LOCUS       NM_002037               3628 bp    mRNA    linear   PRI 11-MAR-2025
DEFINITION  Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN),
            transcript variant 1, mRNA.
ACCESSION   NM_002037
VERSION     NM_002037.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3628)
  AUTHORS   Zhu,J., Shi,L. and Su,Y.
  TITLE     FYN as an emerging biological biomarker for prognosis and potential
            therapeutic target in LGG
  JOURNAL   Neurol Res 46 (9), 787-795 (2024)
   PUBMED   38752708
  REMARK    GeneRIF: FYN as an emerging biological biomarker for prognosis and
            potential therapeutic target in LGG.
REFERENCE   2  (bases 1 to 3628)
  AUTHORS   Shi,Y., Cheng,Y., Wang,W., Tang,L., Li,W., Zhang,L., Yuan,Z.,
            Zhu,F. and Duan,Q.
  TITLE     YANK2 activated by Fyn promotes glioma tumorigenesis via the
            mTOR-independent p70S6K activation pathway
  JOURNAL   Sci Rep 14 (1), 10507 (2024)
   PUBMED   38714727
  REMARK    GeneRIF: YANK2 activated by Fyn promotes glioma tumorigenesis via
            the mTOR-independent p70S6K activation pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3628)
  AUTHORS   Yang,K., Belrose,J., Trepanier,C.H., Lei,G., Jackson,M.F. and
            MacDonald,J.F.
  TITLE     Fyn, a potential target for Alzheimer's disease
  JOURNAL   J Alzheimers Dis 27 (2), 243-252 (2011)
   PUBMED   21799250
  REMARK    GeneRIF: [review] Recent evidence cited in this review suggests
            that alterations in Fyn, a Src family kinase, might contribute to
            Alzheimer's disease pathogenesis.
            Review article
REFERENCE   4  (bases 1 to 3628)
  AUTHORS   Saito,Y.D., Jensen,A.R., Salgia,R. and Posadas,E.M.
  TITLE     Fyn: a novel molecular target in cancer
  JOURNAL   Cancer 116 (7), 1629-1637 (2010)
   PUBMED   20151426
  REMARK    Review article
REFERENCE   5  (bases 1 to 3628)
  AUTHORS   Rigley,K., Slocombe,P., Proudfoot,K., Wahid,S., Mandair,K. and
            Bebbington,C.
  TITLE     Human p59fyn(T) regulates OKT3-induced calcium influx by a
            mechanism distinct from PIP2 hydrolysis in Jurkat T cells
  JOURNAL   J Immunol 154 (3), 1136-1145 (1995)
   PUBMED   7822789
  REMARK    Erratum:[J Immunol 1995 Apr 15;154(8):4223]
REFERENCE   6  (bases 1 to 3628)
  AUTHORS   Gout,I., Dhand,R., Panayotou,G., Fry,M.J., Hiles,I., Otsu,M. and
            Waterfield,M.D.
  TITLE     Expression and characterization of the p85 subunit of the
            phosphatidylinositol 3-kinase complex and a related p85 beta
            protein by using the baculovirus expression system
  JOURNAL   Biochem J 288 (Pt 2) (Pt 2), 395-405 (1992)
   PUBMED   1334406
REFERENCE   7  (bases 1 to 3628)
  AUTHORS   Thomas,P.M. and Samelson,L.E.
  TITLE     The glycophosphatidylinositol-anchored Thy-1 molecule interacts
            with the p60fyn protein tyrosine kinase in T cells
  JOURNAL   J Biol Chem 267 (17), 12317-12322 (1992)
   PUBMED   1351058
REFERENCE   8  (bases 1 to 3628)
  AUTHORS   Brickell,P.M.
  TITLE     The p60c-src family of protein-tyrosine kinases: structure,
            regulation, and function
  JOURNAL   Crit Rev Oncog 3 (4), 401-446 (1992)
   PUBMED   1384720
  REMARK    Review article
REFERENCE   9  (bases 1 to 3628)
  AUTHORS   Kawakami,T., Pennington,C.Y. and Robbins,K.C.
  TITLE     Isolation and oncogenic potential of a novel human src-like gene
  JOURNAL   Mol Cell Biol 6 (12), 4195-4201 (1986)
   PUBMED   3099169
REFERENCE   10 (bases 1 to 3628)
  AUTHORS   Semba,K., Nishizawa,M., Miyajima,N., Yoshida,M.C., Sukegawa,J.,
            Yamanashi,Y., Sasaki,M., Yamamoto,T. and Toyoshima,K.
  TITLE     yes-related protooncogene, syn, belongs to the protein-tyrosine
            kinase family
  JOURNAL   Proc Natl Acad Sci U S A 83 (15), 5459-5463 (1986)
   PUBMED   3526330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA570412.1, M14333.1, Z97989.1
            and BP391373.1.
            
            On Aug 20, 2011 this sequence version replaced NM_002037.4.
            
            Summary: This gene is a member of the protein-tyrosine kinase
            oncogene family. It encodes a membrane-associated tyrosine kinase
            that has been implicated in the control of cell growth. The protein
            associates with the p85 subunit of phosphatidylinositol 3-kinase
            and interacts with the fyn-binding protein. Alternatively spliced
            transcript variants encoding distinct isoforms exist. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M14333.1, M14676.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148, SAMN03267757
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354650.7/ ENSP00000346671.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DA570412.1         1-28
            29-589              M14333.1           1-561
            590-620             DA570412.1         589-619
            621-2606            M14333.1           593-2578
            2607-3161           Z97989.1           77989-78543         c
            3162-3628           BP391373.1         1-467
FEATURES             Location/Qualifiers
     source          1..3628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3628
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /note="FYN proto-oncogene, Src family tyrosine kinase"
                     /db_xref="GeneID:2534"
                     /db_xref="HGNC:HGNC:4037"
                     /db_xref="MIM:137025"
     exon            1..485
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            486..526
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            527..596
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            597..854
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     CDS             608..2221
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /EC_number="2.7.10.2"
                     /note="isoform a is encoded by transcript variant 1;
                     tyrosine-protein kinase Fyn; src-like kinase; c-syn
                     protooncogene; tyrosine kinase p59fyn(T); OKT3-induced
                     calcium influx regulator; src/yes-related novel;
                     proto-oncogene Syn; proto-oncogene c-Fyn; FYN oncogene
                     related to SRC, FGR, YES"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fyn isoform a"
                     /protein_id="NP_002028.1"
                     /db_xref="CCDS:CCDS5094.1"
                     /db_xref="GeneID:2534"
                     /db_xref="HGNC:HGNC:4037"
                     /db_xref="MIM:137025"
                     /translation="MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGV
                     TSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLS
                     FHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAE
                     RQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTR
                     AQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKR
                     LGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS
                     EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLR
                     SANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW
                     SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE
                     ERPTFEYLQSFLEDYFTATEPQYQPGENL"
     exon            855..951
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1050
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1154
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1304
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1469
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1649
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1726
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1880
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2012
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..3628
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2644..2649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /note="hexamer: AATAAA"
     polyA_site      2674
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /note="major polyA site"
     regulatory      3601..3606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
                     /note="hexamer: ATTAAA"
     polyA_site      3628
                     /gene="FYN"
                     /gene_synonym="p59-FYN; SLK; SYN"
ORIGIN      
        1 agagcatcag caagagtagc agcgagcagc cgcgctggtg gcggcggcgc gtcgttgcag
       61 ttgcgccatc tgtcaggagc ggagccggcg aggagggggc tgccgcgggc gaggaggagg
      121 ggtcgccgcg agccgaaggc cttcgagacc cgcccgccgc ccggcggcga gagtagaggc
      181 gaggttgttg tgcgagcggc gcgtcctctc ccgcccgggc gcgccgcgct tctcccagcg
      241 caccgaggac cgcccgggcg cacacaaagc cgccgcccgc gccgcaccgc ccggcggccg
      301 ccgcccgcgc cagggaggga ttcggccgcc gggccgggga caccccggcg ccgccccctc
      361 ggtgctctcg gaaggcccac cggctcccgg gcccgccggg gaccccccgg agccgcctcg
      421 gccgcgccgg aggagggcgg ggagaggacc atgtgagtgg gctccggagc ctcagcgccg
      481 cgcagttttt ttgaagaagc aggatgctga tctaaacgtg gaaaaagacc agtcctgcct
      541 ctgttgtaga agacatgtgg tgtatataaa gtttgtgatc gttggcggac attttggaat
      601 ttagataatg ggctgtgtgc aatgtaagga taaagaagca acaaaactga cggaggagag
      661 ggacggcagc ctgaaccaga gctctgggta ccgctatggc acagacccca cccctcagca
      721 ctaccccagc ttcggtgtga cctccatccc caactacaac aacttccacg cagccggggg
      781 ccaaggactc accgtctttg gaggtgtgaa ctcttcgtct catacgggga ccttgcgtac
      841 gagaggagga acaggagtga cactctttgt ggccctttat gactatgaag cacggacaga
      901 agatgacctg agttttcaca aaggagaaaa atttcaaata ttgaacagct cggaaggaga
      961 ttggtgggaa gcccgctcct tgacaactgg agagacaggt tacattccca gcaattatgt
     1021 ggctccagtt gactctatcc aggcagaaga gtggtacttt ggaaaacttg gccgaaaaga
     1081 tgctgagcga cagctattgt cctttggaaa cccaagaggt acctttctta tccgcgagag
     1141 tgaaaccacc aaaggtgcct attcactttc tatccgtgat tgggatgata tgaaaggaga
     1201 ccatgtcaaa cattataaaa ttcgcaaact tgacaatggt ggatactaca ttaccacccg
     1261 ggcccagttt gaaacacttc agcagcttgt acaacattac tcagagagag ctgcaggtct
     1321 ctgctgccgc ctagtagttc cctgtcacaa agggatgcca aggcttaccg atctgtctgt
     1381 caaaaccaaa gatgtctggg aaatccctcg agaatccctg cagttgatca agagactggg
     1441 aaatgggcag tttggggaag tatggatggg tacctggaat ggaaacacaa aagtagccat
     1501 aaagactctt aaaccaggca caatgtcccc cgaatcattc cttgaggaag cgcagatcat
     1561 gaagaagctg aagcacgaca agctggtcca gctctatgca gtggtgtctg aggagcccat
     1621 ctacatcgtc accgagtata tgaacaaagg aagtttactg gatttcttaa aagatggaga
     1681 aggaagagct ctgaaattac caaatcttgt ggacatggca gcacaggtgg ctgcaggaat
     1741 ggcttacatc gagcgcatga attatatcca tagagatctg cgatcagcaa acattctagt
     1801 ggggaatgga ctcatatgca agattgctga cttcggattg gcccgattga tagaagacaa
     1861 tgagtacaca gcaagacaag gtgcaaagtt ccccatcaag tggacggccc ccgaggcagc
     1921 cctgtacggg aggttcacaa tcaagtctga cgtgtggtct tttggaatct tactcacaga
     1981 gctggtcacc aaaggaagag tgccataccc aggcatgaac aaccgggagg tgctggagca
     2041 ggtggagcga ggctacagga tgccctgccc gcaggactgc cccatctctc tgcatgagct
     2101 catgatccac tgctggaaaa aggaccctga agaacgcccc acttttgagt acttgcagag
     2161 cttcctggaa gactacttta ccgcgacaga gccccagtac caacctggtg aaaacctgta
     2221 aggcccgggt ctgcggagag aggccttgtc ccagaggctg ccccacccct ccccattagc
     2281 tttcaattcc gtagccagct gctccccagc agcggaaccg cccaggatca gattgcatgt
     2341 gactctgaag ctgacgaact tccatggccc tcattaatga cacttgtccc caaatccgaa
     2401 cctcctctgt gaagcattcg agacagaacc ttgttatttc tcagactttg gaaaatgcat
     2461 tgtatcgatg ttatgtaaaa ggccaaacct ctgttcagtg taaatagtta ctccagtgcc
     2521 aacaatccta gtgctttcct tttttaaaaa tgcaaatcct atgtgatttt aactctgtct
     2581 tcacctgatt caactaaaaa aaaaaaagta ttattttcca aaagtggcct ctttgtctaa
     2641 aacaataaaa ttttttttca tgttttaaca aaaaccaatc aggacaggtg tttgtttttg
     2701 ttttcttttt tataaatatg aatatatata atatatatgt ccctgtacat atacaatgtg
     2761 ggtgctaatg tggagactgt ggccggcctg agccaccaag ctgcgggacc cagagggagg
     2821 attttactgc aagtcagcat caaagcaccg gtgttattct gaaaacacca gtggcctcat
     2881 ttttggcttt tgcaaagcat gaattttttc atttggattg cactttcctg gttcatgact
     2941 gtacctgtag gtggttgtta ctttgactct tttcaggaac caccccccaa gctgaattta
     3001 caagttctgt tagcactatt tgcttcaact tactgcgatt tgttctcaaa acttaaaaat
     3061 aagcaagcaa atggctgata ctaccaagag aactggaaga tggataccac acaaacttct
     3121 tgtataaaaa tatgaatgct gaaatgtttc agacattttt aatttaataa acctgtaacc
     3181 acatttaagt gatctaaaac ccatagcatt gtagtcatgg caacccgcta aactttctca
     3241 tgcaactaaa atttctgggg gaaatgaggg tgggggttgt acatttccca ttgtaaaata
     3301 agtgttttaa atgtcctgta ctgctaacga atgactttct atatgtccag gagttctcca
     3361 gtggaataac tatgcactac tttacatttc atggggatgc acaaaaacaa aaaagtatta
     3421 catttttagt tgctgtttgt accaacctta aattacatat gtttaacaac aacaaatcaa
     3481 aaatcctatt tctattgagt ttttaatact gactagcaac tctgaagtct taattccttt
     3541 tttgttatga tttatttgtg agtttacatt tttaaattgt ttaactttct taatttagta
     3601 attaaaaaga gagcatttta catttgaa
//
