LOCUS       NM_001466               3779 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens frizzled class receptor 2 (FZD2), mRNA.
ACCESSION   NM_001466
VERSION     NM_001466.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3779)
  AUTHORS   Tophkhane,S.S., Fu,K., Verheyen,E.M. and Richman,J.M.
  TITLE     Craniofacial studies in chicken embryos confirm the pathogenicity
            of human FZD2 variants associated with Robinow syndrome
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38967226
  REMARK    GeneRIF: Craniofacial studies in chicken embryos confirm the
            pathogenicity of human FZD2 variants associated with Robinow
            syndrome.
REFERENCE   2  (bases 1 to 3779)
  AUTHORS   Han,Z., Ren,H., Sun,J., Jin,L., Wang,Q., Guo,C. and Tian,Z.
  TITLE     Integrated weighted gene coexpression network analysis identifies
            Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic
            adenoma
  JOURNAL   J Transl Med 20 (1), 15 (2022)
   PUBMED   34986855
  REMARK    GeneRIF: Integrated weighted gene coexpression network analysis
            identifies Frizzled 2 (FZD2) as a key gene in invasive malignant
            pleomorphic adenoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3779)
  AUTHORS   Gonzalez-Fernandez,C., Gonzalez,P., Andres-Benito,P., Ferrer,I. and
            Rodriguez,F.J.
  TITLE     Wnt Signaling Alterations in the Human Spinal Cord of Amyotrophic
            Lateral Sclerosis Cases: Spotlight on Fz2 and Wnt5a
  JOURNAL   Mol Neurobiol 56 (10), 6777-6791 (2019)
   PUBMED   30924074
  REMARK    GeneRIF: Fz2 and Wnt5a, might be involved in human Amyotrophic
            lateral sclerosis pathology.
REFERENCE   4  (bases 1 to 3779)
  AUTHORS   Huang,L., Luo,E.L., Xie,J., Gan,R.H., Ding,L.C., Su,B.H., Zhao,Y.,
            Lin,L.S., Zheng,D.L. and Lu,Y.G.
  TITLE     FZD2 regulates cell proliferation and invasion in tongue squamous
            cell carcinoma
  JOURNAL   Int J Biol Sci 15 (11), 2330-2339 (2019)
   PUBMED   31595151
  REMARK    GeneRIF: FZD2 acts as an oncogene in tongue cancer, promoting cell
            growth, invasion and migration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3779)
  AUTHORS   Ou,H., Chen,Z., Xiang,L., Fang,Y., Xu,Y., Liu,Q., Hu,Z., Li,X.,
            Huang,Y. and Yang,D.
  TITLE     Frizzled 2-induced epithelial-mesenchymal transition correlates
            with vasculogenic mimicry, stemness, and Hippo signaling in
            hepatocellular carcinoma
  JOURNAL   Cancer Sci 110 (4), 1169-1182 (2019)
   PUBMED   30677195
  REMARK    GeneRIF: FZD2 could promote clinically relevant EMT, CD44(+)
            stem-like properties, and the VM phenotype in HCC involving a
            potential Hippo signaling pathway-dependent mechanism, and should
            be considered as a promising therapeutic target for the treatment
            of HCC.
REFERENCE   6  (bases 1 to 3779)
  AUTHORS   Li,C., Chen,H., Hu,L., Xing,Y., Sasaki,T., Villosis,M.F., Li,J.,
            Nishita,M., Minami,Y. and Minoo,P.
  TITLE     Ror2 modulates the canonical Wnt signaling in lung epithelial cells
            through cooperation with Fzd2
  JOURNAL   BMC Mol Biol 9, 11 (2008)
   PUBMED   18215320
  REMARK    GeneRIF: Ror2 positively modulates Wnt3a-activated canonical
            signaling in a lung carcinoma, H441 cell line. This activity of
            Ror2 is dependent on cooperative interactions with Fzd2 but not
            Fzd7.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3779)
  AUTHORS   Sagara,N., Toda,G., Hirai,M., Terada,M. and Katoh,M.
  TITLE     Molecular cloning, differential expression, and chromosomal
            localization of human frizzled-1, frizzled-2, and frizzled-7
  JOURNAL   Biochem Biophys Res Commun 252 (1), 117-122 (1998)
   PUBMED   9813155
REFERENCE   8  (bases 1 to 3779)
  AUTHORS   Tanaka,S., Akiyoshi,T., Mori,M., Wands,J.R. and Sugimachi,K.
  TITLE     A novel frizzled gene identified in human esophageal carcinoma
            mediates APC/beta-catenin signals
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 10164-10169 (1998)
   PUBMED   9707618
REFERENCE   9  (bases 1 to 3779)
  AUTHORS   Zhao,Z., Lee,C.C., Baldini,A. and Caskey,C.T.
  TITLE     A human homologue of the Drosophila polarity gene frizzled has been
            identified and mapped to 17q21.1
  JOURNAL   Genomics 27 (2), 370-373 (1995)
   PUBMED   7558010
REFERENCE   10 (bases 1 to 3779)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC052266.1, AC103703.5,
            AW023425.1 and AI376463.1.
            
            On May 17, 2019 this sequence version replaced NM_001466.3.
            
            Summary: This intronless gene is a member of the frizzled gene
            family. Members of this family encode seven-transmembrane domain
            proteins that are receptors for the wingless type MMTV integration
            site family of signaling proteins. This gene encodes a protein that
            is coupled to the beta-catenin canonical signaling pathway.
            Competition between the wingless-type MMTV integration site family,
            member 3A and wingless-type MMTV integration site family, member 5A
            gene products for binding of this protein is thought to regulate
            the beta-catenin-dependent and -independent pathways. [provided by
            RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC052266.1, AB017364.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315323.5/ ENSP00000323901.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2006              BC052266.1         26-2031
            2007-3499           AC103703.5         29089-30581         c
            3500-3764           AW023425.1         7-271
            3765-3779           AI376463.1         16-30               c
FEATURES             Location/Qualifiers
     source          1..3779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..3779
                     /gene="FZD2"
                     /gene_synonym="fz-2; Fz2; fzE2; hFz2; OMOD2"
                     /note="frizzled class receptor 2"
                     /db_xref="GeneID:2535"
                     /db_xref="HGNC:HGNC:4040"
                     /db_xref="MIM:600667"
     exon            1..3779
                     /gene="FZD2"
                     /gene_synonym="fz-2; Fz2; fzE2; hFz2; OMOD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1903
                     /gene="FZD2"
                     /gene_synonym="fz-2; Fz2; fzE2; hFz2; OMOD2"
                     /note="frizzled 2, seven transmembrane spanning receptor;
                     frizzled-2; frizzled homolog 2; frizzled family receptor
                     2"
                     /codon_start=1
                     /product="frizzled-2 precursor"
                     /protein_id="NP_001457.1"
                     /db_xref="CCDS:CCDS11484.1"
                     /db_xref="GeneID:2535"
                     /db_xref="HGNC:HGNC:4040"
                     /db_xref="MIM:600667"
                     /translation="MRPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISI
                     PLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV
                     LEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGA
                     PALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGE
                     RDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYP
                     ERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMML
                     YFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQ
                     IDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGT
                     KTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPA
                     HYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV"
     regulatory      1986..1991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD2"
                     /gene_synonym="fz-2; Fz2; fzE2; hFz2; OMOD2"
                     /note="hexamer: AATAAA"
     polyA_site      2006
                     /gene="FZD2"
                     /gene_synonym="fz-2; Fz2; fzE2; hFz2; OMOD2"
                     /note="major polyA site"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD2"
                     /gene_synonym="fz-2; Fz2; fzE2; hFz2; OMOD2"
                     /note="hexamer: ATTAAA"
     polyA_site      2095
                     /gene="FZD2"
                     /gene_synonym="fz-2; Fz2; fzE2; hFz2; OMOD2"
     regulatory      3754..3759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD2"
                     /gene_synonym="fz-2; Fz2; fzE2; hFz2; OMOD2"
                     /note="hexamer: AATAAA"
     polyA_site      3779
                     /gene="FZD2"
                     /gene_synonym="fz-2; Fz2; fzE2; hFz2; OMOD2"
ORIGIN      
        1 agtccgaccg cggcaagcaa gcgggcaggc gcaccgcccc ctcccccgcc cggcctcccc
       61 aactctgcgg ccgcgagtaa agtttgcaaa gaggcgcggg aggcggcagc cgcagcgagg
      121 aggcggcggg gaagaagcgc agtctccggg ttgggggcgg gggcgggggg ggcgccaagg
      181 agccgggtgg ggggcggcgg ccagcatgcg gccccgcagc gccctgcccc gcctgctgct
      241 gccgctgctg ctgctgcccg ccgccgggcc ggcccagttc cacggggaga agggcatctc
      301 catcccggac cacggcttct gccagcccat ctccatcccg ctgtgcacgg acatcgccta
      361 caaccagacc atcatgccca accttctggg ccacacgaac caggaggacg caggcctaga
      421 ggtgcaccag ttctatccgc tggtgaaggt gcagtgctcg cccgaactgc gcttcttcct
      481 gtgctccatg tacgcacccg tgtgcaccgt gctggaacag gccatcccgc cgtgccgctc
      541 tatctgtgag cgcgcgcgcc agggctgcga agccctcatg aacaagttcg gttttcagtg
      601 gcccgagcgc ctgcgctgcg agcacttccc gcgccacggc gccgagcaga tctgcgtcgg
      661 ccagaaccac tccgaggacg gagctcccgc gctactcacc accgcgccgc cgccgggact
      721 gcagccgggt gccgggggca ccccgggtgg cccgggcggc ggcggcgctc ccccgcgcta
      781 cgccacgctg gagcacccct tccactgccc gcgcgtcctc aaggtgccat cctatctcag
      841 ctacaagttt ctgggcgagc gtgattgtgc tgcgccctgc gaacctgcgc ggcccgatgg
      901 ttccatgttc ttctcacagg aggagacgcg tttcgcgcgc ctctggatcc tcacctggtc
      961 ggtgctgtgc tgcgcttcca ccttcttcac tgtcaccacg tacttggtag acatgcagcg
     1021 cttccgctac ccagagcggc ctatcatttt tctgtcgggc tgctacacca tggtgtcggt
     1081 ggcctacatc gcgggcttcg tgctccagga gcgcgtggtg tgcaacgagc gcttctccga
     1141 ggacggttac cgcacggtgg tgcagggcac caagaaggag ggctgcacca tcctcttcat
     1201 gatgctctac ttcttcagca tggccagctc catctggtgg gtcatcctgt cgctcacctg
     1261 gttcctggca gccggcatga agtggggcca cgaggccatc gaggccaact ctcagtactt
     1321 ccacctggcc gcctgggccg tgccggccgt caagaccatc accatcctgg ccatgggcca
     1381 gatcgacggc gacctgctga gcggcgtgtg cttcgtaggc ctcaacagcc tggacccgct
     1441 gcggggcttc gtgctagcgc cgctcttcgt gtacctgttc atcggcacgt ccttcctcct
     1501 ggccggcttc gtgtcgctct tccgcatccg caccatcatg aagcacgacg gcaccaagac
     1561 cgaaaagctg gagcggctca tggtgcgcat cggcgtcttc tccgtgctct acacagtgcc
     1621 cgccaccatc gtcatcgctt gctacttcta cgagcaggcc ttccgcgagc actgggagcg
     1681 ctcgtgggtg agccagcact gcaagagcct ggccatcccg tgcccggcgc actacacgcc
     1741 gcgcatgtcg cccgacttca cggtctacat gatcaaatac ctcatgacgc tcatcgtggg
     1801 catcacgtcg ggcttctgga tctggtcggg caagacgctg cactcgtgga ggaagttcta
     1861 cactcgcctc accaacagcc gacacggtga gaccaccgtg tgagggacgc ccccaggccg
     1921 gaaccgcgcg gcgctttcct ccgcccgggg tggggcccct acagactccg tattttattt
     1981 ttttaaataa aaaacgatcg aaaccatttc acttttaggt tgctttttaa aagagaactc
     2041 tctgcccaac acccccacaa ggtttgtaat taaaactgta aatagtcttt gtaaatttaa
     2101 ttatatatat tttctattta aaagaaaaaa ggagaaaaaa aaacaggggt gtgggcgcca
     2161 ggactgaaga atgaggtgtg tgtgtgttgg ggagtgtagt tggggggagg gttctctttc
     2221 ttaagtgccc ttcaaaaccc gccccacttt tggagttttt tggtgatatg gcagggctgg
     2281 gcctgatggg agaggcaccc agcctgagcg ctgtttttgt tggctttgag tcgttaggag
     2341 tttgttccat tcaactaata taaaagccaa atttgtgagc ctcctctctg acgctgggcc
     2401 tgtggaagcc gttggatatt tttgaacagg acttggattc gttttgtttc cttccccctt
     2461 ttctttccct actcatttgt cctgtcttct tcactcactc ttggaaaagt cccaacagag
     2521 atgaagacgt ggaaaaaaaa atcggggtcg gggtgtgctg gtggggagag ggcagagatc
     2581 cggtgaggaa tggcttccac cccctggccc attcccctgc aggctggaag atctttctcc
     2641 tgtctggctt ctcttctttt caattcgctg caccaagtgc ttccagtggc ccaaaaatgc
     2701 tttttgaagt gtgttttgaa acagccccca ccaacataca ccccaccagg agtactgatc
     2761 ctgcctccct tcatgtctag gggaagcatt cgcctttgag cacttgtttg caaatctggg
     2821 gagtttgaga cctcctagca tctcttccct tctttccctg cagtctattc actcccgcag
     2881 ccaaaaatct ctggcgttca ggttagcagt ttctgggttg gtttgtgtgg gtttttgttg
     2941 ttgtttgggg cttatttttt tcaaaaagtg ataaagacgg gtgggttgga gggaggggac
     3001 tgatgggctg gtgggctttt tagttttcct ttgagaaaaa gactggttta tttaaaattt
     3061 gtccagaaaa aaatgaaaaa aaaaaaaaag gtggtatctt tgctttagaa gaagtctctg
     3121 gataggccct ttgtggctgt gggggtgggt tgagtgttta cattacattc tatatcacaa
     3181 gattgatagg atgtttaaag cagatgtttc ttatcttccc ctgagcccct acaaataaag
     3241 tcaagacttt tctttttttg agacggagtc ttgctctgtc gcccaggctg gagtgcagtg
     3301 gtgcgatctt ggctcactgc aacctccact gcagcgtttc tcctgcctca gcctcccaag
     3361 tagctgggac tacaggcgca cgccaccact ccttgctaat ttttgtattt ttagtagaca
     3421 cagggtttca ccatattggc caggctggtc tcgaactcct gacctcgtta tctgcctgcc
     3481 tcggcctcct aaagtgctgg gattacagga gtgagccaca gtgcctggcc tgtcaagact
     3541 tctcttaagt taacttcctg agaagtgatg tctaaaagta tctttgctgg tgtgagaact
     3601 ccagtttcca acacatatta tttccctcaa ctatttggaa tattttagaa ttttaattcc
     3661 aaaggattag tttgaataca agtatgccac ataactcagt tttcgccatc ttccatttct
     3721 taacagtgta aattaaaagc taataatcat aataataaag tgcatttaat tatctttga
//
