 aatgtaaaag aaatttcaga ggagttgatt gaaaattttt tgttcagtaa ttattcttaa
     9541 actgcattct taggtttatt acataaatat agttgccaga ttgccatggg caagtgaatg
     9601 tcttcatttg aaatattatt agagatcaat gtggcttgtt atttttaatt tttttctggc
     9661 tatacagaaa atgtttctgg aaaaattcct taattgtcat ctgatataat gtagagattg
     9721 aggccagacg cagtggctca cgcctgtaat cccagcactt tgggaggcca aggtgggcag
     9781 atcacctgag gtcaggagtt cgagaccagc ctgatgaaca tggcaaatcc ccttctgtac
     9841 taaaaataca aaaattagcc aggcgcagtg gctcacgcct gtaatcccaa cactttggga
     9901 ggccgaggcg ggcggatcac gaggtcagga gatcaagacc gtcctggcta acatggtgag
     9961 accctgtctc tactaaaaac aaaaaaatta gttgggcatg gtggcgggca cctgtagtcc
    10021 cagccactcg ggaggctgag gcaggagaat ggcgtgaacc cgggaggcgg agcttgcagt
    10081 gagctgagat cgcaccgctg cactccagcc tgggcaacgg agcgagactc tatctcaaaa
    10141 aaaaaaaaag aaaaaaaaaa aagtagagat tgcattagtt ccatatctcc gcagagttct
    10201 ctggtagatt aaatgttctc tgtgcactag gccaaggaag ttcctgttac ctttgaaaat
    10261 cattgtgttt gctctgattg tctacattag ctcatatcag tcttttgaac actggttcaa
    10321 atctgggtgt tgggttagga tctgatgagt agagaatagt ggaaagttga tataggaagg
    10381 tatactggtt tctggtgtga ttctttagct acatttattc cttgtcttat gtcatttcac
    10441 tggatcatgt aactgtcctg gctttcagaa attatattag atgcccagcc tttctcattc
    10501 agagatgcct gtattattat gttatttcga ttgcctacca aaaaaaaaaa aaaaagaaaa
    10561 ggtttgtttt tagttctctg cctctgcaag tctttgtgat cacatttgtt aaattgaatc
    10621 tgagattcaa atatttcatt taatattttc tgggttttga taatgggata ttctgtaaga
    10681 taaagcaagt aatcctagag tgatttactt tatgtttagc catccaccat tttcctattt
    10741 ctctactcct cccattctcc atttttaaaa ggaaattaac aaatgtcttc ctttatccct
    10801 gcctcagata atttttccct gaactcatct tgtcagcaga aacatttaat gtgaaataat
    10861 tctgtatttc tgagacaaga tcaacacagt agttctttac attgagctga ggtgaatgta
    10921 tacttaaaaa tactctattt tctttttata tgaacttaaa atttttaaaa tcatatatgg
    10981 gactccccaa tgtgaaaata ttagtctgga cattctcttg ccatcaggtg ctatttctac
    11041 cttagctgtg agttagacta aatccaaatt tcgtatcatt catcttttta taatatttaa
    11101 cttccctaga atcaccccat ttcatgtctt taaccccaac ttccaacaac ttttctgctt
    11161 ttattttcaa atgtcaaatt gtatttttgt gttttatttt ctcattgaag tgtaaaagta
    11221 tcacatatat gaaggaatgg ctggtttaga catttacttt ggcatagtaa agattgatat
    11281 tgataccacc caccatcctt tcctctagcc ccagaaagaa aagtttgaca actcaaaaac
    11341 gattaaatta tcttatcttg ttatttaata gaacaatgga agctgtttcg tcaaaattaa
    11401 aatactttac caaaaaaata cttttttgta ttttaatctg atagtgaatt tggggattat
    11461 ttatgtaaat gtatcataat taatagtaat tatgagttat ttcactctct gtaatttgtg
    11521 atacccaaga ttcatattta tttaatgtga ggtgtttttt gaggcttttt tgttttatct
    11581 tgttttctta actttttaca gtgttgttag attatcgcgg tcatctcggc atgtggatcg
    11641 ctcctcctgt agatcagctg ttctctctta gagtcaggac aaggaggttt ttgctacatg
    11701 gtcgtagttg gataatacag cattattctg aactatctga aattgctggt tttattggtc
    11761 aaaaatgatc agatgctagc aatttcataa tagatatatt caagaaggaa ccaaacttta
    11821 aaagatcttt tagaataggt atgttaactt ctcatcctaa ccctatcaat atatcagagg
    11881 ctttatgaag gagactctac agataaccac aaatcttatc aagaaaattc tccttaaaaa
    11941 aagttatcct ttattttgtt gttaaatttc ccagttttta aaagtgtttt atcaaaatga
    12001 cttcataatt gaagcaaata ccttttggaa gtatatatgt tacataagac tttcactaaa
    12061 tctgtgcgta aagcttttat aatctgagat attgttatgt attaggtttg tgcaaaccta
    12121 atataaaagg gttcatctgt aagtatcatt tagaggcaaa ataatttccc cctcacatct
    12181 aatgtggact caaattttgg caactggaat gttatcctct tggtaggcat tctaaattaa
    12241 tgaatactgc tatgtggtgt agtaaacaaa tttgccataa aatgccattt aaggattttc
    12301 tttttacctt tatttcatta taaaagtata tgagttgaag atcatataaa aaatatgaaa
    12361 ctcctacaca ggaaatcccc aattttgtga tttaataggt tgtaaaaaga gttgttccaa
    12421 attcagacta catctcatca tataaataat attatgaata ataagggtaa aagattagcc
    12481 aacaaaagct aatctagtac accccataga ggtactccag gtgtcttggt tttggataaa
    12541 tttttatagt ggagaaaggt tactttgatc tctcaataat tgcttggtac acttcttcct
    12601 aggcaatatg ctcatgatac cctcttcatg tgacctattc ctcaaatgct gcattctcca
    12661 aaacttcctt acctgccttc tatcccctag tcattcttat caatacttcc aaaatataac
    12721 ctatctcaag tgttagaaat ttgctttaac taatttatat taaagtgtta gtgactatag
    12781 cccttttatc tctcttaaag agaaatctgc attaaaagca aacacattgc tgttagctca
    12841 aattaatgtc agtgagtaga atcttaagct ttaaaacaaa agtggaaata atttaaatta
    12901 gtgttgatgg gactattttg aggcaagaga taccattaag tgacctagct tggaaatctg
    12961 ccccctttgc ccaaacccat gtgatgtctg aaactactgt atattttcaa tgaccttgag
    13021 aaagggagct agtcatttgt atttatgggc cttatgaagt cagggcctgc tgatcctgtt
    13081 ttttaagttc aagcgcaatg cctgaagcat cctagatctc cttcaccctc attctacctg
    13141 acagacagct aggtctgtct tccagctctt tctcattgat actaccttta catatgaata
    13201 ctatccatgc ttgttaaaaa aaaaaaaagt ctttccccat tttactgtta caatttttca
    13261 agagctataa aggtagaaaa agtattcctt ttcattattc taaaaaatat gtcattttta
    13321 aatagctggc acttagcagt ttagttttcc aaactttatt ctgaatcaaa ttgctgaggt
    13381 gattctaaat gtctaatgtt gatttatcat ataaacatct aattagaaag tgtttatgct
    13441 aaagacttgt attttgtggc attagttctt catgtttctt ttttatatgt ttattaaaat
    13501 tgttcacttc caaatgagtg gaaaagttgc tgttgttggg atgtacaggg caagtgcact
    13561 tggttagagc atgaactggg aatttcacat tctctgatgt gctttgcact ctgctcttgt
    13621 agatttattt tgtttacagt agactgatgt cagtttttgt aaatgttttt tcttagcact
    13681 ttaactgtga gtgtacaaac tgattttaaa tgtagtggtt gtatattttg gttataaatt
    13741 ggagattttt aataaaatta aataattctc
//
