LOCUS       NM_007197               3277 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens frizzled class receptor 10 (FZD10), mRNA.
ACCESSION   NM_007197
VERSION     NM_007197.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3277)
  AUTHORS   Wang,J., Yu,H., Dong,W., Zhang,C., Hu,M., Ma,W., Jiang,X., Li,H.,
            Yang,P. and Xiang,D.
  TITLE     N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver
            Cancer Stem Cells' Properties and Lenvatinib Resistance Through
            WNT/beta-Catenin and Hippo Signaling Pathways
  JOURNAL   Gastroenterology 164 (6), 990-1005 (2023)
   PUBMED   36764493
  REMARK    GeneRIF: N6-Methyladenosine-Mediated Up-Regulation of FZD10
            Regulates Liver Cancer Stem Cells' Properties and Lenvatinib
            Resistance Through WNT/beta-Catenin and Hippo Signaling Pathways.
REFERENCE   2  (bases 1 to 3277)
  AUTHORS   Wu,X., Zhan,R., Cheng,D., Chen,L., Wang,T. and Tang,X.
  TITLE     [Exosomal FZD10 derived from non-small cell lung cancer cells
            promotes angiogenesis of human umbilical venous endothelial cells
            in vitro]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (9), 1351-1358 (2022)
   PUBMED   36210708
  REMARK    GeneRIF: [Exosomal FZD10 derived from non-small cell lung cancer
            cells promotes angiogenesis of human umbilical venous endothelial
            cells in vitro].
REFERENCE   3  (bases 1 to 3277)
  AUTHORS   Scavo,M.P., Rizzi,F., Depalo,N., Fanizza,E., Ingrosso,C.,
            Curri,M.L. and Giannelli,G.
  TITLE     A Possible Role of FZD10 Delivering Exosomes Derived from Colon
            Cancers Cell Lines in Inducing Activation of Epithelial-Mesenchymal
            Transition in Normal Colon Epithelial Cell Line
  JOURNAL   Int J Mol Sci 21 (18), 6705 (2020)
   PUBMED   32933173
  REMARK    GeneRIF: A Possible Role of FZD10 Delivering Exosomes Derived from
            Colon Cancers Cell Lines in Inducing Activation of
            Epithelial-Mesenchymal Transition in Normal Colon Epithelial Cell
            Line.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3277)
  AUTHORS   Chen,J., Zhang,F., Ren,X., Wang,Y., Huang,W., Zhang,J. and Cui,Y.
  TITLE     Targeting fatty acid synthase sensitizes human nasopharyngeal
            carcinoma cells to radiation via downregulating frizzled class
            receptor 10
  JOURNAL   Cancer Biol Med 17 (3), 740-752 (2020)
   PUBMED   32944403
  REMARK    GeneRIF: Targeting fatty acid synthase sensitizes human
            nasopharyngeal carcinoma cells to radiation via downregulating
            frizzled class receptor 10.
REFERENCE   5  (bases 1 to 3277)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3277)
  AUTHORS   Nagayama,S., Fukukawa,C., Katagiri,T., Okamoto,T., Aoyama,T.,
            Oyaizu,N., Imamura,M., Toguchida,J. and Nakamura,Y.
  TITLE     Therapeutic potential of antibodies against FZD 10, a cell-surface
            protein, for synovial sarcomas
  JOURNAL   Oncogene 24 (41), 6201-6212 (2005)
   PUBMED   16007199
REFERENCE   7  (bases 1 to 3277)
  AUTHORS   Togashi,A., Katagiri,T., Ashida,S., Fujioka,T., Maruyama,O.,
            Wakumoto,Y., Sakamoto,Y., Fujime,M., Kawachi,Y., Shuin,T. and
            Nakamura,Y.
  TITLE     Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for
            renal cell carcinoma and potential target for molecular therapy
  JOURNAL   Cancer Res 65 (11), 4817-4826 (2005)
   PUBMED   15930302
REFERENCE   8  (bases 1 to 3277)
  AUTHORS   Terasaki,H., Saitoh,T., Shiokawa,K. and Katoh,M.
  TITLE     Frizzled-10, up-regulated in primary colorectal cancer, is a
            positive regulator of the WNT - beta-catenin - TCF signaling
            pathway
  JOURNAL   Int J Mol Med 9 (2), 107-112 (2002)
   PUBMED   11786918
REFERENCE   9  (bases 1 to 3277)
  AUTHORS   Koike,J., Takagi,A., Miwa,T., Hirai,M., Terada,M. and Katoh,M.
  TITLE     Molecular cloning of Frizzled-10, a novel member of the Frizzled
            gene family
  JOURNAL   Biochem Biophys Res Commun 262 (1), 39-43 (1999)
   PUBMED   10448064
REFERENCE   10 (bases 1 to 3277)
  AUTHORS   Tanaka,S., Akiyoshi,T., Mori,M., Wands,J.R. and Sugimachi,K.
  TITLE     A novel frizzled gene identified in human esophageal carcinoma
            mediates APC/beta-catenin signals
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 10164-10169 (1998)
   PUBMED   9707618
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC070037.1, AC026336.20,
            BC074997.2, AB027464.1 and AI697875.1.
            
            On Aug 13, 2020 this sequence version replaced NM_007197.3.
            
            Summary: This gene is a member of the frizzled gene family. Members
            of this family encode 7-transmembrane domain proteins that are
            receptors for the Wingless type MMTV integration site family of
            signaling proteins. Most frizzled receptors are coupled to the
            beta-catenin canonical signaling pathway. Using array analysis,
            expression of this intronless gene is significantly up-regulated in
            two cases of primary colon cancer. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC070037.1, AB027464.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229030.5/ ENSP00000229030.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               BC070037.1         7-346
            341-341             AC026336.20        123947-123947       c
            342-458             BC070037.1         348-464
            459-2273            BC074997.2         1-1815
            2274-2321           AB027464.1         1812-1859
            2322-2534           AB027464.1         1861-2073
            2535-2535           AC026336.20        121753-121753       c
            2536-2732           AB027464.1         2075-2271
            2733-3277           AI697875.1         7-551               c
FEATURES             Location/Qualifiers
     source          1..3277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..3277
                     /gene="FZD10"
                     /gene_synonym="CD350; FZ-10; Fz10; FzE7; hFz10"
                     /note="frizzled class receptor 10"
                     /db_xref="GeneID:11211"
                     /db_xref="HGNC:HGNC:4039"
                     /db_xref="MIM:606147"
     exon            1..3277
                     /gene="FZD10"
                     /gene_synonym="CD350; FZ-10; Fz10; FzE7; hFz10"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..2225
                     /gene="FZD10"
                     /gene_synonym="CD350; FZ-10; Fz10; FzE7; hFz10"
                     /note="frizzled 10, seven transmembrane spanning receptor;
                     frizzled-10; frizzled homolog 10; frizzled family receptor
                     10"
                     /codon_start=1
                     /product="frizzled-10 precursor"
                     /protein_id="NP_009128.1"
                     /db_xref="CCDS:CCDS9267.1"
                     /db_xref="GeneID:11211"
                     /db_xref="HGNC:HGNC:4039"
                     /db_xref="MIM:606147"
                     /translation="MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKD
                     IGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTP
                     IPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTR
                     GSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVY
                     WSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVG
                     YLIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTW
                     FLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVN
                     ALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVL
                     YTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKI
                     FMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKAQHPQKT
                     HHGKYEIPAQSPTCV"
     regulatory      3249..3254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD10"
                     /gene_synonym="CD350; FZ-10; Fz10; FzE7; hFz10"
                     /note="hexamer: AATAAA"
     polyA_site      3277
                     /gene="FZD10"
                     /gene_synonym="CD350; FZ-10; Fz10; FzE7; hFz10"
                     /note="major polyA site"
ORIGIN      
        1 cttctcatcc cgggacgcaa acctcgaaac agctgccggc tggtcccggc cgaggccggc
       61 gcagggaggg aggagccgcc cgggctgtgg gggcgccgcg agctgggccg gcctcggtgt
      121 gcccgcgccg ccagcccgct ccagacgcgc cacctgggcg ctccaagaag aggccgaagt
      181 ttgccgcggc cgtgagttgg agctcgcgcc gggccgctgc gccgggagct ccgggggctt
      241 ccctcgcttc ccggtattgt ttgcaaactt tgctgctctc cgccgcggcc cccaactcgg
      301 cggacgccgg gcgcggagag ccgagccggg ggcgctgtgc gcagcgctcg ggccaggccg
      361 ggcgggcatg ggcgggggcc cgagcagggg tggagagccg gggccagcag cagcccgtgc
      421 ccgggagcgg cggcgctgag gggcgcggag ctccccgcga ggacacgtcc aacgccagca
      481 tgcagcgccc gggcccccgc ctgtggctgg tcctgcaggt gatgggctcg tgcgccgcca
      541 tcagctccat ggacatggag cgcccgggcg acggcaaatg ccagcccatc gagatcccga
      601 tgtgcaagga catcggctac aacatgactc gtatgcccaa cctgatgggc cacgagaacc
      661 agcgcgaggc agccatccag ttgcacgagt tcgcgccgct ggtggagtac ggctgccacg
      721 gccacctccg cttcttcctg tgctcgctgt acgcgccgat gtgcaccgag caggtctcta
      781 cccccatccc cgcctgccgg gtcatgtgcg agcaggcccg gctcaagtgc tccccgatta
      841 tggagcagtt caacttcaag tggcccgact ccctggactg ccggaaactc cccaacaaga
      901 acgaccccaa ctacctgtgc atggaggcgc ccaacaacgg ctcggacgag cccacccggg
      961 gctcgggcct gttcccgccg ctgttccggc cgcagcggcc ccacagcgcg caggagcacc
     1021 cgctgaagga cgggggcccc gggcgcggcg gctgcgacaa cccgggcaag ttccaccacg
     1081 tggagaagag cgcgtcgtgc gcgccgctct gcacgcccgg cgtggacgtg tactggagcc
     1141 gcgaggacaa gcgcttcgca gtggtctggc tggccatctg ggcggtgctg tgcttcttct
     1201 ccagcgcctt caccgtgctc accttcctca tcgacccggc ccgcttccgc taccccgagc
     1261 gccccatcat cttcctctcc atgtgctact gcgtctactc cgtgggctac ctcatccgcc
     1321 tcttcgccgg cgccgagagc atcgcctgcg accgggacag cggccagctc tatgtcatcc
     1381 aggagggact ggagagcacc ggctgcacgc tggtcttcct ggtcctctac tacttcggca
     1441 tggccagctc gctgtggtgg gtggtcctca cgctcacctg gttcctggcc gccggcaaga
     1501 agtggggcca cgaggccatc gaagccaaca gcagctactt ccacctggca gcctgggcca
     1561 tcccggcggt gaagaccatc ctgatcctgg tcatgcgcag ggtggcgggg gacgagctca
     1621 ccggggtctg ctacgtgggc agcatggacg tcaacgcgct caccggcttc gtgctcattc
     1681 ccctggcctg ctacctggtc atcggcacgt ccttcatcct ctcgggcttc gtggccctgt
     1741 tccacatccg gagggtgatg aagacgggcg gcgagaacac ggacaagctg gagaagctca
     1801 tggtgcgtat cgggctcttc tctgtgctgt acaccgtgcc ggccacctgt gtgatcgcct
     1861 gctactttta cgaacgcctc aacatggatt actggaagat cctggcggcg cagcacaagt
     1921 gcaaaatgaa caaccagact aaaacgctgg actgcctgat ggccgcctcc atccccgccg
     1981 tggagatctt catggtgaag atctttatgc tgctggtggt ggggatcacc agcgggatgt
     2041 ggatttggac ctccaagact ctgcagtcct ggcagcaggt gtgcagccgt aggttaaaga
     2101 agaagagccg gagaaaaccg gccagcgtga tcaccagcgg tgggatttac aaaaaagccc
     2161 agcatcccca gaaaactcac cacgggaaat atgagatccc tgcccagtcg cccacctgcg
     2221 tgtgaacagg gctggaggga agggcacagg ggcgcccgga gctaagatgt ggtgcttttc
     2281 ttggttgtgt ttttctttct tcttcttctt tttttttttt tataaaagca aaagagaaat
     2341 acataaaaaa gtgtttaccc tgaaattcag gatgctgtga tacactgaaa ggaaaaatgt
     2401 acttaaaggg ttttgttttg ttttggtttt ccagcgaagg gaagctcctc cagtgaagta
     2461 gcctcttgtg taactaattt gtggtaaagt agttgattca gccctcagaa gaaaactttt
     2521 gtttagagcc ctccctaaat atacatctgt gtatttgagt tggctttgct acccatttac
     2581 aaataagagg acagataact gctttgcaaa ttcaagagcc tcccctgggt taacaaatga
     2641 gccatcccca gggcccaccc ccaggaaggc cacagtgctg ggcggcatcc ctgcagagga
     2701 aagacaggac ccggggcccg cctcacaccc cagtggattt ggagttgctt aaaatagact
     2761 ccggccttca ccaatagtct ctctgcaaga cagaaacctc catcaaacct cacatttgtg
     2821 aactcaaacg atgtgcaata catttttttc tctttccttg aaaataaaaa gagaaacaag
     2881 tattttgcta tatataaaga caacaaaaga aatctcctaa caaaagaact aagaggccca
     2941 gccctcagaa acccttcagt gctacatttt gtggcttttt aatggaaacc aagccaatgt
     3001 tatagacgtt tggactgatt tgtggaaagg aggggggaag agggagaagg atcattcaaa
     3061 agttacccaa agggcttatt gactctttct attgttaaac aaatgatttc cacaaacaga
     3121 tcaggaagca ctaggttggc agagacactt tgtctagtgt attctcttca cagtgccagg
     3181 aaagagtggt ttctgcgtgt gtatatttgt aatatatgat atttttcatg ctccactatt
     3241 ttattaaaaa taaaatatgt tctttagttt gctgcta
//
