LOCUS       NM_032288               6733 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens forty-two-three domain containing 1 (FYTTD1),
            transcript variant 1, mRNA.
ACCESSION   NM_032288
VERSION     NM_032288.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6733)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6733)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6733)
  AUTHORS   Tunnicliffe,R.B., Tian,X., Storer,J., Sandri-Goldin,R.M. and
            Golovanov,A.P.
  TITLE     Overlapping motifs on the herpes viral proteins ICP27 and ORF57
            mediate interactions with the mRNA export adaptors ALYREF and UIF
  JOURNAL   Sci Rep 8 (1), 15005 (2018)
   PUBMED   30301920
  REMARK    GeneRIF: In both ORF57 and ICP27 the interaction sites for ALYREF
            and UIF partially overlap, suggestive of mutually exclusive
            binding. The data provide a map of the binding sites responsible
            for promoting herpes virus mRNA export, enabling future studies to
            accurately probe these interactions and reveal the functional
            consequences for UIF and ALYREF redundancy
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6733)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 6733)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 6733)
  AUTHORS   Jackson,B.R., Boyne,J.R., Noerenberg,M., Taylor,A.,
            Hautbergue,G.M., Walsh,M.J., Wheat,R., Blackbourn,D.J., Wilson,S.A.
            and Whitehouse,A.
  TITLE     An interaction between KSHV ORF57 and UIF provides mRNA-adaptor
            redundancy in herpesvirus intronless mRNA export
  JOURNAL   PLoS Pathog 7 (7), e1002138 (2011)
   PUBMED   21814512
REFERENCE   7  (bases 1 to 6733)
  AUTHORS   Hautbergue,G.M., Hung,M.L., Walsh,M.J., Snijders,A.P., Chang,C.T.,
            Jones,R., Ponting,C.P., Dickman,M.J. and Wilson,S.A.
  TITLE     UIF, a New mRNA export adaptor that works together with REF/ALY,
            requires FACT for recruitment to mRNA
  JOURNAL   Curr Biol 19 (22), 1918-1924 (2009)
   PUBMED   19836239
  REMARK    GeneRIF: FYTTD1 was named UIF for UAP56 Interacting Factor. UIF is
            an mRNA export adaptor, recruited to mRNA by SSRP1 of the FACT
            complex. It also binds mRNA and NXF1. It is required for efficient
            nuclear export of mRNA in vertebrates and other animals.
REFERENCE   8  (bases 1 to 6733)
  AUTHORS   Pope,S.N. and Lee,I.R.
  TITLE     Yeast two-hybrid identification of prostatic proteins interacting
            with human sex hormone-binding globulin
  JOURNAL   J Steroid Biochem Mol Biol 94 (1-3), 203-208 (2005)
   PUBMED   15862967
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC035006.2, AJ344094.1, H97483.1 and AC055764.23.
            
            On Nov 23, 2018 this sequence version replaced NM_032288.6.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.114493.1,
                                           SRR1803616.249868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241502.9/ ENSP00000241502.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               BC035006.2         134-481
            349-3453            AJ344094.1         325-3429
            3454-3583           H97483.1           1-130               c
            3584-6733           AC055764.23        55884-59033         c
FEATURES             Location/Qualifiers
     source          1..6733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..6733
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /note="forty-two-three domain containing 1"
                     /db_xref="GeneID:84248"
                     /db_xref="HGNC:HGNC:25407"
                     /db_xref="MIM:616933"
     exon            1..192
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1046
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UAP56-interacting factor; protein 40-2-3; forty-two-three
                     domain-containing protein 1"
                     /codon_start=1
                     /product="UAP56-interacting factor isoform 1"
                     /protein_id="NP_115664.2"
                     /db_xref="CCDS:CCDS3329.1"
                     /db_xref="GeneID:84248"
                     /db_xref="HGNC:HGNC:25407"
                     /db_xref="MIM:616933"
                     /translation="MNRFGTRLVGATATSSPPPKARSNENLDKIDMSLDDIIKLNRKE
                     GKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSGFGKTSLNRRGRVMPGKRRPNGVI
                     TGLAARKTTGIRKGISPMNRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPVAVLKRP
                     SQLSRKNNIPANFTRSGNKLNHQKDTRQATFLFRRGLKVQAQLNTEQLLDDVVAKRTR
                     QWRTSTTNGGILTVSIDNPGAVQCPVTQKPRLTRTAVPSFLTKREQSDVKKVPKGVPL
                     QFDINSVGKQTGMTLNERFGILKEQRATLTYNKGGSRFVTVG"
     exon            193..324
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /inference="alignment:Splign:2.1.0"
     exon            325..473
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /inference="alignment:Splign:2.1.0"
     exon            474..586
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /inference="alignment:Splign:2.1.0"
     exon            587..683
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /inference="alignment:Splign:2.1.0"
     exon            684..745
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /inference="alignment:Splign:2.1.0"
     exon            746..820
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /inference="alignment:Splign:2.1.0"
     exon            821..947
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /inference="alignment:Splign:2.1.0"
     exon            948..6733
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3410..3415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /note="hexamer: AATAAA"
     polyA_site      3435
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /note="major polyA site"
     regulatory      6712..6717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
                     /note="hexamer: AATAAA"
     polyA_site      6733
                     /gene="FYTTD1"
                     /gene_synonym="UIF"
ORIGIN      
        1 ggtgcggcgg gctgcgtgcg cgagtgggag gtggcaggcc tgcgactccg gccttgtccg
       61 cgcccgctct cggcgcgacg tctccagcca tgaaccggtt tggtacccgg ttggtgggag
      121 ccacggcgac ttcttcgccg ccgccgaagg cccgcagcaa tgaaaacctc gacaaaatag
      181 atatgtcttt ggatgatatc atcaagttga atcgaaagga agggaagaag cagaattttc
      241 caagactaaa tagaagactc ctccagcaaa gtggtgccca gcaattcagg atgagagtgc
      301 gatggggaat ccaacagaat tctggttttg gtaagactag tctgaatcgt agaggaagag
      361 taatgcctgg aaagagacgt cctaatggag ttatcactgg ccttgcagct aggaaaacga
      421 ctggaattcg aaaaggaatt agtcctatga atcgtccacc tctaagtgac aagaatatag
      481 aacaatattt tccagtgtta aaaaggaagg caaaccttct gagacaaaat gaagggcaga
      541 ggaaaccagt agcagttctc aagagaccta gccagctaag cagaaaaaat aacattccag
      601 ctaattttac caggagtgga aataaattaa atcatcagaa agatactcgt caggcaactt
      661 ttcttttcag aagaggcctg aaggtgcagg cccagttgaa tacagaacaa ctgctagacg
      721 atgtagtagc aaagagaact cgtcaatggc ggacttccac cacaaatgga gggattttga
      781 ctgtatctat tgacaatcct ggagcagtgc aatgcccagt aactcagaaa ccacgattaa
      841 ctcgtactgc tgtaccttca tttttaacaa agcgggagca aagtgacgtc aagaaagttc
      901 ctaaaggtgt tcccctgcag tttgacataa acagtgtcgg aaaacagaca gggatgacgt
      961 tgaatgagcg gtttgggatc ctgaaggaac aaagagccac tctcacatac aacaaagggg
     1021 gaagccgctt tgtcaccgtg ggataggtcc catgtcaaag gaacttttga gtgatgactc
     1081 tgagaagttg aattgcttga agagttcatc acggaaattc aagaaacttt acttcaaaat
     1141 attcacaagg ctaaataact cttattttta tttttgaagg tttttttttt taaaaaaaaa
     1201 aacgtataaa ataatgccct gaaagaataa tagggattat acctgtctgt tcttaaagat
     1261 ttcatggttg gctcagacag aacaatcatc tgtttgactt ctttggttcc tcatgcagca
     1321 gaaggaagac agaaagatag aaattgatta tttttatgat agcagtattc aggatctcat
     1381 cacctttgcc cgtgttttag actttgtcat ggtaaatcct ggtcttcata aacatgagta
     1441 ggtcccttgg ttgctgtcac ttgcccttta atagtgttga tgtagtcagt gccgttgcct
     1501 tttcttcatt agagacacag aacaatgtat tagaatttcc agctgtgggt ttgaagactt
     1561 agggggacat ccagaacgtg cttcctcttt cagacggtgt aaagtcccct ggaattacac
     1621 agctttagtg ctgagctttt aacaggaaat gtggccctag gtattagtct tagtttaaaa
     1681 tgttggtgtt tagagactgt aaatgcatat tcacaaagtt atctgatagg gccttggagg
     1741 agaaggtcca gttttaaaaa atgacagttt gtgtttaata aatgaaggca tgagaggaag
     1801 taagtagcaa gttgaaggac aggtagttga gatgaaacac ttcaaaaccc tggttataga
     1861 tgtactgttt ggatgtagca tagtcttgag tctagcgtcc acaaagaatt attcaaatga
     1921 tatttagaag aattataact attacattga atggagtccc ttggatattt tgatagtaaa
     1981 attaatagcc ataaagtcct agacttctta tttgaagtta aaatttctta tttgaaaagt
     2041 tgaaatttat gagctttgaa gattgctaaa ttaaataatt tatagctcca aaaacaaaaa
     2101 tatacttgta tatgtcacag agaaaaaaaa tgcaaaattt ataatagagt tacattaacc
     2161 ttgttgttta cctttcactg atttcttata tggtataaat taaagttcag gcatttatgg
     2221 ggagaaaagg ccctccccac cgacccgcca cctgccacct ctgacggagt gggagaagtt
     2281 agtctgtgct aagatagtac tgagtcccca gatgttgtat actgtaaatt acagtataat
     2341 gccaaatgca gcaaaatctt ccagctgtac gttacaagtt tggtcatttt gaagcttgac
     2401 attttagttt gccattatgt taaaaacatc taaataggtg ttagtttctc aggagtagat
     2461 tgttagtgtt gacttttcct gtaaagcaga catcgttctt ggcctgccct gcattgtata
     2521 ctagatttca ttgttgtctc tcatgcttct tgagttgctt catggtttat gctcgccatg
     2581 gaaagctatc agtaacagtt tcatgcttat accaaagaat taaatctgat ctttaatatc
     2641 tgatattttc ctggtactcg tactgataag ggattattgg aagtcagtca cagaatttgg
     2701 aaataaattc tagtctctcc ttagctattt gatgcttttc atataggcca agaactcatt
     2761 gcaaaacatt tttgcaagga tgaatgcctg tatttggtct aggaacagta cattttagtc
     2821 tgatttagaa ttactggtag cttattttaa agcaaggaaa agcagctgag ctcaagtttg
     2881 ctgtctttag aatggtttgt gaaaatatgg tataaaggtg ttttcatttt cctgttctta
     2941 cctattattg tatagagcta ttcatgccat tttttgggaa aactttaaaa attgccccaa
     3001 atactgacat tgagtgcatt aaataacaaa ttatctttga tacattaaac ttttattctt
     3061 catgcatctg taatttaatt ttaagtataa tgttttgcct ttggtacaac taaattaaaa
     3121 ctcttggtgg tcacatattg tatataaaca aaacaatatg ctttgttgaa ggaaaatttt
     3181 ctttattgga atgtggttgt aatccttgtt cagttcttaa gtttcggttt tttttaaaaa
     3241 caggatgcaa cttaaacttt tctttgcatc aaggtatatg caaaacattg gtgccgtgca
     3301 tcaccaaatg aaagtttgta tttaacgagg aggtgcttta cactgtactt tttggtgttt
     3361 tttggaaaag ttacatttag atctattctg aagctgttca tttttaacaa ataaaatgtt
     3421 acaggtttca catgatttat tctcagctct aaagattgag ttgtggtttt tagattgttc
     3481 tatgttacga agaactttgt agtggttatc tatatttgta gtttttaggg tgtgaaacct
     3541 tatctactag caaaattggt aaatcactgt agactcttct attagcatcc ctctctcttt
     3601 tgatgatttc atttgtagct ccaacaaatg aatctaaaaa gaagaatcca ggctgggcac
     3661 ggtggctcat gcctgtaatc ccagaacttg gggaggccaa ggcgggcgga tcatgaggcc
     3721 aggagcaaga ccagcctggc taacataggg agactctatc tttactaaaa atacagacat
     3781 tagctggtgt ggtgacatgt gcctgtggtc ccagctactt gggaggctga ggcgggagaa
     3841 ttgcttgaat ccaggaagca gagattgcag tgagccgaga ccacgccatt gcactccagc
     3901 ctgggtgaca gagtgacact ctgtcttaaa aaaacaaaaa aaaagaatcc agtatacttt
     3961 gcaatgcaga atattgggtt agatgagcct ttagagacta atccagttta acccctcctt
     4021 tttacacctt agtaaagtga gtcctagtgt tttcaagact tgcatgtggc agagttattt
     4081 tttgagctca gatcttctaa ttcttaattg ataataaact gctttggtga attaacaccc
     4141 acagaaaata gtggaatggt gtgtggtttt caaataccta agaattggta atagccatgc
     4201 tttagcattt ttagcatggt aagtaaatct attctaccag tgatggttat actttattac
     4261 tttgctattt gggttaggta gacctgttag aaaagtccag tgttcctaat cagatatgca
     4321 ttttttaaaa acaggcataa actcttcacc acaattttaa ttacagtcat ccctcagtat
     4381 acacggagga ttggttccag gacccttgta tatacccaac cctgcgcaat actgaagtcc
     4441 cacatctgtg taaacgaaaa gttggcccac tgtgtacatg gattttccat tccaagatgt
     4501 ttttttggtt caaaacaatt tgcttataag tagacccagg taattcaaag ccatgttgtt
     4561 gaagggccaa ctgtttaagc caatcgtaaa atactgtgtc tgaggaaaca ggcctcattg
     4621 ctcagcagtg agtttttatt agactaggta tgtatatcat tattaatatt ttactgtaaa
     4681 tagctttgta attcacacaa agtatacggg cccagcaggc ctcattgctc agcagtgagt
     4741 ttttattaga ctaggtatgt atatcattat taatatttta ctgtaaatag ctttgtaatt
     4801 cacacaaagt atacgggccc agaataattt ttgttgattt atttttacta taaggagata
     4861 agagaaaaaa tagctcactt ggcagcacag aaaatgaata ccatattggc aatattaaag
     4921 cagaaaataa ttcatttctg atcagtagtg ctttcagttt tcatcagaat tattattatt
     4981 attattattt tgccactgtg aaaaagcagt taagcatgta aaacttccct ttagagaggg
     5041 ttctttttgg atagatcaat ttggaactag cttctttttt ttttttttaa atgatacttc
     5101 agtaaacaca gcatttacaa caagaattgt ggactatggt ggaccattaa tagggattta
     5161 aagatttact tagaaattgt agacttctaa tatcttttat ttcccttctc accacagttt
     5221 attttctttt ttctttttct tttttttttt ttcttttttt tctttttttg agatggagtt
     5281 tcactcttgt tgcccaggtt ggagtgcaat ggtgcgatct cggctcaccc caacctccgc
     5341 ctcccgggtt caagcaattc tcctgcctca gcctcccaag tggctgggat tacaggtgcc
     5401 caccaccatg cccagttaat tttgcatttt tagtagagac ggggtttctc catgttggtc
     5461 aggctggtct caaactcctg acttcaggtg atctgcctgc ctcggcctcc caaagtgctg
     5521 ggattacagg tgtgagccac cgcacccagc ctacagctta ttttctacct atgtttaaca
     5581 ggaagcttga taacacaagc aaatgtgatg ccattctggg actgaaatgt cgtcttatga
     5641 gtgtattcag atgaggtata ccagtgttta aagattagtt ggaagttatt ctcctagtgt
     5701 gcatatttaa tttctactta ctccatttcc ctttaatgag aaaagaatca tattgtctga
     5761 attttcctgt ataaagttta aaaaagttaa ttattaggac ttgtttttaa aggagtaagc
     5821 aatggaagga tcaaacattt attaaatata ttcagcaaat atttagaatt aaatgtattc
     5881 agcaaggaag agaatgggat tcatactgct tggagtttat aaaagcggag tttttttatt
     5941 ttttgagacg gaatactctg tcacccaggc tgcagtgcag tggcacaatc tcggctcact
     6001 gcagcctctg cctcccagga tcctttccgg gttcaagcaa ttcttgtccc tcagcctcgt
     6061 aagtaggtgg gattacaagc ttgagccacc acagccaact aatttttgtg tttttagtag
     6121 aaatgagttt tcaccatgtt ggccaggctg gtctcgaact cctaccctca ggagatctgc
     6181 ctgcctcagc ttcccaaagt gctgggatta caggtgtgag ccaccacgcc cgccctaaaa
     6241 gtggattctt tttttttttt ttttttttgg agacagtctt gctctgttgc ccaggctgga
     6301 gtgcagtagt gatcttggct cactgcagcc tctgcctccc gggttcaagc gattttcctg
     6361 tctcaacctt ccaagtatct gggattacag gcacgtgcca ctacacccag ctaatttttg
     6421 tactaagacg aggtttcacc atattggcca gtctagtctc aaactcctga cctcaggtga
     6481 tatgcccgcc tctgactccc aaagtgctgg gattacaggc atgagctacg gagcccggcc
     6541 tagaagtgga gtcttagaag gagtgaccat gatatgtttc tactgagtag aagggggaag
     6601 ggaggacata acctttgcat gatatagtga aatgcagagc tggaaagaac tattaagatt
     6661 tgagtgaaac ttttgccccc tgtgttgaat gagttaactt tcagtctgta aaataaacag
     6721 gaagaactgg gaa
//
