LOCUS       NM_001465               4829 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens FYN binding protein 1 (FYB1), transcript variant 1,
            mRNA.
ACCESSION   NM_001465
VERSION     NM_001465.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4829)
  AUTHORS   Li,M., Qiao,R., Zhong,R., Wei,Y., Wang,J., Zhang,Z., Wang,L.,
            Xu,T., Wang,Y., Dai,L., Gu,W., Han,B. and Yang,R.
  TITLE     FYB methylation in peripheral blood as a potential marker for the
            early-stage lung cancer: a case-control study in Chinese population
  JOURNAL   Biomarkers 27 (1), 79-85 (2022)
   PUBMED   34882057
  REMARK    GeneRIF: FYB methylation in peripheral blood as a potential marker
            for the early-stage lung cancer: a case-control study in Chinese
            population.
REFERENCE   2  (bases 1 to 4829)
  AUTHORS   Dadwal,N., Mix,C., Reinhold,A., Witte,A., Freund,C., Schraven,B.
            and Kliche,S.
  TITLE     The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1
            and SKAP2 for TCR/CD3 -Mediated Signaling Events
  JOURNAL   Front Immunol 12, 703534 (2021)
   PUBMED   34295339
  REMARK    GeneRIF: The Multiple Roles of the Cytosolic Adapter Proteins ADAP,
            SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4829)
  AUTHORS   Lewis,J.B., Scangarello,F.A., Murphy,J.M., Eidell,K.P.,
            Sodipo,M.O., Ophir,M.J., Sargeant,R., Seminario,M.C. and
            Bunnell,S.C.
  TITLE     ADAP is an upstream regulator that precedes SLP-76 at sites of TCR
            engagement and stabilizes signaling microclusters
  JOURNAL   J Cell Sci 131 (21) (2018)
   PUBMED   30305305
  REMARK    GeneRIF: Findings reveal that ADAP acts upstream of SLP-76 to
            convert labile, Ca(2+)-competent microclusters into stable adhesive
            junctions with enhanced signaling potential.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4829)
  AUTHORS   Xiong,Y., Ye,C., Yang,N., Li,M. and Liu,H.
  TITLE     Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment,
            Rac1 Activation, and Integrin-Mediated T Cell Adhesion
  JOURNAL   J Immunol 199 (12), 4142-4154 (2017)
   PUBMED   29127148
  REMARK    GeneRIF: Ubc9 is an essential regulator of ADAP where it is
            required for TCR-induced membrane recruitment of the small GTPase
            Rap1 and its effector protein RapL and for activation of the small
            GTPase Rac1 in T cell adhesion.
REFERENCE   5  (bases 1 to 4829)
  AUTHORS   Jung,S.H., Yoo,E.H., Yu,M.J., Song,H.M., Kang,H.Y., Cho,J.Y. and
            Lee,J.R.
  TITLE     ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and
            Integrin-Mediated Adhesion
  JOURNAL   J Immunol 197 (3), 942-952 (2016)
   PUBMED   27335501
  REMARK    GeneRIF: results of this study indicate that a novel T cell adaptor
            protein, activation-dependent, raft-recruited ADAP-like
            phosphoprotein (ARAP), plays a unique role in T cells as a part of
            both the proximal activation signaling and inside-out signaling
            pathways that result in integrin activation and T cell adhesion
REFERENCE   6  (bases 1 to 4829)
  AUTHORS   Marie-Cardine,A., Hendricks-Taylor,L.R., Boerth,N.J., Zhao,H.,
            Schraven,B. and Koretzky,G.A.
  TITLE     Molecular interaction between the Fyn-associated protein SKAP55 and
            the SLP-76-associated phosphoprotein SLAP-130
  JOURNAL   J Biol Chem 273 (40), 25789-25795 (1998)
   PUBMED   9748251
REFERENCE   7  (bases 1 to 4829)
  AUTHORS   Liu,J., Kang,H., Raab,M., da Silva,A.J., Kraeft,S.K. and Rudd,C.E.
  TITLE     FYB (FYN binding protein) serves as a binding partner for lymphoid
            protein and FYN kinase substrate SKAP55 and a SKAP55-related
            protein in T cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8779-8784 (1998)
   PUBMED   9671755
REFERENCE   8  (bases 1 to 4829)
  AUTHORS   da Silva,A.J., Li,Z., de Vera,C., Canto,E., Findell,P. and
            Rudd,C.E.
  TITLE     Cloning of a novel T-cell protein FYB that binds FYN and
            SH2-domain-containing leukocyte protein 76 and modulates
            interleukin 2 production
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7493-7498 (1997)
   PUBMED   9207119
REFERENCE   9  (bases 1 to 4829)
  AUTHORS   Musci,M.A., Hendricks-Taylor,L.R., Motto,D.G., Paskind,M.,
            Kamens,J., Turck,C.W. and Koretzky,G.A.
  TITLE     Molecular cloning of SLAP-130, an SLP-76-associated substrate of
            the T cell antigen receptor-stimulated protein tyrosine kinases
  JOURNAL   J Biol Chem 272 (18), 11674-11677 (1997)
   PUBMED   9115214
REFERENCE   10 (bases 1 to 4829)
  AUTHORS   da Silva,A.J., Janssen,O. and Rudd,C.E.
  TITLE     T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the
            SH2 domain of p59fyn(T)
  JOURNAL   J Exp Med 178 (6), 2107-2113 (1993)
   PUBMED   7504057
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA585094.1, AV761195.1,
            BC117449.1, AK297077.1 and AC008964.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 24, 2019 this sequence version replaced NM_001465.5.
            
            Summary: The protein encoded by this gene is an adapter for the FYN
            protein and LCP2 signaling cascades in T-cells. The encoded protein
            is involved in platelet activation and controls the expression of
            interleukin-2. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2011].
            
            Transcript Variant: This variant (1) differs in the 5' UTR and uses
            a downstream start codon compared  to variant 3. The resulting
            isoform (1) has a shorter N-terminus compared to isoform 3.
            Variants 1 and 4 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.178284.1,
                                           SRR1803613.118254.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000512982.4/ ENSP00000425845.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                DA585094.1         44-93
            51-86               AV761195.1         50-85
            87-2299             BC117449.1         1-2213
            2300-2779           AK297077.1         2268-2747
            2780-4829           AC008964.6         16224-18273
FEATURES             Location/Qualifiers
     source          1..4829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..4829
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /note="FYN binding protein 1"
                     /db_xref="GeneID:2533"
                     /db_xref="HGNC:HGNC:4036"
                     /db_xref="MIM:602731"
     exon            1..121
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            122..1283
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..2638
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adhesion and degranulation-promoting adaptor protein;
                     p120/p130; FYB-120/130; FYN-T-binding protein;
                     SLP-76-associated phosphoprotein"
                     /codon_start=1
                     /product="FYN-binding protein 1 isoform 1"
                     /protein_id="NP_001456.3"
                     /db_xref="CCDS:CCDS54848.1"
                     /db_xref="GeneID:2533"
                     /db_xref="HGNC:HGNC:4036"
                     /db_xref="MIM:602731"
                     /translation="MAKYNTGGNPTEDVSVNSRPFRVTGPNSSSGIQARKNLFNNQGN
                     ASPPAGPSNVPKFGSPKPPVAVKPSSEEKPDKEPKPPFLKPTGAGQRFGTPASLTTRD
                     PEAKVGFLKPVGPKPINLPKEDSKPTFPWPPGNKPSLHSVNQDHDLKPLGPKSGPTPP
                     TSENEQKQAFPKLTGVKGKFMSASQDLEPKPLFPKPAFGQKPPLSTENSHEDESPMKN
                     VSSSKGSPAPLGVRSKSGPLKPAREDSENKDHAGEISSLPFPGVVLKPAASRGGPGLS
                     KNGEEKKEDRKIDAAKNTFQSKINQEELASGTPPARFPKAPSKLTVGGPWGQSQEKEK
                     GDKNSATPKQKPLPPLFTLGPPPPKPNRPPNVDLTKFHKTSSGNSTSKGQTSYSTTSL
                     PPPPPSHPASQPPLPASHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQDGVTHSDGAGN
                     LDEEQDSEGETYEDIEASKEREKKREKEEKKRLELEKKEQKEKEKKEQEIKKKFKLTG
                     PIQVIHLAKACCDVKGGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTA
                     VEIDYDSLKLKKDSLGAPSRPIEDDQEVYDDVAEQDDISSHSQSGSGGIFPPPPDDDI
                     YDGIEEEDADDGSTLQVQEKSNTWSWGILKMLKGKDDRKKSIREKPKVSDSDNNEGSS
                     FPAPPKQLDMGDEVYDDVDTSDFPVSSAEMSQGTNVGKAKTEEKDLKKLKKQEKEEKD
                     FRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESLEVIQTTDDTKVLCRNEE
                     GKYGYVLRSYLADNDGEIYDDIADGCIYDND"
     exon            1284..1440
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1487
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1507
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1542
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1663
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1823
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1965
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..1988
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2055
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2193
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2219
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2286
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2386
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2549
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2583
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2615
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..4829
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4805..4810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /note="hexamer: AATAAA"
     regulatory      4809..4814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /note="hexamer: AATAAT"
     polyA_site      4826
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
                     /note="major polyA site"
     polyA_site      4829
                     /gene="FYB1"
                     /gene_synonym="ADAP; FYB; PRO0823; SLAP-130; SLAP130;
                     THC3"
ORIGIN      
        1 gcagttcttg agttccacat gcagagcaga tgcgacagct agaagtgagt agggcccaga
       61 ccctggccca ggaagatcca ctaaaggagg ccatccttcc gccttcttct gcaggagtca
      121 ggatggaaag gcagatgtaa agtccctcat ggcgaaatat aacacggggg gcaacccgac
      181 agaggatgtc tcagtcaata gccgaccctt cagagtcaca gggccaaact catcttcagg
      241 aatacaagca agaaagaact tattcaacaa ccaaggaaat gccagccctc ctgcaggacc
      301 cagcaatgta cctaagtttg ggtccccaaa gccacctgtg gcagtcaaac cttcttctga
      361 ggaaaagcct gacaaggaac ccaagccccc gtttctaaag cccactggag caggccaaag
      421 attcggaaca ccagccagct tgaccaccag agaccccgag gcgaaagtgg gatttctgaa
      481 acctgtaggc cccaagccca tcaacttgcc caaagaagat tccaaaccta catttccctg
      541 gcctcctgga aacaagccat ctcttcacag tgtaaaccaa gaccatgact taaagccact
      601 aggcccgaaa tctgggccta ctcctccaac ctcagaaaat gaacagaagc aagcgtttcc
      661 caaattgact ggggttaaag ggaaatttat gtcagcatca caagatcttg aacccaagcc
      721 cctcttcccc aaacccgcct ttggccagaa gccgccccta agtaccgaga actcccatga
      781 agacgaaagc cccatgaaga atgtgtcttc atcaaaaggg tccccagctc ccctgggagt
      841 caggtccaaa agcggccctt taaaaccagc aagggaagac tcagaaaata aagaccatgc
      901 aggggagatt tcaagtttgc cctttcctgg agtggttttg aaacctgctg cgagcagggg
      961 aggcccaggt ctctccaaaa atggtgaaga aaaaaaggaa gataggaaga tagatgctgc
     1021 taagaacacc ttccagagca aaataaatca ggaagagttg gcctcaggga ctcctcctgc
     1081 caggttccct aaggcccctt ctaagctgac agtggggggg ccatggggcc aaagtcagga
     1141 aaaggaaaag ggagacaaga attcagccac cccgaaacag aagccattgc ctcccttgtt
     1201 taccttgggt ccacctccac caaaacccaa cagaccacca aatgttgacc tgacgaaatt
     1261 ccacaaaacc tcttctggaa acagtactag caaaggccag acgtcttact caacaacttc
     1321 cctgccacca cctccaccat cccatccggc cagccaacca ccattgccag catctcaccc
     1381 atcacaacca ccagtcccaa gcctacctcc cagaaacatt aaacctccgt ttgacctaaa
     1441 aagccctgtc aatgaagaca atcaagatgg tgtcacgcac tctgatggtg ctggaaatct
     1501 agatgaggaa caagacagtg aaggagaaac atatgaagac atagaagcat ccaaagaaag
     1561 agagaagaaa agggaaaagg aagaaaagaa gaggttagag ctggagaaaa aggaacagaa
     1621 agagaaagaa aagaaagaac aagaaataaa gaagaaattt aaactaacag gccctattca
     1681 agtcatccat cttgcaaaag cttgttgtga tgtcaaagga ggaaagaatg aactgagctt
     1741 caagcaagga gagcaaattg aaatcatccg catcacagac aacccagaag gaaaatggtt
     1801 gggcagaaca gcaaggggtt catatggcta tattaaaaca actgctgtag agattgacta
     1861 tgattctttg aaactgaaaa aagactctct tggtgcccct tcaagaccta ttgaagatga
     1921 ccaagaagta tatgatgatg ttgcagagca ggatgatatt agcagccaca gtcagagtgg
     1981 aagtggaggg atattccctc caccaccaga tgatgacatt tatgatggga ttgaagagga
     2041 agatgctgat gatggctcca cactacaggt tcaagagaag agtaatacgt ggtcctgggg
     2101 gattttgaag atgttaaagg gaaaagatga cagaaagaaa agtatacgag agaaacctaa
     2161 agtctctgac tcagacaata atgaaggttc atctttccct gctcctccta aacaattgga
     2221 catgggagat gaagtttacg atgatgtgga tacctctgat ttccctgttt catcagcaga
     2281 gatgagtcaa ggaactaatg ttggaaaagc taagacagaa gaaaaggacc ttaagaagct
     2341 aaaaaagcag gaaaaagaag aaaaagactt caggaaaaaa tttaaatatg atggtgaaat
     2401 tagagtccta tattcaacta aagttacaac ttccataact tctaaaaagt ggggaaccag
     2461 agatctacag gtaaaacctg gtgaatctct agaagttata caaaccacag atgacacaaa
     2521 agttctctgc agaaatgaag aagggaaata tggttatgtc cttcggagtt acctagcgga
     2581 caatgatgga gagatctatg atgatattgc tgatggctgc atctatgaca atgactagca
     2641 ctcaactttg gtcattctgc tgtgttcatt aggtgccaat gtgaagtctg gattttaatt
     2701 ggcatgttat tgggtatcaa gaaaattaat gcacaaaacc acttattatc atttgttatg
     2761 aaatcccaat tatctttaca aagtgtttaa agtttgaaca tagaaaataa tctctctgct
     2821 taattgttaa ctcagaagac tacattagtg agatgtaaga attattaaat attccatttc
     2881 cgctttggct acaattatga agaagttgaa ggtacttctt ttagaccacc agtaaataat
     2941 cctccttcaa aaaataaaaa taaaagaaaa aggaaaatca ttcaggaaga aatgacctgt
     3001 ctaaaaaaac ctaaggaaga ataataatat aagaaaggaa atttaaaaac attccacaag
     3061 aagaaaaatt attgtttata cttctactta tggttatatc ttatattctc tattcaagtg
     3121 acctgtcttt taaaaaggca gtgctgtctt acctcttgct agtgggttaa atgttttcaa
     3181 aaattatagc agtagtagaa gttttgtata aaatttgtcc ttatttgtta attgtatata
     3241 aatgttaatt atttgatacg aatgttatgc atttagtatg cacattgaag tctaaactgt
     3301 agaagagtct aaaacaagtt ctctttttgc agattcacat actaatggtt taattctgtg
     3361 ctctgtttaa agtactatta taactagagt agatctgaat gaggataacc ctaaaatcat
     3421 gaggaatgga agaatggacc ttgaaactac ctaggctttt atgcatggca cctctttata
     3481 atgaagacac tttttaaagt ttttgttttt gtttcaatta ccgctagatt tttttttctc
     3541 tttttttaaa atccatttta ctggaaagtt ggccagcaga gggagtagaa attattaaaa
     3601 ttctagtgtt tggattgggc ccttctctaa cagtacatac tcattcccaa agcaatccaa
     3661 aaacaaaatg tgaaccattt gggtttcaaa tgttaagaac actaaatagc atgatttaaa
     3721 aaatgaaaaa tgctaacacc caagaaaaga agatattaag tgctttttaa caactcctag
     3781 agtacaaaat gagtacatca taatgctggc tcttctacta atgaaccatc gagtgatatt
     3841 gaataaatta tttatcttct cagtttcctt atctgtaaat tacaatatta gactaagtaa
     3901 gtttttccaa ctcttcacta ccaattacct taggctttta taatgctccg cctacttcag
     3961 tcccatgttt cagaagcttt tgtctatttt ttaaactcat tgattaaata atgattaatg
     4021 cattctccac attttaatat tgcaaaggcc cattggagtt tctgaagtgg ctccacagaa
     4081 ttgaaataat ttcaaataac tgtaaaggaa ctgaaaatct tcacagagat gaagtggggt
     4141 ttccattagg tgctttgaaa tttgataaca aatcatcaac ttccactggt caatatatag
     4201 attttgggtg tctgaggccc caagattaga tgccactaat ctccaaagat tccctccaat
     4261 tatgaaatat tttaatgtct acttttagag agcactagcc agtatatgac catgtgatta
     4321 atttcttttc acactagata aaattacctg gttcaaaagt ggtttttgtt tattaaattt
     4381 ggtaataaat atatataata cacagacagg atagttttta tgctgaagtt tttggccagc
     4441 tttagtttga ggactccttg ataagcttgc taaactttca gagtgccctg agacacttcc
     4501 agccatccct cctcctgcct tcattggggc agacttgcat tgcagtctga cagtaatttt
     4561 ttttctgatt gagaattatg taaattcagt acaatgtcag tttttaaaag tcaaagttag
     4621 atcaagagaa tatttcagag ttttggttta cacatcaaga aacagacaca catacctagg
     4681 aaagatttac acaatagata atcatcttaa tgtgaaagat atttgaagta ttaattttaa
     4741 tatattaaat atgatttctg ttatagtctt ctgtatggaa ttttgtcact taagatgagc
     4801 tgcaaataaa taataccttc aatggataa
//
