LOCUS       NM_003505               6894 bp    mRNA    linear   PRI 26-JUN-2022
DEFINITION  Homo sapiens frizzled class receptor 1 (FZD1), mRNA.
ACCESSION   NM_003505
VERSION     NM_003505.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6894)
  AUTHORS   Palomer E, Martin-Flores N, Jolly S, Pascual-Vargas P, Benvegnu S,
            Podpolny M, Teo S, Vaher K, Saito T, Saido TC, Whiting P and
            Salinas PC.
  TITLE     Epigenetic repression of Wnt receptors in AD: a role for
            Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7
            promoters
  JOURNAL   Mol Psychiatry 27 (7), 3024-3033 (2022)
   PUBMED   35296808
  REMARK    GeneRIF: Epigenetic repression of Wnt receptors in AD: a role for
            Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7
            promoters.
REFERENCE   2  (bases 1 to 6894)
  AUTHORS   Zhang YP, Gao D and Wu P.
  TITLE     [RBM38 Mediates the Proliferation of Acute Myeloid Leukemia Cells
            HL-60 by Regulating FZD1 mRNA Stability]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 29 (6), 1775-1779 (2021)
   PUBMED   34893109
  REMARK    GeneRIF: [RBM38 Mediates the Proliferation of Acute Myeloid
            Leukemia Cells HL-60 by Regulating FZD1 mRNA Stability].
REFERENCE   3  (bases 1 to 6894)
  AUTHORS   Huang Y, He P and Ding J.
  TITLE     Protein disulfide isomerase family 6 promotes the
            imatinib-resistance of renal cell carcinoma by regulation of
            Wnt3a-Frizzled1 axis
  JOURNAL   Bioengineered 12 (2), 12157-12166 (2021)
   PUBMED   34781823
  REMARK    GeneRIF: Protein disulfide isomerase family 6 promotes the
            imatinib-resistance of renal cell carcinoma by regulation of
            Wnt3a-Frizzled1 axis.
REFERENCE   4  (bases 1 to 6894)
  AUTHORS   Liu Z, Sun L, Cai Y, Shen S, Zhang T, Wang N, Wu G, Ma W, Li ST,
            Suo C, Hao Y, Jia WD, Semenza GL, Gao P and Zhang H.
  TITLE     Hypoxia-Induced Suppression of Alternative Splicing of MBD2
            Promotes Breast Cancer Metastasis via Activation of FZD1
  JOURNAL   Cancer Res 81 (5), 1265-1278 (2021)
   PUBMED   33402389
  REMARK    GeneRIF: Hypoxia-Induced Suppression of Alternative Splicing of
            MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1.
REFERENCE   5  (bases 1 to 6894)
  AUTHORS   Wang R, Wang X, Zhang J and Liu Y.
  TITLE     LINC00942 Promotes Tumor Proliferation and Metastasis in Lung
            Adenocarcinoma via FZD1 Upregulation
  JOURNAL   Technol Cancer Res Treat 20, 1533033820977526 (2021)
   PUBMED   34253104
  REMARK    GeneRIF: LINC00942 Promotes Tumor Proliferation and Metastasis in
            Lung Adenocarcinoma via FZD1 Upregulation.
REFERENCE   6  (bases 1 to 6894)
  AUTHORS   DeCostanzo AJ, Huang XP, Wang HY and Malbon CC.
  TITLE     The Frizzled-1/(beta(2))-adrenergic receptor chimera:
            pharmacological properties of a unique G protein-linked receptor
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 365 (5), 341-348 (2002)
   PUBMED   12012019
REFERENCE   7  (bases 1 to 6894)
  AUTHORS   Bafico A, Liu G, Yaniv A, Gazit A and Aaronson SA.
  TITLE     Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1
            interaction with LRP6/Arrow
  JOURNAL   Nat Cell Biol 3 (7), 683-686 (2001)
   PUBMED   11433302
REFERENCE   8  (bases 1 to 6894)
  AUTHORS   Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J and
            Aaronson SA.
  TITLE     Human frizzled 1 interacts with transforming Wnts to transduce a
            TCF dependent transcriptional response
  JOURNAL   Oncogene 18 (44), 5959-5966 (1999)
   PUBMED   10557084
REFERENCE   9  (bases 1 to 6894)
  AUTHORS   Sagara N, Toda G, Hirai M, Terada M and Katoh M.
  TITLE     Molecular cloning, differential expression, and chromosomal
            localization of human frizzled-1, frizzled-2, and frizzled-7
  JOURNAL   Biochem Biophys Res Commun 252 (1), 117-122 (1998)
   PUBMED   9813155
REFERENCE   10 (bases 1 to 6894)
  AUTHORS   Tanaka S, Akiyoshi T, Mori M, Wands JR and Sugimachi K.
  TITLE     A novel frizzled gene identified in human esophageal carcinoma
            mediates APC/beta-catenin signals
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 10164-10169 (1998)
   PUBMED   9707618
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084381.6 and AB017363.1.
            
            On May 17, 2019 this sequence version replaced NM_003505.1.
            
            Summary:  Members of the 'frizzled' gene family encode
            7-transmembrane domain proteins that are receptors for Wnt
            signaling proteins.  The FZD1 protein contains a signal peptide, a
            cysteine-rich domain in the N-terminal extracellular region, 7
            transmembrane domains, and a C-terminal PDZ domain-binding motif.
            The FZD1 transcript is expressed in various tissues. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB017363.1, BC051271.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287934.4/ ENSP00000287934.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC084381.6         78420-78454
            36-4385             AB017363.1         1-4350
            4386-6894           AC084381.6         82805-85313
FEATURES             Location/Qualifiers
     source          1..6894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.13"
     gene            1..6894
                     /gene="FZD1"
                     /note="frizzled class receptor 1"
                     /db_xref="GeneID:8321"
                     /db_xref="HGNC:HGNC:4038"
                     /db_xref="MIM:603408"
     exon            1..6894
                     /gene="FZD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             449..2392
                     /gene="FZD1"
                     /note="Wnt receptor; frizzled 1, seven transmembrane
                     spanning receptor; frizzled family receptor 1; frizzled,
                     Drosophila, homolog of, 1; fz-1; fzE1; hFz1; frizzled
                     homolog 1"
                     /codon_start=1
                     /product="frizzled-1"
                     /protein_id="NP_003496.1"
                     /db_xref="CCDS:CCDS5620.1"
                     /db_xref="GeneID:8321"
                     /db_xref="HGNC:HGNC:4038"
                     /db_xref="MIM:603408"
                     /translation="MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRP
                     PVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQY
                     NGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQ
                     CSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKF
                     PVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSC
                     PRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCAST
                     LFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGART
                     VAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLA
                     AWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLA
                     GFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWE
                     RSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSG
                     KTLNSWRKFYTRLTNSKQGETTV"
     regulatory      4259..4264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD1"
                     /note="hexamer: AATAAA"
     polyA_site      4286
                     /gene="FZD1"
                     /note="major polyA site"
     regulatory      4550..4555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD1"
                     /note="hexamer: ATTAAA"
     polyA_site      4573
                     /gene="FZD1"
     regulatory      4754..4759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD1"
                     /note="hexamer: CATAAA"
     polyA_site      4774
                     /gene="FZD1"
     regulatory      6871..6876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FZD1"
                     /note="hexamer: ATTAAA"
     polyA_site      6894
                     /gene="FZD1"
ORIGIN      
        1 ggtccgaggg cgcgcgaggc agaggagagg gagcgagttg agggattgac acaaatggtc
       61 aggcggcggc ggcggagaag gaggcggagg cgcagggggg agccgagccc gctgggctgc
      121 ggagagttgc gctctctacg gggccgcggc cactagcgcg gcgccgccag ccgggagcca
      181 gcgagccgag ggccaggaag gcgggacacg accccggcgc gccctagcca cccgggttct
      241 ccccgccgcc cgcgcttcat gaatcgcaag tttccgcggc ggcggcggct gcggtacgca
      301 gaacaggagc cgggggagcg ggccgaaagc ggcttgggct cgacggaggg cacccgcgca
      361 gaggtctccc tggccgcagg gggagccgcc gccggccgtg cccctggcag ccccagcgga
      421 gcggcgccaa gagaggagcc gagaaagtat ggctgaggag gaggcgccta agaagtcccg
      481 ggccgccggc ggtggcgcga gctgggaact ttgtgccggg gcgctctcgg cccggctggc
      541 ggaggagggc agcggggacg ccggtggccg ccgccgcccg ccagttgacc cccggcgatt
      601 ggcgcgccag ctgctgctgc tgctttggct gctggaggct ccgctgctgc tgggggtccg
      661 ggcccaggcg gcgggccagg ggccaggcca ggggcccggg ccggggcagc aaccgccgcc
      721 gccgcctcag cagcaacaga gcgggcagca gtacaacggc gagcggggca tctccgtccc
      781 ggaccacggc tattgccagc ccatctccat cccgctgtgc acggacatcg cgtacaacca
      841 gaccatcatg cccaacctgc tgggccacac gaaccaggag gacgcgggcc tggaggtgca
      901 ccagttctac cctctagtga aagtgcagtg ttccgctgag ctcaagttct tcctgtgctc
      961 catgtacgcg cccgtgtgca ccgtgctaga gcaggcgctg ccgccctgcc gctccctgtg
     1021 cgagcgcgcg cgccagggct gcgaggcgct catgaacaag ttcggcttcc agtggccaga
     1081 cacgctcaag tgtgagaagt tcccggtgca cggcgccggc gagctgtgcg tgggccagaa
     1141 cacgtccgac aagggcaccc cgacgccctc gctgcttcca gagttctgga ccagcaaccc
     1201 tcagcacggc ggcggagggc accgtggcgg cttcccgggg ggcgccggcg cgtcggagcg
     1261 aggcaagttc tcctgcccgc gcgccctcaa ggtgccctcc tacctcaact accacttcct
     1321 gggggagaag gactgcggcg caccttgtga gccgaccaag gtgtatgggc tcatgtactt
     1381 cgggcccgag gagctgcgct tctcgcgcac ctggattggc atttggtcag tgctgtgctg
     1441 cgcctccacg ctcttcacgg tgcttacgta cctggtggac atgcggcgct tcagctaccc
     1501 ggagcggccc atcatcttct tgtccggctg ttacacggcc gtggccgtgg cctacatcgc
     1561 cggcttcctc ctggaagacc gagtggtgtg taatgacaag ttcgccgagg acggggcacg
     1621 cactgtggcg cagggcacca agaaggaggg ctgcaccatc ctcttcatga tgctctactt
     1681 cttcagcatg gccagctcca tctggtgggt gatcctgtcg ctcacctggt tcctggcggc
     1741 tggcatgaag tggggccacg aggccatcga agccaactca cagtattttc acctggccgc
     1801 ctgggctgtg ccggccatca agaccatcac catcctggcg ctgggccagg tggacggcga
     1861 tgtgctgagc ggagtgtgct tcgtggggct taacaacgtg gacgcgctgc gtggcttcgt
     1921 gctggcgccc ctcttcgtgt acctgtttat cggcacgtcc tttctgctgg ccggctttgt
     1981 gtcgctcttc cgcatccgca ccatcatgaa gcacgatggc accaagaccg agaagctgga
     2041 gaagctcatg gtgcgcattg gcgtcttcag cgtgctgtac actgtgccag ccaccatcgt
     2101 catcgcctgc tacttctacg agcaggcctt ccgggaccag tgggaacgca gctgggtggc
     2161 ccagagctgc aagagctacg ctatcccctg ccctcacctc caggcgggcg gaggcgcccc
     2221 gccgcacccg cccatgagcc cggacttcac ggtcttcatg attaagtacc ttatgacgct
     2281 gatcgtgggc atcacgtcgg gcttctggat ctggtccggc aagaccctca actcctggag
     2341 gaagttctac acgaggctca ccaacagcaa acaaggggag actacagtct gagacccggg
     2401 gctcagccca tgcccaggcc tcggccgggg cgcagcgatc ccccaaagcc agcgccgtgg
     2461 agttcgtgcc aatcctgaca tctcgaggtt tcctcactag acaactctct ttcgcaggct
     2521 cctttgaaca actcagctcc tgcaaaagct tccgtccctg aggcaaaagg acacgagggc
     2581 ccgactgcca gagggaggat ggacagacct cttgccctca cactctggta ccaggactgt
     2641 tcgcttttat gattgtaaat agcctgtgta agatttttgt aagtatattt gtatttaaat
     2701 gacgaccgat cacgcgtttt tctttttcaa aagtttttaa ttatttaggg cggtttaacc
     2761 atttgaggct tttccttctt gcccttttcg gagtattgca aaggagctaa aactggtgtg
     2821 caaccgcaca gcgctcctgg tcgtcctcgc gcgcctctcc ctaccacggg tgctcgggac
     2881 ggctgggcgc cagctccggg gcgagttcag cactgcgggg tgcgactagg gctgcgctgc
     2941 cagggtcact tcccgcctcc tccttttgcc ccctccccct ccttctgtcc cctccctttc
     3001 tttcctggct tgaggtaggg gctcttaagg tacagaactc cacaaacctt ccaaatctgg
     3061 aggagggccc ccatacatta caattcctcc cttgctcggc ggtggattgc gaaggcccgt
     3121 cccttcgact tcctgaagct ggatttttaa ctgtccagaa ctttcctcca acttcatggg
     3181 ggcccacggg tgtgggcgct ggcagtctca gcctccctcc acggtcacct tcaacgccca
     3241 gacactccct tctcccacct tagttggtta cagggtgagt gagataacca atgccaaact
     3301 ttttgaagtc taatttttga ggggtgagct catttcattc tctagtgtct aaaacctggt
     3361 atgggtttgg ccagcgtcat ggaaagatgt ggttactgag atttgggaag aagcatgaag
     3421 ctttgtgtgg gttggaagag actgaagata tgggttataa aatgttaatt ctaattgcat
     3481 acggatgcct ggcaaccttg cctttgagaa tgagacagcc tgcgcttaga ttttaccggt
     3541 ctgtaaaatg gaaatgttga ggtcacctgg aaagctttgt taaggagttg atgtttgctt
     3601 tccttaacaa gacagcaaaa cgtaaacaga aattgaaaac ttgaaggata tttcagtgtc
     3661 atggacttcc tcaaaatgaa gtgctatttt cttattttta atcaaataac tagacatata
     3721 tcagaaactt taaaatgtaa aagttgtaca ctttcaacat tttattacga ttattattca
     3781 gcagcacatt ctgagggggg aacaattcac accaccaata ataacctggt aagatttcag
     3841 gaggtaaaga aggtggaata attgacgggg agatagcgcc tgaaataaac aaaatatggg
     3901 catgcatgct aaagggaaaa tgtgtgcagg tctactgcat taaatcctgt gtgctcctct
     3961 tttggattta cagaaatgtg tcaaatgtaa atctttcaaa gccatttaaa aatattcact
     4021 ttagttctct gtgaagaaga ggagaaaagc aatcctcctg attgtattgt tttaaacttt
     4081 aagaatttat caaaatgccg gtacttagga cctaaattta tctatgtctg tcatacgcta
     4141 aaatgatatt ggtctttgaa tttggtatac atttattctg ttcactatca caaaatcatc
     4201 tatatttata gaggaataga agtttatata tatataatac catattttta atttcacaaa
     4261 taaaaaattc aaagttttgt acaaaattat atggattttg tgcctgaaaa taatagagct
     4321 tgagctgtct gaactatttt acattttatg gtgtctcata gccaatccca cagtgtaaaa
     4381 attcaggaat tcaatgaaaa aagtctaccc ttaaaccctc agatcagtct ttccaaagaa
     4441 ttactctgtt tgcattgttg tgattgacat ttgtgaagtc ccaagaaaag atctgttttc
     4501 atgacagtag aaaatagaag tttgcaaatt atttctttac tcaaagagga ttaaaagaga
     4561 actctaattt taatattaaa gctttctttt ctttcaggga ataaatttac atgacttttt
     4621 atattatgga ggtttatttt taaatcatca cctttctcat attttttaga ggtattgtct
     4681 tatctcttcc ataatcttgg atattacaaa accctaaata ggcaatcaat aaatggttaa
     4741 ctggctatgt gttcataaac attttaaaca gcaattgggt ttgtaaggct gttttgttgt
     4801 ttgcttctga agaccccttt ttttaatcgt tcaaggaacc ttctccagat aaattatcta
     4861 gttggtctac tcttagtcag aatttatgca tgggtgtata tatgtgtata tatagataag
     4921 tatacacata agtatatatg cattaatttt tataaaatag agatgtaaag tttacttaca
     4981 tttcataata tggaaatatg gttatgagaa atggaaaatg ctagatggaa aacctcaaat
     5041 acctttacag gttaaaaata tctttactaa attttcccat gaaaacattt tgtgataaaa
     5101 tgacaaggga ctaaaatgaa gatcattgat acaatagagt tactttcctt gttacaatgc
     5161 aattgtctta taagtcatta ttcattttaa ggaaaatcaa aaaaattaga tcttactaaa
     5221 aatgtagcat ttgattttaa gtagcaagat gcaattttgt gttccctttt tctttgttac
     5281 attaacataa tatagtagat agagggttta ttgtatagac atacacaaaa aaatagtatt
     5341 cttaggccaa attcacacat atctcctcac taagtagttc aattagataa tttctggaaa
     5401 aacatgtttt tgacattaat tgctatccaa aactatattt taaagcagtc ttattggagg
     5461 tgtccttaac atgatgtaac tataaatttg atgcagaaag gttttacatg ctgtggttaa
     5521 atagctttag aagacatttt taagtcacca ccagccttta ttcttagaaa acaatttatt
     5581 ctaaatgatg atgcatatag aaaaccagtg tattctttta tttcttttaa tactggtggc
     5641 aaaataggac gtgtctggaa aaccataagg ctacttggga tactgtccca ttagcattgc
     5701 tgtttccatg acaaacccta ttttcagatg gtttgatttg cctatttttt ttttaaacca
     5761 gctataaatt ggggtcaatt tcccccctca cagtgtactt aatttagctt ttggagtaaa
     5821 tatataagta gtatgaaaga cttctgaagc tcttctttct aaaaaagcag ttttccactt
     5881 aagctttgtg gggacagaga gtcatatttt taatttcaga gccagccagt gtcaaacacg
     5941 tgcaaaagag ccgggccgga ttttttcagc ttgtcctatg gtagtcactt gtcagcctga
     6001 gtttactggc ctggtccttt tgtctccact gtaagtactg aagccttctg gtgtagttgt
     6061 atcaccttaa tgtccagcat ttaactagga aaggagacta caatgaagag ttggtggcca
     6121 attaagaaaa ataatagact acatcataaa tcatttcagg acttgagtgg ccgcagatca
     6181 ctgtccctga tagcatgttt caaccttggt atacattttt tttaagatgc atatttactg
     6241 tgtgtgcttt tgctttctaa tccatctatt gactattggc cacaatttat ataatgcaca
     6301 tgcaattaat tgaaacctgt gtcatggcat tggatatctc tgattcattt cttattataa
     6361 tagtctgtgt aactggggcc tgagagatta gaagcaaaat gtagtcgtac gtatgtctag
     6421 aggtggacgc tggtgatatt gtcattgaat actttgcaga atacactaat gtcaaaggct
     6481 tgcaggatta atgtgtagga accaacataa gacatggaat atatataaga attatctagt
     6541 tacatgacta aaaaggaatt gcaatactat cttaaattga aggcttttat ttcaatgtcc
     6601 ttacatttaa aatgggatct tacaagggaa gtaccaaaaa agtaaagttt attttgatga
     6661 ctctcaagat atatatgttt gttttgaatg ttggcagatg ccaatagccc ttaacatttg
     6721 aaaaatggta cttgaacatc aattatgtct cagagttccc ttaaactttt tgggcttaaa
     6781 tatttttatt cattttggtc atacctttga caatggatat gttaaacttt aacaattata
     6841 gtgacaaaac agcttgctta gaacctggaa attaaaacac aatttctaga gtaa
//
