LOCUS       NM_001004303            3183 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens FYN binding protein 2 (FYB2), mRNA.
ACCESSION   NM_001004303 XM_496368
VERSION     NM_001004303.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3183)
  AUTHORS   Jung,S.H., Yoo,E.H., Yu,M.J., Song,H.M., Kang,H.Y., Cho,J.Y. and
            Lee,J.R.
  TITLE     ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and
            Integrin-Mediated Adhesion
  JOURNAL   J Immunol 197 (3), 942-952 (2016)
   PUBMED   27335501
  REMARK    GeneRIF: results of this study indicate that a novel T cell adaptor
            protein, activation-dependent, raft-recruited ADAP-like
            phosphoprotein (ARAP), plays a unique role in T cells as a part of
            both the proximal activation signaling and inside-out signaling
            pathways that result in integrin activation and T cell adhesion
REFERENCE   2  (bases 1 to 3183)
  AUTHORS   Qi,Q., Menzaghi,C., Smith,S., Liang,L., de Rekeneire,N.,
            Garcia,M.E., Lohman,K.K., Miljkovic,I., Strotmeyer,E.S.,
            Cummings,S.R., Kanaya,A.M., Tylavsky,F.A., Satterfield,S., Ding,J.,
            Rimm,E.B., Trischitta,V., Hu,F.B., Liu,Y. and Qi,L.
  TITLE     Genome-wide association analysis identifies TYW3/CRYZ and NDST4
            loci associated with circulating resistin levels
  JOURNAL   Hum Mol Genet 21 (21), 4774-4780 (2012)
   PUBMED   22843503
REFERENCE   3  (bases 1 to 3183)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA523424.1, DB193989.1, BX648439.1, BU686304.1, AK093468.1 and
            AL035705.22.
            
            On Nov 23, 2018 this sequence version replaced NM_001004303.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648439.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343433.7/ ENSP00000345972.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               DA523424.1         293-568
            277-590             DB193989.1         244-557
            591-1312            BX648439.1         559-1280
            1313-1907           BU686304.1         70-664              c
            1908-2245           BX648439.1         1876-2213
            2246-2661           AK093468.1         1049-1464
            2662-3168           BX648439.1         2632-3138
            3169-3183           AL035705.22        65274-65288
FEATURES             Location/Qualifiers
     source          1..3183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.2"
     gene            1..3183
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /note="FYN binding protein 2"
                     /db_xref="GeneID:199920"
                     /db_xref="HGNC:HGNC:27295"
                     /db_xref="MIM:618478"
     exon            1..123
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2301
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /note="uncharacterized protein C1orf168; RP4-758N20.2;
                     activation-dependent, raft-recruited ADAP-like
                     phosphoprotein"
                     /codon_start=1
                     /product="FYN-binding protein 2"
                     /protein_id="NP_001004303.3"
                     /db_xref="CCDS:CCDS30729.1"
                     /db_xref="GeneID:199920"
                     /db_xref="HGNC:HGNC:27295"
                     /db_xref="MIM:618478"
                     /translation="MEGEGVRNFKELRAKFQNLDAPPLPGPIKFPAGVSPKGDIGGTQ
                     STQILANGKPLSSNHKQRTPYCSSSESQPLQPQKIKLAQKSEIPKCSNSPGPLGKSTV
                     CSATSSQKASLLLEVTQSNVEIITKEKVMVANSFRNKLWNWEKVSSQKSEMSSALLLA
                     NYGSKAIHLEGQKGMGLTPEEPRKKLETKGAQTLPSQKHVVAPKILHNVSEDPSFVIS
                     QHIRKSWENPPPERSPASSPCQPIYECELASQAPEKQPDVRHHHLPKTKPLPSIDSLG
                     PPPPKPSRPPIVNLQAFQRQPAAVPKTQGEVTVEEGSLSPERLFNAEFEEPHNYEATI
                     SYLRHSGNSINLCTAKEIADPTYEVGIEELQKPGKNFPYPEPSAKHEDKKMKEKQPCE
                     LKPKNTEKEPYSNHVFKVDACEGTPEKIQMTNVHTGRRNMLAGKQEAMIDIIQTNPCP
                     EGPKLARHSQGHCGHLEVLESTKETPDLGVSKTSSISEEIYDDVEYSRKEVPKLNYSS
                     SLASSSEENRELYEDVYKTKNNYPKIDLDGKEALKRLQQFFKKEKDRFKIKKTKSKEN
                     LSAFSILLPDLELKSQEVIIYDDVDLSEKESKDEDKLKMWKPKFLTPKEKKEKNGAEE
                     SESFSPRNFFKTKKQNLEKNRMKREEKLFRERFKYDKEIIVINTAVACSNNSRNGIFD
                     LPISPGEELEVIDTTEQNLVICRNSKGKYGYVLIEHLDFKHQSWSP"
     exon            124..871
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1033
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1067
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1177
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1212
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1244
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1341
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1501
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1616
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1657
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1718
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1817
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1846
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1907
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1994
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2088
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2245
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2279
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..3183
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2448..2453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /note="hexamer: AATAAA"
     polyA_site      2468
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
     regulatory      3083..3088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /note="hexamer: AATAAA"
     polyA_site      3102
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /note="major polyA site"
     regulatory      3150..3155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
                     /note="hexamer: AATAAA"
     polyA_site      3183
                     /gene="FYB2"
                     /gene_synonym="ARAP; C1orf168"
ORIGIN      
        1 gtgggaagtg attgctccct ggctagcaga gacagaggaa agcggattgt tggccccagg
       61 acccagctct gagaggctgg gcttgtttcc ctgactctgc cttggaggaa agcaatggaa
      121 ggggaagggg taagaaactt caaggaactt cgagccaaat ttcaaaatct tgatgctcca
      181 cctcttccag gacctattaa attcccagca ggtgtttctc caaagggtga cattggaggc
      241 acacagtcaa ctcaaatttt ggccaatggg aaacccctct catccaacca caagcagcgc
      301 acaccatact gttccagtag tgagtcccag cctcttcaac ctcagaaaat aaagttggct
      361 cagaagagtg aaattccaaa atgttctaac tccccagggc ctctgggaaa gtctactgta
      421 tgttctgcaa caagttcaca gaaggcttct ctgctgttag aggtgactca atcaaatgtt
      481 gagataatca ctaaggaaaa agtaatggtg gccaatagct tcagaaacaa actctggaac
      541 tgggagaagg tttcatctca gaaaagtgaa atgtcttcag cccttctcct tgccaactat
      601 ggaagtaagg ccatccatct ggaagggcaa aaaggcatgg ggcttactcc agaggaaccc
      661 aggaaaaagc tggaaacaaa aggagcccag actcttcctt cccagaagca cgtggtggcc
      721 cccaaaatat tacataacgt ctctgaagat ccctcttttg taatttctca acatatcaga
      781 aaaagctggg aaaacccacc tcctgagagg agcccggcaa gcagcccctg ccagcccatc
      841 tatgagtgtg agcttgccag tcaggcccca gaaaaacagc cagatgtcag gcatcaccac
      901 cttcccaaaa caaagccatt gccctccatc gactccctgg gtcctcctcc cccaaagcct
      961 tcaagacctc ccatcgtgaa cctccaggcc tttcagaggc agccagctgc tgttcccaag
     1021 actcaggggg aagtgactgt ggaagagggc tccctgtctc cagagaggct tttcaatgca
     1081 gaatttgaag aaccacataa ttacgaggca acaatttcat atctgagaca ctctggcaac
     1141 tccattaacc tgtgcactgc aaaagaaatt gctgatccaa cttatgaagt tggaattgaa
     1201 gaactccaaa agcctgggaa gaattttccc tatccagaac ctagtgctaa acatgaagat
     1261 aaaaaaatga aggaaaaaca accatgtgaa ttgaaaccta aaaacacaga aaaggaacca
     1321 tattcaaacc atgttttcaa ggtagatgcc tgtgaaggga cacctgaaaa aattcagatg
     1381 accaacgtcc acacaggtag aaggaacatg ttggctggaa agcaagaggc catgattgac
     1441 atcatccaga caaatccctg ccctgagggc ccaaagctgg ccaggcactc ccaaggccac
     1501 tgtgggcatc tggaggtttt ggagtcaact aaagaaactc cagacctagg ggtctctaag
     1561 acaagttcca tctcggagga gatatatgat gatgtcgagt actccaggaa agaggtaccg
     1621 aagctgaact actctagctc acttgcctca agtagtgaag aaaatagaga actgtatgaa
     1681 gatgtctaca aaacaaagaa caactaccca aagatagatt tagatggaaa agaagcactc
     1741 aaaagactgc agcaattctt caagaaagaa aaggatagat ttaaaataaa gaaaaccaag
     1801 tcgaaagaaa acttaagtgc attttccatt ttgctgcctg atttagaact taagtctcag
     1861 gaagttatta tttatgatga tgtagacctg agtgaaaaag agtcaaaaga tgaagataaa
     1921 ctgaaaatgt ggaagcccaa gtttctgaca ccaaaggaaa aaaaagagaa aaacggtgct
     1981 gaagaatcag aaagtttctc tcctagaaat ttcttcaaaa ccaagaagca aaacttagaa
     2041 aagaacagaa tgaaaagaga agaaaaacta tttagagaaa ggtttaagta cgacaaagag
     2101 attattgtca tcaatacagc agtggcctgt tccaataatt caagaaatgg aatatttgat
     2161 ttgccaataa gtcctggaga agaattggaa gtcattgata ccaccgaaca aaatctagtg
     2221 atatgtcgta attctaaagg caaatatgga tatgtgctca ttgaacatct agatttcaag
     2281 catcaaagtt ggtcacctta gaaaaatcaa gatcaaatgc tatggactgc acaaaggaga
     2341 actagtccta agatcctagt cctgcgttac atcagtttca gtttacatgt caaaattttg
     2401 agatggtgga atctgtggaa actttcgttc tgaacttaaa agagaaaaat aaaaacaaat
     2461 cctcaacatt tagatgttgg ttttactcct aaaaggttat ctttcaatgt ctatttcagt
     2521 atctacttca ctgtcagttc aagagaatgt gaaacagtat gtgttagcat ttgagcactt
     2581 atttaatgag ccatatccaa agttagaaat catgccttat ggcacctagt cagttgtgca
     2641 gatggttagt ttgcttctaa tattagtata tgagcatttg taatttctag atgttgtgca
     2701 ctcaaacttg gtataattta attctgaaca gtaaacagtg taaccaaggt cttttaaata
     2761 ctcaagttta aggtataatc ttaattatgg ctcagtcttt aaaaaagtat aaatgtcctt
     2821 ttactttatc acaaaaataa actcatatga atactgttcc acatttgttt cttttgggaa
     2881 tagtttgcag aaaaataatt tattcctaaa ttcacccatc attttaagaa gtgcccaaat
     2941 gtatttaaca aaataatata tatgctgtat tactttaaaa catctttttg tccaaaataa
     3001 gaacaattgt cattattttg tctatgccca aataactatt caaataatag cattcatatg
     3061 tactttcatt tatatggaat taaataaaaa tttaaaagct gacatctatt ctgtttttta
     3121 aatgaggtgc actgcatgtc aataagagaa ataaattcta catatgcatt taacagttta
     3181 aaa
//
